메뉴 건너뛰기




Volumn 6, Issue 4, 2011, Pages

A cyclic undecamer peptide mimics a turn in folded alzheimer amyloid β and elicits antibodies against oligomeric and fibrillar amyloid and plaques

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; AMYLOID BETA PROTEIN[1-42]; CYCLO[AMYLOID BETA PROTEIN[1-42] TYROSYLASPARAGINYLGLYCYLLYSINE] CONJUGATE; CYCLO[AMYLOID BETA PROTEIN[1-42] TYROSYLASPARAGINYLGLYCYLLYSINE] TETANUS TOXOID CONJUGATE; CYCLOPEPTIDE; OLIGOMER; TETANUS TOXOID; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; ANTIBODY; ANTIGEN;

EID: 79955404847     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019110     Document Type: Article
Times cited : (14)

References (43)
  • 2
    • 33750705653 scopus 로고    scopus 로고
    • A century of Alzheimer's disease 1
    • Goedert M, Spillantini MG, (2006) A century of Alzheimer's disease 1. Science 314: 777-781.
    • (2006) Science , vol.314 , pp. 777-781
    • Goedert, M.1    Spillantini, M.G.2
  • 3
    • 57649148788 scopus 로고    scopus 로고
    • Structural classification of toxic amyloid oligomers
    • Glabe CG, (2008) Structural classification of toxic amyloid oligomers. J Biol Chem 283: 29639-29643.
    • (2008) J Biol Chem , vol.283 , pp. 29639-29643
    • Glabe, C.G.1
  • 4
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
    • Haass C, Selkoe DJ, (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 8: 101-112.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 5
    • 77955359909 scopus 로고    scopus 로고
    • Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies
    • Hillen H, Barghorn S, Striebinger A, Labkovsky B, Muller R, et al. (2010) Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies. J Neurosci 30: 10369-10379.
    • (2010) J Neurosci , vol.30 , pp. 10369-10379
    • Hillen, H.1    Barghorn, S.2    Striebinger, A.3    Labkovsky, B.4    Muller, R.5
  • 6
    • 2542455537 scopus 로고    scopus 로고
    • Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease
    • Klein WL, Stine WB Jr, Teplow DB, (2004) Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease. Neurobiol Aging 25: 569-580.
    • (2004) Neurobiol Aging , vol.25 , pp. 569-580
    • Klein, W.L.1    Stine Jr., W.B.2    Teplow, D.B.3
  • 8
    • 34248190279 scopus 로고    scopus 로고
    • A beta oligomers - a decade of discovery
    • Walsh DM, Selkoe DJ, (2007) A beta oligomers- a decade of discovery. J Neurochem 101: 1172-1184.
    • (2007) J Neurochem , vol.101 , pp. 1172-1184
    • Walsh, D.M.1    Selkoe, D.J.2
  • 9
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, et al. (1999) Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400: 173-177.
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3    Gordon, G.4    Grajeda, H.5
  • 10
    • 0036853548 scopus 로고    scopus 로고
    • Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease
    • Hock C, Konietzko U, Papassotiropoulos A, Wollmer A, Streffer J, et al. (2002) Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease. Nat Med 8: 1270-1275.
    • (2002) Nat Med , vol.8 , pp. 1270-1275
    • Hock, C.1    Konietzko, U.2    Papassotiropoulos, A.3    Wollmer, A.4    Streffer, J.5
  • 11
    • 20944448555 scopus 로고    scopus 로고
    • Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
    • Gilman S, Koller M, Black RS, Jenkins L, Griffith SG, et al. (2005) Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 64: 1553-1562.
    • (2005) Neurology , vol.64 , pp. 1553-1562
    • Gilman, S.1    Koller, M.2    Black, R.S.3    Jenkins, L.4    Griffith, S.G.5
  • 12
    • 40449086748 scopus 로고    scopus 로고
    • Progress in the active immunotherapeutic approach to Alzheimer's disease: clinical investigations into AN1792-associated meningoencephalitis
    • Pride M, Seubert P, Grundman M, Hagen M, Eldridge J, et al. (2008) Progress in the active immunotherapeutic approach to Alzheimer's disease: clinical investigations into AN1792-associated meningoencephalitis. Neurodegener Dis 5: 194-196.
