Mapping the reaction coordinates of enzymatic defluorination

Journal of the American Chemical Society

Volumn 133, Issue 19, 2011, Pages 7461-7468

  Chan, Peter W Y ^a,c   Yakunin, Alexander F ^b   Edwards, Elizabeth A ^b   Pai, Emil F ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIOCATALYTIC ACTIVITY; DEFLUORINATION; DEHALOGENASE; FLUORIDE ION; FLUOROACETATE; FREE ENZYME; GROWING MARKETS; HALOGEN ATOMS; HIGH RESOLUTION; INDUSTRIAL SECTOR; MICHAELIS COMPLEX; MOLECULAR BASIS; ORGANIC CHEMISTRY; PHYSIOLOGICAL CONDITION; REACTION COORDINATES;

BIODEGRADATION; DETOXIFICATION; ENZYMES; FLUORINE; HYDROGEN BONDS; LEAD COMPOUNDS; REACTION INTERMEDIATES;

SYNTHESIS (CHEMICAL);

CARBON; FLUORINE; FLUOROACETATE DEHALOGENASE; HALIDE; HALOGEN; HYDROLASE; UNCLASSIFIED DRUG;

ARTICLE; BURKHOLDERIA; COMPLEX FORMATION; CRYSTAL STRUCTURE; DEFLUORINATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; NONHUMAN;

BIOCATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; FLUORINE; HYDROGEN BONDING; HYDROLASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

EID: 79955928285     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja200277d     Document Type: Article

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