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Volumn 29, Issue 14, 2011, Pages 1924-1933

Amyloidosis: Pathogenesis and new therapeutic options

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; ALPHA INTERFERON; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; BIOLOGICAL MARKER; BORTEZOMIB; BRAIN NATRIURETIC PEPTIDE; CALCIUM CHANNEL BLOCKING AGENT; COLCHICINE; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOXORUBICIN; IMMUNOGLOBULIN LIGHT CHAIN; LENALIDOMIDE; MELPHALAN; POMALIDOMIDE; PREDNISONE; THALIDOMIDE; TROPONIN I; TROPONIN T; VINCRISTINE;

EID: 79955842001     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2010.32.2271     Document Type: Review
Times cited : (424)

References (103)
  • 1
    • 0042709605 scopus 로고    scopus 로고
    • Molecular mechanisms of amyloidosis
    • DOI 10.1056/NEJMra023144
    • Merlini G, Bellotti V: Molecular mechanisms of amyloidosis. N Engl J Med 349:583-596, 2003 (Pubitemid 36951371)
    • (2003) New England Journal of Medicine , vol.349 , Issue.6 , pp. 583-596
    • Merlini, G.1    Bellotti, V.2
  • 3
    • 59649105575 scopus 로고    scopus 로고
    • Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses
    • Sekijima Y, Kelly JW, Ikeda S: Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses. Curr Pharm Des 14:3219-3230, 2008
    • (2008) Curr Pharm des , vol.14 , pp. 3219-3230
    • Sekijima, Y.1    Kelly, J.W.2    Ikeda, S.3
  • 5
    • 0347569588 scopus 로고    scopus 로고
    • Immunotherapy in Systemic Primary (AL) Amyloidosis Using Amyloid-Reactive Monoclonal Antibodies
    • Solomon A, Weiss DT, Wall JS: Immunotherapy in systemic primary (AL) amyloidosis using amyloid-reactive monoclonal antibodies. Cancer Biother Radiopharm 18:853-860, 2003 (Pubitemid 38064016)
    • (2003) Cancer Biotherapy and Radiopharmaceuticals , vol.18 , Issue.6 , pp. 853-860
    • Solomon, A.1    Weiss, D.T.2    Wall, J.S.3
  • 7
    • 78149282151 scopus 로고    scopus 로고
    • Antibodies to human serum amyloid P component eliminate visceral amyloid deposits
    • Bodin K, Ellmerich S, Kahan MC, et al: Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. Nature 468:93-97, 2010
    • (2010) Nature , vol.468 , pp. 93-97
    • Bodin, K.1    Ellmerich, S.2    Kahan, M.C.3
  • 8
    • 78649315112 scopus 로고    scopus 로고
    • Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis
    • Sipe JD, Benson MD, Buxbaum JN, et al: Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis. Amyloid 17:101-104, 2010
    • (2010) Amyloid , vol.17 , pp. 101-104
    • Sipe, J.D.1    Benson, M.D.2    Buxbaum, J.N.3
  • 9
    • 0026519157 scopus 로고
    • Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989
    • Kyle RA, Linos A, Beard CM, et al: Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. Blood 79:1817-1822, 1992
    • (1992) Blood , vol.79 , pp. 1817-1822
    • Kyle, R.A.1    Linos, A.2    Beard, C.M.3
  • 12
    • 33646241631 scopus 로고    scopus 로고
    • Seeking confidence in the diagnosis of systemic AL (Ig light-chain) amyloidosis: Patients can have both monoclonal gammopathies and hereditary amyloid proteins
    • Comenzo RL, Zhou P, Fleisher M, et al: Seeking confidence in the diagnosis of systemic AL (Ig light-chain) amyloidosis: Patients can have both monoclonal gammopathies and hereditary amyloid proteins. Blood 107:3489-3491, 2006
    • (2006) Blood , vol.107 , pp. 3489-3491
    • Comenzo, R.L.1    Zhou, P.2    Fleisher, M.3
  • 13
    • 11544279355 scopus 로고    scopus 로고
    • Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
    • Lambert MP, Barlow AK, Chromy BA, et al: Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A 95:6448-6453, 1998
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6448-6453
    • Lambert, M.P.1    Barlow, A.K.2    Chromy, B.A.3
  • 15
    • 77749251993 scopus 로고    scopus 로고
    • Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway
    • Shi J, Guan J, Jiang B, et al: Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway. Proc Natl Acad Sci U S A 107:4188-4193, 2010
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 4188-4193
    • Shi, J.1    Guan, J.2    Jiang, B.3
  • 17
    • 78149291059 scopus 로고    scopus 로고
    • The combination of high-sensitivity cardiac troponin T (hs-cTnT) at presentation and changes in N-terminal natriuretic peptide type B (NT-proBNP) after chemotherapy best predicts survival in AL amyloidosis
    • Palladini G, Barassi A, Klersy C, et al: The combination of high-sensitivity cardiac troponin T (hs-cTnT) at presentation and changes in N-terminal natriuretic peptide type B (NT-proBNP) after chemotherapy best predicts survival in AL amyloidosis. Blood 116:3426-3430, 2010
