Synthesis and evaluation of prodrugs for anti-angiogenic pyrrolylmethylidenyl oxindoles

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 6, 2007, Pages 1575-1578

  Maskell, Lesley ^a   Blanche, Emilie A ^b   Colucci, Marie A ^c   Whatmore, Jacqueline L ^a   Moody, Christopher J ^b,c  

^a PENINSULA MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF EXETER   (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Angiogenesis; Bioreduction; Oxindole; Prodrug

Indexed keywords

2 NITROPHENYLACETYL DERIVATIVE; 3 METHYL 3 (3,6 DIMETHYLBENZO 1,4 QUINON 2 YL)BUTANOYL DERIVATIVE; 4 NITROBENZYL DERIVATIVE; 6 HYDROXYSEMAXANIB; ANGIOGENESIS INHIBITOR; BEVACIZUMAB; NITROBENZENE; OXINDOLE; PYRROLYLMETHYLIDENYLOXINDOLE DERIVATIVE; SEMAXANIB; SEMAXANIB DERIVATIVE; UNCLASSIFIED DRUG;

ANTIANGIOGENIC ACTIVITY; ARTICLE; DRUG DETERMINATION; DRUG POTENCY; DRUG SYNTHESIS; EVALUATION; HUMAN; REDUCTION KINETICS;

ANGIOGENESIS INHIBITORS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMANS; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; PRODRUGS; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33847021132     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.12.108     Document Type: Article

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