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Volumn 8, Issue , 2008, Pages 121-137

Field and laboratory studies on pathological and biochemical characterization of microcystin-induced liver and kidney damage in the phytoplanktivorous bighead carp

Author keywords

Kidney; Large fish pen; Liver; Microcystin; Microcystis blooms; Pathological and biochemical characterizations; Phytoplanktivorous bighead carp

Indexed keywords

ANTIOXIDANT; GLUTATHIONE; MICROCYSTIN;

EID: 39449083530     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2008.32     Document Type: Article
Times cited : (27)

References (58)
  • 1
    • 0030623448 scopus 로고
    • Cyanobacterial toxins: Occurrence, modes of action, health effects and exposure routes
    • Seiler, J.P. and Vilanova, E, Eds. Springer, Berlin. pp
    • Codd, G.A., Ward, C.J., and Bell, S.G. (1977) Cyanobacterial toxins: occurrence, modes of action, health effects and exposure routes. In Applied Toxicology. Seiler, J.P. and Vilanova, E., Eds. Springer, Berlin. pp. 399-410.
    • (1977) Applied Toxicology , pp. 399-410
    • Codd, G.A.1    Ward, C.J.2    Bell, S.G.3
  • 2
    • 0034874474 scopus 로고    scopus 로고
    • Toxic cyanobacterial bloom problems in Australian waters: Risks and impacts on human health
    • Falconer, I.R. (2001) Toxic cyanobacterial bloom problems in Australian waters: risks and impacts on human health. Phycologia 40, 228-233.
    • (2001) Phycologia , vol.40 , pp. 228-233
    • Falconer, I.R.1
  • 3
    • 0036390216 scopus 로고    scopus 로고
    • An international intercomparison exercise for the determination of purified microcystin-LR and microcystins in cyanobacterial field material
    • Fastner, J., Codd, G.A., Metcalf, J.S., Woitke, P., Wiedner, C., and Utkilen, H. (2002) An international intercomparison exercise for the determination of purified microcystin-LR and microcystins in cyanobacterial field material. Anal. Biochem. Chem. 374, 437-444.
    • (2002) Anal. Biochem. Chem , vol.374 , pp. 437-444
    • Fastner, J.1    Codd, G.A.2    Metcalf, J.S.3    Woitke, P.4    Wiedner, C.5    Utkilen, H.6
  • 5
    • 0032124844 scopus 로고    scopus 로고
    • The toxicology of microcystin
    • Dawson, R.M. (1998) The toxicology of microcystin. Toxicon 36, 953-962.
    • (1998) Toxicon , vol.36 , pp. 953-962
    • Dawson, R.M.1
  • 6
    • 0141543868 scopus 로고    scopus 로고
    • Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR
    • Li, X.Y., Liu, Y.D., Song, L.R., and Liu, J. (2003) Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR. Toxicon 42, 85-89.
    • (2003) Toxicon , vol.42 , pp. 85-89
    • Li, X.Y.1    Liu, Y.D.2    Song, L.R.3    Liu, J.4
  • 7
    • 0025733722 scopus 로고
    • Histopathological effects of microcystin-LR, a cyclic peptide toxin from the cyanobacterium (blue-green alga) Microcystis aeruginosa, on common carp (Cyprinus carpio L.)
    • Råbergh, C.M.I., Bylund, G., and Erikssonl, J.E. (1991) Histopathological effects of microcystin-LR, a cyclic peptide toxin from the cyanobacterium (blue-green alga) Microcystis aeruginosa, on common carp (Cyprinus carpio L.). Aquat. Toxicol. 20, 131-146.
    • (1991) Aquat. Toxicol , vol.20 , pp. 131-146
    • Råbergh, C.M.I.1    Bylund, G.2    Erikssonl, J.E.3
  • 8
    • 0002304119 scopus 로고    scopus 로고
    • The histopathology of carp, Cyprinus carpio L., exposed to microcystins by gavage, immersion and intraperitoneal administration
    • Carbis, C.R., Rawlin, G.T., Mitchell, G.F., Anderson, J.W., and McCauley, I. (1996) The histopathology of carp, Cyprinus carpio L., exposed to microcystins by gavage, immersion and intraperitoneal administration. J. Fish. Dis. 19, 199-207.