    • (2010) Blood , vol.116 , pp. 3426-3430
    • Palladini, G.1    Barassi, A.2    Klersy, C.3
  • 18
    • 33750616035 scopus 로고    scopus 로고
    • Dangerous small B-cell clones
    • Merlini G, Stone MJ: Dangerous small B-cell clones. Blood 108:2520-2530, 2006
    • (2006) Blood , vol.108 , pp. 2520-2530
    • Merlini, G.1    Stone, M.J.2
  • 19
    • 62149124802 scopus 로고    scopus 로고
    • Identification of amyloidogenic light chains requires the combination of serum-free light chain assay with immunofixation of serum and urine
    • Palladini G, Russo P, Bosoni T, et al: Identification of amyloidogenic light chains requires the combination of serum-free light chain assay with immunofixation of serum and urine. Clin Chem 55:499-504, 2009
    • (2009) Clin Chem , vol.55 , pp. 499-504
    • Palladini, G.1    Russo, P.2    Bosoni, T.3
  • 20
    • 60149096306 scopus 로고    scopus 로고
    • International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders
    • Dispenzieri A, Kyle R, Merlini G, et al: International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia 23:215-224, 2009
    • (2009) Leukemia , vol.23 , pp. 215-224
    • Dispenzieri, A.1    Kyle, R.2    Merlini, G.3
  • 21
    • 0032827077 scopus 로고    scopus 로고
    • Clonal immunoglobulin light chain variable region germline gene use in AL amyloidosis: Association with dominant amyloid-related organ involvement and survival after stem cell transplantation
    • DOI 10.1046/j.1365-2141.1999.01591.x
    • Comenzo RL, Wally J, Kica G, et al: Clonal immunoglobulin light chain variable region germline gene use in AL amyloidosis: Association with dominant amyloid-related organ involvement and survival after stem cell transplantation. Br J Haematol 106: 744-751, 1999 (Pubitemid 29434217)
    • (1999) British Journal of Haematology , vol.106 , Issue.3 , pp. 744-751
    • Comenzo, R.L.1    Wally, J.2    Kica, G.3    Murray, J.4    Ericsson, T.5    Skinner, M.6    Zhang, Y.7
  • 22
    • 0036682487 scopus 로고    scopus 로고
    • Analysis of Vlambda-Jlambda expression in plasma cells from primary (AL) amyloidosis and normal bone marrow identifies 3r (lambdaIII) as a new amyloid-associated germline gene segment
    • DOI 10.1182/blood-2002-01-0114
    • Perfetti V, Casarini S, Palladini G, et al: Analysis of V(lambda)-J(lambda) expression in plasma cells from primary (AL) amyloidosis and normal bone marrow identifies 3r (lambda III) as a new amyloidassociated germline gene segment. Blood 100:948-953, 2002 (Pubitemid 34832622)
    • (2002) Blood , vol.100 , Issue.3 , pp. 948-953
    • Perfetti, V.1    Casarini, S.2    Palladini, G.3    Vignarelli, M.C.4    Klersy, C.5    Diegoli, M.6    Ascari, E.7    Merlini, G.8
  • 24
    • 79955872754 scopus 로고    scopus 로고
    • Pathobiologic associations of plasma cell (PC) overexpression of Cyclin D1 (CCND1) in systemic AL amyloidosis (AL)
    • abstr OP-044
    • Comenzo RL, Hoffman JE, Hassoun H, et al: Pathobiologic associations of plasma cell (PC) overexpression of Cyclin D1 (CCND1) in systemic AL amyloidosis (AL). Amyloid 17:61, 2010 (suppl 1; abstr OP-044)
    • (2010) Amyloid , vol.17 , Issue.SUPPL. 1 , pp. 61
    • Comenzo, R.L.1    Hoffman, J.E.2    Hassoun, H.3
  • 25
    • 43549111441 scopus 로고    scopus 로고
    • CD32B is highly expressed on clonal plasma cells from patients with systemic light-chain amyloidosis and provides a target for monoclonal antibody-based therapy
    • Zhou P, Comenzo RL, Olshen AB, et al: CD32B is highly expressed on clonal plasma cells from patients with systemic light-chain amyloidosis and provides a target for monoclonal antibody-based therapy. Blood 111:3403-3406, 2008
    • (2008) Blood , vol.111 , pp. 3403-3406
    • Zhou, P.1    Comenzo, R.L.2    Olshen, A.B.3
  • 26
    • 68149156426 scopus 로고    scopus 로고
    • Immunophenotype of neoplastic plasma cells in AL amyloidosis
    • Deshmukh M, Elderfield K, Rahemtulla A, et al: Immunophenotype of neoplastic plasma cells in AL amyloidosis. J Clin Pathol 62:724-730, 2009
    • (2009) J Clin Pathol , vol.62 , pp. 724-730
    • Deshmukh, M.1    Elderfield, K.2    Rahemtulla, A.3
  • 27
    • 0141655257 scopus 로고    scopus 로고
    • Bone marrow core biopsy specimens in AL (primary) amyloidosis: A morphologic and immunohistochemical study of 100 cases
    • Swan N, Skinner M, O'Hara CJ: Bone marrow core biopsy specimens in AL (primary) amyloidosis: A morphologic and immunohistochemical study of 100 cases. Am J Clin Pathol 120:610-616, 2003
    • (2003) Am J Clin Pathol , vol.120 , pp. 610-616
    • Swan, N.1    Skinner, M.2    O'Hara, C.J.3
  • 28
