Increased serum phosphate and adverse clinical outcomes: Unraveling mechanisms of disease

Current Opinion in Nephrology and Hypertension

Volumn 20, Issue 3, 2011, Pages 224-228

  Gutiérrez, Orlando M ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

left ventricular hypertrophy; phosphate; phosphorus; socioeconomic status; vascular calcification

Indexed keywords

BIOLOGICAL FACTOR; PHOSPHATE; SEX HORMONE;

ADVERSE OUTCOME; ARTERIAL STIFFNESS; ARTERY CALCIFICATION; CAROTID ARTERY DISEASE; DISEASE PREDISPOSITION; HEART LEFT VENTRICLE HYPERTROPHY; HORMONE BLOOD LEVEL; KIDNEY FUNCTION; LONG TERM CARE; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SEX DIFFERENCE; SOCIOECONOMICS; VASCULAR DISEASE;

CARDIOVASCULAR DISEASES; FEMALE; FIBROBLAST GROWTH FACTORS; HUMANS; MALE; PHOSPHATES; POLYMORPHISM, SINGLE NUCLEOTIDE; SOCIAL CLASS;

EID: 79955045957     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/MNH.0b013e328343ea70     Document Type: Review

References (46)

1. Block GA, Klassen PS, Lazarus JM, et al. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 2004; 15:2208-2218. (Pubitemid 39031360)
2. Dhingra R, Sullivan LM, Fox CS, et al. Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med 2007; 167:879-885. (Pubitemid 46762749)
3. Kestenbaum B, Sampson JN, Rudser KD, et al. Serum phosphate levels and mortality risk among people with chronic kidney disease. J Am Soc Nephrol 2005; 16:520-528. (Pubitemid 41725150)
4. Tonelli M, Sacks F, Pfeffer M, et al. Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 2005; 112:2627-2633. (Pubitemid 41532599)
5. Wolf M. Fibroblast growth factor 23 and the future of phosphorus management. Curr Opin Nephrol Hypertens 2009; 18:463-468.
6. Zisman AL, Wolf M. Recent advances in the rapidly evolving field of fibroblast growth factor 23 in chronic kidney disease. Curr Opin Nephrol Hypertens 2010; 19:335-342.
7. Montes de Oca A, Madueno JA, Martinez-Moreno JM, et al. High-phosphateinduced calcification is related to SM22alpha promoter methylation in vascular smooth muscle cells. J Bone Miner Res 2010; 25:1996-2005.
8. Giachelli CM, Jono S, Shioi A, et al. Vascular calcification and inorganic phosphate. Am J Kidney Dis 2001; 38:S34-S37. (Pubitemid 32927609)
9. Li X, Yang HY, Giachelli CM. BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells. Atherosclerosis 2008; 199:271-277.
10. Mathew S, Tustison KS, Sugatani T, et al. The mechanism of phosphorus as a cardiovascular risk factor in CKD. J Am Soc Nephrol 2008; 19:1092-1105.
11. Villa-Bellosta R, Millan A, Sorribas V. Role of calcium-phosphate deposition in vascular smooth muscle cell calcification. Am J Physiol Cell Physiol 2011; 300:C210-C220.
12. Adeney KL, Siscovick DS, Ix JH, et al. Association of serum phosphate with vascular and valvular calcification in moderate CKD. J Am Soc Nephrol 2009; 20:381-387.
13. Goodman WG, Goldin J, Kuizon BD, et al. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 2000; 342:1478-1483. (Pubitemid 30318271)
14. Maher ER, Young G, Smyth-Walsh B, et al. Aortic and mitral valve calcification in patients with end-stage renal disease. Lancet 1987; 2:875-877. (Pubitemid 17154752)
15. Shigematsu T, Kono T, Satoh K, et al. Phosphate overload accelerates vascular calcium deposition in end-stage renal disease patients. Nephrol Dial Transplant 2003; 18 (Suppl 3):iii86-89. (Pubitemid 36826936)
16. Foley RN, Collins AJ, Herzog CA, et al. Serum phosphorus levels associate with coronary atherosclerosis in young adults. J Am Soc Nephrol 2009; 20:397-404.
17. Tuttle KR, Short RA. Longitudinal relationships among coronary artery calci- fication, serum phosphorus, and kidney function. Clin J Am Soc Nephrol 2009; 4:1968-1973.
18. Ix JH, De Boer IH, Peralta CA, et al. Serum phosphorus concentrations and arterial stiffness among individuals with normal kidney function to moderate kidney disease in MESA. Clin J Am Soc Nephrol 2009; 4:609-615.
19. Meng J, Wassel CL, Kestenbaum BR, et al. Serum phosphorus levels and the spectrum of ankle-brachial index in older men: the Osteoporotic Fractures in Men (MrOS) study. Am J Epidemiol 2010; 171:909-916.
20. Kendrick J, Ix JH, Targher G, et al. Relation of serum phosphorus levels to ankle brachial pressure index (from the Third National Health and Nutrition Examination Survey). Am J Cardiol 2010; 106:564-568.
21. O'Hare AM, Katz R, Shlipak MG, et al. Mortality and cardiovascular risk across the ankle-arm index spectrum: results from the Cardiovascular Health study. Circulation 2006; 113:388-393. (Pubitemid 43803200)
22. Resnick HE, Lindsay RS, McDermott MM, et al. Relationship of high and low ankle brachial index to all-cause and cardiovascular disease mortality: the Strong Heart study. Circulation 2004; 109:733-739. (Pubitemid 38222892)