    • (1996) J. Fish. Dis , vol.19 , pp. 199-207
    • Carbis, C.R.1    Rawlin, G.T.2    Mitchell, G.F.3    Anderson, J.W.4    McCauley, I.5
  • 9
    • 0029945765 scopus 로고    scopus 로고
    • Hepatic and renal pathology of intraperitoneally administered microcystin-LR in rainbow trout (Oncorhynchus mykiss)
    • Kotak, B.J., Semalulu, S., Friytz, D.L., Prepas, E.E., Hrudey, S.E., and Coppock, R.W. (1996) Hepatic and renal pathology of intraperitoneally administered microcystin-LR in rainbow trout (Oncorhynchus mykiss). Toxicon 34, 517-525.
    • (1996) Toxicon , vol.34 , pp. 517-525
    • Kotak, B.J.1    Semalulu, S.2    Friytz, D.L.3    Prepas, E.E.4    Hrudey, S.E.5    Coppock, R.W.6
  • 10
    • 0037674832 scopus 로고    scopus 로고
    • Hepatic accumulation and effects of microcytin-LR on juvenile goldfish Carassius auratus L
    • Malbrouck, C., Trausch, G., Devos, P., and Kestemont, P. (2003) Hepatic accumulation and effects of microcytin-LR on juvenile goldfish Carassius auratus L. Comp. Biochem. Physiol. C 135, 39-48.
    • (2003) Comp. Biochem. Physiol. C , vol.135 , pp. 39-48
    • Malbrouck, C.1    Trausch, G.2    Devos, P.3    Kestemont, P.4
  • 11
    • 0030934727 scopus 로고    scopus 로고
    • Biochemical characterization of microcystin toxicity in rainbow trout (Oncorhynchus Mykiss)
    • Tencalla, F. and Dietrich, D. (1997) Biochemical characterization of microcystin toxicity in rainbow trout (Oncorhynchus Mykiss). Toxicon 35, 583-595.
    • (1997) Toxicon , vol.35 , pp. 583-595
    • Tencalla, F.1    Dietrich, D.2
  • 12
    • 0034176293 scopus 로고    scopus 로고
    • Pathological and biochemical characterization of microcystin-induced hepatopancreas and kidney damage in carp (Cyprinus carpio)
    • Fischer, W.J. and Dietrich, D.R. (2000) Pathological and biochemical characterization of microcystin-induced hepatopancreas and kidney damage in carp (Cyprinus carpio). Toxicol. Appl. Pharmacol. 164, 73-81.
    • (2000) Toxicol. Appl. Pharmacol , vol.164 , pp. 73-81
    • Fischer, W.J.1    Dietrich, D.R.2
  • 13
    • 8644230019 scopus 로고    scopus 로고
    • Subchronic oral toxicity of microcystin in common carp (Cyprinus carpio L.) exposed to Microcystis under laboratory conditions
    • Li, X.Y., Chung, I.K., Kim, J.I., and Lee, J.A. (2004) Subchronic oral toxicity of microcystin in common carp (Cyprinus carpio L.) exposed to Microcystis under laboratory conditions. Toxicon 44, 821-827.
    • (2004) Toxicon , vol.44 , pp. 821-827
    • Li, X.Y.1    Chung, I.K.2    Kim, J.I.3    Lee, J.A.4
  • 14
    • 0031749543 scopus 로고    scopus 로고
    • Studies on oxidative damage induced by cyanobacteria extract in primary cultured rat hepatocytes
    • Ding, W.X., Shen, H.M., Zhu, H.G., and Ong, C.N. (1998) Studies on oxidative damage induced by cyanobacteria extract in primary cultured rat hepatocytes. Environ. Res. 78, 12-18.
