Mitochondrial β-oxidation in Aspergillus nidulans

Molecular Microbiology

Volumn 54, Issue 5, 2004, Pages 1173-1185

  Maggio Hall, Lori A ^a   Keller, Nancy P ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BUTENOYL COENZYME A HYDRATASE; BACTERIAL PROTEIN; ENOYL COENZYME A HYDRATASE; GREEN FLUORESCENT PROTEIN; ISOLEUCINE; LACTOSE; LONG CHAIN FATTY ACID; PROTEIN ECHA; PROTEIN FOXA; RED FLUORESCENT PROTEIN; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG; VALINE; VERY LONG CHAIN FATTY ACID;

ARTICLE; ASPERGILLUS NIDULANS; CELL ORGANELLE; ENZYME ACTIVITY; FATTY ACID OXIDATION; FUNGUS GROWTH; FUNGUS MUTANT; MITOCHONDRIAL RESPIRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PEROXISOME; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; YEAST;

ACYL COENZYME A; ASPERGILLUS NIDULANS; ENOYL-COA HYDRATASE; FATTY ACIDS; FUNGAL PROTEINS; GENE DELETION; GENES, FUNGAL; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; ISOLEUCINE; LACTOSE; LUMINESCENT PROTEINS; MITOCHONDRIA; MULTIENZYME COMPLEXES; OXIDATION-REDUCTION; PEROXISOMES; RECOMBINANT FUSION PROTEINS; VALINE;

ASPERGILLUS; BACTERIA (MICROORGANISMS); EMERICELLA NIDULANS; FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 9644294511     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2004.04340.x     Document Type: Article

References (66)

