PD-1 modulates regulatory T cells and suppresses T-cell responses in HCV-associated lymphoma

Immunology and Cell Biology

Volumn 89, Issue 4, 2011, Pages 535-539

  Ni, Lei ^a,b   Ma, Cheng J ^a   Zhang, Ying ^a   Nandakumar, Subhadra ^c   Zhang, Chun L ^a   Wu, Xiao Y ^a   Borthwick, Thomas ^d   Hamati, Agnes ^d   Chen, Xin Y ^b   Kumaraguru, Uday ^c   Moorman, Jonathan P ^a,c,d   Yao, Zhi Q ^a,d  

^a Division of Infectious Diseases   (United States)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c East Tennessee State University   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

HCV; lymphoma; PD 1; T regulatory cells; T cell suppression

Indexed keywords

PROGRAMMED DEATH 1 LIGAND 1;

ADULT; AGED; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CD8+ CD25+ T LYMPHOCYTE; CELL COUNT; CELL FUNCTION; CELL PROLIFERATION; CLINICAL ARTICLE; EFFECTOR CELL; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; MALE; REGULATORY T LYMPHOCYTE; T CELL DEPLETION; T LYMPHOCYTE ACTIVATION;

ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; APOPTOSIS REGULATORY PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; HEPATITIS C, CHRONIC; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOMA; MALE; MIDDLE AGED; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

HEPATITIS C VIRUS;

EID: 79955783905     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2010.121     Document Type: Article

References (31)

