Stable EET urea agonist and soluble epoxide hydrolase inhibitor regulate rat pulmonary arteries through TRPCs

Hypertension Research

Volumn 34, Issue 5, 2011, Pages 630-639

  Liu, Yun ^a   Wang, Ruifang ^a   Li, Jing ^a   Rao, Jingjing ^a   Li, Weiyang ^b   Falck, John R ^c   Manthati, Vijay L ^c   Medhora, Meetha ^d   Jacobs, Elizabeth R ^d   Zhu, Daling ^a,e  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b MUDANJIANG MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

^e Bio pharmaceutical Key Laboratory of Heilongjiang Province   (China)

Author keywords

12 (3 hexylureido)dodec 8 enoic acid; 8 HUDE; canonical transient receptor potential channel (TRPC); epoxyeicosatrienoic acids (EETs); pulmonary arteries; store operated Ca 2+ channels (SOCCs)

Indexed keywords

2 AMINOETHOXYDIPHENYLBORANE; CAFFEINE; CALCIUM ION; CYCLOPIAZONIC ACID; EPOXIDE HYDROLASE; EPOXYICOSATRIENOIC ACID; LANTHANUM; MESSENGER RNA; NIFEDIPINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; UREA;

ANIMAL CELL; ARTICLE; CALCIUM DEPLETION; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; EXTRACELLULAR CALCIUM; FEMALE; GENE EXPRESSION; LUNG VASCULAR RESISTANCE; MALE; MESENTERIC ARTERY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PULMONARY ARTERY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BORON COMPOUNDS; CAFFEINE; CALCIUM CHANNEL BLOCKERS; CALCIUM SIGNALING; CELLS, CULTURED; ENZYME INHIBITORS; EPOXIDE HYDROLASES; FATTY ACIDS, MONOUNSATURATED; FEMALE; IMIDAZOLES; INDOLES; LANTHANUM; MALE; MESENTERIC ARTERIES; MUSCLE, SMOOTH, VASCULAR; NIFEDIPINE; PULMONARY ARTERY; RATS; RATS, WISTAR; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 79955600318     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2011.5     Document Type: Article

References (38)

