Keeping up with the zone of polarizing activity: New roles for an old signaling center

Developmental Dynamics

Volumn 240, Issue 5, 2011, Pages 915-919

  Harfe, Brian D ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

AER; Limb; Mouse; Shh; ZPA

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 17; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR 8; FIBROBLAST GROWTH FACTOR 9; GREMLIN1 PROTEIN; MESSENGER RNA; PROTEIN; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ECTODERM; FEEDBACK SYSTEM; GENE EXPRESSION; GENITAL SYSTEM; IN SITU HYBRIDIZATION; LIMB BUD; LIMB DEVELOPMENT; MESENCHYME; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; ZONE OF POLARIZING ACTIVITY;

ANIMALS; ECTODERM; EXTREMITIES; HEDGEHOG PROTEINS; LIMB BUDS; SIGNAL TRANSDUCTION;

ERINACEIDAE; VERTEBRATA;

EID: 79955038899     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.22597     Document Type: Article

References (33)

1. Amano T, Sagai T, Tanabe H, Mizushina Y, Nakazawa H, Shiroishi T. 2009. Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription. Dev Cell 16: 47-57.
2. Bastida MF, Ros MA. 2008. How do we get a perfect complement of digits? Curr Opin Genet Dev 18: 374-380.
3. Bastida MF, Sheth R, Ros MA. 2009. A BMP-Shh negative-feedback loop restricts Shh expression during limb development. Development 136: 3779-3789.
4. Bell SM, Schreiner CM, Scott WJ. 1999. Disrupting the establishment of polarizing activity by teratogen exposure. Mech Dev 88: 147-157.
5. Bell SM, Schreiner CM, Goetz JA, Robbins DJ, Scott WJ Jr. 2005. Shh signaling in limb bud ectoderm: potential role in teratogen-induced postaxial ectrodactyly. Dev Dyn 233: 313-325.
6. Benazet JD, Bischofberger M, Tiecke E, Goncalves A, Martin JF, Zuniga A, Naef F, Zeller R. 2009. A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning. Science 323: 1050-1053.
7. Boehm B, Westerberg H, Lesnicar-Pucko G, Raja S, Rautschka M, Cotterell J, Swoger J, Sharpe J. 2010. The role of spatially controlled cell proliferation in limb bud morphogenesis. PLoS Biol 8: e1000420.
8. Bouldin CM, Gritli-Linde A, Ahn S, Harfe BD. 2010. Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning. Proc Natl Acad Sci U S A 107: 5489-5494.
9. Boulet AM, Moon AM, Arenkiel BR, Capecchi MR. 2004. The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. Dev Biol 273: 361-372.
10. Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA. 1996. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383: 407-413.
11. Chiang C, Litingtung Y, Harris MP, Simandl BK, Li Y, Beachy PA, Fallon JF. 2001. Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol 236: 421-435.
12. Harfe BD, Scherz PJ, Nissim S, Tian H, McMahon AP, Tabin CJ. 2004. Evidence for an expansion-based temporal shh gradient in specifying vertebrate digit identities. Cell 118: 517-528.
13. Laufer E, Nelson CE, Johnson RL, Morgan BA, Tabin C. 1994. Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79: 993-1003.
14. Mariani FV, Ahn CP, Martin GR. 2008. Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning. Nature 453: 401-405.
15. Nelson CE, Morgan BA, Burke AC, Laufer E, DiMambro E, Murtaugh LC, Gonzales E, Tessarollo L, Parada LF, Tabin C. 1996. Analysis of Hox gene expression in the chick limb bud. Development 122: 1449-1466.
16. Niswander L, Jeffrey S, Martin GR, Tickle C. 1994. A positive feedback loop coordinates growth and patterning in the vertebrate limb. Nature 371: 609-612.
17. Panman L, Galli A, Lagarde N, Michos O, Soete G, Zuniga A, Zeller R. 2006. Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling. Development 133: 3419-3428.
18. Pearse RV Jr, Vogan KJ, Tabin CJ. 2001. Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis. Dev Biol 239: 15-29.
19. Quirk J, van den Heuvel M, Henrique D, Marigo V, Jones TA, Tabin C, Ingham PW. 1997. The smoothened gene and hedgehog signal transduction in Drosophila and vertebrate development. Cold Spring Harb Symp Quant Biol 62: 217-226.
20. Riddle RD, Johnson RL, Laufer E, Tabin C. 1993. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75: 1401-1416.
21. Sanz-Ezquerro JJ, Tickle C. 2000. Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development. Development 127: 4811-4823.
22. Saunders, Gasseling 1968. Ectodermal-mesodermal interactions in the origin of limb symmetry. Baltimore: Willilams and Wilkins. p 78-97.
23. Scherz PJ, Harfe BD, McMahon AP, Tabin CJ. 2004. The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science 305: 396-399.
24. Seifert AW, Bouldin CM, Choi KS, Harfe BD, Cohn MJ. 2009. Multiphasic and tissue-specific roles of sonic hedgehog in cloacal septation and external genitalia development. Development 136: 3949-3957.
25. Sun X, Lewandoski M, Meyers EN, Liu YH, Maxson RE Jr, Martin GR. 2000. Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat Genet 25: 83-86.
26. Sun X, Mariani FV, Martin GR. 2002. Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature 418: 501-508.
27. Tabin CJ, McMahon AP. 2008. Developmental biology. Grasping limb patterning. Science 321: 350-352.
28. Tickle C. 1981. The number of polarizing region cells required to specify additional digits in the developing chick wing. Nature 289: 295-298.
29. Towers M, Mahood R, Yin Y, Tickle C. 2008. Integration of growth and specification in chick wing digit-patterning. Nature 452: 882-886.
30. Verheyden JM, Sun X. 2008. An Fgf/Gremlin inhbitory feedback loop triggers termination of limb bud outgrowth. Nature 2008; 454: 638-641.
31. Zeller R, Lopez-Rios J, Zuniga A. 2009. Vertebrate limb bud development: moving towards integrative analysis of organogenesis. Nat Rev Genet 10: 845-858.
32. Zhu J, Nakamura E, Nguyen MT, Bao X, Akiyama H, Mackem S. 2008. Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud. Dev Cell 14: 624-632.
33. Zuniga A, Haramis AP, McMahon AP, Zeller R. 1999. Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature 401: 598-602.