Parenchymal expression of CD40 exacerbates adenovirus-induced hepatitis in mice

Hepatology

Volumn 53, Issue 5, 2011, Pages 1455-1467

  Yan, Jiabin ^a   Jie, Zuliang ^a   Hou, Lifei ^a   Wanderley, Joao L ^a,c   Soong, Lynn ^a,b   Gupta, Shalini ^a   Qiu, Suimin ^a   Chan, Tehsheng ^a   Sun, Jiaren ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; CD40 ANTIGEN; CRE RECOMBINASE; GAMMA INTERFERON; GRANZYME B;

ADENOVIRUS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; EFFECTOR CELL; LIVER INJURY; LYMPHOCYTIC INFILTRATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; POPULATION DYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; VIRAL CLEARANCE; VIRUS HEPATITIS; VIRUS REPLICATION; WILD TYPE;

ADENOVIRIDAE INFECTIONS; ANIMALS; ANTIGENS, CD40; HEPATITIS, VIRAL, ANIMAL; LIVER; LYMPHOCYTES; MICE; MICE, TRANSGENIC; SEVERITY OF ILLNESS INDEX;

EID: 79955076634     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24270     Document Type: Article

References (38)

1. Yang Y, Wilson JM. CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. Science 1996; 273: 1862-1864.
2. Raper SE. Gene therapy: The good, the bad, and the ugly. Surgery 2005; 137: 487-492.
3. Kay MA, Meuse L, Gown AM, Linsley P, Hollenbaugh D, Aruffo A, et al. Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver. Proc Nat Acad Sci U S A 1997; 94: 4686-4691.
4. Mochizuki K, Hayashi N, Katayama K, Hiramatsu N, Kanto T, Mita E, et al. B7/BB-1 expression and hepatitis activity in liver tissues of patients with chronic hepatitis C. HEPATOLOGY 1997; 25: 713-718.
5. Leifeld L, Trautwein C, Dumoulin FL, Manns MP, Sauerbruch T, Spengler U. Enhanced expression of CD80 (B7-1), CD86 (B7-2), and CD40 and their ligands CD28 and CD154 in fulminant hepatic failure. Am J Pathol 1999; 154: 1711-1720.
6. Fiore G, Piazzolla G, Galetta V, Caccetta L, Schiraldi O, Antonaci S. Liver tissue expression of CD80 and CD95 antigens in chronic hepatitis C: relationship with biological and histological disease activities. Microbios 1999; 97: 29-38.
7. Shiraki K, Sugimoto K, Okano H, Wagayama H, Fujikawa K, Yamanaka T, et al. CD40 expression in HCV-associated chronic liver diseases. Int J Mol Med 2006; 18: 559-563.
8. Kassel R, Cruise MW, Iezzoni JC, Taylor NA, Pruett TL, Hahn YS. Chronically inflamed livers up-regulate expression of inhibitory B7 family members. HEPATOLOGY 2009; 50: 1625-1637.
9. Sun J, Tumurbaatar B, Jia J, Diao H, Bodola F, Lemon SM, et al. Parenchymal expression of CD86/B7.2 contributes to hepatitis C virus-related liver injury. J Virol 2005; 79: 10730-10739.
10. Torres R, Clark E. Differential increase of an alternatively polyadenylated mRNA species of murine CD40 upon B lymphocyte activation. J Immunol 1992; 148: 620-626.
11. Anton M, Graham FL. Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression. J Virol 1995; 69: 4600-4606.
12. Klaunig JE, Goldblatt PJ, Hinton DE, Lipsky MM, Chacko J, Trump BF. Mouse liver cell culture. I. Hepatocyte isolation. In Vitro 1981; 17: 913-925.
13. Walsh MJ, Vanags DM, Clouston AD, Richardson MM, Purdie DM, Jonsson JR, et al. Steatosis and liver cell apoptosis in chronic hepatitis C: a mechanism for increased liver injury. HEPATOLOGY 2004; 39: 1230-1238.
14. Chen Q, Wei H, Sun R, Zhang J, Tian Z. Therapeutic RNA silencing of Cys-X3-Cys chemokine ligand 1 gene prevents mice from adenovirus vector-induced acute liver injury. HEPATOLOGY 2008; 47: 648-658.
15. Stout-Delgado HW, Getachew Y, Miller BC, Thiele DL. Intrahepatic lymphocyte expression of dipeptidyl peptidase I-processed granzyme B and perforin induces hepatocyte expression of serine proteinase inhibitor 6 (Serpinb9/SPI-6). J Immunol 2007; 179: 6561-6567.