    • 33745055421 scopus 로고    scopus 로고
    • Diagnostic accuracy of subcutaneous abdominal fat tissue aspiration for detecting systemic amyloidosis and its utility in clinical practice
    • van Gameren II, Hazenberg BP, Bijzet J, et al: Diagnostic accuracy of subcutaneous abdominal fat tissue aspiration for detecting systemic amyloidosis and its utility in clinical practice. Arthritis Rheum 54:2015-2021, 2006
    • (2006) Arthritis Rheum , vol.54 , pp. 2015-2021
    • Van Gameren, I.I.1    Hazenberg, B.P.2    Bijzet, J.3
  • 29
    • 33750301431 scopus 로고    scopus 로고
    • The spectrum of localized amyloidosis: A case series of 20 patients and review of the literature
    • DOI 10.1080/13506120600876773, PII W9W82362691284G5
    • Biewend ML, Menke DM, Calamia KT: The spectrum of localized amyloidosis: A case series of 20 patients and review of the literature. Amyloid 13:135-142, 2006 (Pubitemid 44630056)
    • (2006) Amyloid , vol.13 , Issue.3 , pp. 135-142
    • Biewend, M.L.1    Menke, D.M.2    Calamia, K.T.3
  • 30
    • 0023926566 scopus 로고
    • Diagnostic radionuclide imaging of amyloid: Biological targeting by circulating human serum amyloid P component
    • Hawkins PN, Myers MJ, Lavender JP, et al: Diagnostic radionuclide imaging of amyloid: Biological targeting by circulating human serum amyloid P component. Lancet 1:1413-1418, 1988
    • (1988) Lancet , vol.1 , pp. 1413-1418
    • Hawkins, P.N.1    Myers, M.J.2    Lavender, J.P.3
  • 32
    • 50249084455 scopus 로고    scopus 로고
    • Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue
    • Lavatelli F, Perlman DH, Spencer B, et al: Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue. Mol Cell Proteomics 7:1570-1583, 2008
    • (2008) Mol Cell Proteomics , vol.7 , pp. 1570-1583
    • Lavatelli, F.1    Perlman, D.H.2    Spencer, B.3
  • 33
    • 73949091104 scopus 로고    scopus 로고
    • Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimens
    • Vrana JA, Gamez JD, Madden BJ, et al: Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimens. Blood 114:4957-4959, 2009
    • (2009) Blood , vol.114 , pp. 4957-4959
    • Vrana, J.A.1    Gamez, J.D.2    Madden, B.J.3
  • 34
    • 25444434458 scopus 로고    scopus 로고
    • Diagnosis and management of the cardiac amyloidoses
    • Falk RH: Diagnosis and management of the cardiac amyloidoses. Circulation 112:2047-2060, 2005
    • (2005) Circulation , vol.112 , pp. 2047-2060
    • Falk, R.H.1
  • 35
    • 77952541154 scopus 로고    scopus 로고
    • Independent predictors of survival in primary systemic (AL) amyloidosis, including cardiac biomarkers and left ventricular strain imaging: An observational cohort study
    • Bellavia D, Pellikka PA, Al-Zahrani GB, et al: Independent predictors of survival in primary systemic (AL) amyloidosis, including cardiac biomarkers and left ventricular strain imaging: An observational cohort study. J Am Soc Echocardiogr 23:643-652, 2010
    • (2010) J Am Soc Echocardiogr , vol.23 , pp. 643-652
    • Bellavia, D.1    Pellikka, P.A.2    Al-Zahrani, G.B.3
  • 36
    • 77954673020 scopus 로고    scopus 로고
    • Prognostic significance of strain Doppler imaging in light-chain amyloidosis
    • Koyama J, Falk RH: Prognostic significance of strain Doppler imaging in light-chain amyloidosis. JACC Cardiovasc Imaging 3:333-342, 2010
    • (2010) JACC Cardiovasc Imaging , vol.3 , pp. 333-342
    • Koyama, J.1    Falk, R.H.2
  • 41
    • 77956051099 scopus 로고    scopus 로고
    • Treatment with intravenous melphalan and dexamethasone is not able to overcome the poor prognosis of patients with newly diagnosed systemic light chain amyloidosis and severe cardiac involvement
    • Dietrich S, Schönland SO, Benner A, et al: Treatment with intravenous melphalan and dexamethasone is not able to overcome the poor prognosis of patients with newly diagnosed systemic light chain amyloidosis and severe cardiac involvement. Blood 116:522-528, 2010
    • (2010) Blood , vol.116 , pp. 522-528
    • Dietrich, S.1    Schönland, S.O.2    Benner, A.3
  • 42
    • 77949897868 scopus 로고    scopus 로고
    • Bortezomib with or without dexamethasone in primary systemic (light chain) amyloidosis
    • Kastritis E, Wechalekar AD, Dimopoulos MA, et al: Bortezomib with or without dexamethasone in primary systemic (light chain) amyloidosis. J Clin Oncol 28:1031-1037, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 1031-1037
    • Kastritis, E.1    Wechalekar, A.D.2    Dimopoulos, M.A.3
  • 43
    • 4444268210 scopus 로고    scopus 로고
    • Prognostication of survival using cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation
    • Dispenzieri A, Gertz MA, Kyle RA, et al: Prognostication of survival using cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation. Blood 104:1881-1887, 2004
    • (2004) Blood , vol.104 , pp. 1881-1887
    • Dispenzieri, A.1    Gertz, M.A.2    Kyle, R.A.3
  • 44
    • 33645748052 scopus 로고    scopus 로고
    • Absolute values of immunoglobulin free light chains are prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation
    • Dispenzieri A, Lacy MQ, Katzmann JA, et al: Absolute values of immunoglobulin free light chains are prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation. Blood 107:3378-3383, 2006
    • (2006) Blood , vol.107 , pp. 3378-3383
    • Dispenzieri, A.1    Lacy, M.Q.2    Katzmann, J.A.3
  • 45
    • 79955836401 scopus 로고    scopus 로고
    • A new staging system for AL amyloidosis incorporating serum free light chains, cardiac troponin-T and NT-ProBNP
    • abstr 2796
    • Wechalekar AD, Wassef NL, Gibbs SD, et al: A new staging system for AL amyloidosis incorporating serum free light chains, cardiac troponin-T and NT-ProBNP. Blood (ASH Annual Meeting Abstracts) 114, 2009 (abstr 2796)
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Wechalekar, A.D.1    Wassef, N.L.2    Gibbs, S.D.3
  • 46
    • 79955825310 scopus 로고    scopus 로고
    • A novel prognostic staging system for light chain amyloidosis (AL) incorporating markers of plasma cell burden and organ involvement
    • abstr 2797
    • Kumar S, Dispenzieri A, Lacy MQ, et al: A novel prognostic staging system for light chain amyloidosis (AL) incorporating markers of plasma cell burden and organ involvement. Blood (ASH Annual Meeting Abstracts) 114, 2009 (abstr 2797)
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Kumar, S.1    Dispenzieri, A.2    Lacy, M.Q.3
  • 47
    • 23244448608 scopus 로고    scopus 로고
    • Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): A consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis, Tours, France, 18-22 April 2004
    • Gertz MA, Comenzo R, Falk RH, et al: Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): A consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis, Tours, France, 18-22 April 2004. Am J Hematol 79:319-328, 2005
    • (2005) Am J Hematol , vol.79 , pp. 319-328
    • Gertz, M.A.1    Comenzo, R.2    Falk, R.H.3
  • 48
    • 79952007082 scopus 로고    scopus 로고
    • Definition of organ involvement and response to treatment in AL amyloidosis: An updated consensus opinion
    • abstr CP-B
    • Gertz M, Merlini G: Definition of organ involvement and response to treatment in AL amyloidosis: An updated consensus opinion. Amyloid 17:48-49, 2010 (suppl 1; abstr CP-B)
    • (2010) Amyloid , vol.17 , Issue.SUPPL. 1 , pp. 48-49
    • Gertz, M.1    Merlini, G.2
  • 49
    • 36349007621 scopus 로고    scopus 로고
    • Effect of hematologic response on outcome of patients undergoing transplantation for primary amyloidosis: Importance of achieving a complete response
    • DOI 10.3324/haematol.11413
    • Gertz MA, Lacy MQ, Dispenzieri A, et al: Effect of hematologic response on outcome of patients undergoing transplantation for primary amyloidosis: Importance of achieving a complete response. Haematologica 92:1415-1418, 2007 (Pubitemid 350144161)
    • (2007) Haematologica , vol.92 , Issue.10 , pp. 1415-1418
    • Gertz, M.A.1    Lacy, M.Q.2    Dispenzieri, A.3    Hayman, S.R.4    Kumar, S.K.5    Leung, N.6    Gastineau, D.A.7
  • 51
    • 30944433400 scopus 로고    scopus 로고
    • Serum free light-chain responses after high-dose intravenous melphalan and autologous stem cell transplantation for AL (primary) amyloidosis
    • DOI 10.1038/sj.bmt.1705106, PII 1705106
    • Sanchorawala V, Seldin DC, Magnani B, et al: Serum free light-chain responses after high-dose intravenous melphalan and autologous stem cell transplantation for AL (primary) amyloidosis. Bone Marrow Transplant 36:597-600, 2005 (Pubitemid 43115014)
    • (2005) Bone Marrow Transplantation , vol.36 , Issue.7 , pp. 597-600
    • Sanchorawala, V.1    Seldin, D.C.2    Magnani, B.3    Skinner, M.4    Wright, D.G.5
  • 52
    • 79955868900 scopus 로고    scopus 로고
    • N-terminal fragment of brain natriuretic peptide (NT-ProBNP): A new response criterion in AL amyloidosis
    • abstr OP-081
    • Wechalekar AD, Merlini G, Gillmore JD, et al: N-terminal fragment of brain natriuretic peptide (NT-ProBNP): A new response criterion in AL amyloidosis. Amyloid 17:84-85, 2010 (suppl 1; abstr OP-081)
    • (2010) Amyloid , vol.17 , Issue.SUPPL. 1 , pp. 84-85
    • Wechalekar, A.D.1    Merlini, G.2    Gillmore, J.D.3
  • 53
    • 0029939944 scopus 로고    scopus 로고
