Feasibility and response to 1-(4-amino-2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride chemotherapy with pre-treated procarbazine for elderly patients with newly diagnosed glioblastoma

Journal of Neuro-Oncology

Volumn 81, Issue 3, 2007, Pages 265-269

  Terasaki, Mizuhiko ^a   Abe, Toshi ^a   Miyagi, Naohisa ^a   Ogo, Etsuyo ^a   Shigemori, Minoru ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

ACNU; Adjuvant therapy; Elderly; Glioblastoma; Procarbazine

Indexed keywords

CEPHARANTHINE; NIMUSTINE; PROCARBAZINE; VINCRISTINE;

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DRUG FATALITY; ELDERLY CARE; FEASIBILITY STUDY; FEMALE; GLIOBLASTOMA; HISTOPATHOLOGY; HUMAN; KIDNEY DISEASE; MALE; MULTIPLE CYCLE TREATMENT; NEUROLOGIC DISEASE; NEUROSURGERY; NEUTROPENIA; OVERALL SURVIVAL; PERIPHERAL NEUROPATHY; PNEUMOCYSTIS PNEUMONIA; SEPSIS; THROMBOCYTOPENIA; TREATMENT OUTCOME;

AGED; ALKALOIDS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BENZYLISOQUINOLINES; BRAIN NEOPLASMS; DISEASE-FREE SURVIVAL; FEASIBILITY STUDIES; FEMALE; GLIOBLASTOMA; HUMANS; MALE; MIDDLE AGED; NEUTROPENIA; NIMUSTINE; PROCARBAZINE; SURVIVAL ANALYSIS; TREATMENT OUTCOME; VINCRISTINE;

EID: 33846520629     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-006-9223-0     Document Type: Article

References (13)

1. Devaux BC, O'Fallon JR, Kelly PJ (1993) Resection, biopsy, and survival in malignant glial neoplasms: A retrospective study of clinical parameters, therapy, and outcome. J Neurosurg 78:767-775
2. Davis FG, Freels S, Grutsch J, Barlas S, Brem S (1998) Survival rates in patients with primary malignant brain tumors stratified by patient age and tumor histological type: An analysis based on surveillance, epidemiology, and end results (SEER) data, 1973-1991. J Neurosurg 88:1-10
3. Mohan DS, Suh JH, Phan JL, Kupelian PA, Cohen BH, Barnett GH (1998) Outcome in elderly patients undergoing definitive surgery and radiation therapy for supratentorial glioblastoma multiforme at a tertiary care institution. Int Radiat Oncol Biol Phys 42:981-987
4. Mangiola A, Maira G, De Bonis P, Porso M, Pettorini B, Sabatino G, Anile C (2006) Glioblastoma multiforme in the elderly: A therapeutic challenge. J Neurooncol 76:159-163
5. 6 -alkylguanine-DNA alkyltransferase in rat tissues. Carcinogenesis 15:1681-1688
6. Hirai M, Tanaka K, Shimizu T, Tanigawara Y, Yasuhara M, Hori R, Kakehi Y, Yoshida O, Ueda K, Komano T (1995) Cepharantin, a multidrug resistant modifier, is a substrate for p-glycoprotein. J Pharmacol Exp Ther 275:73-78
7. Ogawa K, Yoshii Y, Inoue O, Toita T, Saito A, Kakinohana Y, Adachi G, Ishikawa Y, Kin S, Murayama S (2003) Prospective trial of radiotherapy after hyperbaric oxygenation with chemotherapy for high-grade gliomas. Radiother Oncol 67:63-67
8. Chinot OL, Barrie M, Frauger E, Dufour H, Figarella-Branger D, Palmari J, Braguer D, Hoang-Xuan K, Moktari K, Peragut JC, Martin PM, Grisoli F (2004) Phase II study of temozolomide without radiotherapy in newly diagnosed glioblastoma multiforme in an elderly population. Cancer 100:2208-2214
9. Pierga JY, Hoang-Xuan K, Feuvret L, Simon JM, Cornu P, Baillet F, Mazeron JJ, Delattre JY (1999) Treatment of malignant gliomas in the elderly. J Neuro Oncol 43:187-193
10. Gilbert MR, Friedman HS, Kuttesch JF, Prados MD, Olson JJ, Reaman GH, Zaknoen SL (2002) A phase II study of temozolomide in patients with newly diagnosed supratentorial malignant glioma before radiation therapy. Neuro Oncol 4:261-267
11. Brandes AA, Vastola F, Basso U, Berti F, Pinna G, Rotilio A, Gardiman M, Scienza R, Monfardini S, Ermani M (2003) A prospective study on glioblastoma in the elderly. Cancer 97:657-662
12. Guyotat J, Signorelli F, Frappaz D, Madarassy G, Ricci AC, Bret P (2000) Is reoperation for recurrence of glioblastoma justified? Oncol Rep 7:899-904
13. Grant R, Liang BC, Page MA, Crane DL, Greenberg HS, Junck L (1995) Age influences chemotherapy response in astrocytomas. Neurology 45:929-933