The Claudin family and its role in cancer and metastasis

Frontiers in Bioscience

Volumn 16, Issue 3, 2011, Pages 1069-1083

  Escudero Esparza, Astrid ^a   Jiang, Wen G ^a   Martin, Tracey A ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Cancer; Claudins; Metastasis; Review; Tight junctions; Treatment

Indexed keywords

CLAUDIN; TUMOR MARKER;

ANIMAL; DRUG EFFECT; EPITHELIUM; GENETICS; HUMAN; METASTASIS; NEOPLASM; PATHOPHYSIOLOGY; PERMEABILITY; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; TIGHT JUNCTION;

ANIMALS; CLAUDINS; EPITHELIUM; HUMANS; NEOPLASM METASTASIS; NEOPLASMS; PERMEABILITY; SIGNAL TRANSDUCTION; TIGHT JUNCTIONS; TUMOR MARKERS, BIOLOGICAL;

EID: 79955009775     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3736     Document Type: Article

References (96)

1. J. Yang, S.A. Mani, and R.A. Weinberg: Exploring a new twist on tumour metastasis. Cancer Res 66, 4549-4552 (2006)
2. T.A. Martin, G. Watkins, R.E. Mansel, and W.G. Jiang: Loss of tight junction plaque molecules in breast cancer tissues is associated with a poor prognosis in patients with breast cancer. Eur J Cancer 40, 2717-2725 (2004) (Pubitemid 39574723)
3. L.A. Staehelin: Further observations on the fine structure of freeze-cleaved tight junctions. J Cell Sci 13, 763-786 (1973)
4. M. Cereijido, R.G. Contreras, L. Shoshani, D. Flores- Benitez, and I. Larre: Tight junction and polarity interaction in the transporting epithelial phenotype. Biochim Biophys Acta 1778, 770-793 (2008) (Pubitemid 351317802)
5. P. Claude: Morphological factors influencing transepithelial permeability: a model for the resistance of the zonula occludens. J Membr Biol 39, 219-232 (1978) (Pubitemid 8298689)
6. S. Tsukita, M. Furuse, and M. Itoh: Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol 2, 285-293 (2001) (Pubitemid 33676971)
7. J.M. Anderson and C.M. Van Itallie: Tight junctions and the molecular basis for regulation of paracellular permeability. Am J Physiol 269, G467-475 (1995)
8. S. Tsukita: Isolation of cell-to-cell adherens junctions from rat liver. J Cell Biol 108, 31-41 (1989) (Pubitemid 19050603)
9. G. Krause, L. Winkler, S.L. Mueller, R.F. Haseloff, J. Piontek, and I.E. Blasig: Structure and function of claudins. Biochim Biophys Acta 1778, 631-645 (2008)
10. J. Piontek, L. Winkler, H. Wolburg, S.L. Muller, N. Zuleger, C. Piehl, B. Wiesner, G. Krause, and I.E. Blasig: Formation of tight junction: determinants of homophilic interaction between classic claudins. FASEB J 22, 146-158 (2008)
11. C.M. Van Itallie and J.M. Anderson: Claudins and epithelial paracellular transport. Annu Rev Physiol 68, 403-429 (2006)
12. K. Morita, M. Furuse, K. Fujimoto, and S. Tsukita: Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A 96, 511-516 (1999) (Pubitemid 29061239)
13. M. Furuse, H. Sasaki, and S. Tsukita: Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol 147, 891-903 (1999)
14. T. Ahrens, O. Pertz, D. Haussinger, C. Fauser, T. Schulthess, and J. Engel: Analysis of heterophilic and homophilic interactions of cadherins using the c-Jun/c-Fos dimerization domains. J Biol Chem 277, 19455-19460 (2002) (Pubitemid 34967455)
