Cytokine switch and bystander suppression of autoimmune responses to multiple antigens in experimental autoimmune encephalomyelitis by a single Recombinant T-cell receptor ligand

Journal of Neuroscience

Volumn 29, Issue 12, 2009, Pages 3816-3823

  Sinha, Sushmita ^a   Subramanian, Sandhya ^a   Miller, Lisa ^a   Proctor, Thomas M ^a   Roberts, Chris ^a   Burrows, Gregory G ^a   Vandenbark, Arthur A ^a   Offner, Halina ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LIGAND; MYELIN BASIC PROTEIN[84-104]; PROTEOLIPID PROTEIN[139-151]; PROTEOLIPID PROTEIN[178-191]; RECOMBINANT RECEPTOR; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; CYTOKINE; HYBRID PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; PEPTIDE; RTL401 FUSION PROTEIN; TISSUE EXTRACT;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOIMMUNITY; BYSTANDER EFFECT; CELL ACTIVATION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG SPECIFICITY; DRUG TARGETING; EX VIVO STUDY; FEMALE; HOMOGENATE; IMMUNIZATION; MONOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; SPLEEN CELL; T LYMPHOCYTE; TREATMENT DURATION; ANIMAL; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY;

ANIMALS; BYSTANDER EFFECT; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; LIGANDS; MICE; PEPTIDES; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS; SPINAL CORD; T-CELL ANTIGEN RECEPTOR SPECIFICITY; T-LYMPHOCYTES; TISSUE EXTRACTS;

EID: 64849084182     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5812-08.2009     Document Type: Article

References (22)

1. Anderson AC, Nicholson LB, Legge KL, Turchin V, Zaghouani H, Kuchroo VK (2000) High frequency of autoreactive myelin proteolipid proteinspecific T cells in the periphery of naïve mice: mechanisms of selection of the self-reactive repertoire. J Exp Med 191:761-770.
2. Boonstra A, Rajsbaum R, Holman M, Marques R, Asselin-Paturel C, Pereira JP, Bates EE, Akira S, Vieira P, Liu YJ, Trinchieri G, O'Garra A (2006) Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88and TRIF-dependent TLR signals, and TLR-independent signals. J Immunol 177:7551-7558.
3. Burrows GG, Bebo BE Jr, Adlard KL, Vandenbark AA, Offner H (1998) Two-domain MHC class II molecules form stable complexes with myelin basic protein 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitis. J Immunol 161:5987-5996.
4. Burrows GG, Chang JW, Bächinger HP, Bourdette DN, Offner H, Vandenbark AA (1999) Design, engineering and production of functional single-chain T cell receptor ligands. Protein Eng 12:771-778.
5. Burrows GG, Chou YK, Wang C, Chang JW, Finn TP, Culbertson NE, Kim J, Bourdette DN, Lewinsohn DA, Lewinsohn DM, Ikeda M, Yoshioka T, Allen CN, Offner H, Vandenbark AA (2001) Rudimentary TCR signaling triggers default IL-10 secretion by human Thl cells. J Immunol 167:4386-4395.
6. Chang JW, Mechling DE, Bächinger HP, Burrows GG (2001) Design, engineering, and production of human recombinant T cell receptor ligands derived from human leukocyte antigen DR2. J Biol Chem 276:24170-24176.
7. Chou YK, Culbertson N, Rich C, LaTocha D, Buenafe AC, Huan J, Link J, Wands JM, Born WK, Offner H, Bourdette DN, Burrows GG, Vandenbark AA (2004) T cell hybridoma specific for myelin oligodendrocyte glycoprotein 35-55 peptide produced from HLA-DRBl1501-transgenic mice. J Neurosci Res 77:670-680.
8. Dillon S, Agrawal A, Van Dyke T, Landreth G, McCauley L, Koh A, Maliszewski C, Akira S, Pulendran B (2004) A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signalregulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells. J Immunol 172:4733-4743.
9. Edwards AD, Manickasingham SP, Spörri R, Diebold SS, Schulz O, Sher A, Kaisho T, Akita S, Reise Sousa C (2002) Microbial recognition via Tolllike receptor-dependent and-independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering.J Immunol 169:3652-3660.
10. Huan J, Subramanian S, Jones R, Rich C, Link J, Mooney J, Bourdette DN, Vandenbark AA, Burrows GG, Of'f'ner H (2004) Monomeric recombinant TCR ligand reduces relapse rate and severity of experimental autoimmune encephalomyelitis in SJL/J mice through cytokine switch. J Immunol 172:4556-4566.
11. Legge KL, Min B, Bell JJ, Caprio JC, Li L, Gregg RK, Zaghouani H (2000) Coupling of peripheral tolerance to endogenous interleukin 10 promotes effective modulation of myelin-activated T cells and ameliorates experimental allergic encephalomyelitis. J Exp Med 191:2039-2052.
12. Link JM, Rich CM, Korat M, Burrows GG, Offner H, Vandenbark AA (2007) Monomeric DR2/MOG-35-55 recombinant TCR ligand treats relapses of experimental encephalomyelitis in DR2 transgenic mice. Clin Immunol 123:95-104.
13. McFarland HF, Martin R (2007) Multiple sclerosis: a complicated picture of autoimmunity. Nat Immunol 8:913-919.
14. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19:683-765.
15. Offner H, Subramanian S, Wang C, Afentoulis M, Vandenbark AA, Huan J, Burrows GG (2005) Treatment of passive experimental autoimmune encephalomyelitis in SJL mice with a recombinant TCR ligand induces IL-13 and prevents axonal injury. J Immunol 175:4103-4111.
16. O'Garra A, Vieira P (2004) Regulatory T cells and mechanisms of immune system control. Nat Med 10:801-805.
17. O'Garra A, Vieira P (2007) T (H) 1 cells control themselves by producing interleukin-10. Nat Rev Immunol 7:425-428.
18. Sinha S, Subramanian S, Proctor TM, Kaler LJ, Grate M, Dahan R, Huan J, Vandenbark AA, Burrows GG, Offner H (2007) A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS. J Neurosci 27:12531-12539.
19. Vandenbark AA, Rich C, Mooney J, Zamora A, Wang C, Huan J, Fugger L, Offner H, Jones R, Burrows GG (2003) Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice. } Immunol 171:127-133.
20. Veräjänkorva E, Setälä N, Teros T, Salmi AA, Pöllänen P (2002) Testicular-associated immune deviation: flushing of the testicular lymph sinusoids induces immunosuppression and inhibits formation of EAE in SJL mice. Scand J Immunol 55:478-483.
21. Wang C, Mooney JL, Meza-Romero R, Chou YK, Huan J, Vandenbark AA, Offner H, Burrows GG (2003) Recombinant TCR ligand induces early TCR signaling and a unique pattern of downstream activation. J Immunol 171:1934-1940.
22. Whitham RH, Wingert D, Wineman J, Mass M, Wegmann K, Vandenbark A, Offner H (1996) Treatment of relapsing autoimmune encephalomyelitis with T cell receptor Vbeta-specific antibodies when proteolipid protein is the autoantigen. J Neurosci Res 45:104-116.