1. Altschul, S.F., Gish, W., Miller, W., Myers, E.W., and Lipman, D.J. (1990) Basic local alignment search tool. J Mol Biol 215: 403-410.
2. Amor, C., Dominguez, A.I., De Lucas, J.R., and Laborda, F. (2000) The catabolite inactivation of Aspergillus nidulans isocitrate lyase occurs by specific autophagy of peroxisomes. Arch Microbiol 174: 59-66.
3. Andresen, B.S., Christensen, E., Corydon, T.J., Bross, P., Pilgaard, B., Wanders, R.J., et al. (2000) Isolated 2-methylbutyrylglycinuria caused by short/branched-chain acyl-CoA dehydrogenase deficiency: identification of a new enzyme defect, resolution of its molecular basis, and evidence for distinct acyl-CoA dehydrogenases in isoleucine and valine metabolism. Am J Hum Genet 67: 1095-1103.
4. Bachhawat, B.K., Coon, M.J., Kupiecki, F.P., Nagle, R., and Robinson, W.G. (1957) Coenzyme A thiol esters of isobutyric, methacrylic, and beta-hydroxyisobutyric acids as intermediates in the enzymatic degradation of valine. J Biol Chem 224: 1-11.
5. Baltazar, M.F., Dickinson, M., and Ratledge, C. (1999) Oxidation of medium-chain acyl-CoA esters by extracts of Aspergillus niger. enzymology and characterization of intermediates by HPLC. Microbiology 145: 271-278.
6. Binstock, J.P., Pramalik, A., and Schulz, H. (1977) Isolation of a multienzyme complex of fatty acid oxidation from Escherichia coli. Proc Natl Acad Sci USA 74: 492-495.
7. Black, P.M., and DiRusso, C.C. (2003) Transmembrane movement of exogenous long-chain fatty acids: proteins, enzymes and vectorial esterification. Microbiol Mol Biol Rev 67: 454-472.
8. Bok, J.W., and Keller, N.P. (2004) LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot Cell 3: 527-535.
9. Brown, G.K., Hunt, S.M., Scholem, R., Fowler, K., Grimes, A., Mercer, J.P., et al. (1982) β-Hydroxyisobutyryl coenzyme A deacylase deficiency: a defect in valine metabolism associated with physical malformations. Pediatrics 70: 532-538.
10. Campbell, R.E., Tour, O., Palmer, A.E., Steinbach, P.A., Baird, G.S., Zacharias, D.A., and Tsien, R.Y. (2002) A monomeric red fluorescent protein. Proc Natl Acad Sci USA 99: 7877-7882.
11. Coates, P.M., and Tanaka, K. (1992) Molecular basis of mitochondrial fatty acid oxidation defects. J Lipid Res 33: 1099-1110.
12. De Lucas, J.R., Valenciano, S., Dominguez, A.I., Turner, G., and Laborda, F. (1997) Characterization of oleate-nonutilizing mutants of Aspergillus nidulans isolated by the 3-amino-1,2,4-triazole positive selection method. Arch Microbiol 168: 504-512.
13. Fong, U.C., and Schulz, H. (1977) Purification and properties of pig heart crotonase and the presence of short chain and long chain enoyl coenzyme A hydratase in pig and guinea pig tissues. J Biol Chem 252: 542-547.
14. Frerman, F.E. (1988) Acyl-CoA dehydrogenases, electron transfer flavoprotein and electron transfer flavoprotein dehydrogenase. Biochem Soc Trans 16: 416-418.
15. Gibson, K.M., Burlingame, T.G., Hogema, B., Jakobs, C., Schutgens, R.B., Millington, D., et al. (2000) 2-Methylbu-tyryl-coenzyme A dehydrogenase deficiency: a new inborn error of 1-isoleucine metabolism. Pediatr Res 47: 830-833.
16. Gould, S.J., Keller, G.A., and Subramani, S. (1987) Identification of a peroxisomal targeting signal at the carboxy terminus of firefly luciferase. J Cell Biol 105: 2923-2931.
17. Guerra, C., Koza, R.A., Walsh, K., Kurtz, D.M., Wood, P.A., and Kozak, L.P. (1998) Abnormal nonshivering thermo-genesis in mice with inherited defects of fatty acid oxidation. J Clin Invest 102: 1724-1731.
18. Man, K.H., Seo, J.A., and Yu, J.H. (2004) A putative G protein-coupled receptor negatively controls sexual development in Aspergillus nidulans. Mol Microbiol 51: 1333-1345.
19. Hashimoto, T. (2000) Peroxisomal β-oxidation enzymes. Cell Biochem Biophys 32: 63-72.
20. Hillgartner, F.B., and Charron, T. (1997) Arachidonate and medium-chain fatty acids inhibit transcription of the acetyl-CoA carboxylase gene in hepatocytes in culture. J Lipid Res 38: 2548-2557.
21. Hiltunen, U.K., Wenzel, B., Beyer, A., Erdmann, R., Fosså, A., and Kunau, W.H. (1992) Peroxisomal multifunctional beta-oxidation protein of Saccharomyces cerevisiae. Molecular analysis of the fox2 gene and gene product. J Biol Chem 267: 6646-6653.
