Assessement of anti-inflammatory properties of microspheres prepared with chitosan and 5-amino salicylic acid over inflamed Caco-2 cells

Carbohydrate Polymers

Volumn 85, Issue 3, 2011, Pages 638-644

  Aguzzi, C ^a   Ortega, A ^b   Bonferoni, M C ^c   Sandri, G ^c   Cerezo, P ^a   Salcedo, I ^a   Sanchez R ^a   Viseras, C ^a,d   Caramella, C ^c  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSIDAD PABLO DE OLAVIDE   (Spain)

^c UNIVERSITY OF PAVIA   (Italy)

^d CSIC   (Spain)

Author keywords

5 ASA; Chitosan; Cytokines; Drug release; Inflammation; Spray drying

Indexed keywords

5-AMINO SALICYLIC ACID; 5-ASA; ANTI-INFLAMMATORIES; ANTI-INFLAMMATORY EFFECTS; CACO-2 CELLS; CELL VIABILITY; COLONIC DELIVERY; CYTOKINES; CYTOTOXIC ACTIVITIES; DRUG DISSOLUTION; DRUG RELEASE; HIGH DISSOLUTION RATE; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; MRNA LEVEL; SPRAY DRYING TECHNIQUE;

CHITIN; CHITOSAN; DRUG PRODUCTS; DRYING; MICROSPHERES; NUCLEIC ACIDS; PATHOLOGY; SPRAY DRYING;

DISSOLUTION;

EID: 79955675609     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2011.03.027     Document Type: Article

References (49)

