Aqueous extract of Astragalus mongholicus ameliorates high cholesterol diet induced oxidative injury in experimental rats models

Journal of Medicinal Plants Research

Volumn 5, Issue 5, 2011, Pages 855-858

  Jiangwei, Ma ^a   Zengyong, Qiao ^a   Xia, Xiang ^a  

^a Fengxian Branch of Shanghai 6th People's Hospital   (China)

Author keywords

Astragalus mongholicus extract; Coronary heart disease; High cholesterol diet

Indexed keywords

ASTRAGALUS MONGHOLICUS EXTRACT; CHOLESTEROL; GLUTATHIONE PEROXIDASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLANT EXTRACT; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTRAGALUS MONGHOLICUS; ASTRAGALUS PLANT; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; ENZYME ACTIVITY; HYPERLIPIDEMIA; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALIA; ASTRAGALUS MONGHOLICUS; RATTUS;

EID: 79955440197     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Abdelhalim MAK (2010).The changes of iron and zinc concentrations in heart and aortic tissues of rabbits fed on high fat diet during the progression of atherosclerosis. Afr. J. Microbio. Res., 4(15): 1670-1675.
2. Aebi H (1974). Catalase in vitro. In: U. Bergmeyer, Editor, Methods of Enzymatic Analysis, Academic Press, New York/London, 667-673.
3. Aldarmaa J, Liu Z, Long J, Mo X, Ma J, Liu J (2010). Anti-convulsant effect and mechanism of Astragalus mongholicus extract in vitro and in vivo: protection against oxidative damage and mitochondrial dysfunction, Neurochem. Res., 35: 33-41.
4. Alim A, Goze I, Cetin A, Atas AD, Cetinus SA, Vural N (2009). Chemical composition and in vitro antimicrobial and antioxidant activities of the essential oil of Nepeta nuda L. subsp. Albiflora (Boiss.) gams. Afr. J. Microbiol. Res., 3(8): 463-467.
5. Anderson JW, Johnstone BM, Cook-Newell ME (1995). Meta-analysis of the effects of soy protein intake on serum lipids, N. Engl. J. Med., 333: 276-282.
6. Barzi F, Patel A, Woodward M, Lawes CM, Ohkubo T, Gu D, Lam TH, Ueshima H (2005). A comparison of lipid variables as predictors of cardiovascular disease in the Asia Pacific region, Ann. Epidemiol., 15: 405-413.
7. BeMiller JN (2011). Contributions of Roy L. Whistler to carbohydrate polymer science. Carbohydrate Polymers, 83: 2022-2026.
8. Chen LX, Liao JZ, Guo WQ (1995). Effects of Astragalus membranaceus on left ventricular function and oxygen free radical in acute myocardial infarction patients and mechanisms of its cardiotonic action, Zhongguo Zhong Xi Yi Jie He Ha Zhi, 15: 141-143.
9. Clarkson TB (2002). Soy, soy phytoestrogens and cardiovascular disease, J. Nutr., 132: 566S-569S.
10. Douglas G, Armitage JA, Taylor PD, Lawson JR, Mann GE (2006). Poston, L. Cardiovascular consequences of life long exposure to dietary isoflavones in the rat, J. Physiol., 571: 477-487.
11. Draper HH, Hadley M (1990). Malondialdehyde determination as index of lipid peroxidation, Methods Enzymol., 186: 421-431.
12. Gaziano JM, Hennekens CH, O'Donnell CJ, Breslow JL, Buring JE (1997) Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction, Circ., 96: 2520-2525.
13. Haberland ME, Fong D, Cheng L (1988), Malondialdehyde altered protein occurs in atheroma of Watanabe hyperlipidemic rabbits. Sci., 241: 215.
14. Hakimoglu F, Kizil G, Kanay Z, Kizil M, Iisi H (2007). The effect of ethanol extract of Hypericum lysimachioides on lipid profile in hypercholesterolemic rabbits and its in vitro antioxidant activity, Atherosclerosis, 192: 113-122.
15. Hokanson JE, Austin MA. (1996). Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies, J. Cardiovasc. Risk, 3: 213-219.
16. Kitagawa I, Wang HK, Saponin MS, Sapogenol XXXV (1983a). Chemical constituents of Astragali Radix, the root of Astragalus membranaceus Bunge, (2). Astragalosides I, II, and IV, acetylastragaloside I and isoastragalosides I and II, Chem. Pharmaceut. Bull., 31: 698-708.
17. Kitagawa I, Wang HK, Saponin TA, Sapogenol XXXIV (1983b). Chemical constituents of Astragali Radix, the root of Astragalus membranaceus Bunge. (1) Cycloastragenol, the 9,19-cyclolanostanetype aglycone of astragalosides, artifact aglycone astragenol, Chem. Pharmaceut. Bull., 31: 689-697.
