Phosphodiesterase-5A (PDE5A) is localized to the endothelial caveolae and modulates NOS3 activity

Cardiovascular Research

Volumn 90, Issue 2, 2011, Pages 353-363

  Gebska, Milena A ^a,b   Stevenson, Blake K ^a   Hemnes, Anna R ^c   Bivalacqua, Trinity J ^d   Haile, Azeb ^a   Hesketh, Geoffrey G ^a   Murray, Christopher I ^a   Zaiman, Ari L ^a   Halushka, Marc K ^d   Krongkaew, Nispa ^d   Strong, Travis D ^a   Cooke, Carol A ^a   El Haddad, Hazim ^a   Tuder, Rubin M ^f   Berkowitz, Dan E ^d   Champion, Hunter C ^a,d,e  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DEPARTMENT OF PATHOLOGY   (United States)

^e UNIVERSITY OF PITTSBURGH   (United States)

^f UNIVERSITY OF COLORADO   (United States)

Author keywords

Adenoviral transfection; Caveolin 1; cGMP; Endothelial cells; Lipid rafts; NOS3; PDE5A; Phosphodiesterase; Primary human endothelial cells; Pulmonary circulation; Signalling pathway; Sildenafil

Indexed keywords

ADENOVIRUS VECTOR; CAVEOLIN; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 5A; PHOSPHODIESTERASE INHIBITOR; PROTEIN KINASE; PROTEIN KINASE 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD FLOW; CAVEOLA; CELL CULTURE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FEEDBACK SYSTEM; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LIPID RAFT; LUNG CIRCULATION; LUNG ENDOTHELIUM; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PULMONARY HYPERTENSION; SECOND MESSENGER; UPREGULATION; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; AORTA; CATTLE; CAVEOLAE; CELLS, CULTURED; CORONARY VESSELS; CYCLIC GMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; ENDOTHELIAL CELLS; HUMANS; HYPERTENSION, PULMONARY; MEMBRANE MICRODOMAINS; MICE; NITRIC OXIDE SYNTHASE TYPE III; PULMONARY ARTERY; SIGNAL TRANSDUCTION; UMBILICAL VEINS; VASODILATION;

EID: 79955396915     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvq410     Document Type: Article

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