메뉴 건너뛰기




Volumn 57, Issue 9, 2008, Pages 410-418

Fibrosis, chronic inflammation and new pathways for drug discovery

Author keywords

EMT; Extracellular matrix; Fibrocytes; Fibrosis; Myofibroblasts

Indexed keywords

ALPHAVBETA6 INTEGRIN; ANTIINFLAMMATORY AGENT; CHEMOKINE; CORTICOSTEROID; CYTOKINE; GROWTH FACTOR; INTERFERON; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; VERY LATE ACTIVATION ANTIGEN 2;

EID: 58149113029     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-008-7166-y     Document Type: Review
Times cited : (41)

References (109)
  • 1
    • 0028841375 scopus 로고
    • Fibrosis causes progressive kidney failure
    • Cohen EP. Fibrosis causes progressive kidney failure. Med Hypotheses 1995; 45:459-62.
    • (1995) Med Hypotheses , vol.45 , pp. 459-462
    • Cohen, E.P.1
  • 4
    • 0029863374 scopus 로고    scopus 로고
    • Extracellular matrix proteins and hepatic fibrosis
    • Johnson SJ. Extracellular matrix proteins and hepatic fibrosis. Hepatogastroenterology 1996; 43:44-55.
    • (1996) Hepatogastroenterology , vol.43 , pp. 44-55
    • Johnson, S.J.1
  • 5
    • 0032159827 scopus 로고    scopus 로고
    • Macrophages, myofibroblasts, and extracellular matrix accumulation in interstitial fibrosis of chronic progressive nephropathy in aged rats
    • Nakatsuji S, Yamate J, Sakuma S. Macrophages, myofibroblasts, and extracellular matrix accumulation in interstitial fibrosis of chronic progressive nephropathy in aged rats. Vet Pathol 1998; 35:352-60.
    • (1998) Vet Pathol , vol.35 , pp. 352-360
    • Nakatsuji, S.1    Yamate, J.2    Sakuma, S.3
  • 6
    • 0027939832 scopus 로고
    • The role of extracellular matrix in postinflammatory wound healing and fibrosis
    • Raghow R. The role of extracellular matrix in postinflammatory wound healing and fibrosis. Faseb J 1994; 8:823-31.
    • (1994) Faseb J , vol.8 , pp. 823-831
    • Raghow, R.1
  • 7
    • 0036088906 scopus 로고    scopus 로고
    • Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells
    • Zeisberg M, Maeshima Y, Mosterman B, Kalluri R. Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells. Am J Pathol 2002; 160:2001-8.
    • (2002) Am J Pathol , vol.160 , pp. 2001-2008
    • Zeisberg, M.1    Maeshima, Y.2    Mosterman, B.3    Kalluri, R.4
  • 8
    • 33644985711 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Natural history and prognosis
    • v
    • Noble PW. Idiopathic pulmonary fibrosis: natural history and prognosis. Clin Chest Med 2006; 27:S11-6, v.
    • (2006) Clin Chest Med , vol.27
    • Noble, P.W.1
  • 9
    • 33744901434 scopus 로고    scopus 로고
    • Current perspectives on the treatment of idiopathic pulmonary fibrosis
    • Walter N, Collard HR, King TE, Jr. Current perspectives on the treatment of idiopathic pulmonary fibrosis. Proc Am Thorac Soc 2006; 3:330-8.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 330-338
    • Walter, N.1    Collard, H.R.2    King Jr., T.E.3
  • 12
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003; 112:1776-84.
    • (2003) J Clin Invest , vol.112 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 13
    • 33645302628 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition: New insights in signaling, development, and disease
    • Lee JM, Dedhar S, Kalluri R, Thompson EW. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 2006; 172:973-81.
    • (2006) J Cell Biol , vol.172 , pp. 973-981
    • Lee, J.M.1    Dedhar, S.2    Kalluri, R.3    Thompson, E.W.4
  • 14
    • 37849189626 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for the development of renal tubulointerstitial fibrosis
    • Rastaldi MP. Epithelial-mesenchymal transition and its implications for the development of renal tubulointerstitial fibrosis. J Nephrol 2006; 19:407-12.
    • (2006) J Nephrol , vol.19 , pp. 407-412
    • Rastaldi, M.P.1
  • 15
    • 0036933489 scopus 로고    scopus 로고
    • The myofibroblast in pulmonary fibrosis
    • Phan SH. The myofibroblast in pulmonary fibrosis. Chest 2002; 122:286S-289S.
    • (2002) Chest , vol.122
    • Phan, S.H.1
  • 16
    • 0041827227 scopus 로고    scopus 로고
    • Fibroblast phenotypes in pulmonary fibrosis
    • Phan SH. Fibroblast phenotypes in pulmonary fibrosis. Am J Respir Cell Mol Biol 2003; 29:S87-92.
    • (2003) Am J Respir Cell Mol Biol , vol.29
    • Phan, S.H.1
  • 20
    • 33947723884 scopus 로고    scopus 로고
    • Role of interleukin-13 in cancer, pulmonary fibrosis, and other T(H)2-type diseases
    • Joshi BH, Hogaboam C, Dover P, Husain SR, Puri RK. Role of interleukin-13 in cancer, pulmonary fibrosis, and other T(H)2-type diseases. Vitam Horm 2006; 74:479-504.