15. B.L. Daugherty, C. Ward, T. Smith, J.D. Ritzenthaler, and M. Koval: Regulation of heterotypic claudin compatibility. J Biol Chem 282, 30005-30013 (2007) (Pubitemid 350035274)
16. K. Morita, H. Sasaki, M. Furuse, and S. Tsukita: Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. J Cell Biol 147, 185-194 (1999) (Pubitemid 30211806)
17. F.D. Nunes, L.N. Lopez, H.W. Lin, C. Davies, R.B. Azevedo, A. Gow, and B. Kachar: Distinct subdomain organization and molecular composition of a tight junction with adherens junction features. J Cell Sci 119, 4819-4827 (2006) (Pubitemid 46017795)
18. K. Morita, H. Sasaki, K. Fujimoto, M. Furuse, and S. Tsukita: Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J Cell Biol 145, 579-588 (1999) (Pubitemid 29215721)
19. T. Miyamoto, K. Morita, D. Takemoto, K. Takeuchi, Y. Kitano, T. Miyakawa, K. Nakayama, Y. Okamura, H. Sasaki, Y. Miyachi, M. Furuse, and S. Tsukita: Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice. J Cell Biol 169, 527-538 (2005) (Pubitemid 40686702)
20. S. Tsukita and M. Furuse: Pores in the wall: claudins constitute tight junction strands containing aqueous pores. J Cell Biol 149, 13-16 (2000) (Pubitemid 30196694)
21. S. Angelow, R. Ahstrom, and A.S. Yu: Biology of claudins. Am J Physiol Renal Physiol 295, F867-876 (2008)
22. C.M. Van Itallie and J.M. Anderson: The role of claudins in determining paracellular charge selectivity. Proc Am Thorac Soc 1, 38-41 (2004)
23. S. Angelow, R. El-Husseini, S.A. Kanzawa, and A.S. Yu: Renal localization and function of the tight junction protein, claudin-19. Am J Physiol Renal Physiol 293, F166-177 (2007) (Pubitemid 47345015)
24. M.D. Alexandre, Q. Lu, and Y.H. Chen: Overexpression of claudin-7 decreases the paracellular Clconductance and increases the paracellular Na+ conductance in LLC-PK1 cells. J Cell Sci 118, 2683-2693 (2005) (Pubitemid 40932893)
25. T. D'Souza, R. Agarwal, and P.J. Morin: Phosphorylation of claudin-3 at threonine 192 by cAMPdependent protein kinase regulates tight junction barrier function in ovarian cancer cells. J Biol Chem 280, 26233-26240 (2005) (Pubitemid 41022220)
26. S. Amasheh, T. Schmidt, M. Mahn, P. Florian, J. Mankertz, S. Tavalali, A.H. Gitter, J.D. Schulzke, and M. Fromm: Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells. Cell Tissue Res 321, 89-96 (2005) (Pubitemid 40984842)
27. M. Furuse, M. Hata, K. Furuse, Y. Yoshida, A. Haratake, Y. Sugitani, T. Noda, A. Kubo, and S. Tsukita: Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1- deficient mice. J Cell Biol 156, 1099-1111 (2002) (Pubitemid 34839858)
28. A. Gow, C.M. Southwood, J.S. Li, M. Pariali, G.P. Riordan, S.E. Brodie, J. Danias, J.M. Bronstein, B. Kachar, and R.A. Lazzarini: CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Cell 99, 649-659 (1999) (Pubitemid 30004640)
29. T. Ben-Yosef, I.A. Belyantseva, T.L. Saunders, E.D. Hughes, K. Kawamoto, C.M. Van Itallie, L.A. Beyer, K. Halsey, D.J. Gardner, E.R. Wilcox, J. Rasmussen, J.M. Anderson, D.F. Dolan, A. Forge, Y. Raphael, S.A. Camper, and T.B. Friedman: Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration. Hum Mol Genet 12, 2049-2061 (2003) (Pubitemid 37038814)
