Memory cells specific for myelin oligodendrocyte glycoprotein (MOG) govern the transfer of experimental autoimmune encephalomyelitis

Journal of Neuroimmunology

Volumn 234, Issue 1-2, 2011, Pages 84-92

  Williams, Jessica L ^a   Kithcart, Aaron P ^a   Smith, Kristen M ^a   Shawler, Todd ^a   Cox, Gina M ^a   Whitacre, Caroline C ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Adoptive transfer; Experimental autoimmune encephalomyelitis; Memory T cell; Multiple sclerosis; Myelin oligodendrocyte glycoprotein

Indexed keywords

GAMMA INTERFERON; HERMES ANTIGEN; INTERLEUKIN 17; L SELECTIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; DISEASE TRANSMISSION; EFFECTOR CELL; FEMALE; LYMPHOCYTE DIFFERENTIATION; MALE; MEMORY CELL; MOUSE; MULTIPLE SCLEROSIS; NEUROPATHOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SEX DIFFERENCE; TH1 CELL; TH17 CELL; TRANSGENE; UPREGULATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD; BRAIN; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GLYCOPROTEINS; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SEX FACTORS; SPINAL CORD; T-LYMPHOCYTES; TIME FACTORS;

EID: 79955662935     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2011.02.008     Document Type: Article

References (35)

