T-2 toxin is a cytochrome P450 1A1 inducer and leads to MAPK/p38- but not aryl hydrocarbon receptor-dependent interleukin-8 secretion in the human intestinal epithelial cell line Caco-2

Toxicology

Volumn 284, Issue 1-3, 2011, Pages 34-41

  Kruber, Pierre ^a,b   Trump, Saskia ^a   Behrens, Johann ^c   Lehmann, Irina ^a  

^a HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Aryl hydrocarbon receptor; Caco 2; CYP1A1; IL 8; P38 MAPK; T 2 toxin

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; INTERLEUKIN 1BETA; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; RESVERATROL; T 2 TOXIN;

ARTICLE; CELL LINE; CELL STIMULATION; CELL STRAIN CACO 2; CONTROLLED STUDY; CYTOKINE RELEASE; ENVIRONMENTAL EXPOSURE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INFLAMMATION; INTESTINE EPITHELIUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; CACO-2 CELLS; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; ENZYME INDUCTION; EPITHELIAL CELLS; HUMANS; INTERLEUKIN-8; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, ARYL HYDROCARBON; T-2 TOXIN;

FUSARIUM;

EID: 79955385582     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2011.03.012     Document Type: Article

References (38)

1. Abbas H.K., Mirocha C.J., Meronuck R.A., Pokorny J.D., Gould S.L., Kommedahl T. Mycotoxins and Fusarium spp. associated with infected ears of corn in Minnesota. Appl. Environ. Microbiol. 1988, 54:1930-1933.
2. Banks C., Bateman A., Payne R., Johnson P., Sheron N. Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease. J. Pathol. 2003, 199:28-35.
3. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
4. Chang L., Karin M. Mammalian MAP kinase signalling cascades. Nature 2001, 410:37-40.
5. Creppy E.E. Update of survey, regulation and toxic effects of mycotoxins in Europe. Toxicol. Lett. 2002, 127:19-28.
6. Daig R., Andus T., Aschenbrenner E., Falk W., Schölmerich J., Gross V. Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease. Gut 1996, 38:216-222.
7. Delescluse C., Lemaire G., de Sousa G., Rahmani R. Is CYP1A1 induction always related to AHR signaling pathway?. Toxicology 2000, 153:73-82.
8. Denison M.S., Nagy S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu. Rev. Pharmacol. Toxicol. 2003, 43:309-334.
9. de Waard W.J., Aarts J.M.M.J.G., Peijnenburg A.A.C.M., Baykus H., Talsma E., Punt A., de Kok T.M.C.M., van Schooten F.J., Hoogenboom L.A.P. Gene expression profiling in Caco-2 human colon cells exposed to TCDD, benzo[a]pyrene, and natural Ah receptor agonists from cruciferous vegetables and citrus fruits. Toxicol. In Vitro 2008, 22:396-410.
10. Dong C., Davis R.J., Flavell R.A. MAP kinases in the immune response. Annu. Rev. Immunol. 2002, 20:55-72.
11. Elbi C., Misteli T., Hager G.L. Recruitment of dioxin receptor to active transcription sites. Mol. Biol. Cell 2002, 13:2001-2015.
12. Hagler W.M., Tyczkowska K., Hamilton P.B. Simultaneous occurrence of deoxynivalenol, zearalenone, and aflatoxin in 1982 scabby wheat from the midwestern United States. Appl. Environ. Microbiol. 1984, 47:151-154.
13. Harada A., Sekido N., Akahoshi T., Wada T., Mukaida N., Matsushima K. Essential involvement of interleukin-8 (IL-8) in acute inflammation. J. Leukoc. Biol. 1994, 56:559-564.
14. Hazel C.M., Patel S. Influence of processing on trichothecene levels. Toxicol. Lett. 2004, 153:51-59.
15. Hu W., Sorrentino C., Denison M.S., Kolaja K., Fielden M.R. Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro. Mol. Pharmacol. 2007, 71:1475-1486.
16. Hussein H.S., Brasel J.M. Toxicity, metabolism, and impact of mycotoxins on humans and animals. Toxicology 2001, 167:101-134.
17. Ishida K., Taguchi M., Akao T., Hashimoto Y. Involvement of the CYP1A subfamily in stereoselective metabolism of carvedilol in beta-naphthoflavone-treated Caco-2 cells. Biol. Pharm. Bull. 2009, 32:513-516.
18. Islam Z., Gray J.S., Pestka J.J. p38 Mitogen-activated protein kinase mediates IL-8 induction by the ribotoxin deoxynivalenol in human monocytes. Toxicol. Appl. Pharmacol. 2006, 213:235-244.