18. Kitagawa I, Wang HK, Saponin YM, Sapogenol XXXVII (1983c). Chemical constituents of Astragali Radix, the root of Astragalus membranaceus Bunge. (4) Astragalosides VII and VIII, Chem. Pharmaceut. Bull., 31: 716-722.
19. Lin LZ, He XG, Lindenmaier M, Nolan G, Yang J, Cleary M, Qiu SX, Cordell GA (2000). Liquid chromatography-electrospray ionization mass spectrometry study of the flavonoids of the roots of Astragalus mongholicus and A. membranaceus, J. Chromatogr. A., 876: 87-95.
20. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951). Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193: 265-275.
21. Lung CC, Pinnas JL, Yahya MD, Meinke GC, Mooradian AD (1993), Malondialdehyde modified proteins and their antibodies in the plasma of control and streptozotocin-induced diabetic rats. Life Sci., 52: 329.
22. Mahn K, Borras C, Knock GA, Taylor P, Khan IY, Sugden D, Poston L, Ward JP, Sharpe RM, Vina J, Aaronson PI, Mann GE (2005). Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced bloodpressure in vivo, FASEB J., 19: 1755-1757.
23. McLaughlin T, Abbasi F, Cheal K, Chu J, Lamendola C, Reaven G (2003). Use of metabolic markers to identify overweight individuals who are insulin resistant, Ann. Intern. Med., 139: 802-809.
24. Monograph (2003). Astragalus membranaceus, Altern. Med. Rev., 8: 72-77.
25. Mooradian AD, Lung CC, Pinnas JL(1996), Glycosylation enhances malondialdehyde binding to proteins. Free Rad. Biol. Med., 21: 699.
26. Mooradian AD, Lung CC, Pinnas JL (1995), Cholesterol enriched diet enhances malondialdehyde modification of proteins in cerebral microvessels of rabbits. Neurosci. Lett., 185: 211.
27. Pan DD, Mei XM (2010). Antioxidant activity of an exopolysaccharide purified from Lactococcus lactis subsp. lactis 12. Carbohyd. Polym., 80: 908-914.
28. Park E, Shin JI, Park OJ, Kang MH (2005). Soy isoflavone supplementation alleviates oxidative stress and improves systolic blood pressure in male spontaneously hypertensive rats, J. Nutr. Sci. Vitaminol., (Tokyo) 51: 254-259.
29. Rocha KKR, Souza GA, Ebaid GX, Seiva FRF, Cataneo AC, Novelli ELB (2009). Resveratrol toxicity: Effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets. Food Chem. Toxicol., 47: 1362-1367.
30. Sacks FM, Lichtenstein A, Van HL, Harris W, Kris-Etherton P, Winston M (2006). Soy protein, isoflavones, and cardiovascular health. An American heart association science advisory for professionals from the nutrition committee, Circ., 113: 1034-1044.
31. Sefi M, Fetoui H, Makni M, Zeghal N (2010). Mitigating effects of antioxidant properties of Artemisia campestris leaf extract on hyperlipidemia, advanced glycation end products and oxidative stress in alloxan-induced diabetic rats. Food Chem. Toxicol., 48: 1986-1993.
32. Shah G, Pinnas JL, Lung CC, Mahmoud S, Mooradian AD (1994) Tissue specific distribution of malondialdehyde modified proteins in diabetes mellitus. Life Sci., 55: 1343.
33. Shiga TM, Cordenunsi BR, Lajolo FM. (2009). Effect of cooking on nonstarch polysaccharides of hard-to-cook beans. Carbohydr. Polymers., 76: 100-109.
34. Shuai XH, Hu TJ, Liu HL, Su ZJ, Zeng Y, Li YH (2010). Immunomodulatory effect of a Sophora subprosrate polysaccharide in mice. Int. J. Biol. Macromol., 46: 79-84.
35. Sun Y, Oberley LW, Li Y (1988). A simple method for clinical assay of superoxide dismutase, Clin. Chem., 34: 497-500.
36. Toda S, Shirataki Y (1999). Inhibitory effects of Astragali radix, a crude drug in oriental medicines, on lipid peroxidation and protein oxidative modifications by copper, J. Ethnopharmacol., 68: 331-333.
37. Trujillo J, Ramirez V, Perez J, Torre-Villalvazo I, Torres N, Tovar AR, Munoz RM, Uribe N, Gamba G, Bobadilla NA (2005). Renal protection by a soy diet in obese Zucker rats is associated with restoration of nitric oxide generation, Am. J. Physiol. Renal Physiol., 288: F108-F116.
38. Valko M, Leibfritz D, Moncol J, Cronin V, Mazur M, Telser J (2007). Free radicals and antioxidants in normal physiological functions and human disease, Int. J. Biochem. Cell. Biol., 39: 44-84.
39. Wang D, Shen W, Tian Y, Sun Z, Jiang C, Yuan S (1996). Protective effect of active components extracted from radix Astragali on human erythrocyte membrane damages caused by reactive oxygen species, Zhongguo Zhong Yao Za Zhi, 21: 746-748.