Role of carnitine acetyltransferases in acetyl coenzyme a metabolism in Aspergillus nidulans

Eukaryotic Cell

Volumn 10, Issue 4, 2011, Pages 547-555

  Hynes, Michael J ^a   Murray, Sandra L ^a   Andrianopoulos, Alex ^a   Davis, Meryl A ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; CARNITINE ACETYLTRANSFERASE; FUNGAL PROTEIN; HYBRID PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; ASPERGILLUS NIDULANS; FUNGAL GENE; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR GENETICS; SEQUENCE ALIGNMENT;

ACETYL COENZYME A; AMINO ACID SEQUENCE; ASPERGILLUS NIDULANS; CARNITINE O-ACETYLTRANSFERASE; FUNGAL PROTEINS; GENES, FUNGAL; MOLECULAR SEQUENCE DATA; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT;

EMERICELLA NIDULANS;

EID: 79955394579     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00295-10     Document Type: Article

References (72)

1. Antonenkov, V. D., and J. K. Hiltunen. 2006. Peroxisomal membrane permeability and solute transfer. Biochim. Biophys. Acta 1763:1697-16706.
2. Antonenkov, V. D., S. Mindthoff, S. Grunau, R. Erdmann, and J. K. Hil-tunen. 2009. An involvement of yeast peroxisomal channels in transmem-brane transfer of glyoxylate cycle intermediates. Int. J. Biochem. Cell Biol. 41:2546-2554.
3. Armitt, S., W. McCullough, and C. F. Roberts. 1976. Analysis of acetate non-utilizing (acu) mutants in Aspergillus nidulans. J. Gen. Microbiol. 92: 263-282.
4. Bhambra, G. K., Z.-Y. Wang, D. M. Soanes, G. E. Wakley, and N. J. Talbot. 2006. Peroxisomal carnitine acetyl transferase is required for elaboration of penetration hyphae during plant infection by Magnaporthe grisea. Mol. Microbiol. 61:46-60.
5. Brocard, C., and A. Hartig. 2006. Peroxisome targeting signal 1: is it really a simple tripeptide? Biochim. Biophys. Acta 1763:1565-1573.
6. Brock, M. 2005. Generation and phenotypic characterization of Aspergillus nidulans methylisocitrate lyase deletion mutants: methylisocitrate inhibits growth and conidiation. Appl. Environ. Microbiol. 71:5465-5475.
7. Brock, M. 2009. Fungal metabolism in host niches. Curr. Opin. Microbiol. 12:371-376.
8. Brock, M., R. Fischer, D. Linder, and W. Buckel. 2000. Methylcitrate syn-thase from Aspergillus nidulans: implications for propionate as an antifungal agent. Mol. Microbiol. 35:961-973.
9. Caracuel-Riosa, Z., and N. J. Talbot. 2007. Cellular differentiation and host invasion by the rice blast fungus Magnaporthe grisea. Curr. Opin. Microbiol. 10:339-345.
10. Carman, A. J., S. Vylkova, and M. C. Lorenz. 2008. Role of acetyl coenzyme A synthesis and breakdown in alternative carbon source utilization in Candida albicans. Eukaryot. Cell 7:1733-1741.
11. Claros, M. G., and P. Vincens. 1996. Computational method to predict mitochondrially imported proteins and their targeting sequences. Eur. J. Biochem. 241:779-786.
12. De Lucas, J. R., A. I. Dominguez, S. Valenciano, G. Turner, and F. Laborda. 1999. The acuH gene of Aspergillus nidulans, required for growth on acetate and long-chain fatty acids, encodes a putative homologue of the mammalian carnitine/acylcarnitine carrier. Arch. Microbiol. 171:386-396.
13. De Lucas, J. R., et al. 2001. The Aspergillus nidulans carnitine carrier encoded by the acuH gene is exclusively located in the mitochondria. FEMS Microbiol. Lett. 201:193-198.
14. Dunn, M. F., J. A. Ramírez-Trujillo, and I. Hernandez-Lucas. 2009. Major roles of isocitrate lyase and malate synthase in bacterial and fungal patho-genesis. Microbiology 155:3166-3175.
