Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor ligands: A starting point for searching A2B adenosine receptor antagonists

Drug Development Research

Volumn 53, Issue 2-3, 2001, Pages 225-235

  Baraldi, Pier Giovanni ^a   Cacciari, Barbara ^a   Romagnoli, Romeo ^a   Klotz, Karl Norbert ^b   Spalluto, Giampiero ^c   Varani, Katia ^a   Gessi, Stefania ^a   Merighi, Stefania ^a   Borea, Pier Andrea ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Asub2B receptor antagonists; MRE 3008 F20; SCH 58261

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 5 [[(4 METHOXYPHENYL)AMINO]CARBONYL]AMINO 8 PROPYL 2 (2 FURYL)PYRAZOLO[4,3 E] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 5 AMINO 2 (2 FURYL) 7 (3 PHENYLPROPYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2 RECEPTOR; ADENOSINE A2 RECEPTOR ANTAGONIST; CYCLIC AMP; LIGAND; MRE 3008 F 20; PYRAZOLO[4,3 E] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE DERIVATIVE; RECEPTOR SUBTYPE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; BINDING AFFINITY; CHEMICAL STRUCTURE; CHO CELL; CONFERENCE PAPER; DRUG RECEPTOR BINDING; KIDNEY CELL; LIGAND BINDING; NONHUMAN;

EID: 0034841225     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.1191     Document Type: Article

References (5)

1. 2A adenosine antagonists. J Med Chem 39:1164-1171.
2. 3 Adenosine receptor ligands; history and perspectives. Med Res Rev 20:103-128.
3. Boyle DL, Sajjadi FG, Firestein GS. 1996. Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation. Arthritis Rheum 39:923-930.
4. Bradford MM. 1976. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye-binding. Anal Biochem 72:248-254.
5. Chiang PH, Wu SN, Tsai EM, Wu CC, Shen MR, Huang CH. 1994. Adenosine modulation of neurotransmission in penile erection. Br J Clin Pharmacol 38:357-362.