    • (2006) Vitam Horm , vol.74 , pp. 479-504
    • Joshi, B.H.1    Hogaboam, C.2    Dover, P.3    Husain, S.R.4    Puri, R.K.5
  • 23
    • 0026461350 scopus 로고
    • TNF in autoimmune diseases, graft-versus-host reactions, and pulmonary fibrosis
    • Vassalli P, Grau GE, Piguet PF. TNF in autoimmune diseases, graft-versus-host reactions, and pulmonary fibrosis. Immunol Ser 1992; 56:409-30.
    • (1992) Immunol Ser , vol.56 , pp. 409-430
    • Vassalli, P.1    Grau, G.E.2    Piguet, P.F.3
  • 24
    • 0030975645 scopus 로고    scopus 로고
    • TGF-beta in kidney fibrosis: A target for gene therapy
    • Border WA, Noble NA. TGF-beta in kidney fibrosis: a target for gene therapy. Kidney Int 1997; 51:1388-96.
    • (1997) Kidney Int , vol.51 , pp. 1388-1396
    • Border, W.A.1    Noble, N.A.2
  • 25
    • 33745808765 scopus 로고    scopus 로고
    • Transforming growth factor beta: A central modulator of pulmonary and airway inflammation and fibrosis
    • Sheppard D. Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc 2006; 3:413-7.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 413-417
    • Sheppard, D.1
  • 26
    • 0036838772 scopus 로고    scopus 로고
    • Pathogenesis of fibrosis: Role of TGF-beta and CTGF
    • Ihn H. Pathogenesis of fibrosis: role of TGF-beta and CTGF. Curr Opin Rheumatol 2002; 14:681-5.
    • (2002) Curr Opin Rheumatol , vol.14 , pp. 681-685
    • Ihn, H.1
  • 27
    • 0034285801 scopus 로고    scopus 로고
    • The potential role of PDGF, IGF-1, TGF-beta expression in idiopathic pulmonary fibrosis
    • Cao B, Guo Z, Zhu Y, Xu W. The potential role of PDGF, IGF-1, TGF-beta expression in idiopathic pulmonary fibrosis. Chin Med J (Engl) 2000; 113:776-82.
    • (2000) Chin Med J (Engl) , vol.113 , pp. 776-782
    • Cao, B.1    Guo, Z.2    Zhu, Y.3    Xu, W.4
  • 28
    • 0029882913 scopus 로고    scopus 로고
    • Expression of TGF-beta 1, PDGF and IGF-1 mRNA in lung of bleomycin-A5-induced pulmonary fibrosis in rats
    • Li H, He B, Que C, Weng B. Expression of TGF-beta 1, PDGF and IGF-1 mRNA in lung of bleomycin-A5-induced pulmonary fibrosis in rats. Chin Med J (Engl) 1996; 109:533-6.
    • (1996) Chin Med J (Engl) , vol.109 , pp. 533-536
    • Li, H.1    He, B.2    Que, C.3    Weng, B.4
  • 29
    • 0030074319 scopus 로고    scopus 로고
    • Role of TGF-beta and PDGF on the pathogenesis of pulmonary fibrosis--analysis by in vivo gene transfer]
    • Yoshida M, Hayashi S. [Role of TGF-beta and PDGF on the pathogenesis of pulmonary fibrosis--analysis by in vivo gene transfer]. Nippon Rinsho 1996; 54:418-22.
    • (1996) Nippon Rinsho , vol.54 , pp. 418-422
    • Yoshida, M.1    Hayashi, S.2
  • 30
    • 18144435038 scopus 로고
    • Altered production and regulation of monocyte chemoattractant protein-1 from pulmonary fibroblasts isolated from patients with idiopathic pulmonary fibrosis
    • Standiford TJ, Rolfe MR, Kunkel SL, Lynch JP, 3rd, Becker FS, Orringer MB, et al. Altered production and regulation of monocyte chemoattractant protein-1 from pulmonary fibroblasts isolated from patients with idiopathic pulmonary fibrosis. Chest 1993; 103:121S.
    • (1993) Chest , vol.103
    • Standiford, T.J.1    Rolfe, M.R.2    Kunkel, S.L.3    Lynch 3rd, J.P.4    Becker, F.S.5    Orringer, M.B.6
  • 32
    • 0031201212 scopus 로고    scopus 로고
    • The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis
    • Keane MP, Arenberg DA, Lynch JP, 3rd, Whyte RI, Iannettoni MD, Burdick MD, et al. The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis. J Immunol 1997; 159:1437-43.
    • (1997) J Immunol , vol.159 , pp. 1437-1443
    • Keane, M.P.1    Arenberg, D.A.2    Lynch 3rd, J.P.3    Whyte, R.I.4    Iannettoni, M.D.5    Burdick, M.D.6
  • 33
    • 0033137106 scopus 로고    scopus 로고
    • Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin-induced pulmonary fibrosis
    • Keane MP, Belperio JA, Moore TA, Moore BB, Arenberg DA, Smith RE, et al. Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin-induced pulmonary fibrosis. J Immunol 1999; 162:5511-8.