    • (1998) Environ. Res , vol.78 , pp. 12-18
    • Ding, W.X.1    Shen, H.M.2    Zhu, H.G.3    Ong, C.N.4
  • 15
    • 0035941161 scopus 로고    scopus 로고
    • Critical role of reactive oxygen species formation in microcystin-induced cytoskeleton disruption in primary cultured hepatocytes
    • Ding, W.X., Shen, H.M., and Ong, C.N. (2001) Critical role of reactive oxygen species formation in microcystin-induced cytoskeleton disruption in primary cultured hepatocytes. J. Toxicol. Environ. Health A 64, 507-519.
    • (2001) J. Toxicol. Environ. Health A , vol.64 , pp. 507-519
    • Ding, W.X.1    Shen, H.M.2    Ong, C.N.3
  • 16
    • 16844374445 scopus 로고    scopus 로고
    • Toxic cyanobacterial cells containing microcystins induce oxidative stress in exposed tilapia fish (Oreochromis sp.) under laboratory conditions
    • Jos, Á., Pichardo, S., Prieto, A.I., Repetto, G., Vázquez, C.M., Moreno, I., and Cameán, A.M. (2005) Toxic cyanobacterial cells containing microcystins induce oxidative stress in exposed tilapia fish (Oreochromis sp.) under laboratory conditions. Aquat. Toxicol. 72, 261-271.
    • (2005) Aquat. Toxicol , vol.72 , pp. 261-271
    • Jos, A.1    Pichardo, S.2    Prieto, A.I.3    Repetto, G.4    Vázquez, C.M.5    Moreno, I.6    Cameán, A.M.7
  • 18
    • 0030322756 scopus 로고    scopus 로고
    • Fish antioxidant defenses. A comparative approach
    • Filho, W. (1996) Fish antioxidant defenses. A comparative approach. Braz. J. Med. Biol. Res. 29, 1735-1742.
    • (1996) Braz. J. Med. Biol. Res , vol.29 , pp. 1735-1742
    • Filho, W.1
  • 19
    • 0033057130 scopus 로고    scopus 로고
    • Uptake and effects of microcystin-LR on detoxification enzymes of early life stages of the zebrafish (Danio rerio)
    • Wiegand, C., Pflugmacher, S., Oberemm, A., Meems, N., Beattie, K.A., Steinberg, C., and Codd, G.A. (1999) Uptake and effects of microcystin-LR on detoxification enzymes of early life stages of the zebrafish (Danio rerio). Environ. Toxicol. 14, 89-95.
    • (1999) Environ. Toxicol , vol.14 , pp. 89-95
    • Wiegand, C.1    Pflugmacher, S.2    Oberemm, A.3    Meems, N.4    Beattie, K.A.5    Steinberg, C.6    Codd, G.A.7
  • 20
    • 0037202005 scopus 로고    scopus 로고
    • Effects of enteric bacterial and cyanobacterial lipopolysaccharides, and of microcystin-LR, on glutathione S-transferase activities in zebra fish (Danio rerio)
    • Best, J.H., Pflugmacher, S., Wiegand, C., Eddy, F.B., Metcalf, J.S., and Codd, G.A. (2002) Effects of enteric bacterial and cyanobacterial lipopolysaccharides, and of microcystin-LR, on glutathione S-transferase activities in zebra fish (Danio rerio). Aquat. Toxicol. 60, 223-231.
    • (2002) Aquat. Toxicol , vol.60 , pp. 223-231
    • Best, J.H.1    Pflugmacher, S.2    Wiegand, C.3    Eddy, F.B.4    Metcalf, J.S.5    Codd, G.A.6
  • 21
    • 1642265731 scopus 로고    scopus 로고
    • Effect of microcystin-LR on protein phosphatase activity in fed and fasted juvenile goldfish Carassius auratus L
    • Malbrouck, C., Trausch, G., Devos, P., and Kestemont, P. (2004) Effect of microcystin-LR on protein phosphatase activity in fed and fasted juvenile goldfish Carassius auratus L. Toxicon 43, 295-301.
