메뉴 건너뛰기




Volumn 98, Issue 3, 2011, Pages 277-290

PARP inhibitors: Significant progress in cancer therapy;Inhibiteurs de la PARP: Des avancées significatives dans le traitement des cancers

Author keywords

BRCA1 2; Chimio and radiosensitizers; Genome integrity; Poly(ADP ribose) polymerases inhibitors

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NUCLEAR PROTEIN; POLY(ADENOSINE DIPHOSPHATE RIBOSE); ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RADIOSENSITIZING AGENT;

EID: 79955102726     PISSN: 00074551     EISSN: 17696917     Source Type: Journal    
DOI: 10.1684/bdc.2011.1330     Document Type: Review
Times cited : (5)

References (38)
  • 2
    • 4344685333 scopus 로고    scopus 로고
    • The PARP superfamily
    • DOI 10.1002/bies.20085
    • Ame JC, Spenlehauer C, de Murcia G. The PARP superfamily. Bioessays 2004 ; 26 : 882-93. (Pubitemid 39128102)
    • (2004) BioEssays , vol.26 , Issue.8 , pp. 882-893
    • Ame, J.-C.1    Spenlehauer, C.2    De Murcia, G.3
  • 3
    • 0033580856 scopus 로고    scopus 로고
    • PARP-2. A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase
    • Ame JC, Rolli V, Schreiber V, et al. PARP-2. A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. J Biol Chem 1999 ; 274 : 17860-8.
    • (1999) J Biol Chem , vol.274 , pp. 17860-17868
    • Ame, J.C.1    Rolli, V.2    Schreiber, V.3
  • 4
    • 79952599748 scopus 로고    scopus 로고
    • PolyADP-ribose polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression
    • Boehler C, Gauthier LR, Mortusewicz O, et al. Poly(ADP-ribose polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression. Proc Natl Acad Sci 2011 ; 108 : 2783-8.
    • (2011) Proc Natl Acad Sci , vol.108 , pp. 2783-2788
    • Boehler, C.1    Gauthier, L.R.2    Mortusewicz, O.3
  • 5
    • 70349451172 scopus 로고    scopus 로고
    • Learning how to read ADP-ribosylation
    • Kleine H, Luscher B. Learning how to read ADP-ribosylation. Cell 2009 ; 139 : 17-9.
    • (2009) Cell , vol.139 , pp. 17-19
    • Kleine, H.1    Luscher, B.2
  • 6
    • 53149094334 scopus 로고    scopus 로고
    • Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation
    • Kleine H, Poreba E, Lesniewicz K, et al. Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation. Mol Cell 2008 ; 32 : 57-69.
    • (2008) Mol Cell , vol.32 , pp. 57-69
    • Kleine, H.1    Poreba, E.2    Lesniewicz, K.3
  • 7
    • 0034720734 scopus 로고    scopus 로고
    • Base excision repair is impaired in mammalian cells lacking poly(ADP- Ribose) polymerase-1
    • DOI 10.1021/bi0003442
    • Dantzer F, de La Rubia G, Menissier-De Murcia J, Hostomsky Z, de Murcia G, Schreiber V. Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1. Biochemistry 2000 ; 39 : 7559-69. (Pubitemid 30422075)
    • (2000) Biochemistry , vol.39 , Issue.25 , pp. 7559-7569
    • Dantzer, F.1    De La, R.G.2    Menissier-De, M.J.3    Hostomsky, Z.4    De Murcia, G.5    Schreiber, V.6
  • 9
    • 69849097500 scopus 로고    scopus 로고
    • PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
    • Bryant HE, Petermann E, Schultz N, et al. PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. Embo J 2009 ; 28 : 2601-15.
    • (2009) Embo J , vol.28 , pp. 2601-2615
    • Bryant, H.E.1    Petermann, E.2    Schultz, N.3
  • 10
    • 34447548569 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents
    • DOI 10.1074/jbc.M608406200
    • Haince JF, Kozlov S, Dawson VL, et al. Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents. J Biol Chem 2007 ; 282 : 16441-53. (Pubitemid 47100334)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.22 , pp. 16441-16453
    • Haince, J.-F.1    Kozlov, S.2    Dawson, V.L.3    Dawson, T.M.4    Hendzel, M.J.5    Lavin, M.F.6    Poirier, G.G.7
  • 11
    • 38149057387 scopus 로고    scopus 로고
    • PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites
