Kir4.1 K+ channels are regulated by external cations

Channels

Volumn 5, Issue 3, 2011, Pages

  Edvinsson, Johan M ^a   Shah, Anish J ^a   Palmer, Lawrence G ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

C type inactivation; Cs block; K buffering; K channel gating; K channel permeation; Selectivity filter

Indexed keywords

AMMONIA; BARIUM ION; CATION; CESIUM ION; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR1.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR4.1; POTASSIUM ION; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL;

ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; MEMBRANE PERMEABILITY; MICROENVIRONMENT; NONHUMAN; OOCYTE; PH; POTASSIUM CURRENT; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SUBSTITUTION REACTION; VOLTAGE CLAMP; X RAY CRYSTALLOGRAPHY; XENOPUS;

EID: 79955721017     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.5.3.15827     Document Type: Article

References (57)

1. Hibino H, Inanobe A, Furutani K, Murakami S, Findlay I, Kurachi Y. Inwardly rectifying potassium channels: their structure, function and physiological roles. Physiol Rev 2010; 90:291-366.
2. Zhang YY, Sackin H, Palmer LG. Localization of the pH gate in Kir1.1 channels. Biophys J 2006; 91:2901-9. (Pubitemid 44526480)
3. + channels by intracellular pH. Eur J Biochem 2000; 267:5837-41.
4. Schulte U, Hahn H, Wiesinger H, Ruppersberg JP, Fakler B. pH-dependent gating of ROMK (Kir1.1) channels involves conformational changes in both N and C termini. J Biol Chem 1998; 273:34575-9.
5. Sackin H, Nanazashvili M, Palmer LG, Krambis M, Walters DE. Structural locus of the pH gate in the Kir1.1 inward rectifier channel. Biophys J 2005; 88:2597-606. (Pubitemid 40976128)
6. + channel from a gene cloned from mouse liver. J Physiol 1999; 514:639-53.
7. + and intracellular pH allosterically regulate renal Kir1.1 channels. J Biol Chem 1996; 271:17261-6.
8. Sackin H, Syn S, Palmer LG, Choe H, Walters DE. Regulation of ROMK by extracellular cations. Biophys J 2001; 80:683-97. (Pubitemid 32128322)
9. Sackin H, Nanazashvili M, Li H, Palmer LG, Walters DE. An intersubunit salt bridge near the selectivity filter stabilizes the active state of Kir1.1. Biophys J 2009; 97:1058-66.
10. Schulte U, Weidemann S, Ludwig J, Ruppersberg J, Fakler B. K(+)-dependent gating of K(ir)1.1 channels is linked to pH gating through a conformational change in the pore. J Physiol 2001; 534:49-58. (Pubitemid 32631755)
11. + conduction and selectivity. Science 1998; 280:69-77.
12. + channel. Proc Natl Acad Sci USA 2003; 100:8644-8.
13. + channel. Nature 2001; 414:73-7.
14. + channel-Fab complex at 2.0 A resolution. Nature 2001; 414:43-8.
15. Domene C, Klein ML, Branduardi D, Gervasio FL, Parrinello M. Conformational changes and gating at the selectivity filter of potassium channels. J Am Chem Soc 2008; 130:9474-80. (Pubitemid 352031158)
16. Berneche S, Roux B. A gate in the selectivity filter of potassium channels. Structure 2005; 13:591-600.
17. Sackin H, Vasilyev A, Palmer LG, Krambis M. Permeant cations and blockers modulate pH gating of ROMK channels. Biophys J 2003; 84:910-21. (Pubitemid 36133417)
18. Dahlmann A, Li M, Gao Z, McGarrigle D, Sackin H, Palmer LG. Regulation of Kir channels by intracellular pH and extracellular K(+): mechanisms of coupling. J Gen Physiol 2004; 123:441-54. (Pubitemid 38469286)
19. Lopez-Barneo J, Hoshi T, Heinemann SH, Aldrich RW. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors Channels 1993; 1:61-71.
20. Cordero-Morales JF, Cuello LG, Perozo E. Voltage-dependent gating at the KcsA selectivity filter. Nat Struct Mol Biol 2006; 13:319-22. (Pubitemid 43873502)
21. Cordero-Morales JF, Cuello LG, Zhao Y, Jogini V, Cortes DM, Roux B, et al. Molecular determinants of gating at the potassium-channel selectivity filter. Nat Struct Mol Biol 2006; 13:311-8. (Pubitemid 43873501)
22. Cordero-Morales JF, Jogini V, Lewis A, Vasquez V, Cortes DM, Roux B, et al. Molecular driving forces determining potassium channel slow inactivation. Nat Struct Mol Biol 2007; 14:1062-9. (Pubitemid 350060332)
23. Fakler B, Schultz JH, Yang J, Schulte U, Brandle U, Zenner HP, et al. Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH. EMBO J 1996; 15:4093-9. (Pubitemid 26278692)
24. Schulte U, Hahn H, Konrad M, Jeck N, Derst C, Wild K, et al. pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome. Proc Natl Acad Sci USA 1999; 96:15298-303.
25. Choe H, Zhou H, Palmer LG, Sackin H. A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance and gating. Am J Physiol 1997; 273:516-29.
26. Rapedius M, Haider S, Browne KF, Shang L, Sansom MS, Baukrowitz T, et al. Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel. EMBO Rep 2006; 7:611-6. (Pubitemid 43827328)
27. Somjen GG. Ion regulation in the brain: implications for pathophysiology. Neuroscientist 2002; 8:254-67. (Pubitemid 34538793)
