Identification of benzo[c]phenanthridine metabolites in human hepatocytes by liquid chromatography with electrospray ion-trap and quadrupole time-of-flight mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 15-16, 2011, Pages 1077-1085

  Kosina, Pavel ^a   Vacek, Jan ^a   Papoušková, Barbora ^a   Stiborová, Marie ^b   Stýskala, Jakub ^a   Cankař, Petr ^a   Vrublová, Eva ^a   Vostálová, Jitka ^a   Šimánek, Vilím ^a   Ulrichová, Jitka ^a  

^a PALACKÝ UNIVERSITY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Biotransformation; Chelerythrine; Human hepatocytes; Mass spectrometry; Reduction and oxidation; Sanguinarine

Indexed keywords

ALKALOIDS; BIOCONVERSION; BIOMOLECULES; DETOXIFICATION; IONS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SILICA;

BIOTRANSFORMATION; CHELERYTHRINE; CHROMATOGRAPHIC SYSTEMS; HUMAN HEPATOCYTES; PHENANTHRIDINE ALKALOIDS; QUADRUPOLE TIME OF FLIGHT MASS SPECTROMETRY; QUADRUPOLE-TIME OF FLIGHTS; SANGUINARINE;

METABOLITES;

BENZO[C]PHENANTHRIDINE DERIVATIVE; CHELERYTHRINE; SANGUINARINE;

ARTICLE; BIOTRANSFORMATION; CHEMICAL STRUCTURE; DEMETHYLATION; DETOXIFICATION; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; ION TRAP MASS SPECTROMETRY; LIVER CELL; METABOLITE; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY;

EID: 79955019480     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.03.023     Document Type: Article

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