    • (2008) Neurodegener Dis , vol.5 , pp. 194-196
    • Pride, M.1    Seubert, P.2    Grundman, M.3    Hagen, M.4    Eldridge, J.5
  • 13
    • 47949132196 scopus 로고    scopus 로고
    • Active and passive immunotherapy for neurodegenerative disorders 2
    • Brody DL, Holtzman DM, (2008) Active and passive immunotherapy for neurodegenerative disorders 2. Annu Rev Neurosci 31: 175-193.
    • (2008) Annu Rev Neurosci , vol.31 , pp. 175-193
    • Brody, D.L.1    Holtzman, D.M.2
  • 14
    • 60549112186 scopus 로고    scopus 로고
    • Immunization in Alzheimer's disease: naive hope or realistic clinical potential? 1
    • Foster JK, Verdile G, Bates KA, Martins RN, (2009) Immunization in Alzheimer's disease: naive hope or realistic clinical potential? 1. Mol Psychiatry 14: 239-251.
    • (2009) Mol Psychiatry , vol.14 , pp. 239-251
    • Foster, J.K.1    Verdile, G.2    Bates, K.A.3    Martins, R.N.4
  • 15
    • 36148936671 scopus 로고    scopus 로고
    • Immunotherapy as treatment for Alzheimer's disease
    • Hawkes CA, McLaurin J, (2007) Immunotherapy as treatment for Alzheimer's disease. Expert Rev Neurother 7: 1535-1548.
    • (2007) Expert Rev Neurother , vol.7 , pp. 1535-1548
    • Hawkes, C.A.1    McLaurin, J.2
  • 16
    • 42649120337 scopus 로고    scopus 로고
    • Immunological approaches for amyloid-beta clearance toward treatment for Alzheimer's disease
    • Solomon B, (2008) Immunological approaches for amyloid-beta clearance toward treatment for Alzheimer's disease. Rejuvenation Res 11: 349-357.
    • (2008) Rejuvenation Res , vol.11 , pp. 349-357
    • Solomon, B.1
  • 17
    • 67649662393 scopus 로고    scopus 로고
    • AD vaccines: conclusions and future directions 3
    • Wisniewski T, (2009) AD vaccines: conclusions and future directions 3. CNS Neurol Disord Drug Targets 8: 160-166.
    • (2009) CNS Neurol Disord Drug Targets , vol.8 , pp. 160-166
    • Wisniewski, T.1
  • 18
    • 33847297725 scopus 로고    scopus 로고
    • Vaccination strategies for Alzheimer's disease: A new hope?
    • Woodhouse A, Dickson TC, Vickers JC, (2007) Vaccination strategies for Alzheimer's disease: A new hope? Drugs Aging 24: 107-119.
    • (2007) Drugs Aging , vol.24 , pp. 107-119
    • Woodhouse, A.1    Dickson, T.C.2    Vickers, J.C.3
  • 19
    • 0037384333 scopus 로고    scopus 로고
    • Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid
    • Cribbs DH, Ghochikyan A, Vasilevko V, Tran M, Petrushina I, et al. (2003) Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid. Int Immunol 15: 505-514.
    • (2003) Int Immunol , vol.15 , pp. 505-514
    • Cribbs, D.H.1    Ghochikyan, A.2    Vasilevko, V.3    Tran, M.4    Petrushina, I.5
  • 20
    • 33344460820 scopus 로고    scopus 로고
    • Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch
    • Ghochikyan A, Mkrtichyan M, Petrushina I, Movsesyan N, Karapetyan A, et al. (2006) Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch. Vaccine 24: 2275-2282.
