-
1
-
-
33751547539
-
How many drug targets are there?
-
Overington, J.P.; Al-Lazikani, B.; Hopkins, A.L. How many drug targets are there? Nat. Rev. Drug Discov. 2006, 5, 993-996.
-
(2006)
Nat. Rev. Drug Discov
, vol.5
, pp. 993-996
-
-
Overington, J.P.1
Al-Lazikani, B.2
Hopkins, A.L.3
-
2
-
-
77958152523
-
Class A GPCR heterodimers: Evidence from binding studies
-
Birdsall, N.J. Class A GPCR heterodimers: Evidence from binding studies. Trends Pharmacol. Sci. 2010, 31, 499-508.
-
(2010)
Trends Pharmacol. Sci
, vol.31
, pp. 499-508
-
-
Birdsall, N.J.1
-
3
-
-
0019137579
-
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor
-
De Lean, A.; Stadel, J.M.; Lefkowitz, R.J. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. J. Biol. Chem. 1980, 255, 7108-7117.
-
(1980)
J. Biol. Chem
, vol.255
, pp. 7108-7117
-
-
de Lean, A.1
Stadel, J.M.2
Lefkowitz, R.J.3
-
4
-
-
33847122495
-
Allosteric modulation of G proteincoupled receptors
-
May, L.T.; Leach, K.; Sexton, P.M.; Christopoulos, A. Allosteric modulation of G proteincoupled receptors. Annu. Rev. Pharmacol. Toxicol. 2007, 47, 1-51.
-
(2007)
Annu. Rev. Pharmacol. Toxicol
, vol.47
, pp. 1-51
-
-
May, L.T.1
Leach, K.2
Sexton, P.M.3
Christopoulos, A.4
-
5
-
-
0025766966
-
Complex allosteric interaction of heparin with neurokinin-1 receptors
-
Knaus, G.A.; Knaus, H.G.; Saria, A. Complex allosteric interaction of heparin with neurokinin-1 receptors. Eur. J. Pharmacol. 1991, 207, 267-270.
-
(1991)
Eur. J. Pharmacol
, vol.207
, pp. 267-270
-
-
Knaus, G.A.1
Knaus, H.G.2
Saria, A.3
-
6
-
-
0036006695
-
Allosteric modulation of beta2-adrenergic receptor by Zn(2+)
-
Swaminath, G.; Steenhuis, J.; Kobilka, B.; Lee, T.W. Allosteric modulation of beta2-adrenergic receptor by Zn(2+). Mol. Pharmacol. 2002, 61, 65-72.
-
(2002)
Mol. Pharmacol
, vol.61
, pp. 65-72
-
-
Swaminath, G.1
Steenhuis, J.2
Kobilka, B.3
Lee, T.W.4
-
7
-
-
77949361470
-
A novel bioassay for detecting GPCR heterodimerization: Transactivation of beta 2 adrenergic receptor by bradykinin receptor
-
Haack, K.K.; Tougas, M.R.; Jones, K.T.; El-Dahr, S.S.; Radhakrishna, H.; McCarty, N.A. A novel bioassay for detecting GPCR heterodimerization: transactivation of beta 2 adrenergic receptor by bradykinin receptor. J. Biomol. Screen. 2010, 15, 251-260.
-
(2010)
J. Biomol. Screen
, vol.15
, pp. 251-260
-
-
Haack, K.K.1
Tougas, M.R.2
Jones, K.T.3
El-Dahr, S.S.4
Radhakrishna, H.5
McCarty, N.A.6
-
8
-
-
58149193205
-
Allosteric modulators of GPCRs: A novel approach for the treatment of CNS disorders
-
Conn, P.J.; Christopoulos, A.; Lindsley, C.W. Allosteric modulators of GPCRs: A novel approach for the treatment of CNS disorders. Nat. Rev. Drug Discov. 2009, 8, 41-54.
-
(2009)
Nat. Rev. Drug Discov
, vol.8
, pp. 41-54
-
-
Conn, P.J.1
Christopoulos, A.2
Lindsley, C.W.3
-
9
-
-
53449093828
-
G-protein-coupled receptors: From classical modes of modulation to allosteric mechanisms
-
Bridges, T.M.; Lindsley, C.W. G-protein-coupled receptors: From classical modes of modulation to allosteric mechanisms. ACS Chem. Biol. 2008, 3, 530-541.