    • (1999) J Immunol , vol.162 , pp. 5511-5518
    • Keane, M.P.1    Belperio, J.A.2    Moore, T.A.3    Moore, B.B.4    Arenberg, D.A.5    Smith, R.E.6
  • 34
    • 33847364936 scopus 로고    scopus 로고
    • The role of CXC chemokines in pulmonary fibrosis
    • Strieter RM, Gomperts BN, Keane MP. The role of CXC chemokines in pulmonary fibrosis. J Clin Invest 2007; 117:549-556.
    • (2007) J Clin Invest , vol.117 , pp. 549-556
    • Strieter, R.M.1    Gomperts, B.N.2    Keane, M.P.3
  • 35
    • 0029953496 scopus 로고    scopus 로고
    • Cytokines: The kidney as a model for their role in tissue injury and repair
    • Isbel NM, Atkins RC. Cytokines: the kidney as a model for their role in tissue injury and repair. Aust N Z J Med 1996; 26: 636-9.
    • (1996) Aust N Z J Med , vol.26 , pp. 636-639
    • Isbel, N.M.1    Atkins, R.C.2
  • 36
    • 0033995738 scopus 로고    scopus 로고
    • Overexpression of chemokines, fibrogenic cytokines, and myofibroblasts in human membranous nephropathy
    • Mezzano SA, Droguett MA, Burgos ME, Ardiles LG, Aros CA, Caorsi I, et al. Overexpression of chemokines, fibrogenic cytokines, and myofibroblasts in human membranous nephropathy. Kidney Int 2000; 57:147-58.
    • (2000) Kidney Int , vol.57 , pp. 147-158
    • Mezzano, S.A.1    Droguett, M.A.2    Burgos, M.E.3    Ardiles, L.G.4    Aros, C.A.5    Caorsi, I.6
  • 39
    • 33744919279 scopus 로고    scopus 로고
    • Chemokine/cytokine cocktail in idiopathic pulmonary fibrosis
    • Agostini C, Gurrieri C. Chemokine/cytokine cocktail in idiopathic pulmonary fibrosis. Proc Am Thorac Soc 2006; 3:357-63.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 357-363
    • Agostini, C.1    Gurrieri, C.2
  • 40
    • 0742295936 scopus 로고    scopus 로고
    • Chemokines in liver inflammation and fibrosis
    • Marra F. Chemokines in liver inflammation and fibrosis. Front Biosci 2002; 7:d1899-914.
    • (2002) Front Biosci , vol.7
    • Marra, F.1
  • 41
    • 0041827226 scopus 로고    scopus 로고
    • The epithelial/fibroblastic pathway in the pathogenesis of idiopathic pulmonary fibrosis
    • Selman M, Pardo A. The epithelial/fibroblastic pathway in the pathogenesis of idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 2003; 29:S93-7.
    • (2003) Am J Respir Cell Mol Biol , vol.29
    • Selman, M.1    Pardo, A.2
  • 42
    • 33744924735 scopus 로고    scopus 로고
    • Role of epithelial cells in idiopathic pulmonary fibrosis: From innocent targets to serial killers
    • Selman M, Pardo A. Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers. Proc Am Thorac Soc 2006; 3:364-72.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 364-372
    • Selman, M.1    Pardo, A.2
  • 43
    • 0029887282 scopus 로고    scopus 로고
    • Role of the myofibroblast in pulmonary fibrosis
    • Phan SH. Role of the myofibroblast in pulmonary fibrosis. Kidney Int Suppl 1996; 54:S46-8.
    • (1996) Kidney Int Suppl , vol.54
    • Phan, S.H.1
  • 45
    • 0036737845 scopus 로고    scopus 로고
    • Human lung myofibroblasts as effectors of the inflammatory process: The common receptor gamma chain is induced by Th2 cytokines, and CD40 ligand is induced by lipopolysaccharide, thrombin and TNF-alpha
    • Doucet C, Giron-Michel J, Canonica GW, Azzarone B. Human lung myofibroblasts as effectors of the inflammatory process: the common receptor gamma chain is induced by Th2 cytokines, and CD40 ligand is induced by lipopolysaccharide, thrombin and TNF-alpha. Eur J Immunol 2002; 32:2437-49.
    • (2002) Eur J Immunol , vol.32 , pp. 2437-2449
    • Doucet, C.1    Giron-Michel, J.2    Canonica, G.W.3    Azzarone, B.4
  • 46
    • 33744944779 scopus 로고    scopus 로고
    • Epithelial origin of myofibroblasts during fibrosis in the lung
    • Willis BC, duBois RM, Borok Z. Epithelial origin of myofibroblasts during fibrosis in the lung. Proc Am Thorac Soc 2006; 3:377-82.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 377-382
    • Willis, B.C.1    duBois, R.M.2    Borok, Z.3
  • 48
    • 34347228684 scopus 로고    scopus 로고
    • Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-beta1
    • Jain R, Shaul PW, Borok Z, Willis BC. Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-beta1. Am J Respir Cell Mol Biol 2007; 37:38-47.
    • (2007) Am J Respir Cell Mol Biol , vol.37 , pp. 38-47
    • Jain, R.1    Shaul, P.W.2    Borok, Z.3    Willis, B.C.4
  • 49
    • 34347364932 scopus 로고    scopus 로고
    • Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse
    • Wu Z, Yang L, Cai L, Zhang M, Cheng X, Yang X, et al. Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse. Respir Res 2007; 8:1.