    • (2006) Vaccine , vol.24 , pp. 2275-2282
    • Ghochikyan, A.1    Mkrtichyan, M.2    Petrushina, I.3    Movsesyan, N.4    Karapetyan, A.5
  • 21
    • 41049108826 scopus 로고    scopus 로고
    • Successful adjuvant-free vaccination of BALB/c mice with mutated amyloid beta peptides
    • Cao C, Lin X, Wahi MM, Jackson EA, Potter H Jr, (2008) Successful adjuvant-free vaccination of BALB/c mice with mutated amyloid beta peptides. BMC Neurosci 9: 25.
    • (2008) BMC Neurosci , vol.9 , pp. 25
    • Cao, C.1    Lin, X.2    Wahi, M.M.3    Jackson, E.A.4    Potter Jr., H.5
  • 22
    • 67849130968 scopus 로고    scopus 로고
    • Developing novel immunogens for a safe and effective Alzheimer's disease vaccine 2
    • Lemere CA, (2009) Developing novel immunogens for a safe and effective Alzheimer's disease vaccine 2. Prog Brain Res 175: 83-93.
    • (2009) Prog Brain Res , vol.175 , pp. 83-93
    • Lemere, C.A.1
  • 23
    • 76849091134 scopus 로고    scopus 로고
    • Can Alzheimer disease be prevented by amyloid-beta immunotherapy?
    • Lemere CA, Masliah E, (2010) Can Alzheimer disease be prevented by amyloid-beta immunotherapy? Nat Rev Neurol 6: 108-119.
    • (2010) Nat Rev Neurol , vol.6 , pp. 108-119
    • Lemere, C.A.1    Masliah, E.2
  • 24
    • 63249137056 scopus 로고    scopus 로고
    • Development of Affitope Vaccines for Alzheimer's Disease (AD) - From Concept to Clinical Testing 1
    • Schneeberger A, Mandler M, Otawa O, Zauner W, Mattner F, et al. (2009) Development of Affitope Vaccines for Alzheimer's Disease (AD)- From Concept to Clinical Testing 1. J Nutr Health Aging 13: 264-267.
    • (2009) J Nutr Health Aging , vol.13 , pp. 264-267
    • Schneeberger, A.1    Mandler, M.2    Otawa, O.3    Zauner, W.4    Mattner, F.5
  • 25
    • 24644458809 scopus 로고    scopus 로고
    • Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies
    • Lee M, Bard F, Johnson-Wood K, Lee C, Hu K, et al. (2005) Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies. Ann Neurol 58: 430-435.
    • (2005) Ann Neurol , vol.58 , pp. 430-435
    • Lee, M.1    Bard, F.2    Johnson-Wood, K.3    Lee, C.4    Hu, K.5
  • 26
    • 3042692322 scopus 로고    scopus 로고
    • Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet
    • Lemere CA, Beierschmitt A, Iglesias M, Spooner ET, Bloom JK, et al. (2004) Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet. Am J Pathol 165: 283-297.
    • (2004) Am J Pathol , vol.165 , pp. 283-297
    • Lemere, C.A.1    Beierschmitt, A.2    Iglesias, M.3    Spooner, E.T.4    Bloom, J.K.5
  • 27
    • 77954957153 scopus 로고    scopus 로고
    • Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta
    • Vasilevko V, Pop V, Kim HJ, Saing T, Glabe CC, et al. (2010) Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Neurobiol Dis 39: 301-310.
    • (2010) Neurobiol Dis , vol.39 , pp. 301-310
    • Vasilevko, V.1    Pop, V.2    Kim, H.J.3    Saing, T.4    Glabe, C.C.5
  • 28
    • 33644851439 scopus 로고    scopus 로고
    • The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopy
    • Olofsson A, Sauer-Eriksson AE, Ohman A, (2006) The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopy. J Biol Chem 281: 477-483.
    • (2006) J Biol Chem , vol.281 , pp. 477-483
    • Olofsson, A.1    Sauer-Eriksson, A.E.2    Ohman, A.3
  • 29
    • 64549140676 scopus 로고    scopus 로고
    • Structural characterization of a soluble amyloid beta-peptide oligomer
    • Yu L, Edalji R, Harlan JE, Holzman TF, Lopez AP, et al. (2009) Structural characterization of a soluble amyloid beta-peptide oligomer. Biochemistry 48: 1870-1877.