-
(2008)
ACS Chem. Biol
, vol.3
, pp. 530-541
-
-
Bridges, T.M.1
Lindsley, C.W.2
-
10
-
-
0024230990
-
Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors
-
Frielle, T.; Daniel, K.W.; Caron, M.G.; Lefkowitz, R.J. Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors. Proc. Natl. Acad. Sci. USA 1988, 85, 9494-9498.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 9494-9498
-
-
Frielle, T.1
Daniel, K.W.2
Caron, M.G.3
Lefkowitz, R.J.4
-
11
-
-
58549090142
-
Allosteric modulation of 5-HT(1A) receptors by zinc: Binding Studies
-
Barrondo, S.; Salles, J. Allosteric modulation of 5-HT(1A) receptors by zinc: Binding studies. Neuropharmacology 2009, 56, 455-462.
-
(2009)
Neuropharmacology
, vol.56
, pp. 455-462
-
-
Barrondo, S.1
Salles, J.2
-
12
-
-
0030992175
-
Zinc allosterically modulates antagonist binding to cloned D1 and D2 dopamine receptors
-
Schetz, J.A.; Sibley, D.R. Zinc allosterically modulates antagonist binding to cloned D1 and D2 dopamine receptors. J. Neurochem. 1997, 68, 1990-1997.
-
(1997)
J. Neurochem
, vol.68
, pp. 1990-1997
-
-
Schetz, J.A.1
Sibley, D.R.2
-
13
-
-
0018092470
-
Muscarinic cholinergic receptor modulation of beta-adrenergic receptor affinity for catecholamines
-
Watanabe, A.M.; McConnaughey, M.M.; Strawbridge, R.A.; Fleming, J.W.; Jones, L.R.; Besch, H.R., Jr. Muscarinic cholinergic receptor modulation of beta-adrenergic receptor affinity for catecholamines. J. Biol. Chem. 1978, 253, 4833-4836.
-
(1978)
J. Biol. Chem
, vol.253
, pp. 4833-4836
-
-
Watanabe, A.M.1
McConnaughey, M.M.2
Strawbridge, R.A.3
Fleming, J.W.4
Jones, L.R.5
Besch Jr., H.R.6
-
14
-
-
0003433693
-
Can different receptors interact directly with each other?
-
Birdsall, N.J.M. Can different receptors interact directly with each other? Trends Neurosci. 1982, 5, 138-139.
-
(1982)
Trends Neurosci
, vol.5
, pp. 138-139
-
-
Birdsall, N.J.M.1
-
15
-
-
0021735643
-
Structure of the thyrotropin receptor and thyroid adenylate cyclase system as determined by target analysis
-
Nielsen, T.B.; Totsuka, Y.; Kempner, E.S.; Field, J.B. Structure of the thyrotropin receptor and thyroid adenylate cyclase system as determined by target analysis. Biochemistry 1984, 23, 6009-6016.
-
(1984)
Biochemistry
, vol.23
, pp. 6009-6016
-
-
Nielsen, T.B.1
Totsuka, Y.2
Kempner, E.S.3
Field, J.B.4
-
16
-
-
0021874395
-
Radiation inactivation (target size analysis) of the gonadotropinreleasing hormone receptor: Evidence for a high molecular weight complex
-
Conn, P.M.; Venter, J.C. Radiation inactivation (target size analysis) of the gonadotropinreleasing hormone receptor: evidence for a high molecular weight complex. Endocrinology 1985, 116, 1324-1326.
-
(1985)
Endocrinology
, vol.116
, pp. 1324-1326
-
-
Conn, P.M.1
Venter, J.C.2
-
17
-
-
0023238485
-
Target size of dopamine D-1 receptors in rat corpus striatum estimated by binding of the benzazepine 3H-SCH 23390
-
Gredal, O.; Nielsen, M.; Hyttel, J. Target size of dopamine D-1 receptors in rat corpus striatum estimated by binding of the benzazepine 3H-SCH 23390. Pharmacol. Toxicol. 1987, 60, 255-257.