    • Treatment of 100 patients with primary amyloidosis: A randomized trial of melphalan, prednisone, and colchicine versus colchicine only
    • DOI 10.1016/S0002-9343(97)89487-9
    • Skinner M, Anderson J, Simms R, et al: Treatment of 100 patients with primary amyloidosis: A randomized trial of melphalan, prednisone, and colchicine versus colchicine only. Am J Med 100: 290-298, 1996 (Pubitemid 26111626)
    • (1996) American Journal of Medicine , vol.100 , Issue.3 , pp. 290-298
    • Skinner, M.1    Anderson, J.J.2    Simms, R.3    Falk, R.4    Wang, M.5    Libbey, C.A.6    Jones, L.A.7    Cohen, A.S.8
  • 54
    • 0030895545 scopus 로고    scopus 로고
    • A trial of three regimens for primary amyloidosis: Colchicine alone, melphalan and prednisone, melphalan, prednisone, and colchicine
    • DOI 10.1056/NEJM199704243361702
    • Kyle RA, Gertz MA, Greipp PR, et al: A trial of three regimens for primary amyloidosis: Colchicine alone, melphalan and prednisone, and melphalan, prednisone, and colchicine. N Engl J Med 336:1202-1207, 1997 (Pubitemid 27183649)
    • (1997) New England Journal of Medicine , vol.336 , Issue.17 , pp. 1202-1207
    • Kyle, R.A.1    Gertz, M.A.2    Greipp, P.R.3    Witzig, T.E.4    Lust, J.A.5    Lacy, M.Q.6    Therneau, T.M.7
  • 56
    • 0032796593 scopus 로고    scopus 로고
    • Phase II trial of high-dose dexamethasone for untreated patients with primary systemic amyloidosis
    • Gertz MA, Lacy MQ, Lust JA, et al: Phase II trial of high-dose dexamethasone for untreated patients with primary systemic amyloidosis. Med Oncol 16:104-109, 1999 (Pubitemid 29349856)
    • (1999) Medical Oncology , vol.16 , Issue.2 , pp. 104-109
    • Gertz, M.A.1    Lacy, M.Q.2    Lust, J.A.3    Greipp, P.R.4    Witzig, T.E.5    Kyle, R.A.6
  • 57
    • 0033051717 scopus 로고    scopus 로고
    • Phase II trial of high-dose dexamethasone for previously treated immunoglobulin light-chain amyloidosis
    • DOI 10.1002/(SICI)1096-8652(199906)61:2<115::AID-AJH7>3.0.CO;2-I
    • Gertz MA, Lacy MQ, Lust JA, et al: Phase II trial of high-dose dexamethasone for previously treated immunoglobulin light-chain amyloidosis. Am J Hematol 61:115-119, 1999 (Pubitemid 29252388)
    • (1999) American Journal of Hematology , vol.61 , Issue.2 , pp. 115-119
    • Gertz, M.A.1    Lacy, M.Q.2    Lust, J.A.3    Greipp, P.R.4    Witzig, T.E.5    Kyle, R.A.6
  • 58
    • 6044260269 scopus 로고    scopus 로고
    • Clinical efficacy of high-dose dexamethasone with maintenance dexamethasone/alpha interferon in patients with primary systemic amyloidosis: Results of United States Intergroup Trial Southwest Oncology Group (SWOG) S9628
    • Dhodapkar MV, Hussein MA, Rasmussen E, et al: Clinical efficacy of high-dose dexamethasone with maintenance dexamethasone/alpha interferon in patients with primary systemic amyloidosis: Results of United States Intergroup Trial Southwest Oncology Group (SWOG) S9628. Blood 104:3520-3526, 2004
    • (2004) Blood , vol.104 , pp. 3520-3526
    • Dhodapkar, M.V.1    Hussein, M.A.2    Rasmussen, E.3
  • 59
    • 9144269708 scopus 로고    scopus 로고
    • High-dose melphalan and autologous stemcell transplantation in patients with AL amyloidosis: An 8-year study
    • Skinner M, Sanchorawala V, Seldin DC, et al: High-dose melphalan and autologous stemcell transplantation in patients with AL amyloidosis: An 8-year study. Ann Intern Med 140:85-93, 2004
    • (2004) Ann Intern Med , vol.140 , pp. 85-93
    • Skinner, M.1    Sanchorawala, V.2    Seldin, D.C.3
  • 61
    • 11144358046 scopus 로고    scopus 로고
    • Association of melphalan and high-dose dexamethasone is effective and well tolerated in patients with AL (primary) amyloidosis who are ineligible for stem cell transplantation
    • DOI 10.1182/blood-2003-08-2788
    • Palladini G, Perfetti V, Obici L, et al: Association of melphalan and high-dose dexamethasone is effective and well tolerated in patients with AL (primary) amyloidosis who are ineligible for stem cell transplantation. Blood 103:2936-2938, 2004 (Pubitemid 38451663)
    • (2004) Blood , vol.103 , Issue.8 , pp. 2936-2938
    • Palladini, G.1    Perfetti, V.2    Obici, L.3    Caccialanza, R.4    Semino, A.5    Adami, F.6    Cavallero, G.7    Rustichelli, R.8    Virga, G.9    Merlini, G.10
  • 63
    • 15944395687 scopus 로고    scopus 로고
    • The combination of thalidomide and intermediate-dose dexamethasone is an effective but toxic treatment for patients with primary amyloidosis (AL)
    • DOI 10.1182/blood-2004-08-3231
    • Palladini G, Perfetti V, Perlini S, et al: The combination of thalidomide and intermediate-dose dexamethasone is an effective but toxic treatment for patients with primary amyloidosis (AL). Blood 105:2949-2951, 2005 (Pubitemid 40446290)