19. Jung H.C., Eckmann L., Yang S.K., Panja A., Fierer J., Morzycka-Wroblewska E., Kagnoff M.F. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J. Clin. Invest. 1995, 95:55-65.
20. Lee J.E., Safe S. Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells. Biochem. Pharmacol. 2001, 62:1113-1124.
21. Obremski K., Zielonka L., Gajecka M., Jakimiuk E., Bakuła T., Baranowski M., Gajecki M. Histological estimation of the small intestine wall after administration of feed containing deoxynivalenol, T-2 toxin and zearalenone in the pig. Pol. J. Vet. Sci. 2008, 11:339-345.
22. Parhar K., Ray A., Steinbrecher U., Nelson C., Salh B. The p38 mitogen-activated protein kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells. Immunology 2003, 108:502-512.
23. Podechard N., Lecureur V., Le Ferrec E., Guenon I., Sparfel L., Gilot D., Gordon J.R., Lagente V., Fardel O. Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation. Toxicol. Lett. 2008, 177:130-137.
24. Quintana F.J., Basso A.S., Iglesias A.H., Korn T., Farez M.F., Bettelli E., Caccamo M., Oukka M., Weiner H.L. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 2008, 453:65-71.
25. Rosenberg D.W., Leff T. Regulation of cytochrome P450 in cultured human colonic cells. Arch. Biochem. Biophys. 1993, 300:186-192.
26. Schindler J.F., Monahan J.B., Smith W.G. p38 pathway kinases as anti-inflammatory drug targets. J. Dent. Res. 2007, 86:800-811.
27. Schollenberger M., Müller H., Rüfle M., Suchy S., Plank S., Drochner W. Natural occurrence of 16 fusarium toxins in grains and feedstuffs of plant origin from Germany. Mycopathologia 2006, 161:43-52.
28. Schothorst R.C., van Egmond H.P. Report from SCOOP task 3.2.10 " collection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU member states" Subtask: trichothecenes. Toxicol. Lett. 2004, 153:133-143.
29. Steyn P.S. Mycotoxins, general view, chemistry and structure. Toxicol. Lett. 1995, 82-83:843-851.
30. Sugita-Konishi Y., Pestka J.J. Differential upregulation of TNF-alpha IL-6, and IL-8 production by deoxynivalenol (vomitoxin) and other 8-ketotrichothecenes in a human macrophage model. J. Toxicol. Environ. Health A 2001, 64:619-636.
31. Uguccioni M., Gionchetti P., Robbiani D.F., Rizzello F., Peruzzo S., Campieri M., Baggiolini M. Increased expression of IP-10, IL-8 MCP-1, and MCP-3 in ulcerative colitis. Am. J. Pathol. 1999, 155:331-336.
32. Van De Walle J., Romier B., Larondelle Y., Schneider Y. Influence of deoxynivalenol on NF-kappaB activation and IL-8 secretion in human intestinal Caco-2 cells. Toxicol. Lett. 2008, 177:205-214.
33. Veldhoen M., Hirota K., Westendorf A.M., Buer J., Dumoutier L., Renauld J., Stockinger B. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 2008, 453:106-109.
34. Wannemacher R., Wiener S. Trichothecene mycotoxins. Medical Aspects of Chemical and Biological Warfare 1997, 655-676. Office of The Surgeon General at TMM Publications Borden Institute Walter Reed Army Medical Ctr, Washington, DC 20307-5001, United States, (chapter 34). http://www.ncjrs.gov/App/publications/Abstract.aspx?id=190629, F.R. Sidell, E.T. Takafuji (Eds.).
35. Wichmann G., Herbarth O., Lehmann I. The mycotoxins citrinin, gliotoxin, and patulin affect interferon-gamma rather than interleukin-4 production in human blood cells. Environ. Toxicol. 2002, 17:211-218.
36. Wong S., Schwartz R.C., Pestka J.J. Superinduction of TNF-alpha and IL-6 in macrophages by vomitoxin (deoxynivalenol) modulated by mRNA stabilization. Toxicology 2001, 161:139-149.
37. Wong S.S., Zhou H.R., Marin-Martinez M.L., Brooks K., Pestka J.J. Modulation of IL-1beta, IL-6 and TNF-alpha secretion and mRNA expression by the trichothecene vomitoxin in the RAW 264.7 murine macrophage cell line. Food Chem. Toxicol. 1998, 36:409-419.
38. Ziprin R.L., McMurray D.N. Differential effect of T-2 toxin on murine host resistance to three facultative intracellular bacterial pathogens: Listeria monocytogenes, Salmonella typhimurium, and Mycobacterium bovis. Am. J. Vet. Res. 1988, 49:1188-1192.