-
(1987)
Pharmacol. Toxicol
, vol.60
, pp. 255-257
-
-
Gredal, O.1
Nielsen, M.2
Hyttel, J.3
-
18
-
-
0020261813
-
The size of the mammalian lung beta 2-adrenergic receptor as determined by target size analysis and immunoaffinity chromatography
-
Fraser, C.M.; Venter, J.C. The size of the mammalian lung beta 2-adrenergic receptor as determined by target size analysis and immunoaffinity chromatography. Biochem. Biophys. Res. Commun. 1982, 109, 21-29.
-
(1982)
Biochem. Biophys. Res. Commun
, vol.109
, pp. 21-29
-
-
Fraser, C.M.1
Venter, J.C.2
-
19
-
-
0020609355
-
Molecular size of opiate (enkephalin) receptors in neuroblastoma-glioma hybrid cells as determined by radiation inactivation analysis
-
McLawhon, R.W.; Ellory, J.C.; Dawson, G. Molecular size of opiate (enkephalin) receptors in neuroblastoma-glioma hybrid cells as determined by radiation inactivation analysis. J. Biol. Chem. 1983, 258, 2102-2105.
-
(1983)
J. Biol. Chem
, vol.258
, pp. 2102-2105
-
-
McLawhon, R.W.1
Ellory, J.C.2
Dawson, G.3
-
20
-
-
79955622427
-
Dimerization and ligand binding affect the structure network of A(2A) adenosine receptor
-
unpublished
-
Fanelli, F.; Felline, A. Dimerization and ligand binding affect the structure network of A(2A) adenosine receptor. Biochim. Biophys. Acta 2010, unpublished.
-
(2010)
Biochim. Biophys. Acta
-
-
Fanelli, F.1
Felline, A.2
-
21
-
-
77950690810
-
Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery?
-
Filizola, M. Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery? Life Sci. 2010, 86, 590-597.
-
(2010)
Life Sci
, vol.86
, pp. 590-597
-
-
Filizola, M.1
-
22
-
-
79952393275
-
Making structural sense of dimerization interfaces of delta opioid receptor homodimers
-
unpublished
-
Johnston, J.M.; Aburi, M.; Provasi, D.; Bortolato, A.; Urizar, E.; Lambert, N.A.; Javitch, J.A.; Filizola, M. Making structural sense of dimerization interfaces of delta opioid receptor homodimers. Biochemistry 2011, unpublished.
-
(2011)
Biochemistry
-
-
Johnston, J.M.1
Aburi, M.2
Provasi, D.3
Bortolato, A.4
Urizar, E.5
Lambert, N.A.6
Javitch, J.A.7
Filizola, M.8
-
23
-
-
0032709594
-
3D modeling, ligand binding and activation studies of the cloned mouse delta, mu; and kappa opioid receptors
-
Filizola, M.; Laakkonen, L.; Loew, G.H. 3D modeling, ligand binding and activation studies of the cloned mouse delta, mu; and kappa opioid receptors. Protein Eng. 1999, 12, 927-942.
-
(1999)
Protein Eng
, vol.12
, pp. 927-942
-
-
Filizola, M.1
Laakkonen, L.2
Loew, G.H.3
-
24
-
-
85027927015
-
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists
-
Wu, B.; Chien, E.Y.; Mol, C.D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F.C.; Hamel, D.J.; Kuhn, P.; Handel, T.M.; Cherezov, V.; Stevens, R.C. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science 2010, 330, 1066-1071.
-
(2010)
Science
, vol.330
, pp. 1066-1071
-
-
Wu, B.1
Chien, E.Y.2
Mol, C.D.3
Fenalti, G.4
Liu, W.5
Katritch, V.6
Abagyan, R.7
Brooun, A.8
Wells, P.9
Bi, F.C.10
Hamel, D.J.11
Kuhn, P.12
Handel, T.M.13
Cherezov, V.14
Stevens, R.C.15
-
25
-
-
0037144542
-
β1/β2-adrenergic receptor heterodimerization regulates β2-adrenergic receptor internalization and ERK signaling efficacy
-
Lavoie, C.; Mercier, J.F.; Salahpour, A.; Umapathy, D.; Breit, A.; Villeneuve, L.R.; Zhu, W.Z.; Xiao, R.P.; Lakatta, E.G.; Bouvier, M.; Hebert, T.E. β1/β2-adrenergic receptor heterodimerization regulates β2-adrenergic receptor internalization and ERK signaling efficacy. J. Biol. Chem. 2002, 277, 35402-35410.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 35402-35410
-
-
Lavoie, C.1
Mercier, J.F.2
Salahpour, A.3
Umapathy, D.4
Breit, A.5
Villeneuve, L.R.6
Zhu, W.Z.7
Xiao, R.P.8
Lakatta, E.G.9
Bouvier, M.10
Hebert, T.E.11
-
26
-
-
0034618268
-
AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration
-
AbdAlla, S.; Lother, H.; Quitterer, U. AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration. Nature 2000, 407, 94-98.