    • (2004) Toxicon , vol.43 , pp. 295-301
    • Malbrouck, C.1    Trausch, G.2    Devos, P.3    Kestemont, P.4
  • 22
    • 0027876735 scopus 로고
    • Food habits, feeding behavior and impact of triploid bighead carp, Hypophthalmichthys nobilis, in experimental ponds
    • Opuszynski, K. and Shireman, J.V. (1995) Food habits, feeding behavior and impact of triploid bighead carp, Hypophthalmichthys nobilis, in experimental ponds. J. Fish Biol. 42, 517-530.
    • (1995) J. Fish Biol , vol.42 , pp. 517-530
    • Opuszynski, K.1    Shireman, J.V.2
  • 23
    • 1542601156 scopus 로고    scopus 로고
    • Practical success of biomanipulation using filter-feeding fish to control cyanobacteria blooms: Synthesis of decades of research and application in a subtropical hypereutrophic lake
    • Xie, P. and Liu, J.K. (2001) Practical success of biomanipulation using filter-feeding fish to control cyanobacteria blooms: synthesis of decades of research and application in a subtropical hypereutrophic lake. TheScientificWorldJOURNAL 1, 337-356.
    • (2001) TheScientificWorldJOURNAL , vol.1 , pp. 337-356
    • Xie, P.1    Liu, J.K.2
  • 24
    • 39449124025 scopus 로고
    • Fishery Statistics, Catches and Landing
    • FAO , Food and Agriculture Organization of the United Nations, Rome
    • FAO (1991) Fishery Statistics, Catches and Landing. FAO Yearbook. Food and Agriculture Organization of the United Nations, Rome.
    • (1991) FAO Yearbook
  • 25
    • 0344430177 scopus 로고    scopus 로고
    • Dynamics of microcystins-LR and - RR in the phytoplanktivorous silver carp in a sub-chronic toxicity experiment
    • Xie, L.Q., Xie, P., Ozawa, K., Honma, T., Yokoyama, A., and Park, H.D. (2004) Dynamics of microcystins-LR and - RR in the phytoplanktivorous silver carp in a sub-chronic toxicity experiment. Environ. Pollut. 127, 431-439.
    • (2004) Environ. Pollut , vol.127 , pp. 431-439
    • Xie, L.Q.1    Xie, P.2    Ozawa, K.3    Honma, T.4    Yokoyama, A.5    Park, H.D.6
  • 26
    • 0031719546 scopus 로고    scopus 로고
    • Hepatotoxic microcystins and neurotoxic anatoxin-a in cyanobacterial blooms from Korean lakes
    • Park, H.D., Kim, B., Kim, E., and Okino, T. (1998) Hepatotoxic microcystins and neurotoxic anatoxin-a in cyanobacterial blooms from Korean lakes. Environ. Toxicol. Water Qual. 13, 225-234.
    • (1998) Environ. Toxicol. Water Qual , vol.13 , pp. 225-234
    • Park, H.D.1    Kim, B.2    Kim, E.3    Okino, T.4
  • 27
    • 0037723070 scopus 로고    scopus 로고
    • Gupta, N., Pant, S.C., Vijayaraghavan, R., and Lakshmana Rao, P.V. (2003) Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice. Toxicology 188, 285-296.
    • Gupta, N., Pant, S.C., Vijayaraghavan, R., and Lakshmana Rao, P.V. (2003) Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice. Toxicology 188, 285-296.
  • 29
    • 0021318441 scopus 로고
    • Catalase in vitro
    • Aebi, H. (1984) Catalase in vitro. Methods Enzymol. 105, 121-126.
    • (1984) Methods Enzymol , vol.105 , pp. 121-126
    • Aebi, H.1
  • 30
    • 0023130150 scopus 로고
    • Assaying for superoxide dismutase activity: Some large consequences of minor changes in conditions
    • Bayer, W.F. and Fridovich, J.L. (1987) Assaying for superoxide dismutase activity: some large consequences of minor changes in conditions. Anal. Biochem. 161, 559-566.