    • Haince JF, McDonald D, Rodrigue A, et al. PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. J Biol Chem 2008 ; 283 : 1197-208.
    • (2008) J Biol Chem , vol.283 , pp. 1197-1208
    • Haince, J.F.1    McDonald, D.2    Rodrigue, A.3
  • 12
    • 59449101071 scopus 로고    scopus 로고
    • PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA
    • Sugimura K, Takebayashi S, Taguchi H, Takeda S, Okumura K. PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA. J Cell Biol 2008 ; 183 : 1203-12.
    • (2008) J Cell Biol , vol.183 , pp. 1203-1212
    • Sugimura, K.1    Takebayashi, S.2    Taguchi, H.3    Takeda, S.4    Okumura, K.5
  • 13
    • 11244280890 scopus 로고    scopus 로고
    • Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
    • DOI 10.1074/jbc.M404524200
    • Audebert M, Salles B, Calsou P. Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J Biol Chem 2004 ; 279 : 55117-26. (Pubitemid 40066505)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.53 , pp. 55117-55126
    • Audebert, M.1    Salles, B.2    Calsou, P.3
  • 14
    • 6044261241 scopus 로고    scopus 로고
    • Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair
    • DOI 10.1038/sj.onc.1207984
    • Veuger SJ, Curtin NJ, Smith GC, Durkacz BW. Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and theDNA-dependent protein kinase on enzyme activities and DNA repair. Oncogene 2004 ; 23 : 7322-9. (Pubitemid 39382135)
    • (2004) Oncogene , vol.23 , Issue.44 , pp. 7322-7329
    • Veuger, S.J.1    Curtin, N.J.2    Smith, G.C.M.3    Durkacz, B.W.4
  • 15
    • 33845657443 scopus 로고    scopus 로고
    • PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
    • DOI 10.1093/nar/gkl840
    • Wang M, Wu W, Rosidi B, Zhang L, Wang H, Iliakis G. PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res 2006 ; 34 : 6170-82. (Pubitemid 44942738)
    • (2006) Nucleic Acids Research , vol.34 , Issue.21 , pp. 6170-6182
    • Wang, M.1    Wu, W.2    Wu, W.3    Rosidi, B.4    Zhang, L.5    Wang, H.6    Iliakis, G.7
  • 17
    • 41549155890 scopus 로고    scopus 로고
    • Toward specific functions of poly(ADP-ribose) polymerase-2
    • Yelamos J, Schreiber V, Dantzer F. Toward specific functions of poly(ADP-ribose) polymerase-2. Trends Mol Med 2008 ; 14 : 169-78.
    • (2008) Trends Mol Med , vol.14 , pp. 169-178
    • Yelamos, J.1    Schreiber, V.2    Dantzer, F.3
  • 18
    • 33947380240 scopus 로고    scopus 로고
    • Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology
    • DOI 10.1158/1078-0432.CCR-06-2260
    • Ratnam K, Low JA. Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology. Clin Cancer Res 2007 ; 13 : 1383-8. (Pubitemid 46450426)
    • (2007) Clinical Cancer Research , vol.13 , Issue.5 , pp. 1383-1388
    • Ratnam, K.1    Low, J.A.2
  • 19
  • 20
    • 59449085305 scopus 로고    scopus 로고
    • Phase I study of the poly(ADP-ribose) polymerase inhibitor. AG014699, in combination with temozolomide in patients with advanced solid tumors
    • Plummer R, Jones C, Middleton M, et al. Phase I study of the poly(ADP-ribose) polymerase inhibitor. AG014699, in combination with temozolomide in patients with advanced solid tumors. Clin Cancer Res 2008 ; 14 : 7917-23.
    • (2008) Clin Cancer Res , vol.14 , pp. 7917-7923
    • Plummer, R.1    Jones, C.2    Middleton, M.3
  • 21
    • 68449096428 scopus 로고    scopus 로고
    • Efficacy of BSI-201, a poly(ADP-ribose) polymerase-1(PARP-1) inhibitor, in combination with gemcitabine/carboplatin (G/C) in patients with metastasic triple-negative breast canacr (TNBC): Results of a randomized Phase II trial
    • O'shaughnessy J, Osborne C, Pippen M, et al. Efficacy of BSI-201, a poly(ADP-ribose) polymerase-1(PARP-1) inhibitor, in combination with gemcitabine/carboplatin (G/C) in patients with metastasic triple-negative breast canacr (TNBC): results of a randomized Phase II trial. J Clin Oncol 2009 ; 27 : 3.
    • (2009) J Clin Oncol , vol.27 , pp. 3