-
(2000)
Nature
, vol.407
, pp. 94-98
-
-
Abdalla, S.1
Lother, H.2
Quitterer, U.3
-
27
-
-
21144446486
-
A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers
-
Waldhoer, M.; Fong, J.; Jones, R.M.; Lunzer, M.M.; Sharma, S.K.; Kostenis, E.; Portoghese, P.S.; Whistler, J.L. A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proc. Natl. Acad. Sci. USA 2005, 102, 9050-9055.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 9050-9055
-
-
Waldhoer, M.1
Fong, J.2
Jones, R.M.3
Lunzer, M.M.4
Sharma, S.K.5
Kostenis, E.6
Portoghese, P.S.7
Whistler, J.L.8
-
28
-
-
1242274647
-
Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns
-
Terrillon, S.; Barberis, C.; Bouvier, M. Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns. Proc. Natl. Acad. Sci. USA 2004, 101, 1548-1553.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 1548-1553
-
-
Terrillon, S.1
Barberis, C.2
Bouvier, M.3
-
29
-
-
0035793079
-
Oligomerization of opioid receptors with β2-adrenergic receptors: A role in trafficking and mitogen-activated protein kinase activation
-
Jordan, B.A.; Trapaidze, N.; Gomes, I.; Nivarthi, R.; Devi, L.A. Oligomerization of opioid receptors with β2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation. Proc. Natl. Acad. Sci. USA 2001, 98, 343-348.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 343-348
-
-
Jordan, B.A.1
Trapaidze, N.2
Gomes, I.3
Nivarthi, R.4
Devi, L.A.5
-
30
-
-
0346996861
-
Functional interactions between μ opioid and alpha 2A-adrenergic receptors
-
Jordan, B.A.; Gomes, I.; Rios, C.; Filipovska, J.; Devi, L.A. Functional interactions between μ opioid and alpha 2A-adrenergic receptors. Mol. Pharmacol. 2003, 64, 1317-1324.
-
(2003)
Mol. Pharmacol
, vol.64
, pp. 1317-1324
-
-
Jordan, B.A.1
Gomes, I.2
Rios, C.3
Filipovska, J.4
Devi, L.A.5
-
31
-
-
0346366929
-
Subtype-specific dimerization of alpha 1- adrenoceptors: Effects on receptor expression and pharmacological properties
-
Uberti, M.A.; Hall, R.A.; Minneman, K.P. Subtype-specific dimerization of alpha 1- adrenoceptors: Effects on receptor expression and pharmacological properties. Mol. Pharmacol. 2003, 64, 1379-1390.
-
(2003)
Mol. Pharmacol
, vol.64
, pp. 1379-1390
-
-
Uberti, M.A.1
Hall, R.A.2
Minneman, K.P.3
-
32
-
-
0036382864
-
Oligomerization of opioid receptors
-
Gomes, I.; Filipovska, J.; Jordan, B.A.; Devi, L.A. Oligomerization of opioid receptors. Methods 2002, 27, 358-365.
-
(2002)
Methods
, vol.27
, pp. 358-365
-
-
Gomes, I.1
Filipovska, J.2
Jordan, B.A.3
Devi, L.A.4
-
33
-
-
77249112399
-
Ligand-induced regulation and localization of cannabinoid CB1 and dopamine D2L receptor heterodimers
-
Przybyla, J.A.; Watts, V.J. Ligand-induced regulation and localization of cannabinoid CB1 and dopamine D2L receptor heterodimers. J. Pharmacol. Exp. Ther. 2010, 332, 710-719.
-
(2010)
J. Pharmacol. Exp. Ther
, vol.332
, pp. 710-719
-
-
Przybyla, J.A.1
Watts, V.J.2
-
34
-
-
25844505574
-
Mesangial AT1/B2 receptor heterodimers contribute to angiotensin II hyperresponsiveness in experimental hypertension
-
AbdAlla, S.; Abdel-Baset, A.; Lother, H.; el Massiery, A.; Quitterer, U. Mesangial AT1/B2 receptor heterodimers contribute to angiotensin II hyperresponsiveness in experimental hypertension. J. Mol. Neurosci. 2005, 26, 185-192.
