Paeonia lactiflora Pall inhibits bladder cancer growth involving phosphorylation of Chk2 in vitro and in vivo

Journal of Ethnopharmacology

Volumn 135, Issue 1, 2011, Pages 162-172

  Ou, Ting Tsz ^a   Wu, Cheng Hsun ^b   Hsu, Jeng Dong ^c   Chyau, Charng Cherng ^d   Lee, Huei Jane ^a   Wang, Chau Jong ^a,c  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Bladder carcinogenesis; Cell cycle; Checkpoint kinase 2; G2 M phase; Paeonia lactiflora Pall (RPA)

Indexed keywords

ALBIFLORIN; BENZOYLPAEONIFLORIN; CASPASE 3; CASPASE 9; CELL DIVISION CYCLE 25B PROTEIN; CELL DIVISION CYCLE 25C PROTEIN; CHECKPOINT KINASE 2; CYCLIN B1; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; EPAEONIFLORIN SULFONAT; GALLIC ACID; ISOBENZOYLPAEONIFLORIN; PAEONIA LACTIFLORA EXTRACT; PAEONIFLORIN; PEONOL; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL VIABILITY; CONTROLLED STUDY; DRUG DETERMINATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MEDICINAL PLANT; NONHUMAN; PAEONIA LACTIFLORA; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BUTYLHYDROXYBUTYLNITROSAMINE; CARCINOMA; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; HUMANS; MALE; PAEONIA; PHOSPHORYLATION; PHYTOTHERAPY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; URINARY BLADDER NEOPLASMS; UROTHELIUM;

PAEONIA LACTIFLORA; RATTUS;

EID: 79955474591     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2011.03.011     Document Type: Article

References (44)

