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Volumn 11, Issue 10, 2011, Pages 2071-2078

ITRAQ-based proteomic study of the effects of microcystin-LR on medaka fish liver

Author keywords

Animal proteomics; ITRAQ; Lipids; Liver; Microcystin; Oryzias latipes

Indexed keywords

APOLIPOPROTEIN; MICROCYSTIN LR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; TUMOR PROMOTER;

EID: 79955840237     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201000512     Document Type: Article
Times cited : (27)

References (56)
  • 2
    • 22044455712 scopus 로고    scopus 로고
    • Health risk assessment of cyanobacterial (blue-green algal) toxins in drinking water
    • Falconer, I., Humpage, A., Health risk assessment of cyanobacterial (blue-green algal) toxins in drinking water. Int. J. Environ. Res. Public Health 2005, 2, 43-50.
    • (2005) Int. J. Environ. Res. Public Health , vol.2 , pp. 43-50
    • Falconer, I.1    Humpage, A.2
  • 3
    • 64749090228 scopus 로고    scopus 로고
    • Identification of toxigenic Microcystis strains after incidents of wild animal mortalities in the Kruger National Park, South Africa
    • Oberholster, P., Myburgh, J., Govender, D., Bengis, R., Botha, A., Identification of toxigenic Microcystis strains after incidents of wild animal mortalities in the Kruger National Park, South Africa. Ecotoxicol. Environ. Saf. 2009, 72, 1177-1182.
    • (2009) Ecotoxicol. Environ. Saf. , vol.72 , pp. 1177-1182
    • Oberholster, P.1    Myburgh, J.2    Govender, D.3    Bengis, R.4    Botha, A.5
  • 4
    • 62749130756 scopus 로고    scopus 로고
    • Simultaneous determination of microcystin contaminations in various vertebrates (fish, turtle, duck and water bird) from a large eutrophic Chinese lake, Lake Taihu, with toxic Microcystis blooms
    • Chen, J., Zhang, D., Xie, P., Wang, Q., Ma, Z., Simultaneous determination of microcystin contaminations in various vertebrates (fish, turtle, duck and water bird) from a large eutrophic Chinese lake, Lake Taihu, with toxic Microcystis blooms. Sci. Total Environ. 2009, 407, 3317-3322.
    • (2009) Sci. Total Environ. , vol.407 , pp. 3317-3322
    • Chen, J.1    Zhang, D.2    Xie, P.3    Wang, Q.4    Ma, Z.5
  • 6
    • 0002357912 scopus 로고    scopus 로고
    • Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil
    • Pouria, S., de Andrade, A., Barbosa, J., Cavalcanti, R. L. et al., Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil. Lancet 1998, 352, 21-26.
    • (1998) Lancet , vol.352 , pp. 21-26
    • Pouria, S.1    de Andrade, A.2    Barbosa, J.3    Cavalcanti, R.L.4
  • 7
    • 61349165636 scopus 로고    scopus 로고
    • First identification of the hepatotoxic microcystins in the serum of a chronically exposed human population together with indication of hepatocellular damage
    • Chen, J., Xie, P., Li, L., Xu, J., First identification of the hepatotoxic microcystins in the serum of a chronically exposed human population together with indication of hepatocellular damage. Toxicol. Sci. 2009, 108, 81-89.
    • (2009) Toxicol. Sci. , vol.108 , pp. 81-89
    • Chen, J.1    Xie, P.2    Li, L.3    Xu, J.4
  • 8
    • 11244346943 scopus 로고    scopus 로고
    • Hepatotoxic cyanobacteria: a review of the biological importance of microcystins in freshwater environments
    • Zurawell, R. W., Chen, H., Burke, J. M., Prepas, E. E., Hepatotoxic cyanobacteria: a review of the biological importance of microcystins in freshwater environments. J. Toxicol. Environ. Health B Crit. Rev. 2005, 8, 1-37.
    • (2005) J. Toxicol. Environ. Health B Crit. Rev. , vol.8 , pp. 1-37
    • Zurawell, R.W.1    Chen, H.2    Burke, J.M.3    Prepas, E.E.4
  • 9
    • 0036048536 scopus 로고    scopus 로고
    • Characterization of sublethal microcystin-LR exposure in mice
    • Guzman, R. E., Solter, P. F., Characterization of sublethal microcystin-LR exposure in mice. Vet. Pathol. 2002, 39, 17-26.