1. Harder DR, Campbell WB, Roman RJ. Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. J Vasc Res 1995; 32: 79-92.
2. Ellis EF, Police RJ, Yancey L, McKinney JS, Amruthesh SC. Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid. Am J Physiol 1990; 259: H1171-H1177. (Pubitemid 20352318)
3. Katoh T, Takahashi K, Capdevila J, Karara A, Falck JR, Jacobson HR, Badr KF. Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney. Am J Physiol 1991; 261: F578-F586.
4. Oyekan AO, McGiff JC, Rosencrantz-Weiss P, Quilley J. Relaxant responses of rabbit aorta: influence of cytochrome P450 inhibitors. J Pharmacol Exp Ther 1994; 268: 262-269. (Pubitemid 24039097)
5. Campbell WB, Gebremedhin D, Pratt PF, Harder DR. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res 1996; 78: 415-423. (Pubitemid 26072547)
6. Falck JR, Reddy LM, Reddy YK, Bondlela M, Krishna UM, Ji Y, Sun J, Liao JK. 11,12- epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNFalpha- induced VCAM-1 expression. Bioorg Med Chem Lett 2003; 13: 4011-4014. (Pubitemid 37338437)
7. Falck JR, Kodela R, Manne R, Atcha KR, Puli N, Dubasi N, Manthati VL, Capdevila JH, Yi XY, Goldman DH, Morisseau C, Hammock BD, Campbell WB. 14,15-Epoxyeicosa- 5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. J Med Chem 2009; 52: 5069-5075.
8. Fisslthaler B, Popp R, Kiss L, Potente M, Harder DR, Fleming I, Busse R. Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature 1999; 401: 493-497. (Pubitemid 29470209)
9. Node K, Huo Y, Ruan X, Yang B, Spiecker M, Ley K, Zeldin DC, Liao JK. Antiinflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science 1999; 285: 1276-1279. (Pubitemid 29398616)
10. Zhu D, Bousamra II M, Zeldin DC, Falck JR, Townsley M, Harder DR, Roman RJ, Jacobs ER. Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. Am J Physiol Lung Cell Mol Physiol 2000; 278: L335-L343. (Pubitemid 30131219)
11. Fang X, Weintraub NL, Stoll LL, Spector AA. Epoxyeicosatrienoic acids increase intracellular calcium concentration in vascular smooth muscle cells. Hypertension 1999; 34: 1242-1246. (Pubitemid 30002389)
12. Moghaddam MF, Grant DF, Cheek JM, Greene JF, Williamson KC, Hammock BD. Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase. Nat Med 1997; 3: 562-566. (Pubitemid 27198657)
13. Spector AA, Fang X, Snyder GD, Weintraub NL. Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function. Prog Lipid Res 2004; 43: 55-90. (Pubitemid 37433867)
14. Zeldin DC. Epoxygenase pathways of arachidonic acid metabolism. J Biol Chem2001; 276: 36059-36062.
15. Xiao YF, Huang L, Morgan JP. Cytochrome P450: a novel system modulating Ca2+ channels and contraction in mammalian heart cells. J Physiol 1998; 508: 777-792. (Pubitemid 28220731)
16. Guo L, Tang X, Tian H, Liu Y, Wang Z, Wu H, Wang J, Guo S, Zhu D. Subacute hypoxia suppresses Kv3.4 channel expression and whole-cell K+ currents through endogenous 15-hydroxyeicosatetraenoic acid in pulmonary arterial smooth muscle cells. Eur J Pharmacol 2008; 587: 187-195.
17. Zhu D, Medhora M, Campbell WB, Spitzbarth N, Baker JE, Jacobs ER. Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries. Circ Res 2003; 92: 992-1000. (Pubitemid 36588498)
18. Zheng X, Li Q, Tang X, Liang S, Chen L, Zhang S, Wang Z, Guo L, Zhang R, Zhu D. Source of the elevation Ca2+ evoked by 15-HETE in pulmonary arterial myocytes. Eur J Pharmacol 2008; 601: 16-22.
19. Ma J, Liang S, Wang Z, Zhang L, Jiang J, Zheng J, Yu L, Zheng X, Wang R, Zhu D. ROCK pathway participates in the processes that 15-hydroxyeicosate- traenoic acid (15-HETE) mediated the pulmonary vascular remodeling induced by hypoxia in rat. J Cell Physiol 2010; 222: 82-94.
20. Janiak R, Wilson SM, Montague S, Hume JR. Heterogeneity of calcium stores and elementary release events in canine pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol 2001; 280: C22-C33.
21. Peppiatt CM, Collins TJ, Mackenzie L, Conway SJ, Holmes AB, Bootman MD, Berridge MJ, Seo JT, Roderick HL. 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a usedependent and slowly reversible action on store-operated calcium entry channels. Cell Calcium 2003; 34: 97-108. (Pubitemid 36790448)
22. Lin MJ, Leung GP, Zhang WM, Yang XR, Yip KP, Tse CM, Sham JS. Chronic hypoxiainduced upregulation of store-operated and receptor-operated Ca2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension. Circ Res 2004; 95: 496-505. (Pubitemid 39180930)
23. Michaelis UR, Fisslthaler B, Barbosa-Sicard E, Falck JR, Fleming I, Busse R. Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis. J Cell Sci 2005; 118: 5489-5498. (Pubitemid 43079290)
24. Moffat MP, Ward CA, Bend JR, Mock T, Farhangkhoee P, Karmazyn M. Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes. Am J Physiol 1993; 264: H1154-H1160. (Pubitemid 23115288)
25. Graber MN, Alfonso A, Gill DL. Recovery of Ca2+ pools and growth in Ca2+ pooldepleted cells is mediated by specific epoxyeicosatrienoic acids derived from arachidonic acid. J Biol Chem 1997; 272: 29546-29553.
26. Kaplin AI, Snyder SH, Linden DJ. Reduced nicotinamide adenine dinucleotideselective stimulation of inositol 1,4,5-trisphosphate receptors mediates hypoxic mobilization of calcium. J Neurosci 1996; 16: 2002-2011. (Pubitemid 26144013)
27. Berridge MJ. Inositol trisphosphate and calcium signalling. Nature 1993; 361: 315-325. (Pubitemid 23041621)
28. Du W, Frazier M, McMahon TJ, Eu JP. Redox activation of intracellular calcium release channels (ryanodine receptors) in the sustained phase of hypoxia-induced pulmonary vasoconstriction. Chest 2005; 128: 556S-558S. (Pubitemid 43054116)
29. Jabr RI, Toland H, Gelband CH, Wang XX, Hume JR. Prominent role of intracellular Ca2+ release in hypoxic vasoconstriction of canine pulmonary artery. Br J Pharmacol 1997; 122: 21-30. (Pubitemid 27376015)
30. Morio Y, McMurtry IF. Ca(2+) release from ryanodine-sensitive store contributes to mechanism of hypoxic vasoconstriction in rat lungs. J Appl Physiol 2002; 92: 527-534. (Pubitemid 34671016)
31. Zheng YM, Wang QS, Rathore R, Zhang WH, Mazurkiewicz JE, Sorrentino V, Singer HA, Kotlikoff MI, Wang YX. Type-3 ryanodine receptors mediate hypoxia-, but not neurotransmitter- induced calcium release and contraction in pulmonary artery smooth muscle cells. J Gen Physiol 2005; 125: 427-440.
32. Fabiato A. Time and calcium dependence of activation and inactivation of calciuminduced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell. J Gen Physiol 1985; 85: 247-289. (Pubitemid 15130972)
33. Bezprozvanny I, Bezprozvannaya S, Ehrlich BE. Caffeine-induced inhibition of inositol( 1,4,5)-trisphosphate-gated calcium channels from cerebellum. Mol Biol Cell 1994; 5: 97-103. (Pubitemid 24062035)
34. Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels. Annu Rev Physiol 2006; 68: 619-647.
35. Ng VY, Huang Y, Reddy LM, Falck JR, Lin ET, Kroetz DL. Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. Drug Metab Dispos 2007; 35: 1126-1134. (Pubitemid 46956433)
36. Zulian A, Baryshnikov SG, Linde CI, Hamlyn JM, Ferrari P, Golovina VA. Upregulation of Na+/Ca2+ exchanger and TRPC6 contributes to abnormal Ca2+ homeostasis in arterial smooth muscle cells from Milan hypertensive rats. Am J Physiol Heart Circ Physiol 2010; 299: H624-H633.
37. Keseru B, Barbosa-Sicard E, Popp R, Fisslthaler B, Dietrich A, Gudermann T, Hammock BD, Falck JR, Weissmann N, Busse R, Fleming I. Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response. FASEB J 2008; 22: 4306-4315.
38. Michaelis UR, Fleming I. From endothelium-derived hyperpolarizing factor (EDHF) to angiogenesis: epoxyeicosatrienoic acids (EETs) and cell signaling. Pharmacol Ther 2006; 111: 584-595. (Pubitemid 44160519)