Functional human tissue assays

Drug Discovery Today

Volumn 12, Issue 9-10, 2007, Pages 382-388

  Hillier, Chris ^a   Bunton, David ^a  

^a ReproCELL Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

NEW DRUG;

ADIPOSE TISSUE; BIOASSAY; BIOTECHNOLOGICAL PROCEDURES; BIOTECHNOLOGY; BLOOD VESSEL; DRUG DETERMINATION; DRUG EFFICACY; DRUG INDUSTRY; DRUG MECHANISM; DRUG RESEARCH; DRUG SAFETY; GASTROINTESTINAL MUCOSA; HEALTH CARE ORGANIZATION; HEART; HISTOCHEMISTRY; HUMAN; IN VIVO STUDY; INFLAMMATION; LUNG PARENCHYMA; MEMBRANE TRANSPORT; NERVOUS TISSUE; NONHUMAN; PATHOPHYSIOLOGY; QUALITY CONTROL; REVIEW; SKIN; UTERUS; VASCULAR TISSUE;

ANIMALS; BIOLOGICAL ASSAY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG INDUSTRY; HUMANS; PHARMACOLOGY, CLINICAL; TISSUE AND ORGAN HARVESTING;

EID: 34247511138     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2007.03.012     Document Type: Review

References (48)

1. Soldin S.J. Drug receptor assays: quo vadis?. Ann. Clin. Biochem. 29 (1992) 132-136
2. Garratini S. Toxic effects of chemicals: difficulties in extrapolating data from animals to man. Annu Rev Toxicol Pharmacol 16 (1985) 1-29
3. Olson H., et al. The predictivity of the toxicity of pharmaceuticals in humans from animal data - an interim assessment. Toxicol. Lett. 102-103 (1998) 535-538
4. Halpern W., et al. Mechanical properties of smooth muscle cells in the walls of arterial resistance vessels. J. Physiol. 275 (1978) 85-101
5. Buus N.H., et al. Nitric oxide, prostanoid and non-NO, non-prostanoid involvement in acetylcholine relaxation of isolated human small arteries. Br. J. Pharmacol. 129 (2000) 184-192
6. Johannssen V., et al. Alpha 1-receptors at pre-capillary resistance vessels of the human nasal mucosa. Rhinology 35 (1997) 161-165
7. Mulvany M.J., et al. Structure and function of small arteries. Physiol. Rev. 70 (1990) 921-961
8. Furchgott R.F., et al. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288 (1980) 373-376
9. Palmer R.M., et al. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327 (1987) 524-526
10. 2+ channels. J. Hypertens. 6 (1988) S188-S191
11. Sagar I.K., et al. The role of trace elements and phosphates in the synthesis of vascular-permeability factor by Vibrio cholerae. J. Med. Microbiol. 14 (1981) 243-250
12. Taylor S.G., et al. Endothelium-derived hyperpolarizing factor: a new endogenous inhibitor from the vascular endothelium. Trends Pharmacol. Sci. 9 (1988) 272-274
13. Danese S. Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Gastroenterology 130 (2006) 2060-2073
14. Orosz K.E., et al. Delivery of antiangiogenic and antioxidant drugs of ophthalmic interest through a nanoporous inorganic filter. Mol. Vis. 18 (2004) 555-565
15. Phung M.W., et al. In vitro and in vivo assays for angiogenesis - modulating drug discovery and development. J. Pharm. Pharmacol. 58 (2006) 153-160
16. Jung S.P., et al. Effect of human angiostatin protein on human angiogenesis in vitro. Angiogenesis 6 (2003) 233-240
17. de Jongste J.C., et al. Comparison of human bronchiolar smooth muscle responsiveness in vitro with histological signs of inflammation. Thorax 42 (1987) 870-876
18. Hulsmann A.R., et al. Studies of human airways in vitro: a review of the methodology. J. Pharmacol. Toxicol. Methods 30 (1993) 117-132
19. Armour C.L., et al. The lung parenchymal strip as a model of peripheral airway responsiveness. Bull. Eur. Physiopathol. Respir. 21 (1985) 545-549
20. Back M., et al. Effect of cold storage on cholinergic responses induced by electrical field stimulation in human bronchi. Pulm. Pharmacol. Ther. 19 (2006) 297-302
21. Tunon de Lara J.M., et al. IgE-induced passive sensitization of human isolated bronchi and lung mast cells. Eur. Respir. J. 8 (1995) 1861-1865
22. Opazo Saez A.M., et al. Peripheral airway smooth muscle mechanics in obstructive airways disease. Am. J. Respir. Crit. Care Med. 161 (2000) 910-917
23. Finney M.J., et al. Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation. Br. J. Pharmacol. 85 (1985) 29-36
24. Dow J.W., et al. Isolated cardiac myocytes. I. Preparation of adult myocytes and their homology with the intact tissue. Cardiovasc. Res. 15 (1981) 483-514