30. O.R. Colegio, C. Van Itallie, C. Rahner, and J.M. Anderson: Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. Am J Physiol Cell Physiol 284, C1346-1354 (2003) (Pubitemid 36583375)
31. C.M. Van Itallie, J. Holmes, A. Bridges, and J.M. Anderson: Claudin-2-dependent changes in noncharged solute flux are mediated by the extracellular domains and require attachment to the PDZ-scaffold. Ann N Y Acad Sci 1165, 82-87 (2009)
32. S. Amasheh, S. Milatz, S.M. Krug, A.G. Markov, D. Gunzel, M. Amasheh, and M. Fromm: Tight junction proteins as channel formers and barrier builders. Ann N Y Acad Sci 1165, 211-219 (2009)
33. E.E. Schneeberger: Claudins form ion-selective channels in the paracellular pathway. Focus on "Claudin extracellular domains determine paracellular charge selectively and resistance but not tight junction fibril architecture". Am J Physiol Cell Physiol 284, C1331-1333 (2003) (Pubitemid 36583373)
34. C.M. Van Itallie, S. Rogan, A. Yu, L.S. Vidal, J. Holmes, and J.M. Anderson: Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities. Am J Physiol Renal Physiol 291, F1288-1299 (2006) (Pubitemid 44887242)
35. H. Fujita, H. Chiba, H. Yokozaki, N. Sakai, K. Sugimoto, T. Wada, T. Kojima, T. Yamashita, and N. Sawada: Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestine. J Histochem Cytochem 54, 933-944 (2006) (Pubitemid 44106871)
36. S.I. Kitajiri, M. Furuse, K. Morita, Y. Saishin-Kiuchi, H. Kido, J. Ito, and S. Tsukita: Expression patterns of claudins, tight junction adhesion molecules, in the inner ear. Hear Res 187, 25-34 (2004) (Pubitemid 38091559)
37. N. Charoenphandhu, K. Wongdee, K. Tudpor, J. Pandaranandaka, and N. Krishnamra: Chronic metabolic acidosis upregulated claudin mRNA expression in the duodenal enterocytes of female rats. Life Sci 80, 1729-1737 (2007) (Pubitemid 46527659)
38. D.S. Gerhard, L. Wagner, E.A. Feingold, C.M. Shenmen, L.H. Grouse, G. Schuler, S.L. Klein, S. Old, R. Rasooly, P. Good, M. Guyer, A.M. Peck, J.G. Derge, D. Lipman, F.S. Collins, W. Jang, S. Sherry, M. Feolo, L. Misquitta, E. Lee, K. Rotmistrovsky, S.F. Greenhut, C.F. Schaefer, K. Buetow, T.I. Bonner, D. Haussler, J. Kent, M. Kiekhaus, T. Furey, M. Brent, C. Prange, K. Schreiber, N. Shapiro, N.K. Bhat, R.F. Hopkins, F. Hsie, T. Driscoll, M.B. Soares, T.L. Casavant, T.E. Scheetz, M.J. Brownstein, T.B. Usdin, S. Toshiyuki, P. Carninci, Y. Piao, D.B. Dudekula, M.S. Ko, K. Kawakami, Y. Suzuki, S. Sugano, C.E. Gruber, M.R. Smith, B. Simmons, T. Moore, R. Waterman, S.L. Johnson, Y. Ruan, C.L. Wei, S. Mathavan, P.H. Gunaratne, J. Wu, A.M. Garcia, S.W. Hulyk, E. Fuh, Y. Yuan, A. Sneed, C. Kowis, A. Hodgson, D.M. Muzny, J. McPherson, R.A. Gibbs, J. Fahey, E. Helton, M. Ketteman, A. Madan, S. Rodrigues, A. Sanchez, M. Whiting, A. Madari, A.C. Young, K.D. Wetherby, S.J. Granite, P.N. Kwong, C.P. Brinkley, R.L. Pearson, G.G. Bouffard, R.W. Blakesly, E.D. Green, M.C. Dickson, A.C. Rodriguez, J. Grimwood, J. Schmutz, R.M. Myers, Y.S. Butterfield, M. Griffith, O.L. Griffith, M.I. Krzywinski, N. Liao, R. Morin, D. Palmquist, A.S. Petrescu, U. Skalska, D.E. Smailus, J.M. Stott, A. Schnerch, J.E. Schein, S.J. Jones, R.A. Holt, A. Baross, M.A. Marra, S. Clifton, K.A. Makowski, S. Bosak and J. Malek: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res 14, 2121-2127 (2004) (Pubitemid 39440194)
