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As described in ref 10c the C(21)-C(40) fragment of tetrafibricin was produced in 14 linear steps and 34 total steps from a commercial chiral building block derived from malic acid. Also, as described in ref 9b, a synthesis of the C(23)-C(40) was recently disclosed.
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As described in ref 10c the C(21)-C(40) fragment of tetrafibricin was produced in 14 linear steps and 34 total steps from a commercial chiral building block derived from malic acid. Also, as described in ref 9b, a synthesis of the C(23)-C(40) was recently disclosed.
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The ideal synthesis creates a complex skeleton...in a sequence only of successive construction reactions involving no intermediary refunctionalizations, and leading directly to the structure of the target, not only its skeleton but also its correctly placed functionality
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