22. Hynes, M.J., and Kelly, J.M. (1977) Pleiotrophic mutants of Aspergillus nidulans in carbon metabolism. Mol Gen Genet 150: 193-204.
23. Ikeda, Y., Dabrowski, C., and Tanaka, K. (1983) Separation and properties of five distinct acyl-coA dehydrogenases from rat liver mitochondria. J Biol Chem 258: 1066-1076.
24. Ikeda, Y., Okamura-Ikeda, K., and Tanaka, K. (1985) Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. J Biol Chem 260: 1311-1325.
25. Juarez, M.P., and Napolitano, R. (2000) Effects of organic acids on lipid synthesis and ecdysis in Triatoma infestans eggs. Comp Biochem Physiol B Biochem Mol Biol 125: 503-510.
26. Käfer, E. (1977) Meiotic and mitotic recombination in Aspergillus and its chromosomal aberrations. In Advances in Genetics, Vol. 19. Caspari, E.W. (ed). London: Academic Press, pp. 33-67.
27. Kawasaki, L., Farres, A., and Aguirre, J. (1995) Aspergillus nidulans mutants affected in acetate metabolism isolated as lipid nonutilizers. Exp Mycol 19: 81-85.
28. Kulmburg, P., Mathieu, M., Dowzer, C.E.A., Kelly, J.M., and Felenbok, B. (1993) Specific binding sites in the alcR and alcA promoters of the ethanol regulon for the CreA repressor mediating carbon catabolite repression in Aspergillus nidulans. Mol Microbiol 7: 847-857.
29. Kunau, W.H., Buhne, S., de la Garza, M., Kionka, C., Mateblowski, M., Schultz-Borchard, U., and Thieringer, R. (1988) Comparative enzymology of β-oxidation. Biochem Soc Trans 16: 418-420.
30. Kunau, W.H., Dommes, V., and Schulz, H. (1995) β-oxidation of fatty acids in mitochondria, peroxisomes, and bacteria: a century of continued progress. Prog Lipid Res 34: 267-342.
31. Kurihara, T., Ueda, M., Okada, H., Kamasawa, N., Naito, N., Osumi, M., and Tanaka, A. (1992) β-Oxidation of butyrate, the short-chain-length fatty acid, occurs in peroxisomes in the yeast Candida tropicalis. J Biochem 111: 783-787.
32. Ledley, F.D., Crane, A.M., Klish, K.T., and May, G.S. (1991) Is there methylmalonyl CoA mutase in Aspergillus nidulans? Biochem Biophys Res Commun 177: 1076-1081.
33. Liang, X., Le, W., Zhang, D., and Schulz, H. (2001) Impact of the intramitochondrial enzyme organization on fatty acid oxidation. Biochem Soc Trans 29: 279-282.
34. Luo, M.J., Mao, L-F., and Schulz, H. (1995) Short-chain 3-hydroxy-2-methylacyl-CoA dehydrogenase from rat liver: purification and characterization of a novel enzyme of isoleucine metabolism. Arch Biochem Biophys 321: 214-220.
35. Mullaney, E.J., Hamer, J.E., Roberti, K.A., Yelton, M.M., and Timberlake, W.E. (1985) Primary structure of the trpC gene from Aspergillus nidulans. Mol Gen Genet 199: 37-45.
36. O'Brien, L.K., Sims, H.F., Bennett, M.J., and Strauss, A.W. (2000) A mouse model for medium and short chain L-3-hydroxyacyl-CoA dehydrogenase deficiency. J Inherit Metab Dis 23: 127.
37. O'Connell, M.A., Orr, G., and Shapiro, L. (1990) Purification and characterization of fatty acid β-oxidation enzymes from Caulobacter crescentus. J Bacteriol 172: 997-1004.
38. Pérez, P., Martínez, O., Romero, B., Olivas, I., Pedregosa, A.M., Palmieri, F., et al. (2003) Functional analysis of mutations in the human carnitine/acylcarnitine translocase in Aspergillus nidulans. Fungal Genet Biol 39: 211-220.
39. Pontecorvo, G., Roper, J.A., Hemmons, L.M., MacDonald, K.D., and Button, A.W. (1953) The genetics of Aspergillus nidulans. Adv Genet 5: 141-238.
40. Ramsay, R.R. (2000) The carnitine acyltranserases: modulators of acyl-CoA-dependent reactions. Biochem Soc Trans 28: 182-186.
41. Robinson, W.G., and Coon, M.J. (1957) The purification and properties of β-hydroxyisobutyric dehydrogenase. J Biol Chem 225: 511-521.
42. Robinson, W.G., Bachhawat, B.K., and Coon, M.J. (1956) Tiglyl coenzyme A and α-methylacetoacetyl coenzyme A, intermediates in the enzymatic degradation of isoleucine. J Biol Chem 218: 391-400.
43. Roe, C.R., Cederbaum, S.D., Roe, D.S., Mardach, R., Galindo, A., and Sweetman, L. (1998) Isolated isobutyryl-CoA dehydrogenase deficiency: an unrecognized defect in human valine metabolism. Mol Genet Metab 65: 264-271.
44. Roncero, C., and Goodridge, A.G. (1992) Hexanoate and octanoate inhibit transcription of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture. J Biol Chem 267: 14918-14927.