15. Elgersma, Y., C. W. van Roermund, R. J. Wanders, and H. F. Tabak. 1995. Peroxisomal and mitochondrial carnitine acetyltransferases of Saccharomy-ces cerevisiae are encoded by a single gene. EMBO J. 14:3472-3479.
16. Emanuelsson, O., S. Brunak, G. von Heijne, and H. Nielsen. 2007. Locating proteins in the cell using TargetP, SignalP, and related tools. Nat. Protoc. 2:953-971.
17. Fleck, C. B., and M. Brock. 2008. Characterization of an acyl-CoA:carbox-ylate CoA-transferase from Aspergillus nidulans involved in propionyl-CoA detoxification. Mol. Microbiol. 68:642-656.
18. Fleck, C. B., and M. Brock. 2009. Re-characterisation of Saccharomyces cerevisiae Ach1p: fungal CoA-transferases are involved in acetic acid detoxification. Fungal Genet. Biol. 46:473-485.
19. Franken, J., S. Kroppenstedt, J. H. Swiegers, and F. F. Bauer. 2008. Carnitine and carnitine acetyltransferases in the yeast Saccharomyces cerevisiae: a role for carnitine in stress protection. Curr. Genet. 53:347-360.
20. Gordon, J. L., K. P. Byrne1, and K. H. Wolfe. 2009. Additions, losses, and rearrangements on the evolutionary route from a reconstructed ancestor to the modern Saccharomyces cerevisiae genome. PLoS Genet. 5:e1000485.
21. Grunau, S., et al. 2009. Channel-forming activities of peroxisomal membrane proteins from the yeast Saccharomyces cerevisiae. FEBS J. 276:1698-1708.
22. Haurie, V., et al. 2001. The transcriptional activator Cat8p provides a major contribution to the reprogramming of carbon metabolism during the diauxic shift in Saccharomyces cerevisiae. J. Biol. Chem. 276:76-85.
23. Hettema, E. H., and H. F. Tabak. 2000. Transport of fatty acids and metabolites across the peroxisomal membrane. Biochim. Biophys. Acta 1486:18-27.
24. Hiltunen, J. K., et al. 2003. The biochemistry of peroxisomal 3-oxidation in the yeast Saccharomyces cerevisiae. FEMS Microbiol. Rev. 27:35-64.
25. Hynes, M. J. 1977. Induction of the acetamidase of Aspergillus nidulans by acetate metabolism. J. Bacteriol. 131:770-775.
26. Hynes, M. J., and S. L. Murray. 2010. ATP-citrate lyase is required for production of cytosolic acetyl coenzyme A and development in Aspergillus nidulans. Eukaryot. Cell 9:1039-1048.
27. Hynes, M. J., et al. 2007. Transcriptional control of gluconeogenesis in Aspergillus nidulans. Genetics 176:139-150.
28. Hynes, M. J., S. L. Murray, A. Duncan, G. S. Khew, and M. A. Davis. 2006. Regulatory genes controlling fatty acid catabolism and peroxisomal functions in the filamentous fungus, Aspergillus nidulans. Eukaryot. Cell 5:794-805.
29. Hynes, M. J., S. L. Murray, G. S. Khew, and M. A. Davis. 2008. Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans. Genetics 178:1355-1369.
30. Kohlhaw, G. B., and A. Tan-Wilson. 1977. Carnitine acetyltransferase: candidate for the transfer of acetyl groups through the mitochondrial membrane of yeast. J. Bacteriol. 129:1159-1171.
31. Kunze, M., F. Kragler, M. Binder, A. Hartig, and A. Gurvitz. 2002. Targeting of malate synthase 1 to the peroxisomes of Saccharomyces cerevisiae cells depends on growth on oleic acid medium. Eur. J. Biochem. 269:915-922.
32. Kunze, M., I. Pracharoenwattana, S. M. Smith, and A. Hartig. 2006. A central role for the peroxisomal membrane in glyoxylate cycle function. Biochim. Biophys. Acta 1763:1441-1452.
33. Lavoie, H., H. Hogues, and M. Whiteway. 2009. Rearrangements of the transcriptional regulatory networks of metabolic pathways in fungi. Curr. Opin. Microbiol. 12:655-663.
