Metformin slows down ageing processes at the cellular level in SHR mice

Cell and Tissue Biology

Volumn 5, Issue 2, 2011, Pages 151-159

  Arkadieva, A V ^a   Mamonov, A A ^c   Popovich, I G ^b   Anisimov, V N ^b   Mikhelson, V M ^a   Spivak, I M ^a  

^a INSTITUTE OF CYTOLOGY   (Russian Federation)

^b N N PETROV RESEARCH INSTITUTE OF ONCOLOGY   (Russian Federation)

^c ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

Author keywords

cellular senescence; geroprotector; metformin; mTOR kinase; rapamycin

Indexed keywords

ANIMALIA; MAMMALIA; MUS;

EID: 79955793227     PISSN: 1990519X     EISSN: 19905203     Source Type: Journal    
DOI: 10.1134/S1990519X11020027     Document Type: Article

References (40)

1. Anisimov, V. N., Molekulyarnye i fiziologicheskie mekhanizmy stareniya (Molecular and Physiological Mechanisms of Aging), St. Petersburg: Nauka, 2008a, vol. 2.
2. Anisimov, V. N., Berstein, L. M., Egormin, P. A., Piskunova, T. S., Popovich, I. G., Zabezhinski, M. A., Kovalenko, I. G., Poroshina, T. E., Semenchenko, A. V., Provinciali, M., Re, F., and Franceschi, C., Effect of Metformin on Life Span and on the Development of Spontaneous Mammary Tumors in HER-2/neu Transgenic Mice, Exp. Gerontol., 2005a, vol. 40, pp. 685-693.
3. Anisimov, V. N., Berstein, L. M., Egormin, P. A., Piskunova, T. S., Popovich, I. G., Zabezhinski, M. A., Tyndyk, M. L., Yurova, M. V., Kovalenko, I. G., Poroshina, T. E., and Semenchenko, A. V., Metformin Slows down Aging and Extends Life Span of Female SHR Mice, Cell Cycle, 2008, vol. 7, pp. 2769-2773.
4. Anisimov, V. N., Berstein, L. M., Popovich, I. G., Zabezhinski, M. A., Egormin, P. A., Tyndyk, M. L., Anikin, I. V., Semenchenko, A. V., and Yashin, A. I., Central and Peripheral Effects of Insulin/IGF-1 Signaling in Aging and Cancer: Antidiabetic Drugs as Geroprotectors and Anticarcinogens, Ann. N. Y. Acad. Sci., 2005b, vol. 1057, pp. 220-234.
5. Anisimov, V. N., Egormin, P. A., Piskunova, T. S., Popovich, I. G., Tyndyk, M. L., Yurova, M. V., Zabezhinski, M. A., Anikin, I, V., Karkach, A. S., and Romanyukha, A. A., Metformin Extends Life Span of HER-2/neu Transgenic Mice and in Combination with Melatonin Inhibits Growth of Transplantable Tumors in vivo, Cell Cycle, 2010a, vol. 9, pp. 188-197.
6. Anisimov, V. N., The Role of the Growth Hormone-Insulin-Like Growth Factor-1-Insulin System in Aging and Longevity: An Evolutionary Aspect, Ros. Fiziol. Zh. Im. I. M. Sechenova, 2008b, vol. 94, pp. 1092-1109.
7. Anisimov, V. N., Zabezhinski, M. A., Popovich, I. G., Piskunova, T. S., Semenchenko, A. V., Tyndyk, M. L., Yurova, M. V., Antoch, M. P., and Blagosklonny, M. V., Rapamycin Extends Maximal Life Span in Cancer-Prone Mice, Am. J. Pathol., 2010b, vol. 176, pp. 1092-2096.
8. Blagosklonny, M. V., Aging: ROS or TOR, Cell Cycle, 2008, vol. 7, pp. 3344-3354.
9. Campisi, J., Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors, Cell, 2005, vol. 120, pp. 513-522.
10. Chang, B. D., Watanabe, K., Broude, E. V., Fang, J., Poole, J. C., Kalinichenko, T. V., and Roninson, I. B., Effects of p21Waf1/Cip1/Sdi1 on Cellular Gene Expression: Implications for Carcinogenesis, Senescence, and Age-Related Diseases, Proc. Natl. Acad. Sci. USA, 2000, vol. 97, pp. 4291-4296.
11. 2-Induced Senescent-Like Growth Arrest in Normal Human Fibroblasts: p53 an Rb Control G1 Arrest but not Cell Replication, J. Biochem., 1998, vol. 332, pp. 43-50.
12. Corradetti, M. N., Inoki, K., Bardeesy, N., DePinho, R. A., and Guan, K. L., Regulation of the TSC Pathway by LKB1: Evidence of a Molecular Link between Tuberous Sclerosis Complex and Peutz-Jeghers Syndrome, Genes Dev., 2004, vol. 18, pp. 1533-1538.
13. Demidenko, Z. N., Zubova, S. G., Bukreeva, E. I., Pospelov, V. A., and Blagosklonny, M. V., Rapamycin Decelerates Cellular Senescence, Cell Cycle, 2009, vol. 8, pp. 1888-1895.
14. Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskensi, M., Rubeljii, I., Pereira-Smithii, O., Peacocke, M., and Campisi, J., A Biomarker That Identifies Senescent Human Cells in Culture and in Aging Skin in vivo, Proc. Natl. Acad. Sci. USA, 1995, vol. 92, pp. 9363-9367.
15. Everitt, A. V., Seedsman, N. J., and Jones, F., The Effects of Hypophysectomy and Continuous Food Restriction, Begun at Ages 70 and 400 Days, on Collagen Aging, Proteinuria, Incidence of Pathology and Longevity in the Male Rat, Mech. Ageing Dev., 1980, vol. 12, pp. 161-172.
16. Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., Pahor, M., Javors, M. A., Fernandez, E., and Miller, R. A., Rapamycin Fed Late in Life Extends Lifespan in Genetically Heterogeneous Mice, Nature, 2009, vol. 460, pp. 392-395.
17. Inoki, K., Zhu, T., and Guan, K. L., TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival, Cell, 2003, vol. 115, pp. 577-590.
18. Itahana, K., Campisi, J., and Dimri, G. P., Methods to Detect Biomarkers of Cellular Senescence: the Senescence-Associated γ-Galactosidase, Methods Mol. Biol., 2007, vol. 371, pp. 21-32.
19. Jia, K., Chen, D., and Riddle, D. L., The TOR Pathway Interacts with the Insulin Signaling Pathway to Regulate C. elegans Larval Development, Metabolism and Life Span, Development, 2004, vol.. 131, pp. 3897-3906.
20. Kaeberlein, M., Powers, R. W. 3rd, Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., and Kennedy, B. K., Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients, Science, 2005, vol. 310, pp. 1193-1196.
21. Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., and Benzer, S., Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway, Curr. Biol., 2004, vol. 14, pp. 885-890.
22. Krtolica, A. and Campisi, J., Cancer and Aging: a Model for the Cancer Promoting Effects of the Aging Stroma, Int. J. Biochem. Cell Biol., 2002, vol. 34, pp. 1401-1414.
23. Lorenzini, A., Tresini, M., Austad, S. N., Cristofalo, V. J., Cellular Replicative Capacity Correlates Primarily with Species Body Mass not Longevity, Mech. Ageing Dev., 2005, vol. 126, pp. 1130-1133.
24. Medvedik, O., Lamming, D. W., Kim, K. D., and Sinclair, D. A., MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae, PLoS Biol., 2007, vol. 5, p. 261.
25. Michelson, V. M. and Gamaley, I. A., Shortening of Telomeres-The Basic Mechanism of Natural and Radiation-Induced Aging, Radiat. Biol. Radioecol., 2010, vol. 50, no. 3, pp. 269-275.
26. Michelson, V. M., Aging of Cell Cultures, in Biologiya kletki v kul'ture (The Biology of Cells in Culture), Leningrad: Nauka, 1984, pp. 235-255.
27. Mikhelson, V. M. and Gamaley, I. A., Telomere Shortening Is the Sole Mechanism of Aging, Open Longevity Sci., 2008, vol. 2, pp. 23-28.
28. Narita, M., Nũnez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., and Lowe, S. W., Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence, Cell, 2003, vol. 113, pp. 703-716.
29. Powers, R. Wr., Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., and Fields, S., Extension of Chronological Life Span in Yeast by Decreased TOR Pathway Signaling, Genes Dev., 2006, vol. 20, pp. 174-184.
30. Ryter, S. W., Kim, H. P., Hoetzel, A., Park, J. W., Nakahira, K., Wang, X., and Choi, A. M., Mechanisms of Cell Death in Oxidative Stress, Antioxid. Redox Signal., 2007, vol. 9, pp. 49-59.
31. Scaffidi, P. and Misteli, T., Lamin A-Dependent Nuclear Defects in Human Aging, Science, 2006, vol. 312, pp. 1059-1063.
32. Sharp, Z. D. and Bartke, A., Evidence for Downregulation of Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR)-Dependent Translation Regulatory Signaling Pathways in Ames Dwarf Mice, J. Gerontol. A: Biol. Sci. Med. Sci., 2005, vol. 60, pp. 293-300.
33. Shaw, R. J., Bardeesy, N., Manning, B. D., Lopez, L., Kosmatka, M., DePinho, R. A., and Cantley, L. C., The LKB1 Tumor Suppressor Negatively Regulates mTOR sSignaling, Cancer Cell., 2004, vol. 6, pp. 91-99.
34. Shaw, R. J., LKB1 and AMP-Activated Protein Kinase Control of mTOR Signaling and Growth, Acta Physiol., 2009, vol. 196, pp. 65-80.
35. Shelton, D. N., Chang, E., Whittier, P. S., Choi, D., and Funk, W. D., Microarray Analysis of Replicative Senescence, Curr. Biol., 1999, vol. 9, pp. 939-945.
36. Sonntag, W. E., Lynch, C. D., Cefalu, W. T., Ingram, R. L., Bennett, S. A., Thornton, P. L., and Khan, A. S., Pleiotropic Effects of Growth Hormone and Insulin-Like Growth Factor (IGF)-1 on Biological Aging: Inferences from Moderate Caloric-Restricted Animals, J. Gerontol. A: Biol. Sci. Med. Sci., 1999, vol. 54, pp. B521-538.
37. Spindler, S. R., Caloric Restriction: From Soup to Nuts, Ageing Res. Rev., 2010, vol. 9, pp. 324-353.
38. Spindler, S. R., Use of Microarray Biomarkers to Identify Longevity Therapeutics, Aging Cell., 2006, vol. 5, pp. 39-50.
39. Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L., and Muller, F., Genetics: Influence of TOR Kinase on Lifespan in C. elegans, Nature, 2003, vol. 426, pp. 620.
40. Zhang, H., Pan, K. H., and Cohen, S. N., Senescence-Specific Gene Expression Fingerprints Reveal Cell-Type-Dependent Physical Clustering of up-Regulated Chromosomal Loci, Proc. Natl. Acad. Sci. USA, 2003, vol. 100, pp. 3251-3256.