1. J.M. Adams, and S. Cory The Bcl-2 protein family: arbiters of cell survival Science 281 1998 1322 1326 (Pubitemid 28406819)
2. J.Y. Ahn, J.K. Schwarz, H. Piwnica-Worms, and C.E. Canman Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation Cancer Research 60 2000 5934 5936
3. J.Y. Ahn, X. Li, H.L. Davis, and C.E. Canman Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain Journal of Biological Chemistry 277 2002 19389 19395 (Pubitemid 34967446)
4. J. Bartek, and J. Lukas Mammalian G1- and S-phase checkpoints in response to DNA damage Current Opinion Cell Biology 13 2001 738 747 (Pubitemid 33042735)
5. E.E. Deschner, J. Ruperto, G. Wong, and H.L. Newmark Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia Carcinogenesis 12 1991 1193 1196
6. X. Dong, L. Wang, K. Taniguchi, X. Wang, J.M. Cunningham, S.K. McDonnell, C. Qian, A.F. Marks, S.L. Slager, B.J. Peterson, D.I. Smith, J.C. Cheville, M.L. Blute, S.J. Jacobsen, D.J. Schaid, D.J. Tindall, S.N. Thibodeau, and W. Liu Mutations in CHEK2 associated with prostate cancer risk The American Journal of Human Genetics 72 2003 270 280 (Pubitemid 36194238)
7. W.C. Earnshaw, L.M. Martins, and S.H. Kaufmann Mammalian caspases: structure, activation, substrates, and functions during apoptosis Annual Review of Biochemistry 68 1999 383 424 (Pubitemid 29449198)
8. J. Falck, N. Mailand, R.G. Syljuasen, J. Bartek, and J. Lukas The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis Nature 410 2001 842 847 (Pubitemid 32303786)
9. L.H. Hartwell, and T.A. Weinert Checkpoints: controls that ensure the order of cell cycle events Science 246 1989 629 634 (Pubitemid 19283354)
10. L.H. Hartwell, and M.B. Kastan Cell cycle control and cancer Science 266 1994 1821 1828
11. N. Haruki, H. Saito, Y. Tatematsu, H. Konishi, T. Harano, A. Masuda, H. Osada, Y. Fujii, and T. Takahashi Histological type-selective, tumor-predominant expression of a novel CHK1 isoform and infrequent in vivo somatic CHK2 mutation in small cell lung cancer Cancer Research 60 2000 4689 4692
12. J.H. Hoeijmakers Genome maintenance mechanisms for preventing cancer Nature 411 2001 366 374 (Pubitemid 32467046)
13. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, and M.J. Thun Cancer statistics, 2009 CA - A Cancer Journal of Clinicians 59 2009 225 249
14. A. Jemal, R. Siegel, E. Ward, Y. Hao, and J. Xu Cancer statistics CA - A Cancer Journal of Clinicians 58 2008 71 96
15. N. Khan, F. Afaq, and H. Mukhtar Cancer chemoprevention through dietary antioxidants: progress and promise Antioxidants and Redox Signaling 10 2008 475 510
16. K.K. Khanna, and S.P. Jackson DNA double-strand breaks: signaling, repair and the cancer connection Nature Genetics 27 2001 247 254 (Pubitemid 32201842)
17. R.D. Klein, and S.M. Fischer Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cells Carcinogenesis 23 2002 217 221 (Pubitemid 34213573)
18. K.B. Kwon, E.K. Kim, M.J. Han, B.C. Shin, Y.K. Park, K.S. Kim, Y.R. Lee, J.W. Park, B.H. Park, and G. Ryu do Induction of apoptosis by Radix Paeoniae Alba extract through cytochrome c release and the activations of caspase-9 and caspase-3 in HL-60 cells Biological and Pharmaceutical Bulletin 29 2006 1082 1086 (Pubitemid 43845464)
19. S.M. Lee, M.L. Li, Y.C. Tse, S.C. Leung, M.M. Lee, S.K. Tsui, K.P. Fung, C.Y. Lee, and M.M. Waye Paeoniae radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway Life Sciences 71 2002 2267 2277 (Pubitemid 35246215)
20. S.L. Li, J.Z. Song, F.F. Choi, C.F. Qiao, Y. Zhou, Q.B. Han, and H.X. Xu Chemical profiling of Radix Paeoniae evaluated by ultra-performance liquid chromatography/photo-diode-array/quadrupole time-of-flight mass spectrometry Journal of Pharmaceutical and Biomedical Analysis 49 2009 253 266
21. X. Liang, E. Reed, and J.J. Yu Protein phosphatase 2A interacts with Chk2 and regulates phosphorylation at Thr-68 after cisplatin treatment of human ovarian cancer cells International Journal of Molecular Medicine 17 2006 703 708
22. C. Locatelli, P.C. Leal, R.A. Yunes, R.J. Nunes, and T.B. Creczynski-Pasa Gallic acid ester derivatives induce apoptosis and cell adhesion inhibition in melanoma cells: the relationship between free radical generation, glutathione depletion and cell death Chemico-Biological Interactions 181 2009 175 184
23. R.A. Lubet, C.S. Yang, M.J. Lee, Y. Hara, I.M. Kapetanovic, J.A. Crowell, V.E. Steele, M.M. Juliana, and C.J. Grubbs Preventive effects of polyphenon E on urinary bladder and mammary cancers in rats and correlations with serum and urine levels of tea polyphenols Molecular Cancer Therapeutics 6 2007 2022 2028 (Pubitemid 47052492)