45. Rottensteiner, H., Palmieri, L., Hartig, A., Hamilton, B., Ruis, H., Erdmann, R., and Gurvitz, A. (2002) The peroxisomal transporter gene ANT1 is regulated by a deviant oleate response element (ORE): charcterization of the signal for fatty acid induction. Biochem J 365: 109-117.
46. Sambrook, J., and Russell, D.W. (2001) Molecular Cloning: a Laboratory Manual. Cold Spring Harbor: Cold Spring Harbor Laboratory Press.
47. Sienko, M., and Paszewski, A. (1999) The metG gene of Aspergillus nidulans encoding cystathionine beta-lyase: cloning and analysis. Curr Genet 35: 638-646.
48. Smith, J.J., Brown, T.W., Eitzen, G.A., and Rachubinski, R.A. (2000) Regulation of peroxisome size and number by fatty acid β-oxidation in the yeast Yarrowia lipolytica. J Biol Chem 275: 20168-20178.
49. Sokatch, J.R., Sanders, L.E., and Marshall, V.P. (1968) Oxidation of methylmalonate semialdehyde to propionyl coenzyme A in Pseudomonas aeruginosa grown on valine. J Biol Chem 243: 2500-2506.
50. Speir, T.W., and Barnsley, E.A. (1971) The conjugation of glutathione with unsaturated acyl thiol esters and the metabolic formation of S-carboxyalkylcysteines. Biochem J 125: 267-273.
51. Stern, J.R. (1955) Crystalline crotonase from ox liver. In Methods Enzymol, Vol. 1. Colowick, SP. and Kaplan, N.O. (eds). New York: Academic Press, pp. 559-566.
52. Suelmann, R., and Fischer, R. (2000) Mitochondrial movement and morphology depend on an intact actin cytoskeleton in Aspergillus nidulans. Cell Motil Cytoskeleton 45: 42-50.
53. Thieringer, R., and Kunau, W.H. (1991) The β-oxidation system in catalase-free microbodies of the filamentous fungus Neurospora crassa. J Biol Chem 266: 13110-13117.
54. Trotter, P.J. (2001) The genetics of fatty acid metabolism in Saccharomyces cerevisiae. Annu Rev Nutr 21: 97-119.
55. Tsitsigiannis, D.I., Zarnowski, R., and Keller, N.P. (2004) The lipid body protein, PpoA, coordinates sexual and asexual sporulation in Aspergillus nidulans. J Biol Chem 279: 11344-11353.
56. Turner, G. (1973) Cycloheximide-resistant synthesis of mitochondrial-membrane components in Aspergillus nidulans. Eur J Biochem 40: 201-206.
57. Uchida, Y., Izai, K., Orii, T., and Hashimoto, T. (1992) Novel fatty acid β-oxidation enzymes in rat liver mitochondria. II. Purification and properties of enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase trifunctional protein. J Biol Chem 267: 1034-1041.
58. Valenciano, S., De Lucas, J.R., Pedregosa, A., Monistrol, I.F., and Laborda, F. (1996) Induction of β-oxidation enzymes and microbody proliferation in Aspergillus nidulans. Arch Microbiol 166: 336-341.
59. Vanhove, G.F., Van Veldhoven, P.P., Fransen, M., Denis, S., Eyssen, H.J., Wanders, R.J., and Mannaerts, G.P. (1993) The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney. J Biol Chem 268: 10335-10344.
60. Wanders, R.J.A., Vreken, P., Ferdinandusse, S., Jansen, G.A., Waterham, H.R., van Roermund, C.W.T., and Van Grunsven, E.G. (2001) Peroxisomal fatty acid α- and β-oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases. Biochem Soc Trans 29: 250-267.
61. Weeradechapon, K. (2002) Enzyme targeting and structural studies on Aspergillus nidulans isocitrate lyase. PhD Thesis. Sheffield: University of Sheffield.
62. Weidner, G., d'Enfert, C., Koch, A., Mol, P.C., and Brakhage, A.A. (1998) Development of a homologous transformation system for the human pathogenic fungus Aspergillus fumigatus based on the pyrG gene encoding orotidine 5′-monophosphate decarboxylase. Curr Genet 33: 378-385.
63. Wood, P.A. (1999) Defects in mitochondrial β-oxidation of fatty acids. Curr Opin Lipidol 10: 107-112.
64. Yang, X., and Griffiths, A.J. (1993) Plasmid diversity in senescent and nonsenescent strains of Neurospora. Mol Gen Genet 237: 177-186.
65. Yelton, M.M., Hamer, J.E., and Timberlake, W.E. (1984) Transformation of Aspergillus nidulans by using a trpC plasmid. Proc Natl Acad Sci USA 81: 1470-1474.
66. Zolotukhin, S., Potter, M., Hauswirth, W.W., Guy, J., and Muzyczka, N. (1996) A 'humanized' green fluorescent protein cDNA adapted for high-level expression in mammalian cells. J Virol 70: 4646-4654.