16. Chiba A, Dascher CC, Besra GS, Brenner MB. Rapid NKT cell responses are self-terminating during the course of microbial infection. J Immunol 2008; 181: 2292-2302.
17. Tang Y, Chen Y, Ni B, Yang D, Guo S, Wu Y. Up-regulation of the expression of costimulatory molecule CD40 in hepatocytes by hepatitis B virus X antigen. Biochem Biophys Res Commun 2009; 384: 12-17.
18. Stokes KY, Calahan L, Hamric CM, Russell JM, Granger DN. CD40/CD40L contributes to hypercholesterolemia-induced microvascular inflammation. Am J Physiol Heart Circ Physiol 2009; 296: H689-H697.
19. Choudhury JA, Russell CL, Randhawa S, Young LS, Adams DH, Afford SC. Differential induction of nuclear factor-kappa B and activator protein-1 activity after CD40 ligation is associated with primary human hepatocyte apoptosis or intrahepatic endothelial cell proliferation. Mol Biol Cell 2003; 14: 1334-1345.
20. Day CP. From fat to inflammation. Gastroenterology 2006; 130: 207-210.
21. Henn V, Slupsky JR, Grafe M, Anagnostopoulos I, Forster R, Muller-Berghaus G, et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998; 391: 591-594.
22. Borcherding F, Nitschke M, Hundorfean G, Rupp J, von Smolinski D, Bieber K, et al. The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease. Am J Pathol 2010; 176: 1816-1827.
23. Raper SE, Chirmule N, Lee FS, Wivel NA, Bagg A, Gao GP, et al. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol Genet Metab 2003; 80: 148-158.
24. Bartholdy C, Kauffmann SO, Christensen JP, Thomsen AR. Agonistic anti-CD40 antibody profoundly suppresses the immune response to infection with lymphocytic choriomeningitis virus. J Immunol 2007; 178: 1662-1670.
25. Crispe IN. The liver as a lymphoid organ. Ann Rev Immunol 2009; 27: 147-163.
26. Warren A, Le Couteur DG, Fraser R, Bowen DG, McCaughan GW, Bertolino P. T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. HEPATOLOGY 2006; 44: 1182-1190.
27. + T cells within the liver. J Immunol 2001; 166: 5430-5438.
28. + T cells activated locally within the transplanted liver. J Exp Med 2006; 203: 437-447.
29. + T cells by adeno-associated virus-transduced hepatocytes. HEPATOLOGY 2010; 52: 1068-1077.
30. Yang Y, Ertl HC, Wilson JM. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1994; 1: 433-442.
31. Robbins SH, Tessmer MS, Mikayama T, Brossay L. Expansion and contraction of the NK cell compartment in response to murine cytomegalovirus infection. J Immunol 2004; 173: 259-266.
32. Frese M, Schwèarzle V, Barth K, Krieger N, Lohmann V, Mihm S, et al. Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs. HEPATOLOGY 2002; 35: 694-703.
33. + T cell effector activity is dictated by cognate peptide concentration. J Immunol 2004; 172: 6407-6417.
34. Thimme R, Bukh J, Spangenberg HC, Wieland S, Pemberton J, Steiger C, et al. Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease. Proc Nat Acad Sci U S A 2002; 99: 15661-15668.
35. Stout-Delgado HW, Getachew Y, Rogers TE, Miller BC, Thiele DL. The role of serpinb9/serine protease inhibitor 6 in preventing granzyme B-dependent hepatotoxicity. HEPATOLOGY 2007; 46: 1530-1540.
36. Shen X, Wang Y, Gao F, Ren F, Busuttil RW, Kupiec-Weglinski JW, et al. CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury. HEPATOLOGY 2009; 50: 1537-1546.
37. + T lymphocytes. Immunity 2004; 20: 327-336.
38. Tsukamoto H, Machida K, Dynnyk A, Mkrtchyan H. "Second hit" models of alcoholic liver disease. Semin Liver Dis 2009; 29: 178-187.