39. H. Wolburg, K. Wolburg-Buchholz, J. Kraus, G. Rascher-Eggstein, S. Liebner, S. Hamm, F. Duffner, E.H. Grote, W. Risau, and B. Engelhardt: Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme. Acta Neuropathol 105, 586-592 (2003) (Pubitemid 36798859)
40. T. Nitta, M. Hata, S. Gotoh, Y. Seo, H. Sasaki, N. Hashimoto, M. Furuse, and S. Tsukita: Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol 161, 653-660 (2003) (Pubitemid 36578587)
41. T. Ishizaki, H. Chiba, T. Kojima, M. Fujibe, T. Soma, H. Miyajima, K. Nagasawa, I. Wada, and N. Sawada: Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase Adependent and -independent pathways. Exp Cell Res 290, 275-288 (2003) (Pubitemid 37272172)
42. K. Yamauchi, T. Rai, K. Kobayashi, E. Sohara, T. Suzuki, T. Itoh, S. Suda, A. Hayama, S. Sasaki, and S. Uchida: Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Proc Natl Acad Sci U S A 101, 4690-4694 (2004) (Pubitemid 38437472)
43. R. Tatum, Y. Zhang, Q. Lu, K. Kim, B.G. Jeansonne, and Y.H. Chen: WNK4 phosphorylates ser(206) of claudin- 7 and promotes paracellular Cl(-) permeability. FEBS Lett 581, 3887-3891 (2007) (Pubitemid 47102309)
44. M. Fujibe, H. Chiba, T. Kojima, T. Soma, T. Wada, T. Yamashita, and N. Sawada: Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions. Exp Cell Res 295, 36-47 (2004) (Pubitemid 38407343)
45. F. Carrozzino, P. Pugnale, E. Feraille, and R. Montesano: Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression. Am J Physiol Cell Physiol 297, C775-787 (2009)
46. M. Tanaka, R. Kamata, and R. Sakai: EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability. J Biol Chem 280, 42375-42382 (2005) (Pubitemid 43023209)
47. M. Yamamoto, S.H. Ramirez, S. Sato, T. Kiyota, R.L. Cerny, K. Kaibuchi, Y. Persidsky, and T. Ikezu: Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am J Pathol 172, 521-533 (2008) (Pubitemid 351282037)
48. J. Ikenouchi, M. Matsuda, M. Furuse, and S. Tsukita: Regulation of tight junctions during the epitheliummesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J Cell Sci 116, 1959-1967 (2003) (Pubitemid 36622294)
49. C.M. Van Itallie, T.M. Gambling, J.L. Carson, and J.M. Anderson: Palmitoylation of claudins is required for efficient tight-junction localization. J Cell Sci 118, 1427-1436 (2005) (Pubitemid 40585123)
50. T. Ohkubo and M. Ozawa: The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation. J Cell Sci 117, 1675-1685 (2004) (Pubitemid 38559300)
51. F. Carrozzino, P. Soulie, D. Huber, N. Mensi, L. Orci, A. Cano, E. Feraille, and R. Montesano: Inducible expression of Snail selectively increases paracellular ion permeability and differentially modulates tight junction proteins. Am J Physiol Cell Physiol 289, C1002-1014 (2005) (Pubitemid 41361654)
52. T. Niimi, K. Nagashima, J.M. Ward, P. Minoo, D.B. Zimonjic, N.C. Popescu, and S. Kimura: claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing. Mol Cell Biol 21, 7380-7390 (2001) (Pubitemid 32958540)