    • (1987) Anal. Biochem , vol.161 , pp. 559-566
    • Bayer, W.F.1    Fridovich, J.L.2
  • 31
    • 0001896020 scopus 로고
    • Evidence for glutathione peroxidase activities in cultured plant cells
    • Drotar, A., Phelps, P., and Fall, R. (1985) Evidence for glutathione peroxidase activities in cultured plant cells. Plant Sci. 42, 35-40.
    • (1985) Plant Sci , vol.42 , pp. 35-40
    • Drotar, A.1    Phelps, P.2    Fall, R.3
  • 32
    • 0016275313 scopus 로고
    • Glutathione S-transferases. The first enzymatic step in mercapturic acid formation
    • Habig, W.H., Pabst, M.J., and Jakoby, W.B. (1974) Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249, 7130-7139.
    • (1974) J. Biol. Chem , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 33
    • 0019167355 scopus 로고
    • Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
    • Griffith, O. (1980) Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106, 207-212.
    • (1980) Anal. Biochem , vol.106 , pp. 207-212
    • Griffith, O.1
  • 34
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantification of microgram quantities of protein using the principle of protein dye-binding
    • Braford, M.M. (1976) A rapid and sensitive method for the quantification of microgram quantities of protein using the principle of protein dye-binding. Anal. Biochem. 72, 248-254
    • (1976) Anal. Biochem , vol.72 , pp. 248-254
    • Braford, M.M.1
  • 35
    • 0030955931 scopus 로고    scopus 로고
    • Liver damage in brown trout, Salmo trutta L., and rainbow trout, Oncorhynchus mykiss (Walbaum), following administration of the cyanobacterial hepatotoxin microcystin-LR via the dorsal aorta
    • Bury, N.R., McGeer, J.C., Eddy, F.B., and Codd, G.A. (1997) Liver damage in brown trout, Salmo trutta L., and rainbow trout, Oncorhynchus mykiss (Walbaum), following administration of the cyanobacterial hepatotoxin microcystin-LR via the dorsal aorta. J. Fish. Dis. 20, 209-215.
    • (1997) J. Fish. Dis , vol.20 , pp. 209-215
    • Bury, N.R.1    McGeer, J.C.2    Eddy, F.B.3    Codd, G.A.4
  • 36
    • 0034106372 scopus 로고    scopus 로고
    • Microcystin-LR toxicodynamics, induced pathology, and immunohistochemical location in livers of blue-green algae exposed rainbow trout (Oncorhynchus mykiss)
    • Fischer, W.J., Hitzfeld, B.C., Tencalla, F., Eriksson, J.E., Mikhailov, A., and Dietrich, D.R. (2000) Microcystin-LR toxicodynamics, induced pathology, and immunohistochemical location in livers of blue-green algae exposed rainbow trout (Oncorhynchus mykiss). Toxicol. Sci. 54, 365-372.
    • (2000) Toxicol. Sci , vol.54 , pp. 365-372
    • Fischer, W.J.1    Hitzfeld, B.C.2    Tencalla, F.3    Eriksson, J.E.4    Mikhailov, A.5    Dietrich, D.R.6
  • 37
    • 0030617941 scopus 로고    scopus 로고
    • A study of feral carp, Cyprinus carpio L. exposed to Microcystis aeruginosa at Lake Mokoan, Australia, and possible implications for fish health
    • Carbis, C.R., Rawlin, G.T., Grant, P., Mitchell, G.F., Anderson, J.W., and McCauley, I. (1997) A study of feral carp, Cyprinus carpio L. exposed to Microcystis aeruginosa at Lake Mokoan, Australia, and possible implications for fish health. J. Fish. Dis. 20, 81-91.
    • (1997) J. Fish. Dis , vol.20 , pp. 81-91
    • Carbis, C.R.1    Rawlin, G.T.2    Grant, P.3    Mitchell, G.F.4    Anderson, J.W.5    McCauley, I.6
  • 38
    • 34047100231 scopus 로고    scopus 로고
    • In situ study on the control of toxic Microcystis blooms using phytoplanktivorous fish in the subtropical Lake Taihu of China: A large fish pen experiment
    • Ke, Z.X., Xie, P., Guo, L.G., Liu, Y.Q., and Yang, H. (2007) In situ study on the control of toxic Microcystis blooms using phytoplanktivorous fish in the subtropical Lake Taihu of China: a large fish pen experiment. Aquaculture 265, 127-138.