    • (2002) Vet. Pathol. , vol.39 , pp. 17-26
    • Guzman, R.E.1    Solter, P.F.2
  • 10
    • 39449083530 scopus 로고    scopus 로고
    • Field and laboratory studies on pathological and biochemical characterization of microcystin-induced liver and kidney damage in the phytoplanktivorous bighead carp
    • Li, L., Xie, P., Guo, L., Ke, Z. et al., Field and laboratory studies on pathological and biochemical characterization of microcystin-induced liver and kidney damage in the phytoplanktivorous bighead carp. ScientificWorldJournal 2008, 8, 121-137.
    • (2008) ScientificWorldJournal , vol.8 , pp. 121-137
    • Li, L.1    Xie, P.2    Guo, L.3    Ke, Z.4
  • 11
    • 14644386874 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin
    • Fischer, W., Altheimer, S., Cattori, V., Meier, P. et al., Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin. Toxicol. Appl. Pharmacol. 2005, 203, 257-263.
    • (2005) Toxicol. Appl. Pharmacol. , vol.203 , pp. 257-263
    • Fischer, W.1    Altheimer, S.2    Cattori, V.3    Meier, P.4
  • 12
    • 42149136754 scopus 로고    scopus 로고
    • Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR
    • Lu, H., Choudhuri, S., Ogura, K., Csanaky, I. et al., Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicol. Sci. 2008, 103, 35-45.
    • (2008) Toxicol. Sci. , vol.103 , pp. 35-45
    • Lu, H.1    Choudhuri, S.2    Ogura, K.3    Csanaky, I.4
  • 13
    • 0032124844 scopus 로고    scopus 로고
    • The toxicology of microcystins
    • Dawson, R. M., The toxicology of microcystins. Toxicon 1998, 36, 953-962.
    • (1998) Toxicon , vol.36 , pp. 953-962
    • Dawson, R.M.1
  • 14
    • 33847147603 scopus 로고    scopus 로고
    • The role of ROS in microcystin-LR-induced hepatocyte apoptosis and liver injury in mice
    • Weng, D., Lu, Y., Wei, Y., Liu, Y., Shen, P., The role of ROS in microcystin-LR-induced hepatocyte apoptosis and liver injury in mice. Toxicology 2007, 232, 15-23.
    • (2007) Toxicology , vol.232 , pp. 15-23
    • Weng, D.1    Lu, Y.2    Wei, Y.3    Liu, Y.4    Shen, P.5
  • 15
    • 50549083214 scopus 로고    scopus 로고
    • Different sensitivities of human colon adenocarcinoma (CaCo-2), astrocytoma (IPDDC-A2) and lymphoblastoid (NCNC) cell lines to microcystin-LR induced reactive oxygen species and DNA damage
    • Zegura, B., Volcic, M., Lah, T., Filipic, M., Different sensitivities of human colon adenocarcinoma (CaCo-2), astrocytoma (IPDDC-A2) and lymphoblastoid (NCNC) cell lines to microcystin-LR induced reactive oxygen species and DNA damage. Toxicon 2008, 52, 518-525.
    • (2008) Toxicon , vol.52 , pp. 518-525
    • Zegura, B.1    Volcic, M.2    Lah, T.3    Filipic, M.4
  • 16
    • 0031024815 scopus 로고    scopus 로고
    • Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments
    • Toivola, D., Goldman, R., Garrod, D., Eriksson, J., Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments. J. Cell Sci. 1997, 110, 23-33.
    • (1997) J. Cell Sci. , vol.110 , pp. 23-33
    • Toivola, D.1    Goldman, R.2    Garrod, D.3    Eriksson, J.4
  • 17
    • 0033846898 scopus 로고    scopus 로고
    • Microcystic cyanobacteria extract induces cytoskeletal disruption and intracellular glutathione alteration in hepatocytes
    • Ding, W., Shen, H., Ong, C., Microcystic cyanobacteria extract induces cytoskeletal disruption and intracellular glutathione alteration in hepatocytes. Environ. Health Perspect. 2000, 108, 605-609.
