Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo- pyrimidines as potent human A3 adenosine receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 10, 2011, Pages 2898-2905

  Cheong, Siew Lee ^a   Federico, Stephanie ^b   Venkatesan, Gopalakrishnan ^a   Paira, Priyankar ^a   Shao, Yi Ming ^a   Spalluto, Giampiero ^b   Yap, Chun Wei ^a   Pastorin, Giorgia ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF TRIESTE   (Italy)

Author keywords

2 Aryl pyrazolo triazolo pyrimidine; CoMFA; hA3 Adenosine receptor antagonists; QSAR

Indexed keywords

9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE A3 RECEPTOR ANTAGONIST; PHENYLPYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVE; PYRAZOLOQUINOLINE DERIVATIVE; TRIAZOLOBENZOTRIAZINONE DERIVATIVE; TRIAZOLOPYRAZINONE DERIVATIVE; TRIAZOLOQUINOXALINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPARATIVE MOLECULAR FIELD ANALYSIS; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ADENOSINE A3 RECEPTOR ANTAGONISTS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRAZOLES; PYRIMIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 79955566750     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.03.073     Document Type: Article

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