    • (2007) Aquaculture , vol.265 , pp. 127-138
    • Ke, Z.X.1    Xie, P.2    Guo, L.G.3    Liu, Y.Q.4    Yang, H.5
  • 39
    • 27644577702 scopus 로고    scopus 로고
    • The use of the fish cell lines RTG-2 and PLHC-1 to compare the toxic effects produced by microcystins LR and RR
    • Pichardo, S., Jos, A., Zurita, J.L., Salguero, M., Camean, A.M., and Repetto, G. (2005) The use of the fish cell lines RTG-2 and PLHC-1 to compare the toxic effects produced by microcystins LR and RR. Toxicol. In Vitro 19, 865-873.
    • (2005) Toxicol. In Vitro , vol.19 , pp. 865-873
    • Pichardo, S.1    Jos, A.2    Zurita, J.L.3    Salguero, M.4    Camean, A.M.5    Repetto, G.6
  • 40
    • 0037436437 scopus 로고    scopus 로고
    • Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity
    • Ding, W.X. and Ong, C.N. (2003) Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity. FEMS Microbiol. Lett. 220, 1-7.
    • (2003) FEMS Microbiol. Lett , vol.220 , pp. 1-7
    • Ding, W.X.1    Ong, C.N.2
  • 41
    • 13944255112 scopus 로고    scopus 로고
    • Antioxidant enzyme activity and lipid peroxidation in liver and kidney of rats exposed to microcystin-LR administered intraperitoneally
    • Moreno, I., Pichardo, S., Jos, A., Gomez-Amores, L., Mate, A., Vázquez, C.M., and Cameán, A. (2005) Antioxidant enzyme activity and lipid peroxidation in liver and kidney of rats exposed to microcystin-LR administered intraperitoneally. Toxicon 45, 395-402.
    • (2005) Toxicon , vol.45 , pp. 395-402
    • Moreno, I.1    Pichardo, S.2    Jos, A.3    Gomez-Amores, L.4    Mate, A.5    Vázquez, C.M.6    Cameán, A.7
  • 42
    • 0002828891 scopus 로고    scopus 로고
    • Cytological alterations in fish hepatocytes following in vivo and in vitro sublethal exposure to xenobiotics-structural biomarkers of environmental contamination
    • Braunbeck, T, Hinton, D.E, and Streit, B, Eds. Birkhäuser, Basel. pp
    • Braunbeck, T. (1998) Cytological alterations in fish hepatocytes following in vivo and in vitro sublethal exposure to xenobiotics-structural biomarkers of environmental contamination. In Fish Ecotoxicology. Braunbeck, T., Hinton, D.E., and Streit, B., Eds. Birkhäuser, Basel. pp. 61-40.
    • (1998) Fish Ecotoxicology , pp. 61-40
    • Braunbeck, T.1
  • 43
    • 0035998334 scopus 로고    scopus 로고
    • Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds
    • Ito, E., Takai, A., Kondo, F., Masui, H., Imanishi, S., and Harada, K. (2002). Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds. Toxicon 40, 1017-1025.
    • (2002) Toxicon , vol.40 , pp. 1017-1025
    • Ito, E.1    Takai, A.2    Kondo, F.3    Masui, H.4    Imanishi, S.5    Harada, K.6
  • 44
    • 25144517852 scopus 로고    scopus 로고
    • Uptake, tissue distribution and accumulation of microcystin-RR in Corydoras paleatus, Jenynsia multidentata and Odontesthes bonariensis
    • Cazenave, J., Wunderlin, D.A., Bistoni, M.A., Amé, M.V., Krause, E., Pflugmacher, S., and Wiegand, C. (2005) Uptake, tissue distribution and accumulation of microcystin-RR in Corydoras paleatus, Jenynsia multidentata and Odontesthes bonariensis. Aquat. Toxicol. 75, 178-190.
