Genetic engineering of the pancreatic β-cell line MIN6 to express bacterial globin proteins protects cells from nitrosative stress

Biotechnology and Applied Biochemistry

Volumn 58, Issue 2, 2011, Pages 84-90

  Frey, Alexander D ^a   Schmid, Vinzenz H ^a   Kallio, Pauli T ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

apoptosis; cytoprotection; metabolic engineering; nitrosative stress; pancreatic cells; Ralstonia eutropha flavohemoglobin; Vitreoscilla hemoglobin

Indexed keywords

BACTERIA; CELL CULTURE; CELL DEATH; DETOXIFICATION; GENETIC ENGINEERING; GLYCOPROTEINS; HEMOGLOBIN; MACROPHAGES; MAMMALS; METABOLIC ENGINEERING; NITRIC OXIDE; PROTEINS;

CONSTITUTIVE EXPRESSIONS; CYTOPROTECTION; HETEROLOGOUS EXPRESSION; NITROSATIVE STRESS; RALSTONIA EUTROPHA; TUMOR NECROSIS FACTOR ALPHA; TYPE 1 DIABETES MELLITUS; VITREOSCILLA HEMOGLOBIN;

CELL ENGINEERING;

CASPASE; GAMMA INTERFERON; GLOBIN; HEMOGLOBIN; INTERLEUKIN 1BETA; NITRIC OXIDE; NITROPRUSSIDE SODIUM; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CUPRIAVIDUS NECATOR; ENZYME ACTIVITY; ENZYME INDUCTION; GENETIC ENGINEERING; IN VIVO STUDY; MOUSE; NITROSATIVE STRESS; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; VITREOSCILLA; WILD TYPE;

BACTERIA (MICROORGANISMS); CUPRIAVIDUS NECATOR; MAMMALIA; VITREOSCILLA;

EID: 79955064801     PISSN: 08854513     EISSN: 14708744     Source Type: Journal    
DOI: 10.1002/bab.4     Document Type: Article

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