25. Lareau S., et al. An NMR probe to study function and metabolism simultaneously in isolated human cardiac tissue. Magn. Reson. Med. 20 (1991) 312-318
26. Knapp F.F., et al. Radiolabeled ligands for imaging the muscarinic-cholinergic receptors of the heart and brain. Anticancer Res. 17 (1997) 1559-1572
27. Koretsky A.P. Functional assessment of tissues with magnetic resonance imaging. (Repar Med). Ann. N. Y. Acad. Sci. 961 (2002) 203-205
28. 18F]-BQ3020: in vitro characterization and positron emission tomography (microPET). Exp. Biol. Med. 231 (2006) 736-740
29. Companjen A.R., et al. A modified ex vivo skin organ culture system for functional studies. Arch. Dermatol. Res. 293 (2001) 184-190
30. Ottaviani G., et al. Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. J. Med. Chem. 49 (2006) 3948-3954
31. Misfeldt D.S., et al. Transepithelial transport in cell culture. Proc. Natl. Acad. Sci. U. S. A. 73 (1976) 1212-1216
32. +-ATPase) and carbonic anhydrase II in the human eccrine sweat gland. J. Mol. Histol. 35 (2004) 339-345
33. Freiman T.M., et al. K(+)-evoked [(3)H]-norepinephrine release in human brain slices from epileptic and non-epileptic patients is differentially modulated by gabapentin and pinacidil. Neurosci. Res. 55 (2006) 204-210
34. Stopps M., et al. Design and application of a novel brain slice system that permits independent electrophysiological recordings from multiple slices. J. Neurosci. Methods 132 (2004) 137-148
35. Lappas M., et al. Leptin and adiponectin stimulate the release of proinflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via nuclear factor-kappaB, peroxisomal proliferator-activated receptor-gamma and extracellularly regulated kinase 1/2. Endocrinology 146 (2005) 3334-3342
36. Trujillo M.E., et al. Tumour necrosis factor alpha and glucocorticoid synergistically increase leptin production in human adipose tissue: role for p38 mitogen-activated protein kinase. J. Clin. Endocrinol. Metab. 91 (2006) 1484-1490
37. Lateef H., et al. All-trans-retinoic acid suppresses matrix metalloproteinase activity and increases collagen synthesis in diabetic human skin in organ culture. Am. J. Pathol. 165 (2004) 167-174
38. de Gruijl T.D., et al. A postmigrational switch among skin-derived dendritic cells to a macrophage-like phenotype is predetermined by the intracutaneous cytokine balance. J. Immunol. 176 (2006) 7232-7242
39. Ghelani A.M., et al. Response of human isolated bronchial and lung parenchymal strips to SRS-A and other mediators of asthmatic bronchospasm. Br. J. Pharmacol. 71 (1980) 107-112
40. Peters S.P., et al. Dispersed human lung mast cells. Pharmacologic aspects and comparison with human lung tissue fragments. Am. Rev. Respir. Dis. 126 (1982) 1034-1039
41. Allen D.D., et al. Cell lines as in vitro models for drug screening and toxicity studies. Drug Dev. Ind. Pharm. 31 (2005) 757-768
42. Muller-Schweinitzer E., and Fozard J.R. SCA 40: studies of the relaxant effects on cryopreserved airway and vascular smooth muscle. Br. J. Pharmacol. 120 (1997) 1241-1248
43. Pauwels M. Safety evaluation of cosmetics in the EU. Reality and challenges for the toxicologist. Toxicol. Lett. 151 (2004) 7-17
44. Office of Public Sector Information. Human Tissue Act 2004, HMSO (http://www.opsi.gov.uk/acts/acts2004/20040030.htm)
45. Food and Drug Administration, Department of Health and Human Services (1991) Code of Federal Regulations, Title 45 Public Welfare, Part 46 US Food and Drug Administration (FDA) Protection of Human Subjects (http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?C FRPart=50)
46. Office for Human Research Protections (2004). Human Subject Regulations Decision Charts (http://www.hhs.gov/ohrp/humansubjects/guidance/decisioncharts.htm)
47. National Bioethics Advisory Commission. Ethical and Policy Issues in Research Involving Human Subjects (2001), NBAC. http://www.bioethics.gov
48. Coats P., and Hillier C. Differential responses in human subcutaneous and skeletal muscle vascular beds to critical limb ischaemia. Eur. J. Vasc. Endovasc. Surg. 19 (2000) 387-395