24. S. Madlener, C. Illmer, Z. Horvath, P. Saiko, A. Losert, I. Herbacek, M. Grusch, H.L. Elford, G. Krupitza, A. Bernhaus, M. Fritzer-Szekeres, and T. Szekeres Gallic acid inhibits ribonucleotide reductase and cyclooxygenases in human HL-60 promyelocytic leukemia cells Cancer Letters 245 2007 156 162 (Pubitemid 44959349)
25. S. Matsuoka, G. Rotman, A. Ogawa, Y. Shiloh, K. Tamai, and S.J. Elledge Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro Proceedings of the National Academy of Science of the United States of America 97 2000 10389 10394
26. D.L. McCormick, S.S. Ronan, P.J. Becci, and R.C. Moon Influence of total dose and dose schedule on induction of urinary bladder cancer in the mouse by N-butyl-N-(4-hydroxybutyl) nitrosamine Carcinogenesis 2 1981 251 254 (Pubitemid 11097393)
27. M. Molinari Cell cycle checkpoints and their inactivation in human cancer Cell Proliferation 33 2000 261 274
28. T.T. Ou, C.J. Wang, Y.S. Lee, C.H. Wu, and H.J. Lee Gallic acid induces G2/M phase cell cycle arrest via regulating 14-3-3beta release from Cdc25C and Chk2 activation in human bladder transitional carcinoma cells Molecular Nutrition and Food Research 2010 10.1002/mnfr.201000096
29. S. Priego, F. Feddi, P. Ferrer, S. Mena, M. Benlloch, A. Ortega, J. Carretero, E. Obrador, M. Asensi, and J.M. Estrela Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2- and superoxide dismutase 2-dependent mechanism Molecular Cancer Therapeutics 7 2008 3330 3342
30. K. Raina, S. Rajamanickam, G. Deep, M. Singh, R. Agarwal, and C. Agarwal Chemopreventive effects of oral gallic acid feeding on tumor growth and progression in TRAMP mice Molecular Cancer Therapeutics 7 2008 1258 1267
31. B. Sebastian, A. Kakizuka, and T. Hunter Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15 Proceedings of the National Academy of Sciences of the United States of America 90 1993 3521 3524 (Pubitemid 23111398)
32. Z. Shen, T. Shen, M.G. Wientjes, M.A. O'Donnell, and J.L. Au Intravesical treatments of bladder cancer: review Pharmaceutical Research 25 2008 1500 1510
33. S.V. Singh, A. Herman-Antosiewicz, A.V. Singh, K.L. Lew, S.K. Srivastava, R. Kamath, K.D. Brown, L. Zhang, and R. Baskaran Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C Journal of Biological Chemistry 279 2004 25813 25822 (Pubitemid 38756846)
34. J.P. Stein, G. Lieskovsky, R. Cote, S. Groshen, A.C. Feng, S. Boyd, E. Skinner, B. Bochner, D. Thangathurai, M. Mikhail, D. Raghavan, and D.G. Skinner Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients Journal of Clinical Oncology 19 2001 666 675 (Pubitemid 32120143)
35. A. Sullivan, M. Yuille, C. Repellin, A. Reddy, O. Reelfs, A. Bell, B. Dunne, B.A. Gusterson, P. Osin, P.J. Farrell, I. Yulug, A. Evans, T. Ozcelik, M. Gasco, and T. Crook Concomitant inactivation of p53 and Chk2 in breast cancer Oncogene 21 2002 1316 1324 (Pubitemid 34214497)
36. N.A. Thornberry, and Y. Lazebnik Caspases: enemies within Science 281 1998 1312 1316 (Pubitemid 28406817)
37. M. Tomoda, K. Matsumoto, N. Shimizu, R. Gonda, and N. Ohara Characterization of a neutral and an acidic polysaccharide having immunological activities from the root of Paeonia lactiflora Biological and Pharmaceutical Bulletin 16 1993 1207 1210 (Pubitemid 24049981)
38. M. Tomoda, K. Matsumoto, N. Shimizu, R. Gonda, N. Ohara, and K. Hirabayashi An acidic polysaccharide with immunological activities from the root of Paeonia lactiflora Biological and Pharmaceutical Bulletin 17 1994 1161 1164 (Pubitemid 24316184)
39. P. Turowski, C. Franckhauser, M.C. Morris, P. Vaglio, A. Fernandez, and N.J. Lamb Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells Molecular Biology of Cell 14 2003 2984 2998 (Pubitemid 36871536)
40. K. Vermeulen, Z.N. Berneman, and D.R. Van Bockstaele Cell cycle and apoptosis Cell Proliferation 36 2003 165 175 (Pubitemid 36808272)
41. K. Vermeulen, D.R. Van Bockstaele, and Z.N. Berneman The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer Cell Proliferation 36 2003 131 149 (Pubitemid 36808270)
42. P.Q. Vinh, S. Sugie, T. Tanaka, A. Hara, Y. Yamada, M. Katayama, T. Deguchi, and H. Mori Chemopreventive effects of a flavonoid antioxidant silymarin on N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis in male ICR mice Japanese Journal of Cancer Research 93 2002 42 49 (Pubitemid 34144711)
43. X. Xu, L.M. Tsvetkov, and D.F. Stern Chk2 activation and phosphorylation-dependent oligomerization Molecular Cell Biology 22 2002 4419 4432 (Pubitemid 34556608)
44. M.Y. Yeh, D.S. Yu, S.C. Chen, M.S. Lin, S.Y. Chang, C.P. Ma, and S.H. Han Establishment and characterization of a human urinary bladder carcinoma cell line (TSGH-8301) Journal of Surgical Oncology 37 1988 177 184