K+ channel selectivity depends on kinetic as well as thermodynamic factors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 39, 2006, Pages 14361-14366

  Grabe, Michael ^a,b   Bichet, Delphine ^a   Qian, Xiang ^a   Jan, Yuh Nung ^a   Jan, Lily Yeh ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Electrostatics; Ion permeation; Model; Potassium channel; Simulation

Indexed keywords

POTASSIUM; POTASSIUM CHANNEL; SODIUM;

ANIMAL CELL; ARTICLE; BINDING SITE; CALCULATION; CELL KINETICS; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; ENERGY TRANSFER; ION PERMEABILITY; KINETICS; MEMBRANE FILTER; MOLECULAR MODEL; MUTATION; NONHUMAN; PRIORITY JOURNAL; THERMODYNAMICS;

AMINO ACIDS; ANIMALS; CELL MEMBRANE PERMEABILITY; ELECTROSTATICS; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; ION CHANNEL GATING; KINETICS; MODELS, BIOLOGICAL; MUTANT PROTEINS; MUTATION; OOCYTES; POTASSIUM; SODIUM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THERMODYNAMICS; XENOPUS LAEVIS;

EID: 33749254438     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0606662103     Document Type: Article

References (36)

1. Hille B (2001) Ion Channels of Excitable Membranes (Sinauer, Sunderland, MA), 3rd Ed.
2. Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R (1998) Science 280:69-77.
3. Bezanilla F, Armstrong CM (1972) J Gen Physiol 60:588-608.
4. Zhou Y, Morais-Cabral JH, Kaufman A, MacKinnon R (2001) Nature 414:43-48.
5. Berneche S, Roux B (2001) Nature 414:73-77.
6. Aqvist J, Luzhkov V (2000) Nature 404:881-884.
7. Allen TW, Bliznyuk A, Rendell AP, Kuyucak S, Chung SH (2000) J Chem Phys 112:8191-8204.
8. Nishida M, MacKinnon R (2002) Cell 111:957-965.
9. Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA (2003) Science 300:1922-1926.
10. Pegan S, Arrabit C, Zhou W, Kwiatkowski W, Collins A, Slesinger PA, Choe S (2005) Nat Neurosci 8:279-287.
11. Hille B, Schwarz W (1978) J Gen Physiol 72:409-442.
12. Lopatin AN, Makhina EN, Nichols CG (1995) J Gen Physiol 106:923-955.
13. Spassova M, Lu Z (1998) J Gen Physiol 112:211-221.
14. Haug T, Sigg D, Ciani S, Toro L, Stefani E, Olcese R (2004) J Gen Physiol 124:173-184.
15. Brelidze TI, Niu X, Magleby KL (2003) Proc Natl Acad Sci USA 100:9017-9022.
16. Zhang Y, Niu X, Brelidze TI, Magleby KL (2006) J Gen Physiol 128:185-202.
17. Fujiwara Y, Kubo Y (2006) J Gen Physiol 127:401-419.
18. Chen MF, Chen TY (2003) J Gen Physiol 122:133-145.
19. Morais-Cabral JH, Zhou Y, MacKinnon R (2001) Nature 414:37-42.
20. Kutluay E, Roux B, Heginbotham L (2005) Biophys J 88:1018-1029.
21. Bichet D, Grabe M, Jan YN, Jan LY (2006) Proc Natl Acad Sci USA 103:14355-14360.
22. Roux B, MacKinnon R (1999) Science 285:100-102.
23. Hodgkin AL, Keynes RD (1955) J Physiol (London) 128:28-60.
24. Noskov SY, Berneche S, Roux B (2004) Nature 431:830-834.
25. Qu W, Moorhouse AJ, Chandra M, Pierce KD, Lewis TM, Barry PH (2006) J Gen Physiol 127:375-389.
26. Kubo Y, Murata Y (2001) J Physiol (London) 531:645-660.
27. Guo D, Ramu Y, Klem AM, Lu Z (2003) J Gen Physiol 121:261-275.
28. Stanfield PR, Davies NW, Shelton PA, Sutcliffe MJ, Khan IA, Brammar WJ, Conley EC (1994) J Physiol (London) 478:1-6.
29. Yang J, Jan YN, Jan LY (1995) Neuron 14:1047-1054.
30. Xie LH, John SA, Weiss JN (2003) J Physiol (London) 550:67-82.
31. Lu Z, MacKinnon R (1994) Nature 371:243-246.
32. Sali A, Blundell TL (1993) J Mol Biol 234:779-815.
33. Kale L, Skeel R, Bhandarkar M, Brunner R, Gursoy A, Krawetz N, Phillips J, Shinozaki A, Varadarajan K, Schulten K (1999) J Comp Phys 151:283-312.
34. Baker NA, Sept D, Joseph S, Holst MJ, McCammon JA (2001) Proc Natl Acad Sci USA 98:10037-10041.
35. Grabe M, Lecar H, Jan YN, Jan LY (2004) Proc Natl Acad Sci USA 101:17640-17645.
36. Root MJ, MacKinnon R (1994) Science 265:1852-1856.