Areca-nut extract modulates antigen-specific immunity and augments inflammation in ovalbumin-sensitized mice

Immunopharmacology and Immunotoxicology

Volumn 33, Issue 2, 2011, Pages 315-322

  Wang, Chia Chi ^a   Lin, Hung Li ^a   Wey, Shiaw Pyng ^b   Jan, Tong Rong ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Areca; cytokine; delayed type hypersensitivity; inflammation; ovalbumin

Indexed keywords

ARECA CATECHU EXTRACT; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN M; IMMUNOMODULATING AGENT; OVALBUMIN; PEANUT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; BETEL NUT; CD3+ T LYMPHOCYTE; EDEMA; FOOT PAD; HYPERSENSITIVITY; IMMUNITY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOMODULATION; IN VIVO STUDY; INFLAMMATION; INTERFERON PRODUCTION; MALE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; SPLEEN CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS, PLANT; ARECA; EPITOPES; INFLAMMATION MEDIATORS; MALE; MICE; MICE, INBRED BALB C; NUTS; OVALBUMIN; PHAGOCYTOSIS; PLANT EXTRACTS; RANDOM ALLOCATION; UP-REGULATION;

ARECA; ARECA CATECHU; MUS;

EID: 79955829759     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2010.507208     Document Type: Article

References (36)