53. F. Escaffit, F. Boudreau, and J.F. Beaulieu: Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. J Cell Physiol 203, 15-26 (2005) (Pubitemid 40328168)
54. W.G. Jiang, T.A. Martin, C. Parr, G. Davies, K. Matsumoto, and T. Nakamura: Hepatocyte growth factor, its receptor, and their potential value in cancer therapies. Crit Rev Oncol Hematol 53, 35-69 (2005) (Pubitemid 39656109)
55. J.H. Lipschutz, S. Li, A. Arisco, and D.F. Balkovetz: Extracellular signal-regulated kinases 1/2 control claudin-2 expression in Madin-Darby canine kidney strain I and II cells. J Biol Chem 280, 3780-3788 (2005) (Pubitemid 40223847)
56. A.B. Singh and R.C. Harris: Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells. J Biol Chem 279, 3543-3552 (2004) (Pubitemid 38140594)
57. Y. Peter, A. Comellas, E. Levantini, E.P. Ingenito, and S.D. Shapiro: Epidermal growth factor receptor and claudin-2 participate in A549 permeability and remodeling: implications for non-small cell lung cancer tumour colonization. Mol Carcinog 48, 488-497 (2009)
58. T.A. Martin, R.E. Mansel, and W.G. Jiang: Antagonistic effect of NK4 on HGF/SF induced changes in the transendothelial resistance (TER) and paracellular permeability of human vascular endothelial cells. J Cell Physiol 192, 268-275 (2002) (Pubitemid 34827604)
59. T.A. Martin, G. Watkins, R.E. Mansel, and W.G. Jiang: Hepatocyte growth factor disrupts tight junctions in human breast cancer cells. Cell Biol Int 28, 361-371 (2004) (Pubitemid 38748926)
60. J.G. Swift, T.M. Mukherjee, and R. Rowland: Intercellular junctions in hepatocellular carcinoma. J Submicrosc Cytol 15, 799-810 (1983) (Pubitemid 13046012)
61. H. Robenek, C. Schopper, E. Fasske, R. Fetting, and H. Themann: Structure and function of the junctional complement of spontaneous and transplanted murine mammary carcinomas. J Submicrosc Cytol 13, 347-363 (1981)
62. A.P. Soler, R.D. Miller, K.V. Laughlin, N.Z. Carp, D.M. Klurfeld, and J.M. Mullin: Increased tight junctional permeability is associated with the development of colon cancer. Carcinogenesis 20, 1425-1431 (1999) (Pubitemid 29385425)
63. A.P. Soler, K.V. Laughlin, and J.M. Mullin: Effects of epidermal growth factor versus phorbol ester on kidney epithelial (LLC-PK1) tight junction permeability and cell division. Exp Cell Res 207, 398-406 (1993) (Pubitemid 23246812)
64. S. Boireau, M. Buchert, M.S. Samuel, J. Pannequin, J.L. Ryan, A. Choquet, H. Chapuis, X. Rebillard, C. Avances, M. Ernst, D. Joubert, N. Mottet, and F. Hollande: DNA-methylation-dependent alterations of claudin-4 expression in human bladder carcinoma. Carcinogenesis 28, 246-258 (2007) (Pubitemid 46321840)
65. M.B. Resnick, T. Konkin, J. Routhier, E. Sabo, and V.E. Pricolo: Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study. Mod Pathol 18, 511-518 (2005) (Pubitemid 40478114)
66. T. Kinugasa, Q. Huo, D. Higashi, H. Shibaguchi, M. Kuroki, T. Tanaka, K. Futami, Y. Yamashita, K. Hachimine, S. Maekawa, K. Nabeshima, and H. Iwasaki: Selective up-regulation of claudin-1 and claudin-2 in colorectal cancer. Anticancer Res 27, 3729-3734 (2007) (Pubitemid 47598437)
