On a possible neutral charge state for the catalytic dyad in β-secretase when bound to hydroxyethylene transition state analogue inhibitors

Journal of Medicinal Chemistry

Volumn 54, Issue 8, 2011, Pages 3081-3085

  Sussman, Fredy ^a   Otero, José M ^a   Villaverde, M Carmen ^a   Castro, Marian ^a   Domínguez, José L ^a   González Louro, Lucía ^a   Estévez, Ramón J ^a   Estévez, J Carlos ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; ASPARTIC ACID; BETA SECRETASE 1; BETA SECRETASE INHIBITOR; ETHYLENE DERIVATIVE; HYDROXYETHYLENE DERIVATIVE; OM00 3; OM99 2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; MOLECULAR MECHANICS; PROTEIN BINDING; PROTON TRANSPORT;

AMYLOID PRECURSOR PROTEIN SECRETASES; CATALYSIS; ETHYLENES; HYDROGEN BONDING;

EID: 79955385829     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101568y     Document Type: Article

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