    • (2000) Environ. Health Perspect. , vol.108 , pp. 605-609
    • Ding, W.1    Shen, H.2    Ong, C.3
  • 18
    • 67349129142 scopus 로고    scopus 로고
    • Comparative study of cyanotoxins affecting cytoskeletal and chromatin structures in CHO-K1 cells
    • Gácsi, M., Antal, O., Vasas, G., Máthé, C. et al., Comparative study of cyanotoxins affecting cytoskeletal and chromatin structures in CHO-K1 cells. Toxicol. In Vitro 2009, 23, 710-718.
    • (2009) Toxicol. In Vitro , vol.23 , pp. 710-718
    • Gácsi, M.1    Antal, O.2    Vasas, G.3    Máthé, C.4
  • 19
    • 22844434474 scopus 로고    scopus 로고
    • Transformation of immortalized colorectal crypt cells by microcystin involving constitutive activation of Akt and MAPK cascade
    • Zhu, Y., Zhong, X., Zheng, S., Ge, Z. et al., Transformation of immortalized colorectal crypt cells by microcystin involving constitutive activation of Akt and MAPK cascade. Carcinogenesis 2005, 26, 1207-1214.
    • (2005) Carcinogenesis , vol.26 , pp. 1207-1214
    • Zhu, Y.1    Zhong, X.2    Zheng, S.3    Ge, Z.4
  • 20
    • 34447545755 scopus 로고    scopus 로고
    • Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3
    • Komatsu, M., Furukawa, T., Ikeda, R., Takumi, S. et al., Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3. Toxicol. Sci. 2007, 97, 407-416.
    • (2007) Toxicol. Sci. , vol.97 , pp. 407-416
    • Komatsu, M.1    Furukawa, T.2    Ikeda, R.3    Takumi, S.4
  • 22
    • 20444474242 scopus 로고    scopus 로고
    • Microcystin-LR and embryo-larval development of medaka fish, Oryzias latipes. I. Effects on the digestive tract and associated systems
    • Huynh-Delerme, C., Edery, M., Huet, H., Puiseux-Dao, S. et al., Microcystin-LR and embryo-larval development of medaka fish, Oryzias latipes. I. Effects on the digestive tract and associated systems. Toxicon 2005, 46, 16-23.
    • (2005) Toxicon , vol.46 , pp. 16-23
    • Huynh-Delerme, C.1    Edery, M.2    Huet, H.3    Puiseux-Dao, S.4
  • 23
    • 34249328885 scopus 로고    scopus 로고
    • Toxicity to medaka fish embryo development of okadaic acid and crude extracts of Prorocentrum dinoflagellates
    • Escoffier, N., Gaudin, J., Mezhoud, K., Huet, H. et al., Toxicity to medaka fish embryo development of okadaic acid and crude extracts of Prorocentrum dinoflagellates. Toxicon 2007, 49, 1182-1192.
    • (2007) Toxicon , vol.49 , pp. 1182-1192
    • Escoffier, N.1    Gaudin, J.2    Mezhoud, K.3    Huet, H.4
  • 24
    • 38149000922 scopus 로고    scopus 로고
    • Effects of cyanobacterial crude extracts from Planktothrix agardhii on embryo-larval development of medaka fish, Oryzias latipes
    • Lecoz, N., Malécot, M., Quiblier, C., Puiseux-Dao, S. et al., Effects of cyanobacterial crude extracts from Planktothrix agardhii on embryo-larval development of medaka fish, Oryzias latipes. Toxicon 2008, 51, 262-269.
    • (2008) Toxicon , vol.51 , pp. 262-269
    • Lecoz, N.1    Malécot, M.2    Quiblier, C.3    Puiseux-Dao, S.4
  • 25
    • 1942468733 scopus 로고    scopus 로고
    • Proteomics approach on microcystin binding proteins in mouse liver for investigation of microcystin toxicity
    • Imanishi, S., Harada, K., Proteomics approach on microcystin binding proteins in mouse liver for investigation of microcystin toxicity. Toxicon 2004, 43, 651-659.
