On-line identification of P-glycoprotein substrates by monitoring of extracellular acidification and respiration rates in living cells

Biochimica et Biophysica Acta - Biomembranes

Volumn 1808, Issue 7, 2011, Pages 1827-1831

  Seeland, Swen ^a,c   Treiber, Alexander ^a   Hafner, Mathias ^b,c   Huwyler, Jörg ^d  

^a ACTELION PHARMACEUTICALS LTD   (Switzerland)

^b MANNHEIM UNIVERSITY OF APPLIED SCIENCES   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF BASEL   (Switzerland)

Author keywords

ABCB1; Drug transport; Microsensor; Multi drug resistance; P glycoprotein

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ELACRIDAR; GLYCOPROTEIN P; VERAPAMIL;

ACIDIFICATION; ARTICLE; CELL ADHESION; CELL LABELING; CELL RESPIRATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; EXTRACELLULAR SPACE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MICHAELIS CONSTANT; MICHAELIS MENTEN KINETICS; ONLINE MONITORING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN MICROARRAY; WILD TYPE;

ACIDS; ANIMALS; CELL ADHESION; CELL LINE; HUMANS; HYDROGEN-ION CONCENTRATION; LLC-PK1 CELLS; OXYGEN; P-GLYCOPROTEIN; SWINE;

EID: 79955818654     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2011.03.003     Document Type: Article

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