    • (2007) Respir Res , vol.8 , pp. 1
    • Wu, Z.1    Yang, L.2    Cai, L.3    Zhang, M.4    Cheng, X.5    Yang, X.6
  • 50
    • 27144477683 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition
    • Thomson S, Buck E, Petti F, Griffin G, Brown E, Ramnarine N, et al. Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition. Cancer Res 2005; 65:9455-62.
    • (2005) Cancer Res , vol.65 , pp. 9455-9462
    • Thomson, S.1    Buck, E.2    Petti, F.3    Griffin, G.4    Brown, E.5    Ramnarine, N.6
  • 52
    • 34548145815 scopus 로고    scopus 로고
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    • Zeisberg M, Yang C, Martino M, Duncan M, Rieder F, Tanjore H, et al. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 2007.
    • (2007) J Biol Chem
    • Zeisberg, M.1    Yang, C.2    Martino, M.3    Duncan, M.4    Rieder, F.5    Tanjore, H.6
  • 53
    • 34447250376 scopus 로고    scopus 로고
    • Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT?
    • Radisky DC, Kenny PA, Bissell MJ. Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem 2007; 101:830-9.
    • (2007) J Cell Biochem , vol.101 , pp. 830-839
    • Radisky, D.C.1    Kenny, P.A.2    Bissell, M.J.3
  • 54
    • 34250691430 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in ovarian cancer progression: A crucial role for the endothelin axis
    • Bagnato A, Rosano L. Epithelial-mesenchymal transition in ovarian cancer progression: a crucial role for the endothelin axis. Cells Tissues Organs 2007; 185:85-94.
    • (2007) Cells Tissues Organs , vol.185 , pp. 85-94
    • Bagnato, A.1    Rosano, L.2
  • 55
    • 34249979835 scopus 로고    scopus 로고
    • Epidermal growth factor and transforming growth factor-beta1 enhance HK-2 cell migration through a synergistic increase of matrix metalloproteinase and sustained activation of ERK signaling pathway
    • Tian YC, Chen YC, Chang CT, Hung CC, Wu MS, Phillips A, et al. Epidermal growth factor and transforming growth factor-beta1 enhance HK-2 cell migration through a synergistic increase of matrix metalloproteinase and sustained activation of ERK signaling pathway. Exp Cell Res 2007; 313:2367-77.
    • (2007) Exp Cell Res , vol.313 , pp. 2367-2377
    • Tian, Y.C.1    Chen, Y.C.2    Chang, C.T.3    Hung, C.C.4    Wu, M.S.5    Phillips, A.6
  • 56
    • 27144554645 scopus 로고    scopus 로고
    • TGF-beta control of cell proliferation
    • Huang SS, Huang JS. TGF-beta control of cell proliferation. J Cell Biochem 2005; 96:447-62.
    • (2005) J Cell Biochem , vol.96 , pp. 447-462
    • Huang, S.S.1    Huang, J.S.2
  • 57
    • 0031426654 scopus 로고    scopus 로고
    • Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells
    • Lochter A, Galosy S, Muschler J, Freedman N, Werb Z, Bissell MJ. Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells. J Cell Biol 1997; 139:1861-72.
    • (1997) J Cell Biol , vol.139 , pp. 1861-1872
    • Lochter, A.1    Galosy, S.2    Muschler, J.3    Freedman, N.4    Werb, Z.5    Bissell, M.J.6
  • 58
    • 0035110730 scopus 로고    scopus 로고
    • Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice
    • Ha HY, Moon HB, Nam MS, Lee JW, Ryoo ZY, Lee TH, et al. Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice. Cancer Res 2001; 61:984-90.
    • (2001) Cancer Res , vol.61 , pp. 984-990
    • Ha, H.Y.1    Moon, H.B.2    Nam, M.S.3    Lee, J.W.4    Ryoo, Z.Y.5    Lee, T.H.6
  • 59
    • 33748375828 scopus 로고    scopus 로고
    • Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    • Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A 2006; 103:13180-5.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 13180-13185
    • Kim, K.K.1    Kugler, M.C.2    Wolters, P.J.3    Robillard, L.4    Galvez, M.G.5    Brumwell, A.N.6
  • 60
    • 0033360938 scopus 로고    scopus 로고
    • Interactions of fibroblasts with the extracellular matrix: Implications for the understanding of fibrosis
    • Eckes B, Kessler D, Aumailley M, Krieg T. Interactions of fibroblasts with the extracellular matrix: implications for the understanding of fibrosis. Springer Semin Immunopathol 1999; 21:415-29.
    • (1999) Springer Semin Immunopathol , vol.21 , pp. 415-429
    • Eckes, B.1    Kessler, D.2    Aumailley, M.3    Krieg, T.4
  • 61
    • 0027431199 scopus 로고
    • Extracellular matrix and growth factors: An integrated interplay controlling tissue repair and progression to disease
    • Haralson MA. Extracellular matrix and growth factors: an integrated interplay controlling tissue repair and progression to disease. Lab Invest 1993; 69:369-72.