1. Gupta, P.C., Warnakulasuriya, S. Global epidemiology of areca nut usage. Addict. Biol. 2002, 7, 77-83. (Pubitemid 34087910)
2. Chang, M.C., Chiang, C.P., Lin, C.L., Lee, J.J., Hahn, L.J., Jeng, J.H. Cell-mediated immunity and head and neck cancer: with special emphasis on betel quid chewing habit. Oral Oncol. 2005, 41, 757-775. (Pubitemid 41140017)
3. Jeng, J.H., Chang, M.C., Hahn, L.J. Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives. Oral Oncol. 2001, 37, 477-492. (Pubitemid 32588773)
4. Wu, G.H., Boucher, B.J., Chiu, Y.H., Liao, C.S., Chen, T.H. Impact of chewing betel-nut (Areca catechu) on liver cirrhosis and hepatocellular carcinoma: a population-based study from an area with a high prevalence of hepatitis B and C infections. Public Health Nutr. 2009, 12, 129-135.
5. Chou, C.Y., Cheng, S.Y., Liu, J.H., Cheng, W.C., Kang, I.M., Tseng, Y.H., Shih, C.M., Chen, W. Association between betel-nut chewing and chronic kidney disease in men. Public Health Nutr. 2009, 12, 723-727.
6. Lin, W.Y., Chiu, TY., Lee, L.T., Lin, C.C., Huang, CY., Huang, K.C. Betel nut chewing is associated with increased risk of cardiovascular disease and all-cause mortality in Taiwanese men. Am. J. Clin. Nutr. 2008, 87, 1204-1211.
7. Yen, A.M., Chiu, Y.H., Chen, L.S., Wu, H.M., Huang, C.C., Boucher, B.J., Chen, T.H. A population-based study of the association between betel-quid chewing and the metabolic syndrome in men. Am. J. Clin. Nutr. 2006, 83, 1153-1160. (Pubitemid 44713118)
8. Chang, W.C., Hsiao, C.F., Chang, H.Y, Lan, TY., Hsiung, C.A., Shih, Y.T., Tai, TY. Betel nut chewing and other risk factors associated with obesity among Taiwanese male adults. Int. J. Obes. (Lond). 2006, 30, 359-363.
9. Ranadive, K.J., Gothoskar, S.V., Rao, A.R., Tezabwalla, B.U., Ambaye, RY. Experimental studies on betel nut and tobacco carcinogenicity. Int. J. Cancer 1976, 17, 469-476.
10. Wu, Q., Yang, Y., Simon, J.E. Qualitative and quantitative HPLC/MS determination of proanthocyanidins in areca nut (Areca catechu). Chem. Biodivers. 2007, 4, 2817-2826.
11. Yoshioka, Y., Akiyama, H., Nakano, M., Shoji, T., Kanda, T., Ohtake, Y., Takita, T., Matsuda, R., Maitani, T. Orally administered apple procyanidins protect against experimental infammatory bowel disease in mice. Int. Immunopharmacol. 2008, 8, 1802-1807.
12. Chiang, C.P., Wu, H.Y, Liu, BY., Wang, J.T., Kuo, MY. Quantitative analysis of immunocompetent cells in oral submucous fbrosis in Taiwan. Oral Oncol. 2002, 38, 56-63. (Pubitemid 34076573)
13. Haque, M.F., Meghji, S., Khitab, U., Harris, M. Oral submucous fbrosis patients have altered levels of cytokine production. J. Oral Pathol. Med. 2000, 29, 123-128. (Pubitemid 30156932)
14. Laad, A., Kode, J., Chavan, S., Rao, R., Fakih, A.R., Chiplunkar, S. Limiting dilution analysis of proliferating and cytotoxic lymphocytes in the peripheral blood and tumours of oral cancer patients. Eur. J. Cancer, B, Oral Oncol. 1996, 32B, 337-342.
15. Verastegui, E., Morales, R., Barrera, J.L., Müeller, A., Guzman, B., Meneses, A., Alfaro, G. Immunological approach in the evaluation of regional lymph nodes of patients with squamous cell carcinoma of the head and neck. Clin. Immunol. 2002, 102, 37-47. (Pubitemid 34095223)
16. Hung, S.L., Lee, YY., Liu, TY., Peng, J.L., Cheng, YY., Chen, Y.T. Modulation of phagocytosis, chemotaxis, and adhesion of neutrophils by areca nut extracts. J. Periodontol. 2006, 77, 579-585.
17. Hung, S.L., Cheng, Y.Y., Peng, J.L., Chang, L.Y., Liu, TY., Chen, Y.T. Inhibitory efects of areca nut extracts on phagocytosis of Actinobacillus actinomycetemcomitans ATCC 33384 by neutrophils. J. Periodontol. 2005, 76, 373-379.
18. Chang, L.Y., Wan, H.C., Lai, Y.L., Kuo, Y.F., Liu, TY., Chen, Y.T., Hung, S.L. Areca nut extracts increased expression of infammatory cytokines, tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-8, in peripheral blood mononuclear cells. J. Periodont. Res. 2009, 44, 175-183.
19. Chang, M.C., Wu, H.L., Lee, J.J., Lee, P.H., Chang, H.H., Hahn, L.J., Lin, B.R., Chen, Y.J., Jeng, J.H. Te induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is diferentially regulated by MEK/ERK activation. J. Biol. Chem. 2004, 279, 50676-50683.
20. Jeng, J.H., Wang, Y.J., Chiang, B.L., Lee, P.H., Chan, C.P., Ho, Y.S., Wang, T.M., Lee, J.J., Hahn, L.J., Chang, M.C. Roles of keratinocyte infammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline. Carcinogenesis 2003, 24, 1301-1315.
21. Wang, C.C., Liu, TY., Wey, S.P., Wang, F.I., Jan, T.R. Areca nut extract suppresses T-cell activation and interferon-gamma production via the induction of oxidative stress. Food Chem. Toxicol. 2007, 45, 1410-1418. (Pubitemid 47031386)
22. Liu, TY., Chen, C.L., Chi, C.W. Oxidative damage to DNA induced by areca nut extract. Mutat. Res. 1996, 367, 25-31.
23. Jan, T.R., Su, S.T., Wu, H.Y, Liao, M.H. Suppressive efects of cannabidiol on antigen-specifc antibody production and functional activity of splenocytes in ovalbumin-sensitized BALB/c mice. Int. Immunopharmacol. 2007, 7, 773-780.
24. Morokata, T., Ishikawa, J., Yamada, T. Antigen dose defnes T helper 1 and T helper 2 responses in the lungs of C57BL/6 and BALB/c mice independently of splenic responses. Immunol. Lett. 2000, 72, 119-126. (Pubitemid 30332308)
25. Mukherjee, A., Giri, A.K. Sister chromatid exchange induced by 'pan masala' (a betel quid ingredient) in male mice in vivo. Food Chem. Toxicol. 1991, 29, 401-403.
26. Panigrahi, G.B., Rao, A.R. Study of the genotoxicity of the total aqueous extract of betel nut and its tannin. Carcinogenesis 1986, 7, 37-39. (Pubitemid 16184817)
27. Mosmann, T.R., Sad, S. Te expanding universe of T-cell subsets: T1, T2 and more. Immunol. Today 1996, 17, 138-146. (Pubitemid 26074503)
28. Lipsky, P.E. Te control of antibody production by immunomodulatory molecules. Arthritis Rheum. 1989, 32, 1345-1355. (Pubitemid 20003900)
29. Trinchieri, G. Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-gamma). Curr. Opin. Immunol. 1997, 9, 17-23. (Pubitemid 27095894)
30. Pichler, W.J. Delayed drug hypersensitivity reactions. Ann. Intern. Med. 2003, 139, 683-693.
31. Cher, D.J., Mosmann, T.R. Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones. J. Immunol. 1987, 138, 3688-3694. (Pubitemid 17078235)
32. Wen, X.M., Zhang, Y.L., Liu, X.M., Guo, S.X., Wang, H. Immune responses in mice to arecoline mediated by lymphocyte muscarinic acetylcholine receptor. Cell Biol. Int. 2006, 30, 1048-1053. (Pubitemid 44751544)
33. Dasgupta, R., Saha, I., Pal, S., Bhattacharyya, A., Sa, G., Nag, T.C., Das, T., Maiti, B.R. Immunosuppression, hepatotoxicity and depression of antioxidant status by arecoline in albino mice. Toxicology 2006, 227, 94-104. (Pubitemid 44402852)
34. Selvan, R.S., Selvakumaran, M., Rao, A.R. Infuence of arecoline on immune system: II. Suppression of thymus-dependent immune responses and parameter of non-specifc resistance after short-term exposure. Immunopharmacol. Immunotoxicol. 1991, 13, 281-309.
35. Takano, F., Takata, T., Yoshihara, A., Nakamura, Y., Arima, Y., Ohta, T. Aqueous extract of peanut skin and its main constituent procyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin. Biol. Pharm. Bull. 2007, 30, 922-927. (Pubitemid 46708641)
36. Miyake, M., Ide, K., Sasaki, K., Matsukura, Y., Shijima, K., Fujiwara, D. Oral administration of highly oligomeric procyanidins of Jatoba reduces the severity of collagen-induced arthritis. Biosci. Biotechnol. Biochem. 2008, 72, 1781-1788.