67. E. Montgomery, A.J. Mamelak, M. Gibson, A. Maitra, S. Sheikh, S.S. Amr, S. Yang, M. Brock, A. Forastiere, S. Zhang, K.M. Murphy, and K.D. Berg: Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesions. Appl Immunohistochem Mol Morphol 14, 24-30 (2006)
68. Y. Usami, H. Chiba, F. Nakayama, J. Ueda, Y. Matsuda, N. Sawada, T. Komori, A. Ito, and H. Yokozaki: Reduced expression of claudin-7 correlates with invasion and metastasis in squamous cell carcinoma of the esophagus. Hum Pathol 37, 569-577 (2006)
69. Y. Soini, S. Tommola, H. Helin, and P. Martikainen: Claudins 1, 3, 4 and 5 in gastric carcinoma, loss of claudin expression associates with the diffuse subtype. Virchows Arch 448, 52-58 (2006) (Pubitemid 43177415)
70. Y. Liu, W. Sun, K. Zhang, H. Zheng, Y. Ma, D. Lin, X. Zhang, L. Feng, W. Lei, Z. Zhang, S. Guo, N. Han, W. Tong, X. Feng, Y. Gao, and S. Cheng: Identification of genes differentially expressed in human primary lung squamous cell carcinoma. Lung Cancer 56, 307-317 (2007) (Pubitemid 46679087)
71. S. Paschoud, M. Bongiovanni, J.C. Pache, and S. Citi: Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas. Mod Patho 20, 947-954 (2007) (Pubitemid 47267821)
72. G.M. Sheehan, B.V. Kallakury, C.E. Sheehan, H.A. Fisher, R.P. Kaufman, Jr., and J.S. Ross: Loss of claudins-1 and -7 and expression of claudins-3 and -4 correlate with prognostic variables in prostatic adenocarcinomas. Hum Pathol 38, 564-569 (2007) (Pubitemid 46399893)
73. K.W. Seo, Y.K. Kwon, B.H. Kim, C.I. Kim, H.S. Chang, M.S. Choe, and C.H. Park: Correlation between Claudins Expression and Prognostic Factors in Prostate Cancer. Korean J Urol 51, 239-244 (2010)
74. B. Litkouhi, J. Kwong, C.M. Lo, J.G. Smedley, 3rd, B.A. McClane, M. Aponte, Z. Gao, J.L. Sarno, J. Hinners, W.R. Welch, R.S. Berkowitz, S.C. Mok, and E.I. Garner: Claudin-4 overexpression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using a C-terminal fragment of Clostridium perfringens enterotoxin. Neoplasia 9, 304-314 (2007) (Pubitemid 46608297)
75. R.A. Tassi, E. Bignotti, M. Falchetti, M. Ravanini, S. Calza, A. Ravaggi, E. Bandiera, F. Facchetti, S. Pecorelli, and A.D. Santin: Claudin-7 expression in human epithelial ovarian cancer. Int J Gynecol Cancer 18, 1262-1271 (2008)
76. M. Turunen, A. Talvensaari-Mattila, Y. Soini, and M. Santala: Claudin-5 overexpression correlates with aggressive behavior in serous ovarian adenocarcinoma. Anticancer Res 29, 5185-5189 (2009)
77. K. Borka, P. Kaliszky, E. Szabo, G. Lotz, P. Kupcsulik, Z. Schaff, and A. Kiss: Claudin expression in pancreatic endocrine tumours as compared with ductal adenocarcinomas. Virchows Arch 450, 549-557 (2007) (Pubitemid 46676254)
78. T. Sakaguchi, S. Suzuki, H. Higashi, K. Inaba, S. Nakamura, S. Baba, T. Kato, and H. Konno: Expression of tight junction protein claudin-5 in tumour vessels and sinusoidal endothelium in patients with hepatocellular carcinoma. J Surg Res 147, 123-131 (2008) (Pubitemid 351626080)
79. F. Kramer, K. White, M. Kubbies, K. Swisshelm, and B.H. Weber: Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer. Hum Genet 107, 249-256 (2000)
80. T. Hoevel, R. Macek, O. Mundigl, K. Swisshelm, and M. Kubbies: Expression and targeting of the tight junction protein CLDN1 in CLDN1-negative human breast tumour cells. J Cell Physiol 191, 60-68 (2002) (Pubitemid 34195218)