    • (2004) Toxicon , vol.43 , pp. 651-659
    • Imanishi, S.1    Harada, K.2
  • 26
    • 2642511406 scopus 로고    scopus 로고
    • Proteomic characterization of protein phosphatase complexes of the mammalian nucleus
    • Tran, H., Ulke, A., Morrice, N., Johannes, C., Moorhead, G., Proteomic characterization of protein phosphatase complexes of the mammalian nucleus. Mol. Cell. Proteomics 2004, 3, 257-265.
    • (2004) Mol. Cell. Proteomics , vol.3 , pp. 257-265
    • Tran, H.1    Ulke, A.2    Morrice, N.3    Johannes, C.4    Moorhead, G.5
  • 27
    • 24944453273 scopus 로고    scopus 로고
    • Induction of apoptosis in mouse liver by microcystin-LR: a combined transcriptomic, proteomic, and simulation strategy
    • Chen, T., Wang, Q., Cui, J., Yang, W. et al., Induction of apoptosis in mouse liver by microcystin-LR: a combined transcriptomic, proteomic, and simulation strategy. Mol. Cell. Proteomics 2005, 4, 958-974.
    • (2005) Mol. Cell. Proteomics , vol.4 , pp. 958-974
    • Chen, T.1    Wang, Q.2    Cui, J.3    Yang, W.4
  • 28
    • 29144449939 scopus 로고    scopus 로고
    • Proteomic analysis of cellular response to microcystin in human amnion FL cells
    • Fu, W., Xu, L., Yu, Y., Proteomic analysis of cellular response to microcystin in human amnion FL cells. J. Proteome Res. 2005, 4, 2207-2215.
    • (2005) J. Proteome Res. , vol.4 , pp. 2207-2215
    • Fu, W.1    Xu, L.2    Yu, Y.3
  • 29
    • 36148984571 scopus 로고    scopus 로고
    • Phosphoprotein analysis for investigation of in vivo relationship between protein phosphatase inhibitory activities and acute hepatotoxicity of microcystin-LR
    • Tachi, M., Imanishi, S., Harada, K., Phosphoprotein analysis for investigation of in vivo relationship between protein phosphatase inhibitory activities and acute hepatotoxicity of microcystin-LR. Environ. Toxicol. 2007, 22, 620-629.
    • (2007) Environ. Toxicol. , vol.22 , pp. 620-629
    • Tachi, M.1    Imanishi, S.2    Harada, K.3
  • 30
    • 61849098719 scopus 로고    scopus 로고
    • Identification of temporal differentially expressed protein responses to microcystin in human amniotic epithelial cells
    • Fu, W., Yu, Y., Xu, L., Identification of temporal differentially expressed protein responses to microcystin in human amniotic epithelial cells. Chem. Res. Toxicol. 2009, 22, 41-51.
    • (2009) Chem. Res. Toxicol. , vol.22 , pp. 41-51
    • Fu, W.1    Yu, Y.2    Xu, L.3
  • 31
    • 38749111845 scopus 로고    scopus 로고
    • Global quantitative analysis of protein expression and phosphorylation status in the liver of the medaka fish (Oryzias latipes) exposed to microcystin-LR I. Balneation study
    • Mezhoud, K., Praseuth, D., Puiseux-Dao, S., François, J. et al., Global quantitative analysis of protein expression and phosphorylation status in the liver of the medaka fish (Oryzias latipes) exposed to microcystin-LR I. Balneation study. Aquat. Toxicol. 2008, 86, 166-175.
    • (2008) Aquat. Toxicol. , vol.86 , pp. 166-175
    • Mezhoud, K.1    Praseuth, D.2    Puiseux-Dao, S.3    François, J.4
  • 32
    • 44949126994 scopus 로고    scopus 로고
    • Proteomic and phosphoproteomic analysis of cellular responses in medaka fish (Oryzias latipes) following oral gavage with microcystin-LR
    • Mezhoud, K., Bauchet, A., Château-Joubert, S., Praseuth, D. et al., Proteomic and phosphoproteomic analysis of cellular responses in medaka fish (Oryzias latipes) following oral gavage with microcystin-LR. Toxicon 2008, 51, 1431-1439.
