TCR-like antibodies distinguish conformational and functional differences in two- versus four-domain auto reactive MHC class II-peptide complexes

European Journal of Immunology

Volumn 41, Issue 5, 2011, Pages 1465-1479

  Dahan, Rony ^a   Tabul, Moran ^b   Chou, Yuan K ^c   Meza Romero, Roberto ^c   Andrew, Shayne ^c   Ferro, Adolph J ^d   Burrows, Gregory G ^c,e   Offner, Halina ^c,f   Vandenbark, Arthur A ^c,f   Reiter, Yoram ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b BIO RAD LABORATORIES   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d Artielle ImmunoTherapeutics Inc   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^f PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Autoimmunity; Immune tolerance; MHC class II; Recombinant antibodies

Indexed keywords

HLA DR2 ANTIGEN; IMMUNOGLOBULIN F(AB) FRAGMENT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN OLIGODENDROCYTE GLYCOPROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN STRUCTURE; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CONFORMATIONAL TRANSITION; DRUG BLOOD LEVEL; DRUG MECHANISM; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGEN-PRESENTING CELLS; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GLYCOPROTEINS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-DR2 ANTIGEN; HUMANS; IMMUNE TOLERANCE; IMMUNOGLOBULIN FAB FRAGMENTS; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, TRANSGENIC; MULTIPLE SCLEROSIS; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS;

EID: 79955137620     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201041241     Document Type: Article

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