Mechanisms of leukotriene D4-induced constriction in human small bronchioles

British Journal of Pharmacology

Volumn 133, Issue 2, 2001, Pages 243-252

  Snetkov, V A ^a   Hapgood, K J ^a   McVicker, C G ^a   Lee, T H ^a   Ward, J P T ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Bronchoconstriction; Human; Leukotrienes; PC PLC; Smooth muscle

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; CALCIUM ION; CARBACHOL; CHELERYTHRINE; GADOLINIUM; HISTAMINE; LANTHANUM; LEUKOTRIENE D4; LEUKOTRIENE E4; NIFEDIPINE; PHOSPHOLIPASE C INHIBITOR; PROPRANOLOL; PROTEIN TYROSINE KINASE INHIBITOR; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE; TYRPHOSTIN; CALCIUM;

ADULT; AGED; ARTICLE; BRONCHIOLE; BRONCHOSPASM; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CHANNEL GATING; CONCENTRATION RESPONSE; HUMAN; HUMAN CELL; HUMAN TISSUE; MEMBRANE DEPOLARIZATION; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; BRONCHUS; CALCIUM SIGNALING; CELL SEPARATION; CYTOLOGY; DRUG EFFECT; ELECTROPHYSIOLOGY; IN VITRO STUDY; METABOLISM; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE TONE; PATCH CLAMP; PHYSIOLOGY; SMOOTH MUSCLE;

AGED; AGED, 80 AND OVER; BRONCHI; BRONCHOCONSTRICTION; CALCIUM; CALCIUM SIGNALING; CELL SEPARATION; ELECTROPHYSIOLOGY; HUMANS; LEUKOTRIENE D4; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE TONUS; MUSCLE, SMOOTH; PATCH-CLAMP TECHNIQUES;

EID: 0034743701     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704076     Document Type: Article

References (45)

1. Effects of Bay K 8644 on contraction of the human isolated bronchus and guinea-pig isolated trachea
2. Diversity of phenotype and function of vascular smooth muscle cells
3. Sulphidopeptide leukotrienes in asthma
4. The calcium dependence of histamine, carbachol and potassium chloride-induced contraction in human airways in vitro
5. Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein
6. 4
7. 2+ mobilization triggered by a lipid factor isolated from vitreous body
8. Effects of protein tyrosine kinase inhibitors on contractility of isolated bronchioles of the rat
9. Differences in sensitivity to the specific protein kinase C inhibitor RO31-8220 between small and large bronchioles of the rat
10. Mechanisms of regulation of receptors and signal transduction pathways for the peptidyl leukotrienes
11. 2+ release in agonist-induced contractions in guinea pig trachea
12. ++ release
13. Muscarinic activation and calcium permeation of nonselective cation currents in airway myocytes
14. Effect of a new leukotriene receptor antagonist, ONO-1078, on human bronchial smooth muscle in vitro
15. Structure-function of airway generations 0 to 4 in the preterm lamb
16. 4 contractions in human airways are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry
17. 4-induced calcium influx in human epithelial cells involves protein tyrosine phosphorylation
18. Endothelin-induced contraction and mediator release in human bronchus
19. 4 involve a pertussis toxin sensitive G-protein
20. 4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle
21. 2+ influx
22. 2α and potassium
23. Inhibition of bradykinin- and thapsigargin-induced Ca2+ entry by tyrosine kinase inhibitors
24. 1 receptor
25. 2+ channels
26. 2+-activated but not G protein-mediated inositol phosphate responses in rat neonatal cardiomyocytes involve inositol 1,4,5-trisphosphate generation
27. Role of extracellular calcium in the effects of substance P and neurokinin A on guinea pig trachea and human bronchus
28. Store-operated calcium entry promotes shape change in pulmonary endothelial cells expressing Trp1
29. Mechanics of airway narrowing
30. Receptor-activated calcium influx in human airway smooth muscle cells
31. The contractile response of thiopental in large and small ovine airways
32. Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7
33. 2+ channel from mouse brain
34. 2+ - Like channels in adrenal cells
35. Capacitative calcium entry channels
36. Effect of phospholipase C inhibitor U-73122 on antigen-induced airway smooth muscle contraction in guinea pigs
37. Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5
38. Potassium currents in human freshly isolated bronchial smooth muscle cells
39. Potassium channels in human fetal airway smooth muscle cells
40. + channel
41. 2+ entry mediated by store depletion, S-nitrosylation, and TRP3 channels
42. Signalling pathway for histamine activation of non-selective cation channels in equine tracheal myocytes
43. Effects of tyrosine kinase inhibitors on antigen challenge of guinea pig lung in vitro
44. TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells
45. 2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK) 293 cells