    • O'Shaughnessy, J.1    Osborne, C.2    Pippen, M.3
  • 24
    • 79952747328 scopus 로고    scopus 로고
    • Nonhomologous end joining drives poly(ADP-ribose) polymerase PARP- Inhibitor lethality in homologous recombination-deficient cells
    • Patel AG, Sarkaria JN, Kaufmann SH. Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP- inhibitor lethality in homologous recombination-deficient cells. Proc Natl Acad Sci 2011 ; 108 : 3406-11.
    • (2011) Proc Natl Acad Sci , vol.108 , pp. 3406-3411
    • Patel, A.G.1    Sarkaria, J.N.2    Kaufmann, S.H.3
  • 25
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009 ; 361 : 123-34.
    • (2009) N Engl J Med , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 27
    • 77149157867 scopus 로고    scopus 로고
    • Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
    • Mendes-Pereira AM, Martin SA, Brough R, et al. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol Med 2009 ; 1 : 315-22.
    • (2009) EMBO Mol Med , vol.1 , pp. 315-322
    • Mendes-Pereira, A.M.1    Martin, S.A.2    Brough, R.3
  • 29
    • 18944390248 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors
    • DOI 10.1038/nrd1718
    • Jagtap P, Szabo C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov 2005 ; 4 : 421-40. (Pubitemid 40704125)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.5 , pp. 421-440
    • Jagtap, P.1    Szabo, C.2
  • 30
    • 53149137486 scopus 로고    scopus 로고
    • Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
    • Wang RH, Sengupta K, Li C, et al. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 2008 ; 14 : 312-23.
    • (2008) Cancer Cell , vol.14 , pp. 312-323
    • Wang, R.H.1    Sengupta, K.2    Li, C.3
  • 31
    • 12444253985 scopus 로고    scopus 로고
    • Modulation of DNMT1 activity by ADP-ribose polymers
    • DOI 10.1038/sj.onc.1208005
    • Reale A, Matteis GD, Galleazzi G, Zampieri M, Caiafa P. Modulation of DNMT1 activity by ADP-ribose polymers. Oncogene 2005 ; 24 : 13-9. (Pubitemid 40143860)
    • (2005) Oncogene , vol.24 , Issue.1 , pp. 13-19
    • Reale, A.1    De Matteis, G.2    Galleazzi, G.3    Zampieri, M.4    Caiafa, P.5
  • 32
    • 61449261908 scopus 로고    scopus 로고
    • Epigenetics: Poly(ADP-ribosyl) ation of PARP-1 regulates genomic methylation patterns
    • Caiafa P, Guastafierro T, Zampieri M. Epigenetics: poly(ADP-ribosyl) ation of PARP-1 regulates genomic methylation patterns. Faseb J 2009 ; 23 : 672-8.
    • (2009) Faseb J , vol.23 , pp. 672-678
    • Caiafa, P.1    Guastafierro, T.2    Zampieri, M.3
  • 33
    • 25444468291 scopus 로고    scopus 로고
    • Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis
    • DOI 10.1158/0008-5472.CAN-05-0770
    • Raval-Fernandes S, Kickhoefer VA, Kitchen C, Rome LH. Increased susceptibility of vault poly(ADP-ribose) polymerasedeficient mice to carcinogen-induced tumorigenesis. Cancer Res 2005 ; 65 : 8846-52. (Pubitemid 41377373)
    • (2005) Cancer Research , vol.65 , Issue.19 , pp. 8846-8852
    • Raval-Fernandes, S.1    Kickhoefer, V.A.2    Kitchen, C.3    Rome, L.H.4
  • 34
  • 37
    • 0034672418 scopus 로고    scopus 로고
    • BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration
    • Aguiar RC, Yakushijin Y, Kharbanda S, Salgia R, Fletcher JA, Shipp MA. BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration. Blood 2000 ; 96 : 4328-34.
    • (2000) Blood , vol.96 , pp. 4328-4334
    • Aguiar, R.C.1    Yakushijin, Y.2    Kharbanda, S.3    Salgia, R.4    Fletcher, J.A.5    Shipp, M.A.6
  • 38
    • 63849298103 scopus 로고    scopus 로고
    • PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells
    • Cho SH, Goenka S, Henttinen T, et al. PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells. Blood 2009 ; 113 : 2416-25.
    • (2009) Blood , vol.113 , pp. 2416-2425
    • Cho, S.H.1    Goenka, S.2    Henttinen, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.