    • (1993) Lab Invest , vol.69 , pp. 369-372
    • Haralson, M.A.1
  • 63
    • 3042838388 scopus 로고    scopus 로고
    • Latent TGF-beta binding proteins: Extracellular matrix association and roles in TGF-beta activation
    • Hyytiainen M, Penttinen C, Keski-Oja J. Latent TGF-beta binding proteins: extracellular matrix association and roles in TGF-beta activation. Crit Rev Clin Lab Sci 2004; 41:233-64.
    • (2004) Crit Rev Clin Lab Sci , vol.41 , pp. 233-264
    • Hyytiainen, M.1    Penttinen, C.2    Keski-Oja, J.3
  • 64
    • 0037077212 scopus 로고    scopus 로고
    • Proteolysis of latent transforming growth factor-beta (TGF-beta )-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-beta from bone matrix
    • Dallas SL, Rosser JL, Mundy GR, Bonewald LF. Proteolysis of latent transforming growth factor-beta (TGF-beta )-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-beta from bone matrix. J Biol Chem 2002; 277:21352-60.
    • (2002) J Biol Chem , vol.277 , pp. 21352-21360
    • Dallas, S.L.1    Rosser, J.L.2    Mundy, G.R.3    Bonewald, L.F.4
  • 65
    • 25444501226 scopus 로고    scopus 로고
    • Involvement of alphavbeta5 integrin-mediated activation of latent transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts
    • Asano Y, Ihn H, Yamane K, Jinnin M, Mimura Y, Tamaki K. Involvement of alphavbeta5 integrin-mediated activation of latent transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts. Arthritis Rheum 2005; 52:2897-905.
    • (2005) Arthritis Rheum , vol.52 , pp. 2897-2905
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 66
    • 4444249880 scopus 로고    scopus 로고
    • alpha(v)beta(3) Integrin interacts with the transforming growth factor beta (TGFbeta) type II receptor to potentiate the proliferative effects of TGFbeta1 in living human lung fibroblasts
    • Scaffidi AK, Petrovic N, Moodley YP, Fogel-Petrovic M, Kroeger KM, Seeber RM, et al. alpha(v)beta(3) Integrin interacts with the transforming growth factor beta (TGFbeta) type II receptor to potentiate the proliferative effects of TGFbeta1 in living human lung fibroblasts. J Biol Chem 2004; 279:37726-33.
    • (2004) J Biol Chem , vol.279 , pp. 37726-37733
    • Scaffidi, A.K.1    Petrovic, N.2    Moodley, Y.P.3    Fogel-Petrovic, M.4    Kroeger, K.M.5    Seeber, R.M.6
  • 67
    • 4444304040 scopus 로고    scopus 로고
    • Roles of alphav integrins in vascular biology and pulmonary pathology
    • Sheppard D. Roles of alphav integrins in vascular biology and pulmonary pathology. Curr Opin Cell Biol 2004; 16:552-7.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 552-557
    • Sheppard, D.1
  • 68
    • 0037662109 scopus 로고    scopus 로고
    • Functions of pulmonary epithelial integrins: From development to disease
    • Sheppard D. Functions of pulmonary epithelial integrins: from development to disease. Physiol Rev 2003; 83:673-86.
    • (2003) Physiol Rev , vol.83 , pp. 673-686
    • Sheppard, D.1
  • 69
    • 3442902451 scopus 로고    scopus 로고
    • AlphaV integrins play an important role in myofibroblast differentiation
    • Lygoe KA, Norman JT, Marshall JF, Lewis MP. AlphaV integrins play an important role in myofibroblast differentiation. Wound Repair Regen 2004; 12:461-70.
    • (2004) Wound Repair Regen , vol.12 , pp. 461-470
    • Lygoe, K.A.1    Norman, J.T.2    Marshall, J.F.3    Lewis, M.P.4
  • 70
    • 0034763207 scopus 로고    scopus 로고
    • Regulation of human lung fibroblast phenotype and function by vitronectin and vitronectin integrins
    • Scaffidi AK, Moodley YP, Weichselbaum M, Thompson PJ, Knight DA. Regulation of human lung fibroblast phenotype and function by vitronectin and vitronectin integrins. J Cell Sci 2001; 114:3507-16.
    • (2001) J Cell Sci , vol.114 , pp. 3507-3516
    • Scaffidi, A.K.1    Moodley, Y.P.2    Weichselbaum, M.3    Thompson, P.J.4    Knight, D.A.5
  • 71
    • 0031309902 scopus 로고    scopus 로고
    • The discoidin domain receptor tyrosine kinases are activated by collagen
    • Vogel W, Gish GD, Alves F, Pawson T. The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell 1997; 1:13-23.
    • (1997) Mol Cell , vol.1 , pp. 13-23
    • Vogel, W.1    Gish, G.D.2    Alves, F.3    Pawson, T.4
  • 72
    • 33646341752 scopus 로고    scopus 로고
    • Sensing extracellular matrix: An update on discoidin domain receptor function
    • Vogel WF, Abdulhussein R, Ford CE. Sensing extracellular matrix: an update on discoidin domain receptor function. Cell Signal 2006; 18:1108-16.