23. Sutton-Tyrrell K, Venkitachalam L, Kanaya AM, et al. Relationship of ankle blood pressures to cardiovascular events in older adults. Stroke 2008; 39:863-869. (Pubitemid 351619539)
24. Saab G, Whooley MA, Schiller NB, et al. Association of serum phosphorus with left ventricular mass in men and women with stable cardiovascular disease: data from the Heart and Soul study. Am J Kidney Dis 2010; 56:496-505.
25. Onufrak SJ, Bellasi A, Shaw LJ, et al. Phosphorus levels are associated with subclinical atherosclerosis in the general population. Atherosclerosis 2008; 199:424-431.
26. Onufrak SJ, Bellasi A, Cardarelli F, et al. Investigation of gender heterogeneity in the associations of serum phosphorus with incident coronary artery disease and all-cause mortality. Am J Epidemiol 2009; 169:67-77.
27. Ruan L, Chen W, Srinivasan SR, et al. Relation of serum phosphorus levels to carotid intima-media thickness in asymptomatic young adults (from the Bogalusa Heart study). Am J Cardiol 2010; 106:793-797.
28. de Boer IH, Rue TC, Kestenbaum B. Serum phosphorus concentrations in the third National Health and Nutrition Examination Survey (NHANES III). Am J Kidney Dis 2009; 53:399-407.
29. Mataix J, Aranda P, Lopez-Jurado M, et al. Factors influencing the intake and plasma levels of calcium, phosphorus and magnesium in southern Spain. Eur J Nutr 2006; 45:349-354. (Pubitemid 44386854)
30. Block JP, Scribner RA, DeSalvo KB. Fast food, race/ethnicity, and income: a geographic analysis. Am J Prev Med 2004; 27:211-217. (Pubitemid 39278320)
31. Butt S, Leon JB, David CL, et al. The prevalence and nutritional implications of fast food consumption among patients receiving hemodialysis. J Ren Nutr 2007; 17:264-268. (Pubitemid 46936232)
32. Powell LM, Chaloupka FJ, Bao Y. The availability of fast-food and full-service restaurants in the United States: associations with neighborhood characteristics. Am J Prev Med 2007; 33:S240-S245. (Pubitemid 47404780)
33. Sullivan CM, Leon JB, Sehgal AR. Phosphorus-containing food additives and the accuracy of nutrient databases: implications for renal patients. J Ren Nutr 2007; 17:350-354. (Pubitemid 47284907)
34. Bell RR, Draper HH, Tzeng DY, et al. Physiological responses of human adults to foods containing phosphate additives. J Nutr 1977; 107:42-50. (Pubitemid 8030952)
35. Gutierrez OM, Isakova T, Enfield G, et al. Impact of poverty on serum phosphate concentrations in the Third National Health and Nutrition Examination Survey. J Ren Nutr 2010 [Epub ahead of print]. This study was the first to report an independent association of poverty with higher serum phosphate among US adults.
36. Gutierrez OM, Anderson C, Isakova T, et al. Low socioeconomic status associates with higher serum phosphate irrespective of race. J Am Soc Nephrol 2010; 21:1953-1960.
37. Oenning LL, Vogel J, Calvo MS. Accuracy of methods estimating calcium and phosphorus intake in daily diets. J Am Diet Assoc 1988; 88:1076-1080.
38. Uribarri J, Calvo MS. Hidden sources of phosphorus in the typical American diet: does it matter in nephrology? Semin Dial 2003; 16:186-188. (Pubitemid 37363217)
39. Carrillo-Lopez N, Roman-Garcia P, Rodriguez-Rebollar A, et al. Indirect regulation of PTH by estrogens may require FGF23. J Am Soc Nephrol 2009; 20:2009-2017.
40. Faroqui S, Levi M, Soleimani M, et al. Estrogen downregulates the proximal tubule type IIa sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia. Kidney Int 2008; 73:1141-1150. (Pubitemid 351620434)
41. Meng J, Ohlsson C, Laughlin GA, et al. Associations of estradiol and testosterone with serum phosphorus in older men: the Osteoporotic Fractures in Men study. Kidney Int 2010; 78:415-422.
42. Adami S, Gatti D, Bertoldo F, et al. The effects of menopause and estrogen replacement therapy on the renal handling of calcium. Osteoporos Int 1992; 2:180-185.
43. Stock JL, Coderre JA, Posillico JT. Effects of estrogen on mineral metabolism in postmenopausal women as evaluated by multiple assays measuring parathyrin bioactivity. Clin Chem 1989; 35:18-22. (Pubitemid 19046776)
44. Uemura H, Irahara M, Yoneda N, et al. Close correlation between estrogen treatment and renal phosphate reabsorption capacity. J Clin EndocrinolMetab 2000; 85:1215-1219. (Pubitemid 32269375)
45. KestenbaumB, Glazer NL, Kottgen A, et al. Common genetic variants associate with serum phosphorus concentration. J Am Soc Nephrol 2010; 21:1223-1232.
46. Norris KC, Greene T, Kopple J, et al. Baseline predictors of renal disease progression in the African American Study of Hypertension and Kidney Disease. J Am Soc Nephrol 2006; 17:2928-2936. (Pubitemid 44484684)