    • (2009) Biochemistry , vol.48 , pp. 1870-1877
    • Yu, L.1    Edalji, R.2    Harlan, J.E.3    Holzman, T.F.4    Lopez, A.P.5
  • 30
    • 0242418197 scopus 로고    scopus 로고
    • Immunogenicity of peptide-vaccine candidates predicted by molecular dynamics simulations
    • Oomen CJ, Hoogerhout P, Bonvin AM, Kuipers B, Brugghe H, et al. (2003) Immunogenicity of peptide-vaccine candidates predicted by molecular dynamics simulations. J Mol Biol 328: 1083-1089.
    • (2003) J Mol Biol , vol.328 , pp. 1083-1089
    • Oomen, C.J.1    Hoogerhout, P.2    Bonvin, A.M.3    Kuipers, B.4    Brugghe, H.5
  • 31
    • 23644432855 scopus 로고    scopus 로고
    • Crystal structure of an Anti-meningococcal subtype P1.4 PorA antibody provides basis for peptide-vaccine design
    • Oomen CJ, Hoogerhout P, Kuipers B, Vidarsson G, van AL, et al. (2005) Crystal structure of an Anti-meningococcal subtype P1.4 PorA antibody provides basis for peptide-vaccine design. J Mol Biol 351: 1070-1080.
    • (2005) J Mol Biol , vol.351 , pp. 1070-1080
    • Oomen, C.J.1    Hoogerhout, P.2    Kuipers, B.3    Vidarsson, G.4    van, A.L.5
  • 32
    • 0038176528 scopus 로고    scopus 로고
    • In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis
    • Stine WB Jr, Dahlgren KN, Krafft GA, LaDu MJ, (2003) In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis. J Biol Chem 278: 11612-11622.
    • (2003) J Biol Chem , vol.278 , pp. 11612-11622
    • Stine Jr., W.B.1    Dahlgren, K.N.2    Krafft, G.A.3    LaDu, M.J.4
  • 33
    • 0028296432 scopus 로고
    • Simultaneous multiple synthesis and selective conjugation of cyclized peptides derived from a surface loop of a meningococcal class 1 outer membrane protein
    • Brugghe HF, Timmermans HA, Van Unen LM, Ten Hove GJ, Van de Werken G, et al. (1994) Simultaneous multiple synthesis and selective conjugation of cyclized peptides derived from a surface loop of a meningococcal class 1 outer membrane protein. Int J Pept Protein Res 43: 166-172.
    • (1994) Int J Pept Protein Res , vol.43 , pp. 166-172
    • Brugghe, H.F.1    Timmermans, H.A.2    van Unen, L.M.3    Ten Hove, G.J.4    van de Werken, G.5
  • 34
    • 79955419857 scopus 로고    scopus 로고
    • Methods of preparing peptide-carrier conjugates
    • In: Chan WC, White PD, editors, Oxford University Press
    • Drijfhout JW, Hoogerhout P, (2000) Methods of preparing peptide-carrier conjugates. In: Chan WC, White PD, editors. Fmoc Solid Phase Peptide Synthesis: A Practical Approach: Oxford University Press pp. 229-241.
    • (2000) Fmoc Solid Phase Peptide Synthesis: A Practical Approach: , pp. 229-241
    • Drijfhout, J.W.1    Hoogerhout, P.2
  • 35
    • 47149112621 scopus 로고    scopus 로고
    • Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial 1
    • Holmes C, Boche D, Wilkinson D, Yadegarfar G, Hopkins V, et al. (2008) Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial 1. Lancet 372: 216-223.