    • (2005) Blood , vol.105 , Issue.7 , pp. 2949-2951
    • Palladini, G.1    Perfetti, V.2    Perlini, S.3    Obici, L.4    Lavatelli, F.5    Caccialanza, R.6    Invernizzi, R.7    Comotti, B.8    Merlini, G.9
  • 64
    • 33846263334 scopus 로고    scopus 로고
    • Safety and efficacy of risk-adapted cyclophosphamide, thalidomide, and dexamethasone in systemic AL amyloidosis
    • DOI 10.1182/blood-2006-07-035352
    • Wechalekar AD, Goodman HJ, Lachmann HJ, et al: Safety and efficacy of risk-adapted cyclophosphamide, thalidomide, and dexamethasone in systemic AL amyloidosis. Blood 109:457-464, 2007 (Pubitemid 46105938)
    • (2007) Blood , vol.109 , Issue.2 , pp. 457-464
    • Wechalekar, A.D.1    Goodman, H.J.B.2    Lachmann, H.J.3    Offer, M.4    Hawkins, P.N.5    Gillmore, J.D.6
  • 67
    • 79955858649 scopus 로고    scopus 로고
    • Weekly and twice-weekly bortezomib in AL amyloidosis: Results of a phase II study
    • abstr 8023
    • Reece DE, Hegenbart U, Sanchorawala V, et al: Weekly and twice-weekly bortezomib in AL amyloidosis: Results of a phase II study. J Clin Oncol 28:578s, 2010 (suppl; abstr 8023)
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Reece, D.E.1    Hegenbart, U.2    Sanchorawala, V.3
  • 68
    • 79955818826 scopus 로고    scopus 로고
    • A phase II study of pomalidomide and dexamethasone in previously treated light-chain (AL) amyloidosis
    • abstr 8025
    • Dispenzieri A, Gertz MA, Hayman SR, et al: A phase II study of pomalidomide and dexamethasone in previously treated light-chain (AL) amyloidosis. J Clin Oncol 28:579s, 2010 (suppl; abstr 8025)
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Dispenzieri, A.1    Gertz, M.A.2    Hayman, S.R.3
  • 70
    • 0032952933 scopus 로고    scopus 로고
    • Prospective randomized trial of melphalan and prednisone versus vincristine, carmustine, melphalan, cyclophosphamide, and prednisone in the treatment of primary systemic amyloidosis
    • Gertz MA, Lacy MQ, Lust JA, et al: Prospective randomized trial of melphalan and prednisone versus vincristine, carmustine, melphalan, cyclophosphamide, and prednisone in the treatment of primary systemic amyloidosis. J Clin Oncol 17:262-267, 1999 (Pubitemid 29022401)
    • (1999) Journal of Clinical Oncology , vol.17 , Issue.1 , pp. 262-267
    • Gertz, M.A.1    Lacy, M.Q.2    Lust, J.A.3    Greipp, P.R.4    Witzig, T.E.5    Kyle, R.A.6
  • 71
    • 34547137414 scopus 로고    scopus 로고
    • Treatment with oral melphalan plus dexamethasone produces long-term remissions in AL amyloidosis
    • DOI 10.1182/blood-2007-02-076034
    • Palladini G, Russo P, Nuvolone M, et al: Treatment with oral melphalan plus dexamethasone produces long-term remissions in AL amyloidosis. Blood 110:787-788, 2007 (Pubitemid 47105419)
    • (2007) Blood , vol.110 , Issue.2 , pp. 787-788
    • Palladini, G.1    Russo, P.2    Nuvolone, M.3    Lavatelli, F.4    Perfetti, V.5    Obici, L.6    Merlini, G.7
  • 72
    • 78649734473 scopus 로고    scopus 로고
    • Oral melphalan and dexamethasone for AL amyloidosis: Efficacy, prognostic factors and response criteria
    • abstr OP-076
    • Palladini G, Foli A, Milani P, et al: Oral melphalan and dexamethasone for AL amyloidosis: Efficacy, prognostic factors and response criteria. Amyloid 17:81-82, 2010 (suppl 1; abstr OP-076)
    • (2010) Amyloid , vol.17 , Issue.SUPPL. 1 , pp. 81-82
    • Palladini, G.1    Foli, A.2    Milani, P.3
  • 73
    • 54049148697 scopus 로고    scopus 로고
    • Predictors of survival in patients with systemic lightchain amyloidosis and cardiac involvement initially ineligible for stem cell transplantation and treated with oral melphalan and dexamethasone
    • Lebovic D, Hoffman J, Levine BM, et al: Predictors of survival in patients with systemic lightchain amyloidosis and cardiac involvement initially ineligible for stem cell transplantation and treated with oral melphalan and dexamethasone. Br J Haematol 143:369-373, 2008
    • (2008) Br J Haematol , vol.143 , pp. 369-373
    • Lebovic, D.1    Hoffman, J.2    Levine, B.M.3
  • 77
    • 33845929988 scopus 로고    scopus 로고
    • Long-term results of a risk-adapted approach to melphalan conditioning in autologous peripheral blood stem cell transplantation for primary (AL) amyloidosis
    • Perfetti V, Siena S, Palladini G, et al: Longterm results of a risk-adapted approach to melphalan conditioning in autologous peripheral blood stem cell transplantation for primary (AL) amyloidosis. Haematologica 91:1635-1643, 2006 (Pubitemid 46032961)
    • (2006) Haematologica , vol.91 , Issue.12 , pp. 1635-1643
