-
1
-
-
0032779341
-
Epidemiology of constipation (EPOC) study in the United States: Relation of clinical subtypes to sociodemographic features
-
Stewart WF, Liberman JN, Sandler RS, et al. Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features. Am J Gastroenterol 1994;7:3530-40
-
(1994)
Am J Gastroenterol
, vol.7
, pp. 3530-40
-
-
Stewart, W.F.1
Liberman, J.N.2
Sandler, R.S.3
-
2
-
-
34250870646
-
The burden of constipation on quality of life: Results of a multinational survey
-
DOI 10.1111/j.1365-2036.2007.03376.x
-
Wald A, Scarpignato C, Kamm MA, et al. The burden of constipation on quality of life: results of a multinational survey. Aliment Pharmacol Ther 2007;26:227-36 (Pubitemid 46985504)
-
(2007)
Alimentary Pharmacology and Therapeutics
, vol.26
, Issue.2
, pp. 227-236
-
-
Wald, A.1
Scarpignato, C.2
Kamm, M.A.3
Mueller-Lissner, S.4
Helfrich, I.5
Schuijt, C.6
Bubeck, J.7
Limoni, C.8
Petrini, O.9
-
3
-
-
76349088961
-
Guanylate cyclase C-mediated antinociceptive effects of linaclitide in rodent models of visceral pain
-
Eutamene E, Bradesi S, Laruche M, et al. Guanylate cyclase C-mediated antinociceptive effects of linaclitide in rodent models of visceral pain. Neurogastroenterol Motil 2010;22:312-e84
-
(2010)
Neurogastroenterol Motil
, vol.22
-
-
Eutamene, E.1
Bradesi, S.2
Laruche, M.3
-
4
-
-
77249162216
-
Taking a lesson from microbial diarrheagenesis in the management of chronic constipation
-
Bharucha AE, Waldman SA. Taking a lesson from microbial diarrheagenesis in the management of chronic constipation. Gastroenterology 2010;138:813-25
-
(2010)
Gastroenterology
, vol.138
, pp. 813-25
-
-
Bharucha, A.E.1
Waldman, S.A.2
-
5
-
-
37849024665
-
Multicenter, 4 week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation
-
Johanson JF, Morton D, Geenen J, et al. Multicenter, 4 week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation. Am J Gastroenterol 2008;103:170-7
-
(2008)
Am J Gastroenterol
, vol.103
, pp. 170-7
-
-
Johanson, J.F.1
Morton, D.2
Geenen, J.3
-
6
-
-
58149084950
-
Clinical trial: The efficacy, impact of quality of life and safety and tolerability of prucalopride in severe chronic constipation-A 12 week, randomized, double-blind, placebo controlled trial
-
Quigley EM, Vandeplassche L, Kerstens R, et al. Clinical trial: the efficacy, impact of quality of life and safety and tolerability of prucalopride in severe chronic constipation-a 12 week, randomized, double-blind, placebo controlled trial. Aliment Pharmacol Ther 2009;29:315-28
-
(2009)
Aliment Pharmacol Ther
, vol.29
, pp. 315-28
-
-
Quigley, E.M.1
Vandeplassche, L.2
Kerstens, R.3
-
7
-
-
78649489728
-
Clinical trial: The efficacy and tolerability of velusetrag, a selective 5-HT4 agonist with high intrinsic activity, in chronic idiopathic constipation-A 4 week randomized, double blind, placebo controlled, dose-response study
-
Goldberg M, Li YP, Mangel AM, et al. Clinical trial: the efficacy and tolerability of velusetrag, a selective 5-HT4 agonist with high intrinsic activity, in chronic idiopathic constipation-a 4 week randomized, double blind, placebo controlled, dose-response study. Aliment Pharm Ther 2010;32:1102-12
-
(2010)
Aliment Pharm Ther
, vol.32
, pp. 1102-12
-
-
Goldberg, M.1
Li, Y.P.2
Mangel, A.M.3
-
8
-
-
33745396435
-
Effects of a single dose administration of MD-1100 on safety, tolerability, exposure, and stool consistency in healthy subjects
-
Currie MG, Kurtz CB, Mahajan-Miklos S, et al. Effects of a single dose administration of MD-1100 on safety, tolerability, exposure, and stool consistency in healthy subjects. Am J Gastroenterol 2005;100:S328
-
(2005)
Am J Gastroenterol
, vol.100
-
-
Currie, M.G.1
Kurtz, C.B.2
Mahajan-Miklos, S.3
-
9
-
-
7044269199
-
Uroguanylin and guanylin peptides: Pharmacology and experimental therapeutics
-
Forte LJ. Uroguanylin and guanylin peptides: pharmacology and experimental therapeutics. Pharmacol Ther 2004;104:137-62