-
(2005)
J. Mol. Neurosci
, vol.26
, pp. 185-192
-
-
Abdalla, S.1
Abdel-Baset, A.2
Lother, H.3
el Massiery, A.4
Quitterer, U.5
-
35
-
-
79251591614
-
A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors
-
Doumazane, E.; Scholler, P.; Zwier, J.M.; Eric, T.; Rondard, P.; Pin, J.P. A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors. FASEB J. 2011, 25, 66-77.
-
(2011)
FASEB J
, vol.25
, pp. 66-77
-
-
Doumazane, E.1
Scholler, P.2
Zwier, J.M.3
Eric, T.4
Rondard, P.5
Pin, J.P.6
-
36
-
-
0005169503
-
GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2
-
Jones, K.A.; Borowsky, B.; Tamm, J.A.; Craig, D.A.; Durkin, M.M.; Dai, M.; Yao, W.J.; Johnson, M.; Gunwaldsen, C.; Huang, L.Y.; et al. GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. Nature 1998, 396, 674-679.
-
(1998)
Nature
, vol.396
, pp. 674-679
-
-
Jones, K.A.1
Borowsky, B.2
Tamm, J.A.3
Craig, D.A.4
Durkin, M.M.5
Dai, M.6
Yao, W.J.7
Johnson, M.8
Gunwaldsen, C.9
Huang, L.Y.10
-
37
-
-
0035807875
-
Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors
-
Margeta-Mitrovic, M.; Jan, Y.N.; Jan, L.Y. Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors. Proc. Natl. Acad. Sci. USA 2001, 98, 14649-14654.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 14649-14654
-
-
Margeta-Mitrovic, M.1
Jan, Y.N.2
Jan, L.Y.3
-
38
-
-
4644308014
-
Different functional roles of T1R subunits in the heteromeric taste receptors
-
Xu, H.; Staszewski, L.; Tang, H.; Adler, E.; Zoller, M.; Li, X. Different functional roles of T1R subunits in the heteromeric taste receptors. Proc. Natl. Acad. Sci. USA 2004, 101, 14258-14263.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 14258-14263
-
-
Xu, H.1
Staszewski, L.2
Tang, H.3
Adler, E.4
Zoller, M.5
Li, X.6
-
39
-
-
0033578005
-
G-protein-coupled receptor heterodimerization modulates receptor function
-
Jordan, B.A.; Devi, L.A. G-protein-coupled receptor heterodimerization modulates receptor function. Nature 1999, 399, 697-700.
-
(1999)
Nature
, vol.399
, pp. 697-700
-
-
Jordan, B.A.1
Devi, L.A.2
-
40
-
-
38349054282
-
Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling
-
Vilardaga, J.P.; Nikolaev, V.O.; Lorenz, K.; Ferrandon, S.; Zhuang, Z.; Lohse, M.J. Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling. Nat. Chem. Biol. 2008, 4, 126-131.
-
(2008)
Nat. Chem. Biol
, vol.4
, pp. 126-131
-
-
Vilardaga, J.P.1
Nikolaev, V.O.2
Lorenz, K.3
Ferrandon, S.4
Zhuang, Z.5
Lohse, M.J.6
-
41
-
-
35648971157
-
Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers
-
Sohy, D.; Parmentier, M.; Springael, J.Y. Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers. J. Biol. Chem. 2007, 282, 30062-30069.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 30062-30069
-
-
Sohy, D.1
Parmentier, M.2
Springael, J.Y.3
-
42
-
-
59449103028
-
Lack of evidence for AT1R/B2R heterodimerization in COS-7, HEK293, and NIH3T3 cells: How common is the AT1R/B2R heterodimer?
-
Hansen, J.L.; Hansen, J.T.; Speerschneider, T.; Lyngso, C.; Erikstrup, N.; Burstein, E.S.; Weiner, D.M.; Walther, T.; Makita, N.; Iiri, T.; Merten, N.; Kostenis, E.; Sheikh, S.P. Lack of evidence for AT1R/B2R heterodimerization in COS-7, HEK293, and NIH3T3 cells: How common is the AT1R/B2R heterodimer? J. Biol. Chem. 2009, 284, 1831-1839.