    • (2008) Lancet , vol.372 , pp. 216-223
    • Holmes, C.1    Boche, D.2    Wilkinson, D.3    Yadegarfar, G.4    Hopkins, V.5
  • 36
    • 33646066257 scopus 로고    scopus 로고
    • Amyloid-beta immunotherapy for the prevention and treatment of Alzheimer disease: lessons from mice, monkeys, and humans
    • Lemere CA, Maier M, Jiang L, Peng Y, Seabrook TJ, (2006) Amyloid-beta immunotherapy for the prevention and treatment of Alzheimer disease: lessons from mice, monkeys, and humans. Rejuvenation Res 9: 77-84.
    • (2006) Rejuvenation Res , vol.9 , pp. 77-84
    • Lemere, C.A.1    Maier, M.2    Jiang, L.3    Peng, Y.4    Seabrook, T.J.5
  • 37
    • 70350061949 scopus 로고    scopus 로고
    • Multimodal techniques for diagnosis and prognosis of Alzheimer's disease
    • Perrin RJ, Fagan AM, Holtzman DM, (2009) Multimodal techniques for diagnosis and prognosis of Alzheimer's disease. Nature 461: 916-922.
    • (2009) Nature , vol.461 , pp. 916-922
    • Perrin, R.J.1    Fagan, A.M.2    Holtzman, D.M.3
  • 38
    • 78649264552 scopus 로고    scopus 로고
    • The art of brain banking in Europe: ethical, legal and practical guidelines for donor recruitment, tissue handling and tissue distribution
    • Huitinga I, Rademaker M, Klioueva N, (2008) The art of brain banking in Europe: ethical, legal and practical guidelines for donor recruitment, tissue handling and tissue distribution. J Neural Transm 115: 1715.
    • (2008) J Neural Transm , vol.115 , pp. 1715
    • Huitinga, I.1    Rademaker, M.2    Klioueva, N.3
  • 40
    • 0028361169 scopus 로고
    • The presence or absence of a vimentin-type intermediate filament network affects the shape of the nucleus in human SW-13 cells
    • Sarria AJ, Lieber JG, Nordeen SK, Evans RM, (1994) The presence or absence of a vimentin-type intermediate filament network affects the shape of the nucleus in human SW-13 cells. J Cell Sci 107 (Pt 6): 1593-1607.
    • (1994) J Cell Sci , vol.107 , Issue.Pt 6 , pp. 1593-1607
    • Sarria, A.J.1    Lieber, J.G.2    Nordeen, S.K.3    Evans, R.M.4
  • 41
    • 79955379601 scopus 로고    scopus 로고
    • Development and optimization of a quantitative Western blot and dot blot procedure for the determination of residual host cell proteins present in inactivated polio vaccine using GZ11 based signal reagent
    • In: Shen X, Yang XL, Zhang XR, Cui ZJ, Kricka LJ, editors, Biology and Scientific Applications: World Scientific
    • Zomer G, Hamzink M, de Haan A, Kersten G, Reubsaet K, (2009) Development and optimization of a quantitative Western blot and dot blot procedure for the determination of residual host cell proteins present in inactivated polio vaccine using GZ11 based signal reagent. In: Shen X, Yang XL, Zhang XR, Cui ZJ, Kricka LJ, editors. Bioluminescence and Chemiluminescence Light Emission: Biology and Scientific Applications: World Scientific pp. 287-290.
    • (2009) Bioluminescence and Chemiluminescence Light Emission: , pp. 287-290
    • Zomer, G.1    Hamzink, M.2    de Haan, A.3    Kersten, G.4    Reubsaet, K.5
  • 42
    • 0030753890 scopus 로고    scopus 로고
    • Quantification of cell-associated and free antigens in Bordetella pertussis suspensions by antigen binding ELISA
    • Westdijk J, van den IJssel J, Thalen M, Beuvery C, Jiskoot W, (1997) Quantification of cell-associated and free antigens in Bordetella pertussis suspensions by antigen binding ELISA. J Immunoassay 18: 267-284.
    • (1997) J Immunoassay , vol.18 , pp. 267-284
    • Westdijk, J.1    van den IJssel, J.2    Thalen, M.3    Beuvery, C.4    Jiskoot, W.5
  • 43
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E, (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82: 239-259.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.