-
(2004)
Pharmacol Ther
, vol.104
, pp. 137-62
-
-
Forte, L.J.1
-
10
-
-
12644271196
-
Regulation of intestinal uroguanylin/guanylin receptor-mediated responses by mucosal acidity
-
DOI 10.1073/pnas.94.6.2705
-
Hamra FK, Eber SL, Chin DT, et al. Regulation of intestinal uroguanylin/guanylin receptor mediated responses by mucosal acidity. Proc Natl Acad Sci USA 1997;94:2705-10 (Pubitemid 27136940)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.6
, pp. 2705-2710
-
-
Kent Hamra, F.1
Eber, S.L.2
Chin, D.T.3
Currie, M.G.4
Forte, L.R.5
-
11
-
-
78049283798
-
Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit
-
Busby RW, Bryant AP, Bartolini WP, et al. Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit. Eur J Pharm 2010;649:328-35
-
(2010)
Eur J Pharm
, vol.649
, pp. 328-35
-
-
Busby, R.W.1
Bryant, A.P.2
Bartolini, W.P.3
-
13
-
-
33746879328
-
Effects of multidose administration of MD-1100 on safety, tolerability, exposure, and pharmcodynamics in healthy subjects
-
Kurtz CB, Fitch D, Busby RW, et al. Effects of multidose administration of MD-1100 on safety, tolerability, exposure, and pharmcodynamics in healthy subjects. Gastroenterology 2006;130(Suppl 2):A 26
-
(2006)
Gastroenterology
, vol.130
, Issue.SUPPL. 2
-
-
Kurtz, C.B.1
Fitch, D.2
Busby, R.W.3
-
14
-
-
34548500315
-
Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome
-
DOI 10.1053/j.gastro.2007.06.067, PII S0016508507012991
-
Andresen V, Camilleri M, Busciglio IA, et al. Effect of 5 days of linaclotide on transit and bowel function in females with constipation- predominant irritable bowel syndrome. Gastroenterology 2007;133:761-8 (Pubitemid 47374145)
-
(2007)
Gastroenterology
, vol.133
, Issue.3
, pp. 761-768
-
-
Andresen, V.1
Camilleri, M.2
Busciglio, I.A.3
Grudell, A.4
Burton, D.5
McKinzie, S.6
Foxx-Orenstein, A.7
Kurtz, C.B.8
Sharma, V.9
Johnston, J.M.10
Currie, M.G.11
Zinsmeister, A.R.12
-
15
-
-
60749099506
-
Pilot study on the effects of linaclotide in patients with chronic constipation
-
Johnston JM, Kurtz CB, Drossman DA, et al. Pilot study on the effects of linaclotide in patients with chronic constipation. Am J Gastroenterol 2009;104:125-32
-
(2009)
Am J Gastroenterol
, vol.104
, pp. 125-32
-
-
Johnston, J.M.1
Kurtz, C.B.2
Drossman, D.A.3
-
16
-
-
77249122338
-
Efficacy of linaclotide for patients with chronic constipation
-
Lembo AJ, Johnston JM, MacDougall JE, et al. Efficacy of linaclotide for patients with chronic constipation. Gastroenterology 2010;138:886-95
-
(2010)
Gastroenterology
, vol.138
, pp. 886-95
-
-
Lembo, A.J.1
Johnston, J.M.2
MacDougall, J.E.3
-
17
-
-
78649690668
-
Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome
-
Johnston JM, Kurtz CB, MacDougall JE, et al. Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome. Gastroenterology 2010;139(6):1877-86
-
(2010)
Gastroenterology
, vol.139
, Issue.6
, pp. 1877-1886
-
-
Johnston, J.M.1
Kurtz, C.B.2
MacDougall, J.E.3
-
18
-
-
79955096978
-
Efficacy and safety of once daily linaclotide administered orally for 12-weeks in patients with chronic constipation: Results from 2 randomized, double-blind, placebo-controlled phase 3 trials (abstract 286)
-
in New Orleans, LA
-
Lembo A, Schneier H, Lavins BJ, et al. Efficacy and safety of once daily linaclotide administered orally for 12-weeks in patients with chronic constipation: results from 2 randomized, double-blind, placebo-controlled phase 3 trials (abstract 286). Presented at Digestive Disease Week (DDW) 2010 in New Orleans, LA
-
(2010)
Digestive Disease Week (DDW)
-
-
Lembo, A.1
Schneier, H.2
Lavins, B.J.3
-
19
-
-
76349111067
-
Linaclotide-A secretagogue and antihyperalgesic agent-What next?
-
Bharucha AE, Linden DR. Linaclotide-a secretagogue and antihyperalgesic agent-what next? Neurogastro Motil 2010;22:227-31
-
(2010)
Neurogastro Motil
, vol.22
, pp. 227-31
-
-
Bharucha, A.E.1
Linden, D.R.2
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