Anti-convulsant effect and mechanism of astragalus mongholicus extract in vitro and in vivo: Protection against oxidative damage and mitochondrial dysfunction

Neurochemical Research

Volumn 35, Issue 1, 2010, Pages 33-41

  Aldarmaa, Jalsrai ^a,b,c   Liu, Zhongbo ^b   Long, Jiangang ^a   Mo, Xiaoyan ^a   Ma, Jiangang ^a   Liu, Jiankang ^a,d  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^c Traditional Medicine Science Technology and Production Corporation   (Mongolia)

^d UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Hydroxyl radical; Lipid radical; Malate dehydrogenase; Mitochondrial enzyme complexes; Mitochondrial membrane potential; Oxidative stress

Indexed keywords

ASTRAGALUS EXTRACT; FREE RADICAL; HYDROXYL RADICAL; PENTETRAZOLE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASTRAGALUS MONGHOLICUS; ASTRAGALUS PLANT; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MECHANISM; DRUG POTENCY; ELECTRIC SHOCK; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; ENZYME INHIBITION; LIPID PEROXIDATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PLANT ROOT; PRIORITY JOURNAL; RAT; SCAVENGING SYSTEM; SEIZURE;

ANIMALS; ANTICONVULSANTS; ASTRAGALUS PLANT; BRAIN; ELECTRIC STIMULATION; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICAL SCAVENGERS; MALE; MICE; MICE, INBRED BALB C; MITOCHONDRIA; OXIDATIVE STRESS; PENTYLENETETRAZOLE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES;

ASTRAGALUS MONGHOLICUS; MUS;

EID: 76849105175     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-009-0027-4     Document Type: Article

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