Rudimentary TCR signaling triggers default IL-10 secretion by human TH1 cells

Journal of Immunology

Volumn 167, Issue 8, 2001, Pages 4386-4395

  Burrows, G G ^a   Chou, Y K ^a   Wang, C ^a   Chang, J W ^a   Finn, T P ^a   Culbertson, N E ^a   Kim, J ^a   Bourdette, D N ^a   Lewinsohn, D A ^a   Lewinsohn, D M ^a   Ikeda, M ^a   Yoshioka, T ^a   Allen, C N ^a   Offner, H ^a   Vandenbark, A A ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CALCIUM ION; GAMMA INTERFERON; HLA DR2 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; MYELIN BASIC PROTEIN; PEPTIDE; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; CALCIUM MOBILIZATION; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIGAND BINDING; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL;

EID: 0035887638     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.8.4386     Document Type: Article

References (53)

1. Major histocompatibility complex-dependent antigen processing and peptide presentation: Providing ligands for the clonal activation of T lymphocytes
2. Signals and signs for lymphocyte responses
3. Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins
4. Functional diversity of helper T lymphocytes
5. Presidential address to The American Association of Immunologists: The road less traveled by: The role of innate immunity in the adaptive immune response
6. The instructive role of innate immunity in the acquired immune response
7. Cutting edge: Trimolecular interaction of TCR with MHC class II and bacterial superantigen shows a similar affinity to MHC:peptide ligands
8. Differential susceptibility of human Th1 versus Th2 cells to induction of anergy and apoptosis by ECD1/antigen-coupled antigen-presenting cells
9. Ligand recognition by αβT cell receptors
10. A site for CD4 binding in the β-1 domain of the MHC class II protein HLA-DRI
11. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor
12. 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitis
13. Design, engineering and production of functional single-chain T cell receptor ligands
14. Design, engineering, and production of human recombinant T cell receptor ligands derived from human leukocyte antigen DR2
15. Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planer lipid membranes: Specific induction of a long-lived state of proliferative nonresponsiveness
16. Recognition of peptides corresponding to the joining region of p210BCR-ABL protein by human T cells
17. HLA-DR typing by PCR amplification with sequence specific primers (PCR-SSP) in two hours: An alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation
18. + T lymphocytes derived from Mycobacterium tuberculosis-infected cells: Definition of antigenic specificity
19. Immunity to TCR peptides in multiple sclerosis. II. T cell recognition of Vβ5.2 and Vβ6.1 CDR2 peptides
20. Androgens alter the cytokine profile and reduce encephalitogenicity of myelin reactive T cells
21. + cytotoxic T cell response specific for the immunodominant myelin basic pepfide peptide 87-106
22. Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein
23. Three dimensional structure of the human class II histocompatibility antigen HLA-DR1
24. The class II MHC protein HLA-DRI in complex with an endogenous peptide: Implications for the structural basis of the specificity of peptide binding
25. Structures of an MHC class II molecule with covalently bound single peptides
26. Structure of scorpion toxin variant-3 at 1.2 angstroms resolution
27. Solvent-accessible surfaces of proteins and nucleic acids
28. A new approach to the display of local lipophilicity/hydrophilicity mapped on molecular surfaces
29. Partial T cell signaling: Altered phospho-ζ and lack of Zap70 recruitment in APL-induced T cell anergy
30. Partially phosphorylated T cell receptor ζ molecules can inhibit T cell activation
31. Kinetics and extent of T cell activation as measured with the calcium signal
32. + T cells
33. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
34. Role of monocytes in the up-regulation of the early activation marker CD69 on B and T murine lymphocytes induced by microbial mitogens
35. Beneficial effect of monoclonal antibody to interleukin 2 receptor on activated T cells in rheumatoid arthritis
36. Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis
37. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
38. Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes
39. Identification of a ten-amino acid proline-rich SH3 binding site
40. Structure of the regulatory domains of the Src-family tyrosine kinase Lck
41. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes
42. lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line
43. Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways
44. Polarity of T cell shape, motility, and sensitivity to antigen
45. An experimentally validated panel of subfamily-specific oligonucleotide primers (Val-w29/Vbl-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction
46. Human T-cell receptor variable gene segment families
47. Interaction of Staphylococcus aureus toxin "superantigens" with human T cells
48. Diversity and structure of human T-cell receptor β-chain variable region genes
49. Sequences and repertoire of the human T cell receptor α and β chain variable region genes in thymocytes
50. The human T cell receptor β-chain gene complex contains at least 57 variable gene segments. Identification of six Vβgenes in four new gene families