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Volumn 86, Issue 6, 2009, Pages 595-598

Current understanding of the pharmacogenomics of metformin

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; CIMETIDINE; METFORMIN; OCTAMER TRANSCRIPTION FACTOR 1; OCTAMER TRANSCRIPTION FACTOR 2; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN KINASE; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

EID: 70450149001     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2009.144     Document Type: Review
Times cited : (31)

References (13)
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    • Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics
    • Shu, Y. et al. Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin. Pharmacol. Ther. 83, 273-280 (2008).
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    • Shu, Y.1
  • 2
    • 54249106729 scopus 로고    scopus 로고
    • Genetic variants of the organic cation transporter 2 influence the disposition of metformin
    • Song, I.S. et al. Genetic variants of the organic cation transporter 2 influence the disposition of metformin. Clin. Pharmacol. Ther. 84, 559-562 (2008).
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    • Song, I.S.1
  • 3
    • 53049095113 scopus 로고    scopus 로고
    • OCT2 polymorphisms and in-vivo renal functional consequence: Studies with metformin and cimetidine
    • Wang, Z.J., Yin, O.Q., Tomlinson, B. & Chow, M.S. OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine. Pharmacogenet. Genomics 18, 637-645 (2008).
    • (2008) Pharmacogenet. Genomics , vol.18 , pp. 637-645
    • Wang, Z.J.1    Yin, O.Q.2    Tomlinson, B.3    Chow, M.S.4
  • 4
    • 34248156160 scopus 로고    scopus 로고
    • Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
    • Shu, Y. et al. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J. Clin. Invest. 117, 1422-1431 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 1422-1431
    • Shu, Y.1
  • 5
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    • The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin
    • Tzvetkov, M.V. et al. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Clin. Pharmacol. Ther. 86, 299-306 (2009).
    • (2009) Clin. Pharmacol. Ther. , vol.86 , pp. 299-306
    • Tzvetkov, M.V.1
  • 6
    • 0034935038 scopus 로고    scopus 로고
    • Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene
    • Jonker, J.W. et al. Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene. Mol. Cell. Biol. 21, 5471-5477 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 5471-5477
    • Jonker, J.W.1
  • 7
    • 66649121405 scopus 로고    scopus 로고
    • Reduced function SLC22A1 polymorphisms encoding Organic Cation Transporter 1 (OCT1) and glycaemic response to metformin: A Go-DARTS study
    • Zhou, K. et al. Reduced function SLC22A1 polymorphisms encoding Organic Cation Transporter 1 (OCT1) and glycaemic response to metformin: a Go-DARTS study. Diabetes 58, 1434-1439 (2009).
    • (2009) Diabetes , vol.58 , pp. 1434-1439
    • Zhou, K.1
  • 8
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    • Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin
    • Shikata, E. et al. Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin. J. Hum. Genet. 52, 117-122 (2007).
    • (2007) J. Hum. Genet. , vol.52 , pp. 117-122
    • Shikata, E.1
  • 9
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    • Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: A preliminary study
    • Becker, M.L., Visser, L.E., van Schaik, R.H., Hofman, A., Uitterlinden, A.G. & Stricker, B.H. Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study. Diabetes 58, 745-749 (2009).
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  • 10
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    • Sirtori, C.R.1
  • 12
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    • Targeted disruption of the multidrug and toxin extrusion 1 (Mate1) gene in mice reduces renal secretion of metformin
    • Tsuda, M., Terada, T., Mizuno, T., Katsura, T., Shimakura, J. & Inui, K. Targeted disruption of the multidrug and toxin extrusion 1 (Mate1) gene in mice reduces renal secretion of metformin. Mol. Pharmacol. 75, 1280-1286 (2009).
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    • Tsuda, M.1    Terada, T.2    Mizuno, T.3    Katsura, T.4    Shimakura, J.5    Inui, K.6
  • 13
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    • Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin
    • Chen, Y. et al. Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin, Pharmacogenet. Genomics 19, 497-504 (2009).
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    • Chen, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.