28. Heinemann U, Lux HD. Ceiling of stimulus induced rises in extracellular potassium concentration in the cerebral cortex of cat. Brain Res 1977; 120:231-49.
29. Kofuji P, Newman EA. Potassium buffering in the central nervous system. Neuroscience 2004; 129:1045-56. (Pubitemid 39556255)
30. Walz W. Role of astrocytes in the clearance of excess extracellular potassium. Neurochem Int 2000; 36:291-300. (Pubitemid 30101570)
31. Takumi T, Ishii T, Horio Y, Morishige K, Takahashi N, Yamada M, et al. A novel ATP-dependent inward rectifier potassium channel expressed predominantly in glial cells. J Biol Chem 1995; 270:16339-46.
32. Olsen ML, Higashimori H, Campbell SL, Hablitz JJ, Sontheimer H. Functional expression of Kir4.1 channels in spinal cord astrocytes. Glia 2006; 53:516-28.
33. Kucheryavykh YV, Kucheryavykh LY, Nichols CG, Maldonado HM, Baksi K, Reichenbach A, et al. Downregulation of Kir4.1 inward rectifying potassium channel subunits by RNAi impairs potassium transfer and glutamate uptake by cultured cortical astrocytes. Glia 2007; 55:274-81. (Pubitemid 46225959)
34. + buffering properties of astrocytes in the ventral respiratory group: impact on extracellular K+ regulation. J Neurophysiol 2006; 95:1843-52.
35. Higashi K, Fujita A, Inanobe A, Tanemoto M, Doi K, Kubo T, et al. An inwardly rectifying K(+) channel, Kir4.1, expressed in astrocytes surrounds synapses and blood vessels in brain. Am J Physiol Cell Physiol 2001; 281:922-31.
36. Poopalasundaram S, Knott C, Shamotienko OG, Foran PG, Dolly JO, Ghiani CA, et al. Glial heterogeneity in expression of the inwardly rectifying K(+) channel, Kir4.1, in adult rat CNS. Glia 2000; 30:362-72. (Pubitemid 30334337)
37. Rapedius M, Fowler PW, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. H bonding at the helix-bundle crossing controls gating in Kir potassium channels. Neuron 2007; 55:602-14. (Pubitemid 47223642)
38. Xu H, Yang Z, Cui N, Chanchevalap S, Valesky WW, Jiang C. A single residue contributes to the difference between Kir4.1 and Kir1.1 channels in pH sensitivity, rectification and single channel conductance. J Physiol 2000; 528:267-77.
39. Yang Z, Jiang C. Opposite effects of pH on open-state probability and single channel conductance of kir4.1 channels. J Physiol 1999; 520:921-7. (Pubitemid 29533046)
40. Kutluay E, Roux B, Heginbotham L. Rapid intracellular TEA block of the KcsA potassium channel. Biophys J 2005; 88:1018-29. (Pubitemid 40975935)
41. Grabe M, Bichet D, Qian X, Jan YN, Jan LY. K+ channel selectivity depends on kinetic as well as thermodynamic factors. Proc Natl Acad Sci USA 2006; 103:14361-6. (Pubitemid 44484755)
42. Jiang Y, Lee A, Chen J, Cadene M, Chait BT, MacKinnon R. The open pore conformation of potassium channels. Nature 2002; 417:523-6. (Pubitemid 34595913)
43. +]: a tale of two inactivation mechanisms. Neuron 1995; 15:951-60.
44. + channels. Proc Natl Acad Sci USA 1991; 88:5092-5.
45. + selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates. J Mol Biol 2003; 333:965-75.
46. Luzhkov VB, Aqvist J. K(+)/Na(+) selectivity of the KcsA potassium channel from microscopic free energy perturbation calculations. Biochim Biophys Acta 2001; 1548:194-202. (Pubitemid 32769939)
47. Chakrapani S, Cordero-Morales JF, Perozo E. A quantitative description of KcsA gating I: macroscopic currents. J Gen Physiol 2007; 130:465-78. (Pubitemid 350036734)
48. + channels: effects of alterations in the carboxy-terminal region. Neuron 1991; 7:547-56.
49. Gao L, Mi X, Paajanen V, Wang K, Fan Z. Activation-coupled inactivation in the bacterial potassium channel KcsA. Proc Natl Acad Sci USA 2005; 102:17630-5. (Pubitemid 41803548)
50. Panyi G, Deutsch C. Cross talk between activation and slow inactivation gates of Shaker potassium channels. J Gen Physiol 2006; 128:547-59. (Pubitemid 44664632)
51. Cuello LG, Jogini V, Cortes DM, Pan AC, Gagnon DG, Dalmas O, et al. Structural basis for the coupling between activation and inactivation gates in K(+) channels. Nature 2010; 466:272-5.
52. + channels. Nature 2010; 466:203-8.
53. Bockenhauer D, Feather S, Stanescu HC, Bandulik S, Zdebik AA, Reichold M, et al. Epilepsy, ataxia, sensorineural deafness, tubulopathy and KCNJ10 mutations. N Engl J Med 2009; 360:1960-70.
54. Scholl UI, Choi M, Liu T, Ramaekers VT, Hausler MG, Grimmer J, et al. Seizures, sensorineural deafness, ataxia, mental retardation and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10. Proc Natl Acad Sci USA 2009; 106:5842-7.
55. Shi M, Zhao G. The EAST syndrome and KCNJ10 mutations. N Engl J Med 2009; 361:630.
56. Reichold M, Zdebik AA, Lieberer E, Rapedius M, Schmidt K, Bandulik S, et al. KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness and tubulopathy) disrupt channel function. Proc Natl Acad Sci USA 2010; 107:14490-5.
57. Sala-Rabanal M, Kucheryavykh LY, Skatchkov SN, Eaton MJ, Nichols CG. Molecular mechanisms of EAST/SeSAME syndrome mutations in Kir4.1 (KCNJ10). J Biol Chem 2010; 285:36040-8.