Normoxically overexpressed hypoxia inducible factor 1-alpha is involved in arsenic trioxide resistance acquisition in hepatocellular carcinoma

Annals of Surgical Oncology

Volumn 18, Issue 5, 2011, Pages 1492-1500

  Tung, Jia Nien ^a,b   Cheng, Ya Wen ^a   Hsu, Chung Huei ^c   Liu, Tsan Zon ^d   Hsieh, Pei Ying ^d   Ting, Lai Lei ^e   Ko, Hui Ling ^e   Chang, Yu Jia ^f   Chiou, Jeng Fong ^d,e,f   Wu, Alexander T H ^d,e,f  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b TUNGS' TAICHUNG METROHARBOR HOSPITAL   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^f TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC TRIOXIDE; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; GLUTATHIONE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIFICIGUAT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN HEP J5; CELL STRAIN SK HEP 1; CONTROLLED STUDY; DRUG EFFECT; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATION; OXIDATIVE STRESS; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CASPASE 7; CELL CYCLE; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HEAT-SHOCK PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIPID PEROXIDATION; LIVER NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NITRIC OXIDE; OXIDES; OXYGEN; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED;

EID: 79955866746     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-010-1444-y     Document Type: Article

References (32)

1. A Jemal R Siegel E Ward Y Hao J Xu T Murray, et al. 2008 Cancer statistics, 2008 CA Cancer J Clin. 58 71 96 18287387 10.3322/CA.2007.0010 (Pubitemid 351521864)
2. PP Anthony 2001 Hepatocellular carcinoma: an overview Histopathology. 39 109 118 11493326 10.1046/j.1365-2559.2001.01188.x 1:STN:280: DC%2BD3Mvks1CntQ%3D%3D (Pubitemid 34225036)
3. S Badvie 2000 Hepatocellular carcinoma Postgrad Med J. 76 4 11 10622772 10.1136/pmj.76.891.4 1:STN:280:DC%2BD3c7mtVymuw%3D%3D (Pubitemid 30055017)
4. JT Erler CJ Cawthorne KJ Williams M Koritzinsky BG Wouters C Wilson, et al. 2004 Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance Mol Cell Biol. 24 2875 2889 15024076 10.1128/MCB.24.7.2875- 2889.2004 1:CAS:528:DC%2BD2cXis1emtr4%3D (Pubitemid 38381277)
5. BJ Moeller MW Dewhirst 2004 Raising the bar: how HIF-1 helps determine tumor radiosensitivity Cell Cycle. 3 1107 1110 15326390 10.4161/cc.3.9.1099 1:CAS:528:DC%2BD2MXntVantbg%3D (Pubitemid 40268623)
6. J Song Z Qu X Guo Q Zhao X Zhao L Gao, et al. 2009 Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells Autophagy. 5 1131 1144 19786832 10.4161/auto.5.8.9996 1:CAS:528: DC%2BC3cXkvVeitrc%3D
7. BG Wouters M Koritzinsky 2008 Hypoxia signalling through mTOR and the unfolded protein response in cancer Nat Rev Cancer. 8 851 864 18846101 10.1038/nrc2501 1:CAS:528:DC%2BD1cXht1yjtbnI
8. JF Chiou CJ Tai MT Huang PL Wei YH Wang J An, et al. 2010 Glucose-regulated protein 78 is a novel contributor to acquisition of resistance to sorafenib in hepatocellular carcinoma Ann Surg Oncol. 17 603 612 19830497 10.1245/s10434-009-0718-8
9. AS Lee 2001 The glucose-regulated proteins: stress induction and clinical applications Trends Biochem Sci. 26 504 510 11504627 10.1016/S0968-0004(01) 01908-9 1:CAS:528:DC%2BD3MXlslCjtLc%3D (Pubitemid 32735452)
10. P Pyrko AH Schonthal FM Hofman TC Chen AS Lee 2007 The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas Cancer Res. 67 9809 9816 17942911 10.1158/0008-5472.CAN-07- 0625 1:CAS:528:DC%2BD2sXhtFOnsb3P (Pubitemid 47621228)
11. S Daneshmand ML Quek E Lin C Lee RJ Cote D Hawes, et al. 2007 Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival Hum Pathol. 38 1547 1552 17640713 10.1016/j.humpath.2007.03.014 1:CAS:528:DC%2BD2sXhtVOgu77E (Pubitemid 47418966)
12. R Su Z Li H Li H Song C Bao J Wei, et al. 2010 Grp78 promotes the invasion of hepatocellular carcinoma BMC Cancer 10 20 20082722 10.1186/1471-2407-10-20
13. YJ Chang CC Chiu CH Wu J An CC Wu TZ Liu, et al. 2010 Glucose-regulated protein 78 (GRP78) silencing enhances cell migration but does not influence cell proliferation in hepatocellular carcinoma Ann Surg Oncol. 17 1703 1709 20087778 10.1245/s10434-010-0912-8
