Prognostic factors for survival and response after high-dose therapy and autologous stem cell transplantation in systemic AL amyloidosis: A report on 21 patients

British Journal of Haematology

Volumn 101, Issue 4, 1998, Pages 766-769

  Moreau, Philippe ^a   Leblond, Véronique ^a   Bourquelot, Priscille ^a   Facon, Thierry ^a   Huynh, Anne ^a   Caillot, Denis ^a   Hermine, Olivier ^a   Attal, Michel ^a   Hamidou, Mohamed ^a   Nedellec, Gérard ^a   Ferrant, Augustin ^a   Audhuy, Bruno ^a   Bataille, Régis ^a   Milpied, Noël ^a   Harousseau, Jean Luc ^a  

^a HÔTEL DIEU   (France)

Author keywords

Autologous stem cell transplantation; Systemic AL amyloidosis

Indexed keywords

ALKALINE PHOSPHATASE; DEXAMETHASONE; DOXORUBICIN; MELPHALAN; PREDNISONE; VINCRISTINE;

ADULT; AMYLOIDOSIS; ARTICLE; AUTOTRANSPLANTATION; CLINICAL ARTICLE; CLINICAL FEATURE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CREATININE CLEARANCE; DRUG MEGADOSE; DRUG RESPONSE; FEMALE; HEPATOMEGALY; HUMAN; MALE; NEPHROTIC SYNDROME; NEUROPATHY; PRIORITY JOURNAL; PROGNOSIS; PROTEINURIA; RETROSPECTIVE STUDY; STEM CELL TRANSPLANTATION; SURVIVAL; WHOLE BODY RADIATION;

ADULT; AMYLOIDOSIS; ANTINEOPLASTIC AGENTS, ALKYLATING; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEMALE; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MELPHALAN; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; TRANSPLANTATION, AUTOLOGOUS; WHOLE-BODY IRRADIATION;

EID: 7144251173     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00772.x     Document Type: Article

References (12)

1. Comenzo, R.L., Falk, R.H., Reisinger, J., Dubrey, S., Finn, K., Sarnacki, D., Berk, J., Dember, L., Bergethon, P., LaValley, M., Sanchorawala, V., Vosburgh, E. & Skinner, M. (1997) AL amyloidosis frequently remits after dose-intensive melphalan with blood stem cell support: outcomes in 55 patients. VI International Workshop on Multiple Myeloma, Boston, abstract 6-5.
2. Comenzo, R.L., Vosburgh, E., Simms, R.W., Bergethon, P., Sarnacki, D., Finn, K., Dubrey, S., Faller D.V., Wright, D.G., Falk, R.H. & Skinner, M. (1996) Dose-intensive melphalan with blood stem cell support for the treatment of AL amyloidosis: one-year follow-up in live patients. Blood, 88, 2801-2806.
3. Falk, R.H., Comenzo, R.L. & Skinner, M. (1997) The systemic amyloidoses. New England Journal of Medicine, 337, 898-909.
4. Gertz, M.A., Kyle, R.A. & Greipp, P.R. (1991) Response rates and survival in primary systemic amyloidosis. Blood, 77, 257-262.
5. Gillmore, J.D., Hawkins, P.N. & Pepys, M.B. (1997) Amyloidosis: a review of recent diagnosis and therapeutic developments. British Journal of Haematology, 99, 245-256.
6. Kyle, R.A. & Gertz, M.A. (1995) Primary systemic amyloidosis: clinical and laboratory features in 474 cases. Seminars in Hematology, 32, 45-59.
7. Kyle, R.A., Gertz, M.A., Greipp, P.R., Witzig, T.E., Lust, J.A., Lacy, M.Q. & Therneau, T.M. (1997) A trial of three regimens for primary amyloidosis: colchicine alone, melphalan and prednisone, and melphalan, prednisone and colchicine. New England Journal of Medicine, 336, 1202-1207.
8. Kyle, R.A., Greipp, P.R. & O'Fallon, W.M. (1986) Primary systemic amyloidosis: multivariant analysis for prognostic factors in 168 cases. Blood, 68, 220-224.
9. Mariette, X., Clauvel, J.P. & Brouet, J.C. (1995) Intensive therapy in AL amyloidosis and light-chain deposition disease. (Letter). Annals of Internal Medicine, 123, 553.
10. Moreau, P., Milpied, N., de Faucal, P., Petit, T., Herbouiller, P., Bataille, R. & Harousseau, J.L. (1996) High-dose melphalan and autologous bone marrow transplantation for systemic AL amyloidosis with cardiac involvement. (Letter). Blood, 87, 3063-3064.
11. Skinner, M., Anderson, J.J., Simms, R., Falk, R., Wang, M., Libbey, C.A., Jones, L.A. & Cohen, A.S. (1996) Treatment of 100 patients with primary amyloidosis: a randomized trial of melphalan, prednisone, and colchicine versus colchicine only. American Journal of Medicine, 100, 290-298.
12. van Buren, M., Hené, R.J., Verdonck, L.F., Verzijlbergen, F.J. & Lokhorst, H.M. (1995) Clinical remission after syngeneic bone marrow transplantation in a patient with AL amyloidosis. Annals of Internal Medicine, 122, 508-510.