    • (2008) Toxicon , vol.51 , pp. 1431-1439
    • Mezhoud, K.1    Bauchet, A.2    Château-Joubert, S.3    Praseuth, D.4
  • 33
    • 68249107159 scopus 로고    scopus 로고
    • Proteomic study of the effects of microcystin-LR on organelle and membrane proteins in medaka fish liver
    • Malécot, M., Mezhoud, K., Marie, A., Praseuth, D. et al., Proteomic study of the effects of microcystin-LR on organelle and membrane proteins in medaka fish liver. Aquat. Toxicol. 2009, 94, 153-161.
    • (2009) Aquat. Toxicol. , vol.94 , pp. 153-161
    • Malécot, M.1    Mezhoud, K.2    Marie, A.3    Praseuth, D.4
  • 34
    • 79952110835 scopus 로고    scopus 로고
    • Quantification of proteins by iTRAQ
    • Unwin, R. D., Quantification of proteins by iTRAQ. Methods Mol. Biol. 2010, 658, 205-215.
    • (2010) Methods Mol. Biol. , vol.658 , pp. 205-215
    • Unwin, R.D.1
  • 35
    • 0141955057 scopus 로고    scopus 로고
    • A method for reducing the time required to match protein sequences with tandem mass spectra
    • Craig, R., Beavis, R., A method for reducing the time required to match protein sequences with tandem mass spectra. Rapid Commun. Mass Spectrom. 2003, 17, 2310-2316.
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , pp. 2310-2316
    • Craig, R.1    Beavis, R.2
  • 36
    • 0042338362 scopus 로고    scopus 로고
    • A statistical model for identifying proteins by tandem mass spectrometry
    • Nesvizhskii, A., Keller, A., Kolker, E., Aebersold, R., A statistical model for identifying proteins by tandem mass spectrometry. Anal. Chem. 2003, 75, 4646-4658.
    • (2003) Anal. Chem. , vol.75 , pp. 4646-4658
    • Nesvizhskii, A.1    Keller, A.2    Kolker, E.3    Aebersold, R.4
  • 37
    • 0037108887 scopus 로고    scopus 로고
    • Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search
    • Keller, A., Nesvizhskii, A. I., Kolker, E., Aebersold, R., Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. Anal. Chem. 2002, 74, 5383-5392.
    • (2002) Anal. Chem. , vol.74 , pp. 5383-5392
    • Keller, A.1    Nesvizhskii, A.I.2    Kolker, E.3    Aebersold, R.4
  • 39
    • 45549089420 scopus 로고    scopus 로고
    • High-throughput functional annotation and data mining with the Blast2GO suite
    • Götz, S., García-Gómez, J., Terol, J., Williams, T. et al., High-throughput functional annotation and data mining with the Blast2GO suite. Nucleic Acids Res. 2008, 36, 3420-3435.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 3420-3435
    • Götz, S.1    García-Gómez, J.2    Terol, J.3    Williams, T.4
  • 40
    • 58149177166 scopus 로고    scopus 로고
    • Reactome knowledgebase of human biological pathways and processes
    • Matthews, L., Gopinath, G., Gillespie, M., Caudy, M. et al., Reactome knowledgebase of human biological pathways and processes. Nucleic Acids Res. 2009, 37, D619-D622.
    • (2009) Nucleic Acids Res. , vol.37
    • Matthews, L.1    Gopinath, G.2    Gillespie, M.3    Caudy, M.4
  • 41
    • 33750931268 scopus 로고    scopus 로고
    • The acute effects of microcystin LR on the transcription of nine glutathione S-transferase genes in common carp Cyprinus carpio L
    • Fu, J., Xie, P., The acute effects of microcystin LR on the transcription of nine glutathione S-transferase genes in common carp Cyprinus carpio L. Aquat. Toxicol. 2006, 80, 261-266.
    • (2006) Aquat. Toxicol. , vol.80 , pp. 261-266
    • Fu, J.1    Xie, P.2
  • 42
    • 34548824068 scopus 로고    scopus 로고
    • Dynamics of glutathione-S-transferases in Mytilus galloprovincialis exposed to toxic Microcystis aeruginosa cells, extracts and pure toxins
    • Vasconcelos, V., Wiegand, C., Pflugmacher, S., Dynamics of glutathione-S-transferases in Mytilus galloprovincialis exposed to toxic Microcystis aeruginosa cells, extracts and pure toxins. Toxicon 2007, 50, 740-745.
