Chronic effects of single and fractionated γ-irradiation on an impairment of Th1-related immune response

International Journal of Radiation Biology

Volumn 87, Issue 5, 2011, Pages 534-543

  Park, Hae Ran ^a   Jo, Sung Kee ^a   Eom, Hyeon Soo ^a  

^a Korea Atomic Energy Research Institute   (South Korea)

Author keywords

fractionated irradiation; immune function; ionising radiation; Th1 related immune response

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 12P70; INTERLEUKIN 4; STAT4 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL POPULATION; CONTROLLED STUDY; CYTOLYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REPRESSION; FEMALE; FLOW CYTOMETRY; GAMMA IRRADIATION; GAMMA RADIATION; GENE OVEREXPRESSION; IMMUNE RESPONSE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL; TH1 CELL; WESTERN BLOTTING; WHOLE BODY RADIATION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GAMMA RAYS; IMMUNE SYSTEM; INTERLEUKIN-12; INTERLEUKIN-4; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, BIOLOGICAL; STAT4 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TH1 CELLS; WHOLE-BODY IRRADIATION;

MUS;

EID: 79955608098     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2011.542540     Document Type: Article

References (41)

1. AlexanderWS. 2002. Suppressors of cytokine signaling (SOCS) in the immune system. Nature Review Immunology 2:410-416. (Pubitemid 37328748)
2. Bacon CM, Petricoin EF, Ortaldo JR, Ress RC, Larner AC, Johnston JA, O'Shea JJ. 1995. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proceedings of the National Academy of Sciences of the USA 92:7307-7311.
3. Bass H, Mosmann T, Strober S. 1989. Evidence for mouse Th1- and Th2-like helper T cells in vivo. Selective reduction of Th1-like cells after total lymphoid irradiation. Journal of Experimental Medicine 170:1495-1511. (Pubitemid 19284554)
4. Chambers KA, Harrington NP, Ross WM, Filion LG. 1998. Relative alterations in blood mononuclear cell populations reflect radiation injury in mice. Cytometry 31:45-52. (Pubitemid 28050062)
5. Chua AO, Wilkinson WL, Presky DH, Gubler U. 1995. Cloning and characterization of a mouse IL-12 receptor-b component. Journal of Immunology 155:4286-4294.
6. Dorr W, Hendry JH. 2001. Consequential late effects in normal tissues. Radiotherapy and Oncology 61:223-231. (Pubitemid 33127227)
7. Dunn PL, North RJ. 1991. Early g interferon production by natural killer cells is important in defense against murine listeriosis. Infection and Immunology 59:2892-2900.
8. Egwuagu CE, Yu CR, Zhang M, Mahdi RM, Kim SJ, Gery I. 2002. Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: Implications for Th cell lineage commitment and maintenance. Journal of Immunology 168:3181-3187. (Pubitemid 34250377)
9. Garely MK, Carvajal DM, Connaughton SE, Gillessen S, Warrier RR, Kolinsky KD, Wilkinson VL, Dwyer CM, Higgins GF, Jr, Podlaski FJ, Faherty DA, Familletti PC, Stern AS, Presky DH. 1996. Interleukin-12 antagonist activity of mouse interleukin- 12 p40 homodimer in vitro and in vivo. Annual New York Academic Science 795:1-12. (Pubitemid 27029550)
10. Gillessen S, Carvajal D, Ling P, Podlaski FJ, Stremlo DL, Familetti PC, Gubler U, Presky DH, Stern AS, Gately MK, 1995. Mouse interleukin 12 (IL-12) p40 homodimer: a potent IL-12 antagonist. European Journal of Immunology 25:200-206.
11. Gubler U, Chua AO, Schoenhaut DS, Dwyer CM, McComes W, Motvka R, Nabavi N, Wolitzky AG, Quinn PM, Familletti PC, Gately MK, 1991. Co-expression of two distinct genes is required to generate secreted, bioactive cytotoxic lymphocyte maturation factor. Processings of the National Academic Sciency USA 88:4143-4147. (Pubitemid 21914495)
12. Fulop T, Larbi A, Douziech N, Levesque I, Varin A, Herbein G. 2006. Cytokine receptor signaling and aging. Mechanisms of Aging and Development 127:526-537.
13. Hayashi T, Kusunoki Y, Hakoda M, Morishita Y, Kubo Y, Maki M, Kasagi F, Kodama K, Macphee DG, Kyoizumi S. 2003. Radiation dose-dependent increase in inflammatory response markers in A-bomb survivors. International Journal of Radiation Biology 79:129-136. (Pubitemid 36183071)
14. Jacobson NG, Szabo SJ, Weber-Nordt RM, Zhong Z, Schreiber RD, Darnell JE Jr, Murphy KM. 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. Journal of Experimental Medicine 181:1755-1762.
15. Jung H, Beck-Bornholdt HP, Svoboda V, Alberti W, Herrmann T. 2001. Quantification of late complications after radiation therapy. Radiotherapy and Oncology 61:233-246. (Pubitemid 33127228)
16. Kajioka EH, Andres ML, Li J,Mao XW,Moyers MF, Nelson GA, Slater JM, Gridley DS. 2000. Acute effects of whole-body proton irradiation on the immune system of the mouse. Radiation Research 153:587-594. (Pubitemid 30252607)
