Pharmacokinetic modulation of oral etoposide by ketoconazole in patients with advanced cancer

Cancer Chemotherapy and Pharmacology

Volumn 60, Issue 6, 2007, Pages 811-819

  Yong, Wei Peng ^a   Desai, Apurva A ^a   Innocenti, Federico ^a   Ramirez, Jacqueline ^a   Shepard, Dale ^a   Kobayashi, Ken ^a   House, Larry ^a   Fleming, Gini F ^a   Vogelzang, Nicholas J ^a   Schilsky, Richard L ^a   Ratain, Mark J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Drug interaction; Etoposide; Ketoconazole; Pharmacokinetic modulation

Indexed keywords

ETOPOSIDE; KETOCONAZOLE;

ADULT; ADVANCED CANCER; AGED; ANEMIA; ANOREXIA; ANTIFUNGAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BREAST CANCER; CLINICAL ARTICLE; COLORECTAL CANCER; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE INCREASE; DRUG METABOLISM; ENZYME INHIBITION; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; GLUCURONIDATION; HUMAN; INFECTION; LUNG CANCER; MALE; METABOLIC DISORDER; MONOTHERAPY; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUTROPENIA; OVARY CANCER; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROSTATE CANCER; SARCOMA; SINGLE DRUG DOSE; THROMBOCYTOPENIA; TOXICITY; VOMITING;

ADMINISTRATION, ORAL; ADULT; AGED; AGED, 80 AND OVER; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AREA UNDER CURVE; BILIRUBIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ETOPOSIDE; FATIGUE; FEMALE; HUMANS; KETOCONAZOLE; MALE; MIDDLE AGED; NEUTROPENIA;

EID: 34548565615     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-007-0428-5     Document Type: Article

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