    • (2007) Toxicon , vol.50 , pp. 740-745
    • Vasconcelos, V.1    Wiegand, C.2    Pflugmacher, S.3
  • 43
    • 52949147144 scopus 로고    scopus 로고
    • The effect of cyanobacterial crude extract on the transcription of GST mu, GST kappa and GST rho in different organs of goldfish (Carassius auratus)
    • Hao, L., Xie, P., Fu, J., Li, G. et al., The effect of cyanobacterial crude extract on the transcription of GST mu, GST kappa and GST rho in different organs of goldfish (Carassius auratus). Aquat. Toxicol. 2008, 90, 1-7.
    • (2008) Aquat. Toxicol. , vol.90 , pp. 1-7
    • Hao, L.1    Xie, P.2    Fu, J.3    Li, G.4
  • 44
    • 63449109207 scopus 로고    scopus 로고
    • Hepatic and branchial glutathione S-transferases of two fish species: substrate specificity and biotransformation of microcystin-LR
    • Setlíková, I., Wiegand, C., Hepatic and branchial glutathione S-transferases of two fish species: substrate specificity and biotransformation of microcystin-LR. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2009, 149, 515-523.
    • (2009) Comp. Biochem. Physiol. C Toxicol. Pharmacol. , vol.149 , pp. 515-523
    • Setlíková, I.1    Wiegand, C.2
  • 45
    • 0031788805 scopus 로고    scopus 로고
    • Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: the first step of detoxication
    • Pflugmacher, S., Wiegand, C., Oberemm, A., Beattie, K. et al., Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: the first step of detoxication. Biochim. Biophys. Acta 1998, 1425, 527-533.
    • (1998) Biochim. Biophys. Acta , vol.1425 , pp. 527-533
    • Pflugmacher, S.1    Wiegand, C.2    Oberemm, A.3    Beattie, K.4
  • 46
    • 33751528289 scopus 로고    scopus 로고
    • Structural and functional characterization of microcystin detoxification-related liver genes in a phytoplanktivorous fish, Nile tilapia (Oreochromis niloticus)
    • Wang, L., Liang, X., Liao, W., Lei, L., Han, B., Structural and functional characterization of microcystin detoxification-related liver genes in a phytoplanktivorous fish, Nile tilapia (Oreochromis niloticus). Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2006, 144, 216-227.
    • (2006) Comp. Biochem. Physiol. C Toxicol. Pharmacol. , vol.144 , pp. 216-227
    • Wang, L.1    Liang, X.2    Liao, W.3    Lei, L.4    Han, B.5
  • 47
    • 34247204165 scopus 로고    scopus 로고
    • Toxicogenomic evaluation of microcystin-LR treated with ultrasonic irradiation
    • Hudder, A., Song, W., O'Shea, K., Walsh, P., Toxicogenomic evaluation of microcystin-LR treated with ultrasonic irradiation. Toxicol. Appl. Pharmacol. 2007, 220, 357-364.
    • (2007) Toxicol. Appl. Pharmacol. , vol.220 , pp. 357-364
    • Hudder, A.1    Song, W.2    O'Shea, K.3    Walsh, P.4
  • 48
    • 33646114525 scopus 로고    scopus 로고
    • Differential oxidative stress responses to microcystins LR and RR in intraperitoneally exposed tilapia fish (Oreochromis sp)
    • Prieto, A., Jos, A., Pichardo, S., Moreno, I., Cameán, A., Differential oxidative stress responses to microcystins LR and RR in intraperitoneally exposed tilapia fish (Oreochromis sp). Aquat. Toxicol. 2006, 77, 314-321.
    • (2006) Aquat. Toxicol. , vol.77 , pp. 314-321
    • Prieto, A.1    Jos, A.2    Pichardo, S.3    Moreno, I.4    Cameán, A.5
  • 49
    • 73049083343 scopus 로고    scopus 로고
    • Alteration and recovery of the antioxidant system induced by sub-chronic exposure to microcystin-LR in mice: its relation to liver lipid composition
    • Sedan, D., Andrinolo, D., Telese, L., Giannuzzi, L. et al., Alteration and recovery of the antioxidant system induced by sub-chronic exposure to microcystin-LR in mice: its relation to liver lipid composition. Toxicon 2010, 55, 333-342.