    • Perfetti, V.1    Siena, S.2    Palladini, G.3    Bregni, M.4    Di, N.M.5    Obici, L.6    Magni, M.7    Brunetti, L.8    Gianni, A.M.9    Merlini, G.10
  • 79
    • 33845267235 scopus 로고    scopus 로고
    • Successful treatment of AL amyloidosis with high-dose melphalan and autologous stem cell transplantation in patients over age 65
    • DOI 10.1182/blood-2006-06-029728
    • Seldin DC, Anderson JJ, Skinner M, et al: Successful treatment of AL amyloidosis with highdose melphalan and autologous stem cell transplantation in patients over age 65. Blood 108:3945-3947, 2006 (Pubitemid 44864581)
    • (2006) Blood , vol.108 , Issue.12 , pp. 3945-3947
    • Seldin, D.C.1    Anderson, J.J.2    Skinner, M.3    Malek, K.4    Wright, D.G.5    Quillen, K.6    Finn, K.7    Oran, B.8    Sanchorawala, V.9
  • 80
    • 36348976450 scopus 로고    scopus 로고
    • Long-term outcome of patients with AL amyloidosis treated with high-dose melphalan and stem-cell transplantation
    • DOI 10.1182/blood-2007-07-099481
    • Sanchorawala V, Skinner M, Quillen K, et al: Long-term outcome of patients with AL amyloidosis treated with high-dose melphalan and stem-cell transplantation. Blood 110:3561-3563, 2007 (Pubitemid 350159622)
    • (2007) Blood , vol.110 , Issue.10 , pp. 3561-3563
    • Sanchorawala, V.1    Skinner, M.2    Quillen, K.3    Finn, K.T.4    Doros, G.5    Seldin, D.C.6
  • 82
  • 83
    • 4444363999 scopus 로고    scopus 로고
    • Improvement in quality of life of patients with AL amyloidosis treated with high-dose melphalan and autologous stem cell transplantation
    • Seldin DC, Anderson JJ, Sanchorawala V, et al: Improvement in quality of life of patients with AL amyloidosis treated with high-dose melphalan and autologous stem cell transplantation. Blood 104: 1888-1893, 2004
    • (2004) Blood , vol.104 , pp. 1888-1893
    • Seldin, D.C.1    Anderson, J.J.2    Sanchorawala, V.3
  • 85
    • 60749115105 scopus 로고    scopus 로고
    • Treatment of patients with advanced cardiac AL amyloidosis with oral melphalan, dexamethasone, and thalidomide
    • Palladini G, Russo P, Lavatelli F, et al: Treatment of patients with advanced cardiac AL amyloidosis with oral melphalan, dexamethasone, and thalidomide. Ann Hematol 88:347-350, 2009
    • (2009) Ann Hematol , vol.88 , pp. 347-350
    • Palladini, G.1    Russo, P.2    Lavatelli, F.3
  • 86
    • 78649759752 scopus 로고    scopus 로고
    • Lenalidomide in combination with melphalan and dexamethasone in patients with newly-diagnosed light-chain (AL)-amyloidosis: A multicenter phase I/II dose escalation study
    • Moreau P, Jaccard A, Benboubker L, et al: Lenalidomide in combination with melphalan and dexamethasone in patients with newly-diagnosed light-chain (AL)-amyloidosis: A multicenter phase I/II dose escalation study. Blood 116:4777-4782, 2010
    • (2010) Blood , vol.116 , pp. 4777-4782
    • Moreau, P.1    Jaccard, A.2    Benboubker, L.3
  • 87
    • 77952702406 scopus 로고    scopus 로고
    • A phase II trial of lenalidomide, cyclophosphamide and dexamethasone (RCD) in patients with light chain amyloidosis
    • abstr 3853
    • Kumar S, Hayman SR, Buadi F, et al: A phase II trial of lenalidomide, cyclophosphamide and dexamethasone (RCD) in patients with light chain amyloidosis. Blood (ASH Annual Meeting Abstracts) 114, 2009 (abstr 3853)
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Kumar, S.1    Hayman, S.R.2    Buadi, F.3
  • 88
    • 77952726083 scopus 로고    scopus 로고
    • A phase I/II study of lenalidomide (R) with low-dose dexamethasone (d) and cyclophosphamide (C) for patients with primary systemic (AL) amyloidosis
    • abstr 428
    • Kastritis E, Roussou M, Migkou M, et al: A phase I/II study of lenalidomide (R) with low-dose dexamethasone (d) and cyclophosphamide (C) for patients with primary systemic (AL) amyloidosis. Blood (ASH Annual Meeting Abstracts) 114, 2009 (abstr 428)
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Kastritis, E.1    Roussou, M.2    Migkou, M.3
  • 89
    • 77952701381 scopus 로고    scopus 로고
    • A phase II trial of cyclophosphamide, lenalidomide, and dexamethasone (CLD) in previously treated patients with AL amyloidosis
    • abstr 2863
    • Palladini G, Russo P, Zenone-Bragotti L, et al: A phase II trial of cyclophosphamide, lenalidomide, and dexamethasone (CLD) in previously treated patients with AL amyloidosis. Blood (ASH Annual Meeting Abstracts) 114, 2009 (abstr 2863)
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Palladini, G.1    Russo, P.2    Zenone-Bragotti, L.3
  • 90
    • 36348934009 scopus 로고    scopus 로고
    • Bortezomib in the treatment of AL amyloidosis: Targeted therapy?
