In vitro system for the prediction of hepatotoxic effects in primary hepatocytes

Altex

Volumn 24, Issue 1, 2007, Pages 22-34

  Thedinga, Elka ^a,d   Ullrich, Anett ^b   Drechsler, Sabine ^a   Niendorf, Ricarda ^a   Kob, Axel ^a   Runge, Dieter ^b   Keuer, Andreas ^a   Freund, Ingo ^c   Lehmann, Mirko ^c   Ehret, Ralf ^a  

^a Bionas GmbH   (Germany)

^b PRIMACYT Cell Culture Technology GmbH   (Germany)

^c Micronas GmbH Freiburg   (Germany)

^d NONE   (Germany)

Author keywords

Acetaminophen; Cell metabolism; Hepatotoxic effects; In vitro method; Label free; Non invasive; Primary hepatocytes; Remaining IC50 (RIC)

Indexed keywords

ALBUMIN; PARACETAMOL; UREA;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL ASSAY; CELL DIFFERENTIATION; CELL HYPOXIA; CELL METABOLISM; CELL SECRETION; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CULTURE TECHNIQUE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERMETHOD COMPARISON; LIVER CELL; LIVER CELL CULTURE; LIVER TOXICITY; MALE; NONHUMAN; OXYGEN CONSUMPTION; PREDICTION; PROTEIN SECRETION; SENSOR; TOXICITY TESTING; UREA CYCLE;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMAL TESTING ALTERNATIVES; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; HUMANS; HYDROGEN-ION CONCENTRATION; LIVER; LIVER NEOPLASMS; OXYGEN CONSUMPTION;

EID: 34147113426     PISSN: 09467785     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

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