    • (2010) Toxicon , vol.55 , pp. 333-342
    • Sedan, D.1    Andrinolo, D.2    Telese, L.3    Giannuzzi, L.4
  • 50
    • 37749000841 scopus 로고    scopus 로고
    • Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery
    • Wasan, K., Brocks, D., Lee, S., Sachs-Barrable, K., Thornton, S., Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery. Nat. Rev. Drug Discov. 2008, 7, 84-99.
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 84-99
    • Wasan, K.1    Brocks, D.2    Lee, S.3    Sachs-Barrable, K.4    Thornton, S.5
  • 51
    • 38849140840 scopus 로고    scopus 로고
    • Is raising HDL a futile strategy for atheroprotection?
    • Joy, T., Hegele, R., Is raising HDL a futile strategy for atheroprotection? Nat. Rev. Drug Discov. 2008, 7, 143-155.
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 143-155
    • Joy, T.1    Hegele, R.2
  • 52
    • 67649414226 scopus 로고    scopus 로고
    • Morphological and ultrastructural effects of microcystin-LR from Microcystis aeruginosa extract on a kidney cell line
    • Alverca, E., Andrade, M., Dias, E., Sam Bento, F. et al., Morphological and ultrastructural effects of microcystin-LR from Microcystis aeruginosa extract on a kidney cell line. Toxicon 2009, 54, 283-294.
    • (2009) Toxicon , vol.54 , pp. 283-294
    • Alverca, E.1    Andrade, M.2    Dias, E.3    Sam Bento, F.4
  • 53
    • 72149119995 scopus 로고    scopus 로고
    • Time-dependent protective efficacy of Trolox (vitamin E analog) against microcystin-induced toxicity in tilapia (Oreochromis niloticus)
    • Prieto, A., Jos, A., Pichardo, S., Moreno, I. et al., Time-dependent protective efficacy of Trolox (vitamin E analog) against microcystin-induced toxicity in tilapia (Oreochromis niloticus). Environ. Toxicol. 2009, 24, 563-579.
    • (2009) Environ. Toxicol. , vol.24 , pp. 563-579
    • Prieto, A.1    Jos, A.2    Pichardo, S.3    Moreno, I.4
  • 54
    • 24344481760 scopus 로고    scopus 로고
    • In vivo studies on toxin accumulation in liver and ultrastructural changes of hepatocytes of the phytoplanktivorous bighead carp i.p.-injected with extracted microcystins
    • Li, L., Xie, P., Chen, J., In vivo studies on toxin accumulation in liver and ultrastructural changes of hepatocytes of the phytoplanktivorous bighead carp i.p.-injected with extracted microcystins. Toxicon 2005, 46, 533-545.
    • (2005) Toxicon , vol.46 , pp. 533-545
    • Li, L.1    Xie, P.2    Chen, J.3
  • 55
    • 42649101990 scopus 로고    scopus 로고
    • Toxic response indicators of microcystin-LR in F344 rats following a single-dose treatment
    • Billam, M., Mukhi, S., Tang, L., Gao, W., Wang, J., Toxic response indicators of microcystin-LR in F344 rats following a single-dose treatment. Toxicon 2008, 51, 1068-1080.
    • (2008) Toxicon , vol.51 , pp. 1068-1080
    • Billam, M.1    Mukhi, S.2    Tang, L.3    Gao, W.4    Wang, J.5
  • 56
    • 34548429270 scopus 로고    scopus 로고
    • Hepatic gene expression changes in mice associated with prolonged sublethal microcystin exposure
    • Clark, S., Davis, M., Ryan, T., Searfoss, G., Hooser, S., Hepatic gene expression changes in mice associated with prolonged sublethal microcystin exposure. Toxicol. Pathol. 2007, 35, 594-605.
    • (2007) Toxicol. Pathol. , vol.35 , pp. 594-605
    • Clark, S.1    Davis, M.2    Ryan, T.3    Searfoss, G.4    Hooser, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.