    • (2006) Cell Signal , vol.18 , pp. 1108-1116
    • Vogel, W.F.1    Abdulhussein, R.2    Ford, C.E.3
  • 73
    • 0028799694 scopus 로고
    • Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer
    • Alves F, Vogel W, Mossie K, Millauer B, Hofler H, Ullrich A. Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer. Oncogene 1995; 10:609-18.
    • (1995) Oncogene , vol.10 , pp. 609-618
    • Alves, F.1    Vogel, W.2    Mossie, K.3    Millauer, B.4    Hofler, H.5    Ullrich, A.6
  • 74
    • 0036274730 scopus 로고    scopus 로고
    • Collagens, integrins, and the discoidin domain receptors in arterial occlusive disease
    • Franco CD, Hou G, Bendeck MP. Collagens, integrins, and the discoidin domain receptors in arterial occlusive disease. Trends Cardiovasc Med 2002; 12:143-8.
    • (2002) Trends Cardiovasc Med , vol.12 , pp. 143-148
    • Franco, C.D.1    Hou, G.2    Bendeck, M.P.3
  • 75
    • 18644366031 scopus 로고    scopus 로고
    • Activation of discoidin domain receptor 1 on CD14-positive bronchoalveolar lavage fluid cells induces chemokine production in idiopathic pulmonary fibrosis
    • Matsuyama W, Watanabe M, Shirahama Y, Oonakahara K, Higashimoto I, Yoshimura T, et al. Activation of discoidin domain receptor 1 on CD14-positive bronchoalveolar lavage fluid cells induces chemokine production in idiopathic pulmonary fibrosis. J Immunol 2005; 174:6490-8.
    • (2005) J Immunol , vol.174 , pp. 6490-6498
    • Matsuyama, W.1    Watanabe, M.2    Shirahama, Y.3    Oonakahara, K.4    Higashimoto, I.5    Yoshimura, T.6
  • 76
    • 33644649577 scopus 로고    scopus 로고
    • Discoidin domain receptor 1 contributes to the survival of lung fibroblast in idiopathic pulmonary fibrosis
    • Matsuyama W, Watanabe M, Shirahama Y, Mitsuyama H, Higashimoto I, Osame M, et al. Discoidin domain receptor 1 contributes to the survival of lung fibroblast in idiopathic pulmonary fibrosis. Am J Pathol 2006; 168:866-77.
    • (2006) Am J Pathol , vol.168 , pp. 866-877
    • Matsuyama, W.1    Watanabe, M.2    Shirahama, Y.3    Mitsuyama, H.4    Higashimoto, I.5    Osame, M.6
  • 77
    • 33747113061 scopus 로고    scopus 로고
    • Discoidin domain receptor 1-deficient mice are resistant to bleomycin-induced lung fibrosis
    • Avivi-Green C, Singal M, Vogel WF. Discoidin domain receptor 1-deficient mice are resistant to bleomycin-induced lung fibrosis. Am J Respir Crit Care Med 2006; 174:420-7.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 420-427
    • Avivi-Green, C.1    Singal, M.2    Vogel, W.F.3
  • 78
    • 33847122893 scopus 로고    scopus 로고
    • Interaction of Discoidin Domain Receptor 1 with Collagen type 1
    • Agarwal G, Mihai C, Iscru DF. Interaction of Discoidin Domain Receptor 1 with Collagen type 1. J Mol Biol 2007; 367:443-55.
    • (2007) J Mol Biol , vol.367 , pp. 443-455
    • Agarwal, G.1    Mihai, C.2    Iscru, D.F.3
  • 79
    • 33746901276 scopus 로고    scopus 로고
    • Discoidin domain receptor 2 inhibits fibrillogenesis of collagen type 1
    • Mihai C, Iscru DF, Druhan LJ, Elton TS, Agarwal G. Discoidin domain receptor 2 inhibits fibrillogenesis of collagen type 1. J Mol Biol 2006; 361:864-76.
    • (2006) J Mol Biol , vol.361 , pp. 864-876
    • Mihai, C.1    Iscru, D.F.2    Druhan, L.J.3    Elton, T.S.4    Agarwal, G.5
  • 80
    • 1242336980 scopus 로고    scopus 로고
    • Apoptosis: The nexus of liver injury and fibrosis
    • Canbay A, Friedman S, Gores GJ. Apoptosis: the nexus of liver injury and fibrosis. Hepatology 2004; 39:273-8.
    • (2004) Hepatology , vol.39 , pp. 273-278
    • Canbay, A.1    Friedman, S.2    Gores, G.J.3
  • 81
    • 0041827247 scopus 로고    scopus 로고
    • Possible roles for apoptosis and apoptotic cell recognition in inflammation and fibrosis
    • Henson PM. Possible roles for apoptosis and apoptotic cell recognition in inflammation and fibrosis. Am J Respir Cell Mol Biol 2003; 29:S70-6.
    • (2003) Am J Respir Cell Mol Biol , vol.29
    • Henson, P.M.1
  • 83
    • 0141530032 scopus 로고    scopus 로고
    • Epithelial apoptosis in the initiation of lung fibrosis
    • Uhal BD. Epithelial apoptosis in the initiation of lung fibrosis. Eur Respir J Suppl 2003; 44:7s-9s.