17. Kaplan MH, Sun YL, Hoey T, Grusby MJ. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4- deficient mice. Nature 382:174-177. (Pubitemid 26242885)
18. Kunikata T, Torigoe K, Ushio S, Okura T, Ushio C, Yamaushi H, Ikeda M, Ikegami H, Kurimoto M. 1998. Constitutive and induced IL-18 receptor expression by various peripheralblood- cell subsets as determined by anti-hIL-18R monoclonal antibody. Cellular Immunology 189:135-143. (Pubitemid 28507254)
19. Ling P, Gately MK, Gubler U, Stem AS, Lin P, Hollfelder K, Su C, Pan YC, Hakimi J. 1995. Human IL-12p40 homodimer binds to the IL-12 receptor but does not mediated biologic activity. Journal of Immunology 154:116-127.
20. Martin-Fontecha A, Thomsen LL, Brett S, Gerard C, Lipp M, Lanzavecchia A, Sallusto F. 2004. Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nature Immunology 5:1260-1265. (Pubitemid 41057741)
21. Nakahira M, Tomura M, Iwasaki M, Ahn HJ, Blan Y, Hamaoka T, Ohta T, Kurimoto M, Fujiwara H. 2001. An absolute requirement for Stat4 and a role for IFN-g as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex. Journal of Immunology 167:1306-1312. (Pubitemid 32703126)
22. Nias AHW. 1998. An introduction to radiobiology. In: Wholebody radiation 2nd ed, Chichester, UK: John Wiley & Sons Ltd.
23. Park HR, Jo SK, Paik SG. 2005. Factors affecting the Th2-like immune response after gamma-irradiation: low production of IL-12 heterodimer in antigen-presenting cells and small expression of the IL-12 receptor in T cells. International Journal of Radiation Biology 81:221-231.
24. Park HR, Jo SK, Paik SG. 2006. The NK1.1 T cells alive in irradiated mice play an important role in a Th1/Th2 balance. International Journal of Radiation Biology 82:161-170.
25. Park HR, Jung UH, Jo SK. 2007. Impairment of Natural Killer (NK) cells is an important factor in a weak Th1-lkie response in irradiated mice. Radiation Research 168:446-452.
26. Presky DH, Yang H, Minetti LJ, Chua AO, Nabavi N, Wu CY, Gately MK, Gubler U. 1996. A functional interleukin 12 receptor complex is composed of two b-type cytokine receptor subunits. Proceedings of the National Academy of Sciences of the USA 93:14002-14007.
27. Puddu P, Fantuzzi L, Borghi P, Varano B, Rainaldi G. 1997. IL-12 induces IFN-g expression and secretion in mouse peritoneal macrophages. Journal of Immunology 159: 3490-3497. (Pubitemid 127482108)
28. + Tcells in mice. Radiation Research 173:148-157.
29. Romagnani S, Kapsenberg M, Radbruch A, Adorini L. 1989. Th1 and Th2 cells. Research in Immunology 149:871-873.
30. Romagnani S. 1997. The Th1/Th2 paradigm. Immunology Today 19:263-266. (Pubitemid 27261442)
31. + Tcell subsets and induces early resistance to Leishmania major in mice. Journal of Experimental Medicine 178:567-577. (Pubitemid 23218205)
32. Sinigaglia F, D'Ambrosio D, Panina-Bordignon P, Rogge L. 1999. Regulation of the IL-12/IL-12R axis: A critical step in T-helper cell differentiation and effector function. Immunological Reviews 170:65-72. (Pubitemid 29490745)
33. Snapper CM, Paul WE. 1987. Interferon-g and B cell stimulatoryfactor- I reciprocally regulate Ig isotype production. Science 263:944-947. (Pubitemid 17107942)
34. Szabo SJ, Dighe AS, Gubler U. 1997. Murphy KM. Regulation of the interleukin (IL)- 12R b2 subunit expression in developing T helper 1 (Th1) and Th2 cells. Journal of Experimental Medicine 185:817-824. (Pubitemid 27119865)
35. Szabo SJ, Sullivan BM, Peng SL, Glimcher LH. 2003. Molecular mechanisms regulating Th1 immune responses. Annual Review of Immunology 21:713-758. (Pubitemid 37174546)
36. Tanay A, Strober S. 1984. Opposite effects of total lymphoid irradiation on T cell-dependent and T cell-independent antibody responses. Journal of Immunology 132:979-984. (Pubitemid 14189127)
37. Thierfelder WE, Van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Vignali DA, Doherty PC, Grosveld GC, Ihle JN. 2000. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cell. Nature 382:171-174.
38. Yasukawa H, Sasaki A, Yoshimura A. 2000. Negative regulation of cytokine signaling pathways. Annual Review of Immunology 18:143-164. (Pubitemid 30365377)
39. Xu X, Sun YL, Hoey T. 1996. Cooperative DNA binding and sequence-selective recognition conferred by the STAT aminoterminal domain. Science 273:794-797. (Pubitemid 26271524)
40. Wolf SF, Temple PA, Kobayashi M, Young D, Dicig M. Lowe L, Dzialo R, Fitz L, Ferenz C, Hewick RM, Kelleher K, Hermann SH, Clark SC, Azzoni L, Chan SH, Trinchieri G, Perussia B. 1991. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer-cells. Journal of Immunology 146:3074-3081.
41. Zhuang Y, Huang Z, Nishida J, Zhang L, Huang H. 2009. Signaling pathways that lead to the silencing of the interleukin- 4-producing potential in Th1 cells. Journal of Interferon & Cytokine Research 29:399-406.