    • (2005) Aquat. Toxicol , vol.75 , pp. 178-190
    • Cazenave, J.1    Wunderlin, D.A.2    Bistoni, M.A.3    Amé, M.V.4    Krause, E.5    Pflugmacher, S.6    Wiegand, C.7
  • 45
    • 33847278410 scopus 로고    scopus 로고
    • In situ studies on the distribution patterns and dynamics of microcystins in a biomanipulation fish - bighead carp (Aristichthys nobilis)
    • Chen, J., Xie, P, Zhang, D.W., and Lei, H.H. (2006) In situ studies on the distribution patterns and dynamics of microcystins in a biomanipulation fish - bighead carp (Aristichthys nobilis). Environ. Pollut. 147, 150-157.
    • (2006) Environ. Pollut , vol.147 , pp. 150-157
    • Chen, J.1    Xie, P.2    Zhang, D.W.3    Lei, H.H.4
  • 46
    • 23944517789 scopus 로고    scopus 로고
    • Oral exposure to Microcystis increases activity-augmented antioxidant enzymes in the liver of loach (Misgurnus mizolepis) and has no effect on lipid peroxidation
    • Li, X.Y., Chun, I., Kim, J., and Lee, J. (2005) Oral exposure to Microcystis increases activity-augmented antioxidant enzymes in the liver of loach (Misgurnus mizolepis) and has no effect on lipid peroxidation. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 141, 292-296.
    • (2005) Comp. Biochem. Physiol. C Toxicol. Pharmacol , vol.141 , pp. 292-296
    • Li, X.Y.1    Chun, I.2    Kim, J.3    Lee, J.4
  • 47
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Droge, W. (2002) Free radicals in the physiological control of cell function. Phys. Rev. 82, 47-95.
    • (2002) Phys. Rev , vol.82 , pp. 47-95
    • Droge, W.1
  • 48
    • 0031788805 scopus 로고    scopus 로고
    • Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: The first step of detoxication
    • Pflugmacher, S., Wiegand, C., Oberemm, A., Beattie, K.A., Krause, E., Codd, G.A., and Steinberg, C.E.W. (1998) Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: the first step of detoxication. Biochim. Biophys. Acta 1425, 527-533.
    • (1998) Biochim. Biophys. Acta , vol.1425 , pp. 527-533
    • Pflugmacher, S.1    Wiegand, C.2    Oberemm, A.3    Beattie, K.A.4    Krause, E.5    Codd, G.A.6    Steinberg, C.E.W.7
  • 49
    • 0035065923 scopus 로고    scopus 로고
    • Covalent glutathione to cyanobacterial hepatotoxin microcystin-LR by F344 rat cytosolic and microsomal glutathione-S-transferases
    • Takenaka, S. (2001) Covalent glutathione to cyanobacterial hepatotoxin microcystin-LR by F344 rat cytosolic and microsomal glutathione-S-transferases. Environ. Toxicol. Pharm. 9, 135-139.
    • (2001) Environ. Toxicol. Pharm , vol.9 , pp. 135-139
    • Takenaka, S.1
  • 52
    • 8644263817 scopus 로고    scopus 로고
    • Promotion of oxidative stress in the aquatic macrophyte Ceratophyllum demersum during biotransformation of the cyanobacterial toxin microcystin-LR
    • Pflugmacher, S. (2004) Promotion of oxidative stress in the aquatic macrophyte Ceratophyllum demersum during biotransformation of the cyanobacterial toxin microcystin-LR. Aquat. Toxicol. 70, 169-178.
    • (2004) Aquat. Toxicol , vol.70 , pp. 169-178
    • Pflugmacher, S.1
  • 53
    • 0033846898 scopus 로고    scopus 로고
    • Microcystic cyanobacteria extract induces cytoskeletal disruption and intracellular glutathione alteration in hepatocytes
    • Ding, W.X, Shen, H.M., and Ong, C.N. (2000) Microcystic cyanobacteria extract induces cytoskeletal disruption and intracellular glutathione alteration in hepatocytes. Environ. Health Perspect. 108, 605-609.