81. S. Morohashi, T. Kusumi, F. Sato, H. Odagiri, H. Chiba, S. Yoshihara, K. Hakamada, M. Sasaki, and H. Kijima: Decreased expression of claudin-1 correlates with recurrence status in breast cancer. Int J Mol Med 20, 139-143 (2007)
82. T.A. Martin, G.M. Harrison, G. Watkins, and W.G. Jiang: Claudin-16 reduces the aggressive behavior of human breast cancer cells. J Cell Biochem 105, 41-52 (2008)
83. S.L. Kominsky, P. Argani, D. Korz, E. Evron, V. Raman, E. Garrett, A. Rein, G. Sauter, O.P. Kallioniemi, and S. Sukumar: Loss of the tight junction protein claudin- 7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. Oncogene 22, 2021-2033 (2003) (Pubitemid 36523639)
84. T. Sauer, M.K. Pedersen, K. Ebeltoft, and O. Naess: Reduced expression of Claudin-7 in fine needle aspirates from breast carcinomas correlate with grading and metastatic disease. Cytopathology 16, 193-198 (2005) (Pubitemid 41112978)
85. M. Osanai, M. Murata, H. Chiba, T. Kojima, and N. Sawada: Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells. Cancer Sci 98, 1557-1562 (2007) (Pubitemid 47308450)
86. Q. Wu, Y. Liu, Y. Ren, X. Xu, L. Yu, Y. Li, and C. Quan: Tight junction protein, claudin-6, downregulates the malignant phenotype of breast carcinoma. Eur J Cancer Prev 19, 186-194 (2010)
87. Y. Soini: Claudins 2, 3, 4, and 5 in Paget's disease and breast carcinoma. Hum Pathol 35, 1531-1536 (2004) (Pubitemid 40017994)
88. S.L. Kominsky, M. Vali, D. Korz, T.G. Gabig, S.A. Weitzman, P. Argani, and S. Sukumar: Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4. Am J Pathol 164, 1627-1633 (2004) (Pubitemid 38529765)
89. A.M. Tokes, J. Kulka, S. Paku, A. Szik, C. Paska, P.K. Novak, L. Szilak, A. Kiss, K. Bogi, and Z. Schaff: Claudin- 1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study. Breast Cancer Res 7, R296-305 (2005)
90. S. Tsukita, Y. Yamazaki, T. Katsuno, and A. Tamura: Tight junction-based epithelial microenvironment and cell proliferation. Oncogene 27, 6930-6938 (2008)
91. S.L. Kominsky: Claudins: emerging targets for cancer therapy. Expert Rev Mol Med 8, 1-11 (2006) (Pubitemid 44184255)
92. K. Fujita, J. Katahira, Y. Horiguchi, N. Sonoda, M. Furuse, and S. Tsukita: Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein. FEBS Lett 476, 258-261 (2000) (Pubitemid 30410828)
93. R. Saeki, M. Kondoh, H. Kakutani, S. Tsunoda, Y. Mochizuki, T. Hamakubo, Y. Tsutsumi, Y. Horiguchi, and K. Yagi: A novel tumour-targeted therapy using a claudin- 4-targeting molecule. Mol Pharmacol 76, 918-926 (2009)
94. R. Saeki, M. Kondoh, H. Kakutani, K. Matsuhisa, A. Takahashi, H. Suzuki, Y. Kakamu, A. Watari, and K. Yagi: A claudin-targeting molecule as an inhibitor of tumour metastasis. J Pharmacol Exp Ther
95. H. Kakutani, M. Kondoh, R. Saeki, M. Fujii, Y. Watanabe, H. Mizuguchi, and K. Yagi: Claudin-4-targeting of diphtheria toxin fragment A using a C-terminal fragment of Clostridium perfringens enterotoxin. Eur J Pharm Biopharm
96. M. Kondoh and K. Yagi: Tight junction modulators: promising candidates for drug delivery. Curr Med Chem 14, 2482-2488 (2007) (Pubitemid 47618036)