34. Lorenz, M. C, J. A. Bender, and G. R. Fink. 2004. Transcriptional response of Candida albicans upon internalization by macrophages. Eukaryot. Cell 3:1076-1087.
35. Lorenz, M. C, and G. R. Fink. 2002. Life and death in a macrophage: role of the glyoxylate cycle in virulence. Eukaryot. Cell 1:657-662.
36. Maggio-Hall, L. A., and N. P. Keller. 2004. Mitochondrial 3-oxidation in Aspergillus nidulans. Mol. Microbiol. 54:1173-1185.
37. McCammon, M. T. 1996. Mutants of Saccharomyces cerevisiae with defects in acetate metabolism: isolation and characterization of Acn mutants. Genetics 144:57-69.
38. Midgley, M. 1993. Carnitine acetyltransferase is absent from acuJ mutants of Aspergillus nidulans. FEMS Microbiol. Lett. 108:7-10.
39. Murray, S. L., and M. J. Hynes. 2010. Metabolic and developmental effects resulting from deletion of the citA gene encoding citrate synthase in Aspergillus nidulans. Eukaryot. Cell 9:656-666.
40. Nayak, T., et al. 2006. A versatile and efficient gene-targeting system for Aspergillus nidulans. Genetics 172:1557-1566.
41. Ntamack, A. G., I. V. Karpichev, S. J. Gould, G. M. Small, and H. Schulz. 2009. Oleate beta-oxidation in yeast involves thioesterase but not Yor180c protein that is not a dienoyl-CoA isomerase. Biochim. Biophys. Acta 1791: 371-378.
42. Palmieri, L., et al. 1999. Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae. FEBS Lett. 462:472-476.
43. Palmieri, L., et al. 2001. Identification and functional reconstitution of the yeast peroxisomal adenine nucleotide transporter. EMBO J. 20:5049-5059.
44. Palmieri, L., M. J. Runswick, G. Fiermonte, J. E. Walker, and F. Palmieri. 2000. Yeast mitochondrial carriers: bacterial expression, biochemical identification and metabolic significance. J. Bioenerg. Biomembr. 32:67-77.
45. Petriv, O. I., L. Tang, V. I. Titorenko, and R. A. Rachubinski. 2004. A new definition for the consensus sequence of the peroxisome targeting signal type 2. J. Mol. Biol. 341:119-134.
46. Piekarska, K., et al. 2006. Peroxisomal fatty acid beta oxidation is not essential for virulence of Candida albicans. Eukaryot. Cell 5:1847-1856.
47. Piekarska, K., et al. 2008. The activity of the glyoxylate cycle in peroxisomes of Candida albicans depends on a functional beta-oxidation pathway: evidence for reduced metabolite transport across the peroxisomal membrane. Microbiology 154:3061-3072.
48. Ramirez, M. A., and M. C. Lorenz. 2007. Mutations in alternative carbon utilization pathways in Candida albicans attenuate virulence and confer pleiotropic phenotypes. Eukaryot. Cell 6:280-290.
49. Ramirez, M. A., and M. C. Lorenz. 2009. The transcription factor homolog CTF1 regulates beta-oxidation in Candida albicans. Eukaryot. Cell 8:1604- 1614.
50. Ramos-Pamplona, M., and N. I. Naqvi. 2006. Host invasion during rice-blast disease requires carnitine-dependent transport of peroxisomal acetyl-CoA. Mol. Microbiol. 61:61-75.
51. Rottensteiner, H., A. J. Kal, B. Hamilton, H. Ruis, and H. F. Tabak. 1997. A heterodimer of the Zn2Cys6 transcription factors Pip2p and Oaf1p controls induction of genes encoding peroxisomal proteins in Saccharomyces cerevi-siae. Eur. J. Biochem. 247:776-783.
52. Rottensteiner, H., and F. L. Theodoulou. 2006. The ins and outs of peroxi-somes: co-ordination of membrane transport and peroxisomal metabolism. Biochim. Biophys. Acta 1763:1527-1540.
53. Roze, L. V., A. Chanda, and J. E. Linz. 2011. Compartmentalization and molecular traffic in secondary metabolism: a new understanding of established cellular processes. Fungal Genet. Biol. 48:35-48.
54. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
55. Schuller, H.-J. 2003. Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae. Curr. Genet. 43:139-160.
56. Starai, V. J., and J. C. Escalante-Semerena. 2004. Acetyl-coenzyme A syn-thetase (AMP forming). Cell. Mol. Life Sci. 61:2020-2030.
57. Stemple, C. J., M. A. Davis, and M. J. Hynes. 1998. The facC gene of Aspergillus nidulans encodes an acetate-inducible carnitine acetyltransferase. J. Bacteriol. 180:6242-6251.
58. Strijbis, K., et al. 2010. Contributions of carnitine acetyl-transferases to intracellular acetyl unit transport in Candida albicans. J. Biol. Chem. 285: 24335-24346.
59. Strijbis, K., et al. 2008. Carnitinedependent transport of acetyl coenzyme A in Candida albicans is essential for growth on nonfermentable carbon sources and contributes to biofilm formation. Eukaryot. Cell 7:610-618.
60. Swiegers, J. H., N. Dippenaar, I. S. Pretorius, and F. F. Bauer. 2001. Car-nitine-dependent metabolic activities in Saccharomyces cerevisiae: three car-nitine acetyltransferases are essential in a carnitine-dependent strain. Yeast 18:585-595.
61. Szewczyk, E., A. Andrianopoulos, M. A. Davis, and M. J. Hynes. 2001. A single gene produces mitochondrial, cytoplasmic, and peroxisomal NADP dependent isocitrate dehydrogenase in Aspergillus nidulans. J. Biol. Chem. 276:37722-37729.
62. Tachibana, C., et al. 2005. Combined global localization analysis and tran-scriptome data identify genes that are directly coregulated by Adr1 and Cat8. Mol. Cell. Biol. 25:2138-2146.
63. Takahashi, H., J. M. McCaffery, R. A. Irizarry, and J. D. Boeke. 2006. Nucleocytosolic acetyl-coenzyme A synthetase is required for histone acet-ylation and global transcription. Mol. Cell 23:207-217.
64. Thompson, J. D., D. G. Higgins, and T. J. Gibson. 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.
65. Todd, R. B., A. Andrianopoulos, M. A. Davis, and M. J. Hynes. 1998. FacB, the Aspergillus nidulans activator of acetate utilization genes, binds dissimilar DNA sequences. EMBO J. 17:2042-2054.
66. Todd, R. B., J. A. Fraser, K. H. Wong, M. A. Davis, and M. J. Hynes. 2005. Nuclear accumulation of the GATA factor AreA in response to complete nitrogen starvation by regulation of nuclear export. Eukaryot. Cell 4:1646- 1653.
67. Todd, R. B., M. A. Davis, and M. J. Hynes. 2007. Genetic manipulation of Aspergillus nidulans: meiotic progeny for genetic analysis and strain construction. Nat. Protoc. 2:811-821.
68. van Roermund, C. W., E. H. Hettema, M. van den Berg, H. F. Tabak, and R. J. Wanders. 1999. Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p. EMBO J. 18:5843-5852.
69. van Roermund, C. W., et al. 2001. Identification of a peroxisomal ATP carrier required for medium-chain fatty acid beta-oxidation and normal peroxisome proliferation in Saccharomyces cerevisiae. Mol. Cell. Biol. 21: 4321-4329.
70. van Roermund, C. W. T., Y. Elgersma, N. Singh, R. J. A. Wanders, and H. Tabak. 1995. The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions. EMBO J. 14:3480-3486.
71. Young, E. T., K. M. Dombek, C. Tachibana, and T. Ideker. 2003. Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8. J. Biol. Chem. 278:26146-26158.
72. Zhou, H., and M. C. Lorenz. 2008. Carnitine acetyltransferases are required for growth on non-fermentable carbon sources but not for pathogenesis in Candida albicans. Microbiology 154:500-509.