1. C. Aguzzi, P. Capra, C. Bonferoni, P. Cerezo, I. Salcedo, and R. Sánchez Chitosan-silicate biocomposites to be used in modified drug release of 5-aminosalicylic acid (5-ASA) Applied Clay Science 50 2010 106 111
2. M. Baggiolini Chemokines in patology and medicine Journal of Internal Medicine 250 2001 91 104
3. D.C. Baumgart, K. Vierziger, A. Sturm, B. Wiedenmann, and A.U. Dignass Mesalamine promotes intestinal epithelial wound healing in vitro through a TGF-beta-independent mechanism Scandinavian Journal of Gastroenterology 40 2005 958 964 (Pubitemid 41117021)
4. K.F. Bruin, D.W. Hommes, J. Jansen, G.N. Tytgat, Wouter Ten, and J. Cate Modulation of cytokine release from human monocytes by drugs used in the therapy of inflammatory bowel diseases European Journal of Gastroenterology & Hepatology 7 1995 791 795
5. I. Cendrowska, M. Drewnowska, A. Grzeszkiewicz, and K. Butkierwicz Investigation of the stability of 5-aminosalicylic acid in tablets and suppositories by high-performance liquid chromatography Journal of Chromatography 509 1990 195 199 (Pubitemid 20205011)
6. D. Clemett, and A. Markham Prolonged-release mesalazine. A review of its therapeutic potential in ulcerative Colitis and Crohn's disease Drugs 59 2000 929 956 (Pubitemid 30232329)
7. B. Crotty, and J.P. Jewel Drug therapy of ulcerative colitis British Journal of Clinical Pharmacology 34 1992 189 198
8. S. Davaran, J. Hanaee, and A. Khosravi Release of 5-amino salicylic acid from acrylic type polymeric prodrugs designed for colon-specific drug delivery Journal of Controlled Release 58 1999 279 287 (Pubitemid 29142452)
9. J.J. De Dooy, L.M. Mahieu, and H.P. Van Bever The role of inflammation in the development of chronic lung desease in neonates European Journal of Pediatrics 160 2001 457 463 (Pubitemid 32695823)
10. D.F. Evans, G. Pye, R. Bramley, A.G. Clark, T.J. Dyson, and J.D. Hardcastle Measurement of gastrointestinal pH profiles in normal ambulant human subjects Gut 29 1988 1035 1041
11. D.L. French, and J.W. Mauger Evaluation of the physicochemical properties and dissolution characteristics of mesalamine: Relevance to controlled intestinal drug delivery Pharmaceutical Research 10 1993 1285 1289
12. I. Genta, F. Pavanetto, B. Conti, P. Giunchedi, and U. Conte Improvement of dexamethasone dissolution rate from spray-dried chitosan microspheres STP Pharma Sciences 5 1995 202 207
13. V.S. Gupta, T.E. Beckert, and J.C. Price A novel pH- and time- based multi-unit potential colonic drug delivery system. I. Development International Journal of Pharmaceutics 213 2001 83 91 (Pubitemid 32119464)
14. J.G. Hardy, C.G. Wilson, and E. Wood Drug delivery to the proximal colon Journal of Pharmacology 37 1985 874 877 (Pubitemid 16222321)
15. M. Hiorth, I. Tho, and S.A. Sande The formation and permeability of drugs across free pectin and chitosan films prepared by a spraying method European Journal of Pharmaceutics and Biopharmaceutics 56 2003 175 182 (Pubitemid 37072100)
16. R. Jayakumara, K. Deepthy Menona, S.V. Manzoora, H. Naira, and C. Tamurab Biomedical applications of chitin and chitosan based nanomaterials - A short review Carbohydrate Polymers 82 2010 227 232
17. Y.J. Jung, J.S. Lee, and Y.M. Kim Colon-specific prodrugs of 5-aminosalicylic acid: Synthesis and in vitro/in vivo properties of acidic amino acid derivatives of 5-aminosalicylic acid Journal of Pharmaceutical Sciences 90 2001 1767 1775 (Pubitemid 33062597)
18. A. Lamprecht, U. Schäfer, and C.-M. Lehr Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa Pharmaceutical Research 18 2001 788 793 (Pubitemid 32783514)
19. A. Lamprecht, H. Yamamoto, H. Takeuchi, and Y. Kawashima Nanoparticles enhance therapeutic efficiency by selectively increased local drug dose in experimental colitis in rats Journal of Pharmacology and Experimental Therapeutics 315 2005 196 202 (Pubitemid 41380512)
20. M.L. Lorenzo-Lamosa, C. Remuñán-López, J.L. Vila-Jato, and M.J. Alonso Design of microencapsulated chitosan microspheres for colonic drug delivery Journal of Controlled Release 52 1998 109 118 (Pubitemid 28123178)
21. F. Maestrelli, N. Zerrouk, C. Chemtob, and P. Mura Influence of chitosan and its glutamate and hydrochloride salts on naproxen dissolution rate and permeation across Caco-2 cells International Journal of Pharmaceutics 271 2004 257 267 (Pubitemid 38210104)
22. Y.R. Mahida, C.E.D. Lamming, A. Gallagher, A.B. Hawthorne, and C.J. Hawkey 5-Aminosalicylic acid is a potent inhibitor of interleukin 1β production in organ culture of colonic biopsy specimens from patients with inflammatory bowel disease Gut 32 1991 50 54
23. S.M. McKenzie, W.F. Doe, and G.D. Buffinton 5-Aminosalicylic acid prevents oxidant mediated damage of glyceraldehyde-3-phosphate dehydrogenase in colon epithelial cells Gut 44 1999 180 185 (Pubitemid 29119360)
24. T. Mori, M. Okumura, M. Matsuura, K. Ueno, S. Tokura, and Y. Okamoto Effects of chitin and its derivatives on the proliferation and cytokine production of fibroblasts in vitro Biomaterials 18 1997 947 951 (Pubitemid 27270221)
25. B. Moulari, D. Pertuit, Y. Pellequer, and A. Lamprecht The targeting of surface modified silica nanoparticles to inflamed tissue in experimental colitis Biomaterials 29 2008 4554 4560