    • (2000) Environ. Health Perspect , vol.108 , pp. 605-609
    • Ding, W.X.1    Shen, H.M.2    Ong, C.N.3
  • 54
    • 84878747338 scopus 로고    scopus 로고
    • Xu, L.H., Zhou, B, Lam, P.K.S., Chen, J.P., Zhang, Y.Y., and Harada, K.-I. (2000) In In vivo protein phosphatase 2A inhibition and GSH reduction by microcystin-LR in grass carp (Ctenopharyngodon idellus), Proceedings of the Ninth International Conference on Harmful Algal Blooms, Hobart, Australia, 7-11 February. Hallegraeff, G.M., Blackburn, S., Bolch, C.J., and Lewis, R., Eds. Intergovernmental Oceanographic Commission of UNESCO. pp. 399-402.
    • Xu, L.H., Zhou, B, Lam, P.K.S., Chen, J.P., Zhang, Y.Y., and Harada, K.-I. (2000) In In vivo protein phosphatase 2A inhibition and GSH reduction by microcystin-LR in grass carp (Ctenopharyngodon idellus), Proceedings of the Ninth International Conference on Harmful Algal Blooms, Hobart, Australia, 7-11 February. Hallegraeff, G.M., Blackburn, S., Bolch, C.J., and Lewis, R., Eds. Intergovernmental Oceanographic Commission of UNESCO. pp. 399-402.
  • 55
    • 11844260104 scopus 로고    scopus 로고
    • Oxidative stress biomarkers are modulated in silver carp (Hypophthalmichthys molitrix Val) exposed to microcystin-producing cyanobacterial water bloom
    • Blaha, L., Kopp, R., Simkova, K., and Mares, J. (2004) Oxidative stress biomarkers are modulated in silver carp (Hypophthalmichthys molitrix Val) exposed to microcystin-producing cyanobacterial water bloom. Acta Vet. Brno. 73, 477-482.
    • (2004) Acta Vet. Brno , vol.73 , pp. 477-482
    • Blaha, L.1    Kopp, R.2    Simkova, K.3    Mares, J.4
  • 56
    • 34247619211 scopus 로고    scopus 로고
    • Effects of copper and its complex compound (Cu-EDTA) on the glutathione system of liver in Carassius auratus
    • Chinese
    • Liu, H., Wang, X.R., Zhang, J.F., and Shen, H. (2004). Effects of copper and its complex compound (Cu-EDTA) on the glutathione system of liver in Carassius auratus. J. Nanjing Univ. 40, 356-361. [Chinese]
    • (2004) J. Nanjing Univ , vol.40 , pp. 356-361
    • Liu, H.1    Wang, X.R.2    Zhang, J.F.3    Shen, H.4
  • 57
    • 14644425290 scopus 로고    scopus 로고
    • Ecotoxicological effects of selected cyanobacterial secondary metabolites: A short review
    • Wiegand, C. and Pflugmacher, S. (2005) Ecotoxicological effects of selected cyanobacterial secondary metabolites: a short review. Toxicol. Appl. Pharmacol. 203, 201-218.
    • (2005) Toxicol. Appl. Pharmacol , vol.203 , pp. 201-218
    • Wiegand, C.1    Pflugmacher, S.2
  • 58
    • 0033991693 scopus 로고    scopus 로고
    • Effects of L-cysteine and reduced glutathione on the toxicities of microcystin-LR: The effect for acute liver failure and inhibition of protein phosphatase activity
    • Takenaka, S. and Otsu, R. (1999) Effects of L-cysteine and reduced glutathione on the toxicities of microcystin-LR: the effect for acute liver failure and inhibition of protein phosphatase activity. Aquat. Toxicol. 48, 65-68.
    • (1999) Aquat. Toxicol , vol.48 , pp. 65-68
    • Takenaka, S.1    Otsu, R.2


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