Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction

Nature Biotechnology

Volumn 29, Issue 5, 2011, Pages 428-435

  Chen, Guo Yun ^a   Chen, Xi ^b   King, Samantha ^c   Cavassani, Karen A ^a   Cheng, Jiansong ^b   Zheng, Xincheng ^d   Cao, Hongzhi ^b   Yu, Hai ^b   Qu, Jingyao ^b   Fang, Dexing ^d   Wu, Wei ^d   Bai, Xue Feng ^e   Liu, Jin Qing ^e   Woodiga, Shireen A ^c   Chen, Chong ^a   Sun, Lei ^a   Hogaboam, Cory M ^a   Kunkel, Steven L ^a   Zheng, Pan ^a   Liu, Yang ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONWIDE CHILDREN S HOSPITAL   (United States)

^d OncoImmune Inc   (United States)

^e OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EFFECTIVE THERAPY; HIGH RATE; INFECTIOUS DISEASE; INFLAMMATORY RESPONSE; MOLECULAR PATTERNS; NEW OPTIONS; PATHOGEN-ASSOCIATED MOLECULAR PATTERNS; SIALIDASE INHIBITORS; SIALIDASES;

CARBOXYLIC ACIDS; DISEASE CONTROL; GENES; PATTERN RECOGNITION;

PATHOLOGY;

2,3 DEHYDRO 2 DEOXY N GLYCOLYLNEURAMINIC ACID; CD24 ANTIGEN; IMMUNOGLOBULIN; LECTIN; N ACETYL 2,3 DIDEHYDRO 2 DEOXYNEURAMINIC ACID; PROTEIN SIGLECG; SIALIDASE; SIALIDASE INHIBITOR; SIGLEC10; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DISEASE EXACERBATION; GENE MUTATION; INTESTINE PERFORATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; SEPSIS; SIALYLATION;

ANIMALS; ANTIGENS, CD24; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; ENZYME INHIBITORS; FLOW CYTOMETRY; INFLAMMATION; INTERLEUKIN-6; LECTINS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURAMINIDASE; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, ANTIGEN, B-CELL; SEPSIS; STREPTOCOCCUS PNEUMONIAE; TUMOR NECROSIS FACTOR-ALPHA;

BACTERIA (MICROORGANISMS); MUS;

EID: 79955777060     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1846     Document Type: Article

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