26. P. Mura, N. Zerrouk, N. Mennini, F. Maestrelli, and C. Chemtob Development and characterization of naproxen-chitosan solid systems with improved drug dissolution properties European Journal of Pharmaceutical Sciences 19 2003 67 75 (Pubitemid 36506939)
27. Y. Murata, Y. Ishiguro, J. Itoh, A. Munakata, and Y. Yoshida The role of proinflammatory and immunoregulatory cytokines in the pathogeneis of ulcerative colitis Gastroenterology 30 Suppl. 8 1995 56 60
28. R.A.A. Muzzarelli, and C. Muzzarelli Chitin and chitosan hydrogels G.O. Phillips, P.A. Williams, Handbook of hydrocolloids second ed. 2009 Woodhead Publishing Ltd. Cambridge UK 849 888
29. S.G. Nugent, D. Kumar, D.S. Rampton, and D.F. Evans Intestinal luminal pH in inflammatory bowel disease: Possible determinants and implications for therapy with aminosalicylates and other drugs Gut 48 2001 571 577 (Pubitemid 32234805)
30. K. Ofori-Kwakye, and J.T. Fell Biphasic drug release: The permeability of films containing pectin, chitosan and HPMC International Journal of Pharmaceutics 226 2001 139 145 (Pubitemid 32800789)
31. G.F. Oliveira, P.C. Ferrari, L.Q. Carvalho, C. Raul, and R.C. Evangelista Chitosan-pectin multiparticulate systems associated with enteric polymers for colonic drug delivery Carbohydrate Polymers 82 2010 1004 1009
32. J.H. Park, G. Saravanakumar, K. Kim, and I. Chan Kwon Targeted delivery of low molecular drugs using chitosan and its derivatives Advanced Drug Delivery Reviews 62 2010 28 41
33. D. Pertuit, B. Moulari, T. Betz, A. Nadaradjane, D. Neumann, and L. Ismaïli 5-amino salicylic acid bound nanoparticles for the therapy of inflammatory bowel disease Journal of Controlled Release 123 2007 211 218 (Pubitemid 350007824)
34. A. Portero, C. Remuñán-López, and J.L. Vila-lato Effect of chitosan and chitosan glutamate enhancing the dissolution properties of the poorly water soluble drug nifedipine International Journal of Pharmaceutics 175 1998 75 84 (Pubitemid 28487017)
35. M. Prasitsilp, R. Jenwithisuk, K. Kongsuwan, N. Damrongchai, and P. Watts Cellular responses to chitosan in vitro: The importance of deacetylation Journal of Materials-Science Materials in Medicine 11 2000 773 778 (Pubitemid 32014530)
36. D. Rachmilewitz, F. Karmeli, L.W. Schwartz, and P.L. Simon Effect of aminophenols (5-ASA and 4-ASA) on colonic interleukin-1 generation Gut 33 1992 929 932
37. M.N.V. Ravi Kumar, R.A.A. Muzzarelli, C. Muzzarelli, H. Sashiwa, and A.J. Domb Chitosan chemistry and pharmaceutical perspectives Chemical Reviews 104 2004 6017 6084 (Pubitemid 40025733)
38. M.W. Rudolph, S. Kleina, T.E. Beckertb, H.-U. Petereitb, and J.B. Dressman A new 5-aminosalicylic acid multi-unit dosage form for the therapy of ulcerative colitis European Journal of Pharmaceutics and Biopharmaceutics 51 2001 183 190 (Pubitemid 32422095)
39. M.R. Saboktakin, R.M. Tabatabaie, A. Maharramov, and M.A. Ramazanov Synthesis and characterization of chitosan hydrogels containing 5-aminosalicylic acid nanopendents for colon: Specific drug delivery Journal of Pharmaceutical Sciences 99 2010 4955 4961
40. N. Shimono, T. Takatori, M. Ueda, M. Mori, Y. Higashi, and Y. Nakamura Chitosan dispersed system for colon-specific drug delivery International Journal of Pharmaceutics 245 2002 45 54 (Pubitemid 35299890)
41. A. Stallmach, T. Giese, C. Schmidt, B. Ludwig, I. Mueller-Molaian, and S.C. Meuer Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn's disease International Journal of Colorectal Disease 19 2004 308 315 (Pubitemid 38868295)
42. H. Takeuchi, T. Yasuji, H. Yamamoto, and Y. Kawashima Spray-dried lactose composite particles containing an ion complex of alginate-chitosan for designing a dry-coated tablet having a time-controlled releasing function Pharmaceutical Research 17 2000 94 99 (Pubitemid 30121106)
43. H. Tozaki, T. Odoriba, N. Okada, T. Fujita, A. Terabe, and T. Suzuki Chitosan capsules for colon-specific drug delivery: Enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats Journal of Controlled Release 82 2002 51 61 (Pubitemid 34775047)
44. J. Varshosaz, A. Jaffarian Dehkordi, and G. Golafshan Colon-specific delivery of mesalazine chitosan microspheres Journal of Microencapsulation 23 2006 329 339 (Pubitemid 43977084)
45. J.G. Williams, and M.B. Hallett Effect of sulphasalazine and its active metabolite, 5-amino-salicylic acid, on toxic oxygen metabolite production by neutrophils Gut 30 1989 1581 1587 (Pubitemid 20001162)
46. Y. Zambito, and G. Di Colo Preparation and in vitro evaluation of chitosan matrices for colonic controlled drug delivery Journal of Pharmacy and Pharmaceutical Sciences 6 2003 274 281
47. H. Zhang, I.A. Alsarra, and S.H. Neau An in vitro evaluation of a chitosan-containing multiparticulate system for macromolecule delivery to the colon International Journal of Pharmaceutics 239 2002 197 205 (Pubitemid 34615809)
48. H. Zhang, and S.H. Neau In vitro degradation of chitosan by bacterial enzymes from rat cecal and colonic contents Biomaterials 23 2002 2761 2766 (Pubitemid 34465735)
49. M. Zou, H. Okamoto, G. Cheng, X. Hao, J. Sun, and F. Cui Synthesis and properties of polysaccharide prodrugs of 5-aminosalicylic acid as potential colon-specific delivery systems European Journal of Pharmaceutics and Biopharmaceutics 59 2005 155 160 (Pubitemid 39573448)