-
(2009)
J. Biol. Chem
, vol.284
, pp. 1831-1839
-
-
Hansen, J.L.1
Hansen, J.T.2
Speerschneider, T.3
Lyngso, C.4
Erikstrup, N.5
Burstein, E.S.6
Weiner, D.M.7
Walther, T.8
Makita, N.9
Iiri, T.10
Merten, N.11
Kostenis, E.12
Sheikh, S.P.13
-
43
-
-
34447638166
-
Allosteric enhancers, allosteric agonists and ago-allosteric modulators: Where do they bind and how do they act?
-
Schwartz, T.W.; Holst, B. Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act? Trends Pharmacol. Sci. 2007, 28, 366-373.
-
(2007)
Trends Pharmacol. Sci
, vol.28
, pp. 366-373
-
-
Schwartz, T.W.1
Holst, B.2
-
44
-
-
0033669603
-
Modeling the functional effects of allosteric modulators at pharmacological receptors: An extension of the two-state model of receptor activation
-
Hall, D.A. Modeling the functional effects of allosteric modulators at pharmacological receptors: an extension of the two-state model of receptor activation. Mol. Pharmacol. 2000, 58, 1412-1423.
-
(2000)
Mol. Pharmacol
, vol.58
, pp. 1412-1423
-
-
Hall, D.A.1
-
45
-
-
0042626108
-
Adenosine A(2A) receptor antagonist treatment of Parkinson's disease
-
Bara-Jimenez, W.; Sherzai, A.; Dimitrova, T.; Favit, A.; Bibbiani, F.; Gillespie, M.; Morris, M.J.; Mouradian, M.M.; Chase, T.N. Adenosine A(2A) receptor antagonist treatment of Parkinson's disease. Neurology 2003, 61, 293-296.
-
(2003)
Neurology
, vol.61
, pp. 293-296
-
-
Bara-Jimenez, W.1
Sherzai, A.2
Dimitrova, T.3
Favit, A.4
Bibbiani, F.5
Gillespie, M.6
Morris, M.J.7
Mouradian, M.M.8
Chase, T.N.9
-
46
-
-
0036780743
-
G-protein-coupled receptor oligomerization and its potential for drug discovery
-
George, S.R.; O'Dowd, B.F.; Lee, S.P. G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat. Rev. Drug Discov. 2002, 1, 808-820.
-
(2002)
Nat. Rev. Drug Discov
, vol.1
, pp. 808-820
-
-
George, S.R.1
O'Dowd, B.F.2
Lee, S.P.3
-
47
-
-
0037114028
-
Adenosine A2A antagonism reverses levodopainduced motor alterations in hemiparkinsonian rats
-
Bove, J.; Marin, C.; Bonastre, M.; Tolosa, E. Adenosine A2A antagonism reverses levodopainduced motor alterations in hemiparkinsonian rats. Synapse 2002, 46, 251-257.
-
(2002)
Synapse
, vol.46
, pp. 251-257
-
-
Bove, J.1
Marin, C.2
Bonastre, M.3
Tolosa, E.4
-
48
-
-
0037870163
-
Oligomerization of adenosine A2A and dopamine D2 receptors in living cells
-
Kamiya, T.; Saitoh, O.; Yoshioka, K.; Nakata, H. Oligomerization of adenosine A2A and dopamine D2 receptors in living cells. Biochem. Biophys. Res. Commun. 2003, 306, 544-549.
-
(2003)
Biochem. Biophys. Res. Commun
, vol.306
, pp. 544-549
-
-
Kamiya, T.1
Saitoh, O.2
Yoshioka, K.3
Nakata, H.4
-
49
-
-
0030861647
-
Adenosine-dopamine receptorreceptor interactions as an integrative mechanism in the basal ganglia
-
Ferre, S.; Fredholm, B.B.; Morelli, M.; Popoli, P.; Fuxe, K. Adenosine-dopamine receptorreceptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci. 1997, 20, 482-487.
-
(1997)
Trends Neurosci
, vol.20
, pp. 482-487
-
-
Ferre, S.1
Fredholm, B.B.2
Morelli, M.3
Popoli, P.4
Fuxe, K.5
|