    • (2003) Eur Respir J Suppl , vol.44
    • Uhal, B.D.1
  • 84
    • 0032146551 scopus 로고    scopus 로고
    • Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
    • Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998; 102:538-49.
    • (1998) J Clin Invest , vol.102 , pp. 538-549
    • Iredale, J.P.1    Benyon, R.C.2    Pickering, J.3    McCullen, M.4    Northrop, M.5    Pawley, S.6
  • 85
    • 0038544594 scopus 로고    scopus 로고
    • Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma
    • Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol 2003; 171:380-9.
    • (2003) J Immunol , vol.171 , pp. 380-389
    • Schmidt, M.1    Sun, G.2    Stacey, M.A.3    Mori, L.4    Mattoli, S.5
  • 86
    • 0042368890 scopus 로고    scopus 로고
    • Fibrocytes: A unique cell population implicated in wound healing
    • Metz CN. Fibrocytes: a unique cell population implicated in wound healing. Cell Mol Life Sci 2003; 60:1342-50.
    • (2003) Cell Mol Life Sci , vol.60 , pp. 1342-1350
    • Metz, C.N.1
  • 87
    • 33646914221 scopus 로고    scopus 로고
    • The role of circulating fibrocytes in fibrosis
    • Quan TE, Cowper SE, Bucala R. The role of circulating fibrocytes in fibrosis. Curr Rheumatol Rep 2006; 8:145-50.
    • (2006) Curr Rheumatol Rep , vol.8 , pp. 145-150
    • Quan, T.E.1    Cowper, S.E.2    Bucala, R.3
  • 89
    • 30444443812 scopus 로고    scopus 로고
    • Focal interstitial CC chemokine receptor 7 (CCR7) expression in idiopathic interstitial pneumonia
    • Choi ES, Pierce EM, Jakubzick C, Carpenter KJ, Kunkel SL, Evanoff H, et al. Focal interstitial CC chemokine receptor 7 (CCR7) expression in idiopathic interstitial pneumonia. J Clin Pathol 2006; 59:28-39.
    • (2006) J Clin Pathol , vol.59 , pp. 28-39
    • Choi, E.S.1    Pierce, E.M.2    Jakubzick, C.3    Carpenter, K.J.4    Kunkel, S.L.5    Evanoff, H.6
  • 90
    • 0041303386 scopus 로고    scopus 로고
    • Nephrogenic fibrosing dermopathy: Suspect identified, motive unclear
    • Cowper SE, Bucala R. Nephrogenic fibrosing dermopathy: suspect identified, motive unclear. Am J Dermatopathol 2003; 25:358.
    • (2003) Am J Dermatopathol , vol.25 , pp. 358
    • Cowper, S.E.1    Bucala, R.2
  • 91
    • 7044224913 scopus 로고    scopus 로고
    • Cellular origins of fibroblasts: Possible implications for organ fibrosis in systemic sclerosis
    • Postlethwaite AE, Shigemitsu H, Kanangat S. Cellular origins of fibroblasts: possible implications for organ fibrosis in systemic sclerosis. Curr Opin Rheumatol 2004; 16:733-8.
    • (2004) Curr Opin Rheumatol , vol.16 , pp. 733-738
    • Postlethwaite, A.E.1    Shigemitsu, H.2    Kanangat, S.3
  • 93
    • 34547956524 scopus 로고    scopus 로고
    • Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma
    • Hong KM, Belperio JA, Keane MP, Burdick MD, Strieter RM. Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma. J Biol Chem 2007; 282:22910-20.
    • (2007) J Biol Chem , vol.282 , pp. 22910-22920
    • Hong, K.M.1    Belperio, J.A.2    Keane, M.P.3    Burdick, M.D.4    Strieter, R.M.5
  • 94
    • 0028925088 scopus 로고
    • Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis
    • Manolagas SC, Jilka RL. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 1995; 332:305-11.
    • (1995) N Engl J Med , vol.332 , pp. 305-311
    • Manolagas, S.C.1    Jilka, R.L.2
  • 95
    • 19344371471 scopus 로고    scopus 로고
    • Metabolic activity of chondrocytes in human osteoarthritis as a result of cell-extracellular matrix interactions
    • Lapadula G, Iannone F. Metabolic activity of chondrocytes in human osteoarthritis as a result of cell-extracellular matrix interactions. Semin Arthritis Rheum 2005; 34:9-12.
    • (2005) Semin Arthritis Rheum , vol.34 , pp. 9-12
    • Lapadula, G.1    Iannone, F.2
  • 96
    • 33747339465 scopus 로고    scopus 로고
    • Wnt signaling: Multiple pathways, multiple receptors, and multiple transcription factors
    • Gordon MD, Nusse R. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 2006; 281:22429-33.
    • (2006) J Biol Chem , vol.281 , pp. 22429-22433
    • Gordon, M.D.1    Nusse, R.2
  • 97
    • 0036056189 scopus 로고    scopus 로고
    • Wnt5a participates in distal lung morphogenesis
    • Li C, Xiao J, Hormi K, Borok Z, Minoo P. Wnt5a participates in distal lung morphogenesis. Dev Biol 2002; 248:68-81.