1. King E, Trabue C, Yin D, Yao ZQ, Moorman JP. Hepatitis C: the complications of immune dysfunction. Expert Rev Clin Immunol 2007; 3: 145-157.
2. Sansonno D, Dammacco F. Hepatitis C virus, cryoglobulinaemia, and vasculitis: immune complex relations. Lancet Infect Dis 2005; 5: 227-236. (Pubitemid 40410068)
3. Rehermann B, Chang KM, McHutchison JG, Kokka R, Houghton M, Chisari FV. Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in subjects with chronic hepatitis C virus infection. J Clin Invest 1996; 98: 1432-1440. (Pubitemid 26322069)
4. Chang KM, Rehermann B, McHutchison JG, Pasquinelli C, Southwood S, Sette A et al. Immunological significance of cytotoxic T lymphocyte epitope variants in subjects chronically infected by the hepatitis C virus. J Clin Invest 1997; 100: 2376-2385. (Pubitemid 27500163)
5. Wedemeyer H, He XS, Nascimbeni M, Davis AR, Greenberg HB, Hoofnagle JH et al. Impaired effector function of hepatitis C virus specific CD8+ T cells in chronic hepatitis C virus infection. J Immunol 2002; 169: 3447-3458. (Pubitemid 35013196)
6. Lechmann M, Woitas RP, Langhans B, Kaiser R, Ihlenfeldt HG, Jung G et al. Decreased frequency of HCV core-specific peripheral blood mononuclear cells with type 1 cytokine secretion in chronic hepatitis C. J Hepatol 1999; 31: 971-978.
7. Eisen-Vandervelde A, Yao ZQ, Hahn YS. The molecular basis of HCV-mediated immune dysregulation. Clin Immunol 2004; 111: 16-21. (Pubitemid 38482077)
8. Yao ZQ, Ray S, Eisen-Vandervelde A, Waggoner S, Hahn YS. Hepatitis C virus: immunosuppression by complement regulatory pathway. Viral Immunology 2001; 14: 277-295. (Pubitemid 34309058)
9. Sugimoto O, Ikeda F, Stadanlick J, Nunes FA, Alter HJ, Chang KM. Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology 2003; 38: 1437-1448. (Pubitemid 37466970)
10. Boettler T, Spangenberg HC, Neumann-Haefelin C, Panther E, Urbani S, Ferrari C et al. T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol 2005; 79: 7860-7867. (Pubitemid 40756821)
11. Cabrera R, Tu Z, Xu Y, Firpi RJ, Rosen HR, Liu C et al. An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology 2004; 40: 1062-1071. (Pubitemid 39425561)
12. Rushbrook SM, Ward SM, Unitt E, Vowler SL, Lucas M, Klenerman P et al. Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection. J Virol 2005; 79: 7852-7859. (Pubitemid 40756820)
13. MacDonald AJ, Duffy M, Brady MT, Mckiernan S, Hall W, Hegarty J et al. CD4T helper type 1 and regulatory T cells induced against the same epitopes on the core protein in hepatitis C virus-infected persons. J Infect Dis 2002; 185: 720-727. (Pubitemid 34226199)
14. Accapezzato D, Francavilla V, Paroli M, Casciaro M, Chircu LV, Cividini A et al. Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection. J Clin Invest 2004; 113: 963-972. (Pubitemid 38544117)
15. Franceschini D, Paroli M, Francavilla V, Videtta M, Morrone S, Labbadia G et al. PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in subjects chronically infected with HCV. J Clin Invest 2009; 119: 551-564.
16. Manigold T, Shin EC, Mizukoshi E, Mihalik K, Murthy KK, Rice CM et al. Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees recovered from Hepatitis C. Blood 2006; 107: 4424-4432. (Pubitemid 43801369)
17. Nishimura H, Honjo T. PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. Trends in Immunol 2001; 22: 265-268. (Pubitemid 32667515)
18. Penna A, Pilli M, Zerbini A, Orlandini A, Mezzadri S, Sacchelli L et al. Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection. Hepatology 2007; 45: 588-601. (Pubitemid 46450610)
19. Golden-Mason L, Palmer B, Klarguist J, Mengshol JA, Gastelblanco N, Rosen HR. Upregulation of PD-1 expression on circulating and hepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol 2007; 81: 9249-9258. (Pubitemid 47311467)
20. Golden-Mason L, Klarguist J, Wahed AS, Rosen HR. Cutting edge: programmed death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy, race-dependent differences. J Immunol 2008; 180: 3637-3641.
21. Kittlesen DJ, Chianese-Bullick KA, Yao ZQ, Braciale TJ, Hahn YS. Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T lymphocyte proliferation. J Clin Invest 2000; 106: 1239-1249.
22. Yao ZQ, Nguyen DT, Hiotellis AI, Hahn YS. Hepatitis C virus core protein inhibits human T lymphocyte responses by a complement-dependent regulatory pathway. J Immunol 2001; 167: 5264-5272. (Pubitemid 33009764)
23. Yao ZQ, Eisen-Vandervelde A, Ray S, Hahn YH. HCV core/gC1qR interaction arrests T cell cycle progression through stabilization of the cell cycle inhibitor p27kip1. Virology 2003; 314: 271-282. (Pubitemid 37153316)
24. Yao ZQ, Eisen-Vandervelde A, Waggoner SN, Cale EM, Hahn YS. Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt. J Virol 2004; 78: 6409-6419. (Pubitemid 38715939)
25. Yao ZQ, King E, Prayther D, Yin D, Zhang Y, Moorman JP. T cell dysfunction by hepatitis C virus core protein involves PD-1/PD-L1 signaling. Viral Immunol 2007; 20: 276-287. (Pubitemid 47076209)
26. Yao ZQ, Prayther D, Trabu C, Dong ZP, Moorman J. Differential regulation of SOCS-1 signaling in T and B lymphocytes by HCV core protein. Immunology 2008; 125: 197-207.
27. Moorman JP, Dong ZP, Ni L, Zhang CL, Borthwick T, Yao ZQ. Abnormal B lymphocyte activation associated with TALL-1 overexpression and SOCS-1 deregulation in chronic HCV infection. Immunology 2009; 128: 227-235.
28. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-1061. (Pubitemid 36222930)
29. Shevach EM. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 2009; 30: 636-645.
30. Gavin MA, Clarke SR, Negrou E, Gallegos A, Rudensky A. Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol 2002; 3: 33-41. (Pubitemid 34065615)
31. Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25 high regulatory cells in human peripheral blood. J Immunol 2001; 167: 1245-1253. (Pubitemid 32703119)