1. Bebo B.F., Schuster J.C., Vandenbark A.A., Offner H. Androgens alter the cytokine profile and reduce encephalogenicity of myelin-reactive T cells. J. Immunol. 1999, 162:35-40.
2. Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., Weiner H.L., Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-238.
3. Bettelli E., Pagany M., Weiner H.L., Linington C., Sobel R.A., Kuchroo V.K. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J. Exp. Med. 2003, 197:1073-1081.
4. Bielekova B., Goodwin B., Richert N., Cortese I., Kondo T., Afshar G., Gran B., Eaton J., Antel J., Frank J.A., McFarland H.F., Martin R. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat. Med. 2000, 6:1167-1175.
5. Brocke S., Piercy C., Steinman L., Weissman I.L., Veromaa T. Antibodies to CD44 and integrin α4, but not l-selectin, prevent central nervous system inflammation and experimental autoimmune encephalomyelitis by blocking secondary leukocyte recruitment. Proc. Natl. Acad. Sci. USA 1999, 96:6896-6901.
6. Cerghet M., Skoff R.P., Bessert D., Zhang Z., Mullins C., Ghandour M.S. Proliferation and death of oligodendrocytes and myelin proteins are differentially regulated in male and female rodents. J. Neurosci. 2006, 26:1439-1447.
7. DeGrendele H.C., Estess P., Picker L.J., Siegelman M.H. CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte-endothelial cell primary adhesion pathway. J. Exp. Med. 1996, 183:1119-1130.
8. Egg R., Reindl M., Deisenhammer F., Linington C., Berger T. Anti-MOG and anti-MBP antibody subclasses in multiple sclerosis. Mult. Scler. 2001, 7:285-289.
9. Ferber I.A., Brocke S., Taylor-Edwards C., Ridgway W., Dinisco C., Steinman L., Dalton D., Fathman C.G. Mice with disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 1996, 156:5-7.
10. Haak S., Croxford A.L., Kreymborg K., Heppner F.L., Pouly S., Becher B., Waisman A. IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J. Clin. Invest. 2009, 119:61-69.
11. Jäger A., Dardalhon V., Sobel R.A., Bettelli E., Kuchroo V.K. Th1, Th17, Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J. Immunol. 2009, 183:7169-7177.
12. Johns J.G., Bernard C.C.A. The structure and function of myelin oligodendrocyte glycoprotein. J. Neurochem. 1999, 72:1-9.
13. Kebir H., Kreymborg K., Ifergan I., Dodelet-Devillers A., Cayrol R., Bernard M., Giuliani F., Arbour N., Becher B., Prat A. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat. Med. 2007, 13:1173-1175.
14. Kerlero de Rosbo N., Hoffman M., Mendel I., Yust I., Kaye J., Bakimer R., Flechter S., Abramsky O., Milo R., Karni A., Ben-Nun A. Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions. Eur. J. Immunol. 1997, 27:3059-3069.
15. Langrish C.L., Chen Y., Blumenschein W.M., Mattson J., Basham B., Sedgwick J.D., McClanahan T., Kastelein R.A., Cua D.J. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 2005, 201:233-240.
16. Li M.O., Wan Y.Y., Flavell R.A. T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 2007, 26:579-591.
17. Lock C., Hermans G., Pedotti R., Brendolan A., Schadt E., Garren H., Langer-Gould A., Strober S., Cannella B., Allard J., Klonowski P., Austin A., Lad N., Kaminski N., Galli S.J., Oksenberg J.R., Raine C.S., Heller R., Steinman L. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 2002, 8:500-508.
18. Lovett-Racke A.E., Trotter J.L., Lauber J., Perrin P.J., June C.H., Racke M.K. Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. J. Clin. Invest. 1998, 101:725-730.
19. Markiewicz M.A., Girao C., Opferman J.T., Sun J., Hu Q., Agulnik A.A., Bishop C.E., Thompson C.B., Ashton-Rickardt P.G. Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules. Proc. Natl. Sci. USA 1998, 95:3065-3070.
20. Mendel I., Kerlero de Rosbo N., Ben-Nun A. A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells. Eur. J. Immunol. 1995, 25:1951-1959.
21. Nandi A., Estess P., Siegelman M. Bimolecular complex between rolling and firm adhesion receptors required for cell arrest: CD44 association with VLA-4 in T cell extravasation. Immunity 2004, 20:455-465.
22. Pettinelli C.B., McFarlin D.E. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vivo activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes. J. Immunol. 1981, 127:1420-1423.
23. Polanczyk M.J., Carson B.D., Subramanian S., Afentoulis M., Vandenbark A.A., Ziegler S.F., Offner H. Estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment. J. Immunol. 2004, 173:2227-2230.
24. Polanczyk M.J., Hopke C., Huan J., Vandenbark A.A., Offner H. Enhanced FoxP3 expression and Treg cell function in pregnancy and estrogen-treated mice. J. Neuroimmunol. 2005, 170:85-92.
25. Rep M.H.G., van Oosten B.W., Roos M.T.L., Adèr H.J., Polman C.H., van Lier R.A.W. Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naïve T cells but does not affect IFN-γ secreting TH1 cells in humans. J. Clin. Invest. 1997, 99:2225-2231.
26. Sallusto F., Lenig D., Reinhold F., Lipp M., Lanzavecchia Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999, 401:708-712.
27. Siegelman M.H., Stanescu D., Estess P. The CD44-initiated pathway of T-cell extravasation uses VLA-4 but not LFA-1 for firm adhesion. J. Clin. Invest. 2000, 105:683-691.
28. Stromnes I.M., Cerretti L.M., Liggitt D., Harris R.A., Goverman J.M. Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells. Nat. Med. 2008, 14:337-342.
29. Sun J., Link H., Olsson T., Xiao B., Andersson G., Ekre H., Linington C., Diener P. T and B cell responses to myelin oligodendrocyte glycoprotein in multiple sclerosis. J. Immunol. 1991, 146:1490-1495.
30. Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., Glimcher L.H. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000, 100:655-669.
31. Tuohy V.K., Lu Z., Sobel R.A., Laursen R.A., Lees M.B. Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J. Immunol. 1989, 142:1523-1527.
32. van Oosten B.W., Lai M., Hodgkinson S., Barkhof F., Miller D.H., Moseley I.F., Thompson A.J., Rudge P., McDougall A., McLeod J.G., Adèr H.J., Polman C.H. Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: results of a randomized, double-blind, placebo-controlled, MR-monitored phase II trial. Neurology 1997, 49:351-357.
33. Yang Y., Weiner J., Liu Y., Smith A.J., Huss D.J., Winger R., Peng H., Cravens P.D., Racke M.K., Lovett-Racke A.E. T-bet is essential for encephalitogenicity of both Th1 and Th17 cells. J. Exp. Med. 2009, 206:1549-1564.
34. Zamvil S.S., Mitchell D.J., Moore A.C., Kitamura K., Steinman L., Rothbard J.B. T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 1986, 324:258-260.
35. Zamvil S.S., Steinman L. Diverse targets of intervention during inflammatory and neurodegenerative phases of multiple sclerosis. Neuron 2003, 38:685-688.