    • (2002) Dev Biol , vol.248 , pp. 68-81
    • Li, C.1    Xiao, J.2    Hormi, K.3    Borok, Z.4    Minoo, P.5
  • 98
    • 0036802645 scopus 로고    scopus 로고
    • Wnt7b regulates mesenchymal proliferation and vascular development in the lung
    • Shu W, Jiang YQ, Lu MM, Morrisey EE. Wnt7b regulates mesenchymal proliferation and vascular development in the lung. Development 2002; 129:4831-42.
    • (2002) Development , vol.129 , pp. 4831-4842
    • Shu, W.1    Jiang, Y.Q.2    Lu, M.M.3    Morrisey, E.E.4
  • 99
    • 27744454665 scopus 로고    scopus 로고
    • Wnt5a regulates Shh and Fgf10 signaling during lung development
    • Li C, Hu L, Xiao J, Chen H, Li JT, Bellusci S, et al. Wnt5a regulates Shh and Fgf10 signaling during lung development. Dev Biol 2005; 287:86-97.
    • (2005) Dev Biol , vol.287 , pp. 86-97
    • Li, C.1    Hu, L.2    Xiao, J.3    Chen, H.4    Li, J.T.5    Bellusci, S.6
  • 100
    • 11144317908 scopus 로고    scopus 로고
    • Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung
    • De Langhe SP, Sala FG, Del Moral PM, Fairbanks TJ, Yamada KM, Warburton D, et al. Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung. Dev Biol 2005; 277:316-31.
    • (2005) Dev Biol , vol.277 , pp. 316-331
    • De Langhe, S.P.1    Sala, F.G.2    Del Moral, P.M.3    Fairbanks, T.J.4    Yamada, K.M.5    Warburton, D.6
  • 101
    • 0242500879 scopus 로고    scopus 로고
    • Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis
    • Chilosi M, Poletti V, Zamo A, Lestani M, Montagna L, Piccoli P, et al. Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol 2003; 162:1495-502.
    • (2003) Am J Pathol , vol.162 , pp. 1495-1502
    • Chilosi, M.1    Poletti, V.2    Zamo, A.3    Lestani, M.4    Montagna, L.5    Piccoli, P.6
  • 102
    • 33746511526 scopus 로고    scopus 로고
    • Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation
    • Jiang F, Parsons CJ, Stefanovic B. Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol 2006; 45:401-9.
    • (2006) J Hepatol , vol.45 , pp. 401-409
    • Jiang, F.1    Parsons, C.J.2    Stefanovic, B.3
  • 103
    • 34250207000 scopus 로고    scopus 로고
    • Wnt signaling enhances the activation and survival of human hepatic stellate cells
    • Myung SJ, Yoon JH, Gwak GY, Kim W, Lee JH, Kim KM, et al. Wnt signaling enhances the activation and survival of human hepatic stellate cells. FEBS Lett 2007; 581:2954-8.
    • (2007) FEBS Lett , vol.581 , pp. 2954-2958
    • Myung, S.J.1    Yoon, J.H.2    Gwak, G.Y.3    Kim, W.4    Lee, J.H.5    Kim, K.M.6
  • 105
    • 33846869496 scopus 로고    scopus 로고
    • Beta-catenin signaling in fibroproliferative disease
    • Bowley E, O'Gorman DB, Gan BS. Beta-catenin signaling in fibroproliferative disease. J Surg Res 2007; 138:141-50.
    • (2007) J Surg Res , vol.138 , pp. 141-150
    • Bowley, E.1    O'Gorman, D.B.2    Gan, B.S.3
  • 106
    • 33746513742 scopus 로고    scopus 로고
    • Upregulation of the Wnt/beta-catenin pathway induced by transforming growth factor-beta in hypertrophic scars and keloids
    • Sato M. Upregulation of the Wnt/beta-catenin pathway induced by transforming growth factor-beta in hypertrophic scars and keloids. Acta Derm Venereol 2006; 86:300-7.
    • (2006) Acta Derm Venereol , vol.86 , pp. 300-307
    • Sato, M.1
  • 107
    • 33644679351 scopus 로고    scopus 로고
    • Wnt signaling induces epithelial differentiation during cutaneous wound healing
    • Fathke C, Wilson L, Shah K, Kim B, Hocking A, Moon R, et al. Wnt signaling induces epithelial differentiation during cutaneous wound healing. BMC Cell Biol 2006; 7:4.
    • (2006) BMC Cell Biol , vol.7 , pp. 4
    • Fathke, C.1    Wilson, L.2    Shah, K.3    Kim, B.4    Hocking, A.5    Moon, R.6
  • 108
    • 34447131518 scopus 로고    scopus 로고
    • The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition
    • Dissanayake SK, Wade M, Johnson CE, O'Connell MP, Leotlela PD, French AD, et al. The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem 2007; 282:17259-71.
    • (2007) J Biol Chem , vol.282 , pp. 17259-17271
    • Dissanayake, S.K.1    Wade, M.2    Johnson, C.E.3    O'Connell, M.P.4    Leotlela, P.D.5    French, A.D.6
  • 109
    • 28444468088 scopus 로고    scopus 로고
    • Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis
    • Surendran K, Schiavi S, Hruska KA. Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol 2005; 16:2373-84.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2373-2384
    • Surendran, K.1    Schiavi, S.2    Hruska, K.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.