14. JR Berenson J Matous RA Swift R Mapes B Morrison HS Yeh 2007 A phase I/II study of arsenic trioxide/bortezomib/ascorbic acid combination therapy for the treatment of relapsed or refractory multiple myeloma Clin Cancer Res. 13 1762 1768 17363530 10.1158/1078-0432.CCR-06-1812 1:CAS:528:DC%2BD2sXivV2gt7Y%3D (Pubitemid 46952943)
15. HM Pettersson A Pietras PM Munksgaard J Karlsson L Johansson MC Shoshan, et al. 2009 Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells Mol Cancer Ther. 8 160 170 19139125 10.1158/1535-7163.MCT-08-0595 1:CAS:528:DC%2BD1MXjvFSmtw%3D%3D
16. HM Pettersson J Karlsson A Pietras I Ora S Pahlman 2007 Arsenic trioxide and neuroblastoma cytotoxicity J Bioenerg Biomembr. 39 35 41 17549641 10.1007/s10863-006-9058-6 1:CAS:528:DC%2BD2sXmtFentro%3D (Pubitemid 46877171)
17. J Karlsson A Pietras S Beckman HM Pettersson C Larsson S Pahlman 2007 Arsenic trioxide-induced neuroblastoma cell death is accompanied by proteolytic activation of nuclear Bax Oncogene. 26 6150 6159 17404572 10.1038/sj.onc.1210439 1:CAS:528:DC%2BD2sXhtVeisLvL (Pubitemid 47414374)
18. WH Miller Jr HM Schipper JS Lee J Singer S Waxman 2002 Mechanisms of action of arsenic trioxide Cancer Res. 62 3893 3903 12124315 1:CAS:528:DC%2BD38XlsV2lsrg%3D (Pubitemid 34792653)
19. CY Chen TZ Liu YW Liu WC Tseng RH Liu FJ Lu, et al. 2007 6-shogaol (alkanone from ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism J Agric Food Chem. 55 948 954 17263498 10.1021/jf0624594 1:CAS:528: DC%2BD2sXhs12ntA%3D%3D
20. TJ Hsieh TZ Liu FJ Lu PY Hsieh CH Chen 2006 Actinodaphnine induces apoptosis through increased nitric oxide, reactive oxygen species and down-regulation of NF-kappaB signaling in human hepatoma Mahlavu cells Food Chem Toxicol. 44 344 354 16168547 10.1016/j.fct.2005.08.005 1:CAS:528: DC%2BD2MXhtlaitb7M (Pubitemid 41779434)
21. M Fei M Lu Y Wang Y Zhao S He S Gao, et al. 2009 Arsenic trioxide-induced growth arrest of human hepatocellular carcinoma cells involving FOXO3a expression and localization Med Oncol. 26 178 185 18937079 10.1007/s12032-008- 9105-8 1:CAS:528:DC%2BD1MXmtVKit78%3D
22. 3-induced apoptosis in liver cancer cells J Gastroenterol. 44 460 469 19333544 10.1007/s00535-009-0030-1 1:CAS:528:DC%2BD1MXlslCrsLk%3D
23. XS Zhao PL Song B Sun HC Jiang TF Liu 2009 Arsenic trioxide inhibits metastatic potential of mouse hepatoma H22 cells in vitro and in vivo Hepatobiliary Pancreat Dis Int. 8 510 517 19822495 1:CAS:528:DC%2BD1MXhtl2ksLvM
24. RV Rao A Peel A Logvinova RG Del E Hermel T Yokota, et al. 2002 Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78 FEBS Lett. 514 122 128 11943137 1:CAS:528:DC%2BD38Xis1ejsbY%3D (Pubitemid 34273925)
25. RK Reddy C Mao P Baumeister RC Austin RJ Kaufman AS Lee 2003 Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation J Biol Chem. 278 20915 20924 12665508 10.1074/jbc.M212328200 1:CAS:528:DC%2BD3sXkt1Wisb8%3D (Pubitemid 36806399)
26. G Kroemer TH De 1999 Arsenic trioxide, a novel mitochondriotoxic anticancer agent? J Natl Cancer Inst. 91 743 745 10328097 10.1093/jnci/91.9.743 1:STN:280:DyaK1M3lvVKnuw%3D%3D (Pubitemid 29239052)
27. J Lu EH Chew A Holmgren 2007 Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide Proc Natl Acad Sci U S A. 104 12288 12293 17640917 10.1073/pnas.0701549104 1:CAS:528:DC%2BD2sXos1ehsbw%3D (Pubitemid 47206130)
28. I Papandreou RA Cairns L Fontana AL Lim NC Denko 2006 HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption Cell Metab. 3 187 197 16517406 10.1016/j.cmet.2006.01.012 1:CAS:528:DC%2BD28Xislyhtr0%3D
29. NS Chandel PT Schumacker 2000 Cellular oxygen sensing by mitochondria: old questions, new insight J Appl Physiol. 88 1880 1889 10797153 10.1063/1.1303764 1:CAS:528:DC%2BD3cXjvFSks70%3D (Pubitemid 30336942)
30. R Fukuda H Zhang JW Kim L Shimoda CV Dang GL Semenza 2007 HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells Cell. 129 111 122 17418790 10.1016/j.cell.2007.01.047 1:CAS:528: DC%2BD2sXkvVeltLg%3D (Pubitemid 46507584)
31. JW Kim I Tchernyshyov GL Semenza CV Dang 2006 HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia Cell Metab. 3 177 185 16517405 10.1016/j.cmet.2006.02.002
32. H Zhang P Gao R Fukuda G Kumar B Krishnamachary KI Zeller, et al. 2007 HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity Cancer Cell. 11 407 420 17482131 10.1016/j.ccr.2007.04.001 1:CAS:528:DC%2BD2sXlsVahu7Y%3D (Pubitemid 46670080)