Phosphoprotein analysis for investigation of in vivo relationship between protein phosphatase inhibitory activities and acute hepatotoxicity of microcystin-LR

Environmental Toxicology

Volumn 22, Issue 6, 2007, Pages 620-629

  Tachi, Masahiko ^a   Imanishi, Susumu Y ^a   Harada, Ken Ichi ^a  

^a MEIJO UNIVERSITY   (Japan)

Author keywords

Acute hepatotoxicity; Microcystins; Okadaic acid; Phosphoprotein analysis; Protein phosphatases

Indexed keywords

ACUTE HEPATOTOXICITY; HEPATOTOXINS; OKADAIC ACIDS; PHOSPHOPROTEIN ANALYSIS; PHOSPHOPROTEINS;

BACTERIA; CELL CULTURE; CELL DEATH; MASS SPECTROMETRY; PHOSPHORYLATION; TOXICITY;

ENZYME ACTIVITY;

CYANOGINOSIN LR; CYTOKERATIN; FORMYLTETRAHYDROFOLATE DEHYDROGENASE; OKADAIC ACID; OXIDOREDUCTASE; PHOSPHOPROTEIN; PROTEIN SERINE THREONINE PHOSPHATASE 1; PROTEIN SERINE THREONINE PHOSPHATASE 2A; SERINE; UNCLASSIFIED DRUG;

AMINO ACID; APOPTOSIS; CYANOBACTERIUM; ENZYME ACTIVITY; FRESHWATER ENVIRONMENT; HYPOTHESIS TESTING; MORPHOLOGY; PEPTIDE; PROTEIN; RODENT; TOXICITY;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; CELL CULTURE; COLOR; CONTROLLED STUDY; CULTURE MEDIUM; CYTOPLASM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; LIQUID CHROMATOGRAPHY; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TANDEM MASS SPECTROMETRY;

ANIMALS; CYANOBACTERIA; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; LIVER; MALE; MICE; MICE, INBRED BALB C; MICROCYSTINS; PHOSPHOPROTEIN PHOSPHATASES;

CYANOBACTERIA; MUS;

EID: 36148984571     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20294     Document Type: Article

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