    • Sitia R, Palladini G, Merlini G: Bortezomib in the treatment of AL amyloidosis: Targeted therapy? Haematologica 92:1302-1307, 2007
    • (2007) Haematologica , vol.92 , pp. 1302-1307
    • Sitia, R.1    Palladini, G.2    Merlini, G.3
  • 91
    • 79952003103 scopus 로고    scopus 로고
    • Proteasome activity and stress in light chain amyloidosis
    • abstr P-019
    • Oliva L, Pengo N, Palladini G, et al: Proteasome activity and stress in light chain amyloidosis. Amyloid 17:99, 2010 (suppl 1; abstr P-019)
    • (2010) Amyloid , vol.17 , Issue.SUPPL. 1 , pp. 99
    • Oliva, L.1    Pengo, N.2    Palladini, G.3
  • 93
    • 40849139507 scopus 로고    scopus 로고
    • Efficacy of bortezomib in systemic AL amyloidosis with relapsed/refractory clonal disease
    • DOI 10.3324/haematol.11627
    • Wechalekar AD, Lachmann HJ, Offer M, et al: Efficacy of bortezomib in systemic AL amyloidosis with relapsed/refractory clonal disease. Haematologica 93:295-298, 2008 (Pubitemid 351397721)
    • (2008) Haematologica , vol.93 , Issue.2 , pp. 295-298
    • Wechalekar, A.D.1    Lachmann, H.J.2    Offer, M.3    Hawkins, P.N.4    Gillmore, J.D.5
  • 94
    • 70349575412 scopus 로고    scopus 로고
    • Weekly and twice-weekly bortezomib in patients with systemic AL amyloidosis: Results of a phase 1 dose-escalation study
    • Reece DE, Sanchorawala V, Hegenbart U, et al: Weekly and twice-weekly bortezomib in patients with systemic AL amyloidosis: Results of a phase 1 dose-escalation study. Blood 114:1489-1497, 2009
    • (2009) Blood , vol.114 , pp. 1489-1497
    • Reece, D.E.1    Sanchorawala, V.2    Hegenbart, U.3
  • 95
    • 77952695467 scopus 로고    scopus 로고
    • Adjuvant bortezomib and dexamethasone following risk-adapted melphalan and stem cell transplant in systemic light-chain amyloidosis (AL): A phase II study
    • abstr 533
    • Landau H, Hassoun H, Cohen AD, et al: Adjuvant bortezomib and dexamethasone following risk-adapted melphalan and stem cell transplant in systemic light-chain amyloidosis (AL): A phase II study. Blood (ASH Annual Meeting Abstracts) 114, 2009 (abstr 533)
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Landau, H.1    Hassoun, H.2    Cohen, A.D.3
  • 96
    • 84856089226 scopus 로고    scopus 로고
    • Use of melphalan (M)/dexamethasone (D)/ bortezomib in AL amyloidosis
    • abstr 8024
    • Gasparetto C, Sanchorawala V, Snyder RM, et al: Use of melphalan (M)/dexamethasone (D)/ bortezomib in AL amyloidosis. J Clin Oncol 28:579s, 2010 (suppl; abstr 8024)
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Gasparetto, C.1    Sanchorawala, V.2    Snyder, R.M.3
  • 97
    • 77951017780 scopus 로고    scopus 로고
    • Cyclophosphamide, bortezomib and dexamethasone (CyBORD) induces rapid and complete responses in patients with amyloidosis not eligible for peripheral blood stem cell transplant
    • abstr 1857
    • Jimenez-Zepeda VH, Reeder CB, Mikhael JR, et al: Cyclophosphamide, bortezomib and dexamethasone (CyBORD) induces rapid and complete responses in patients with amyloidosis not eligible for peripheral blood stem cell transplant- .Blood (ASH Annual Meeting Abstracts) 114, 2009 (abstr 1857)
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Jimenez-Zepeda, V.H.1    Reeder, C.B.2    Mikhael, J.R.3
  • 98
    • 79952126085 scopus 로고    scopus 로고
    • Kidney dysfunction during lenalidomide treatment for AL amyloidosis
    • epub ahead of print on August 5, 2010
    • Specter R, Sanchorawala V, Seldin DC, et al: Kidney dysfunction during lenalidomide treatment for AL amyloidosis. Nephrol Dial Transplant [epub ahead of print on August 5, 2010]
    • Nephrol Dial Transplant
    • Specter, R.1    Sanchorawala, V.2    Seldin, D.C.3
  • 99
    • 33644824008 scopus 로고    scopus 로고
    • Sudden death in nondilated cardiomyopathies: Pathophysiology and prevention
    • Soni A, LeLorier P: Sudden death in nondilated cardiomyopathies: Pathophysiology and prevention. Curr Heart Fail Rep 2:118-123, 2005
    • (2005) Curr Heart Fail Rep , vol.2 , pp. 118-123
    • Soni, A.1    LeLorier, P.2
  • 100
    • 38649104792 scopus 로고    scopus 로고
    • Prophylactic implantation of cardioverter-defibrillator in patients with severe cardiac amyloidosis and high risk for sudden cardiac death
    • Kristen AV, Dengler TJ, Hegenbart U, et al: Prophylactic implantation of cardioverter-defibrillator in patients with severe cardiac amyloidosis and high risk for sudden cardiac death. Heart Rhythm 5:235-240, 2008
    • (2008) Heart Rhythm , vol.5 , pp. 235-240
    • Kristen, A.V.1    Dengler, T.J.2    Hegenbart, U.3
  • 102
    • 47749109821 scopus 로고    scopus 로고
    • Autologous stem cell transplant after heart transplant for light chain (AL) amyloid cardiomyopathy
    • Lacy MQ, Dispenzieri A, Hayman SR, et al: Autologous stem cell transplant after heart transplant for light chain (AL) amyloid cardiomyopathy. J Heart Lung Transplant 27:823-829, 2008
    • (2008) J Heart Lung Transplant , vol.27 , pp. 823-829
    • Lacy, M.Q.1    Dispenzieri, A.2    Hayman, S.R.3


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